Doctor insights on:
Natural Angiotensin Receptor Blockers
Losartan: Losartan is the only generic angiotensin receptor blocker available at this time. There are however several inexpensive angiotensin converting enzyme inhibitors available which generally work as well and would be a good option unless you have side effects such as cough from it. ...Read more
An organ, cell or molecule that accepts an outside signal and causes an internal change. Eyes receive light, touch receptors send messages to the brain when stimulated by pressure and estrogen receptors bind Estradiol causing responses of normal breast, ovary and uterus cells to rising and falling levels of the female steroid hormones. Most of the time "receptor" refers to one ...Read more
None: Not yet. There are none available in the USA. ...Read more
Does angiotensin receptor blockers protect or harm the kidneys and can used for my father
with hypertension and blood creatinine level of 1.7 mg/dl.
Names say it all: Angiotensin converting enzyme(ACE) inhibitor vs angiotensin receptor blocker(ARB). The names really say it all. Angiotensin which raises blood pressure needs to be activated to work. ACEs prevent that activation. ARBs directly block the activity of angiotensin. Both have similar effects but there is more evidence for heart protection with ACEs than ARBs but slightly more side effects with ACEs. ...Read more
Test: You can measure angiotensin two levels. I would talk to your cardiologist or renal specialist about the need to do this. ...Read more
Angiotensin II: Angiotensin ii stimulates the adrenal cortex to produce aldosterone which regulates salt and water reabsorption in the kidney. It is a vasoconstrictor and has effects to drive up BP through both these mechanisms. It potentates sympathetic neural output at the pregnant livonia level. ...Read more
Hypertension: Angiorensin ii is a potent vasoconstrictor and proinflammatory chemical that has effects on vascular endothelium that contribute to atherosclerosis and hypertension. In the heart it increases hypertrophy and increases arrhythmic potential. It stimulates aldosterone . It is formed through a chemical conversion of angiotensin i to angiotensin ii mediated by sympathetic activation of ace. ...Read more
Major BP problems...: Angiotensin-1-converting enzyme converts angiotensi-1 to angiotensin-2, an extremely potent vasoconstrictor, leading to high bp. It is triggered by renin, produced in the kidneys due to low blood flow. The angiotensin converting enzyme inhibitors, or acei's are used to block this, but some still gets converted in the tissue, so we use angiotensin receptor blockers, or arb's. ...Read more
peptide hormone: Produced mostly in liver, angiotensin 1 is formed after renin cleaves angiotesinogen. Renin is produced in kidneys. Angiotensin 2 is formed after ace cleaves part of it off. This than causes increased vasomotor tone as well as salt and h20 retention . This is the target for the acei drugs. ...Read more
Physiology: Angiotensin is converted from angiotensinogen and functions to help the body secrete aldosterone (which results in salt and water retention). Angiotensin i converts to angiotensin ii, and angiotensin ii has potent vasoconstrictor and proinflammatory effects on the vasculature. ...Read more
67 yrs. angiotensin 1 converting enzyme (ace) serum 126.7 , what should be done? Bad? What does this mean? Life style changes. Medication? Thank you
51 M Notes: 67 yrs angiotensin 1 converting enzyme (ace) serum 126.7 , what should be done? Bad? What does this mean? Life style changes. Medication? Thank you
ANS: not enough information to help at this point. Are you 51 or 67? Need to know why it was measured, what meds, other illnesses, & what is normal in that lab. Get this information & will be happy to do 2nd opinion as I specialize in RAAS ...Read more
AII vs aldo and salt:
Aldo causes more Na retention and water follows salt.
But depends on circumstances. AII is major drive to aldo production so if AII high get same effect if you don't die form the severe HTN from excess AII.
Both can be counteracted if you eat less salt. I am a specialist in the renin angiotensin aldosterone system and happy to consult with you. ...Read more
If someone was to have low angiotensin II and low aldosterone would you expect to see a lower renin also?
Renin levels: If one has a low aldosterone and angiotensin ii, one would expect a high renin level. Renin leads to angiotensin i and ii synthesis. If those levels are low and the person is ambulatory, the person's renin would be expected to be high. For a diagram of the renin-angiotensin-aldosterone system go to this link; http://www.Google.Com/search?Hl=en;site=imghp;tbm=isch;source=hp;biw=2556;bih=1234;q=renin+angiotensin+system;oq=+angiotensin+sy;gs_l=img.1.1.0j0i5l9.576.4679.0.9029.16.9.0.22.214.171.124.974.0j5j1.6.0....0...1ac.1.35.Img..5.11.985.Luxw_l48srm#fa. ...Read more
Why does Primary hypoaldosteronism lead to increased renin and Angiotensin II, but secondary hypoaldosteroninim does not?
Renin-AT II-ALD axis: With primary (1°) hypoaldosteronism, feedback on the renin-angiotensin (AT) II-aldosterone (ALD) axis would cause the kidneys to increase renin and thereby AT II to try ^ adrenal ALD. In 2° hypoaldo, there is usually kidney damage (for example, due to diabetes) which decreases renin and hence AT II (which is produced in response to renin). This causes ALD (which depends on AT II) to v (hence 2°). ...Read more
I have a slightly elevated angiotensin conv. Enzyme the cut off was 53 and i was 64. Does this mean I have sarcoidosis? And is that a fatal illness?
See below: Sarcoidosis can be such a mild disorder that no treatment is needed or can be life-threatening. Most of the time simple treatments - not steroids - will control the disease. Workup for underlying causes/mimics is essential. Ace levels are meaningful only related to clinical symptoms. Rheumatologist should provide clarification. ...Read more
If there is a normal level of renin, there should be a normal level of angiotensin II and aldosterone right? So low angiotensin II = low aldosterone?
Aldosterone: Not really. It depends upon sensitivity of adrenal galnds to angitensin ii. ...Read more
Is there anyway to increase angiotensin ii, my body does not produce it despite normal renin, autonomic nerve issue.
Meaningless: If your renin is normal, you don't need any higher angiotensin ii which is an intermediate step in the synthesis of renin. From you posts, it sounds like you might have hypothalamic/pituitary insufficiency - have you seen an endocrinologist? ...Read more
Very low angiotensin ii, normal ACTH, aldosterone, cortisol and renin? Why angiotensin ii very low if everything else normal? Doesn't make sense?
Data: Need more data. You should see a good endocrinologist. ...Read more
Aldosterone 161 pmol/l - renin/aldosterone ratio 5 - renin 11.4 ng/l - angiotensin II 8ng/l. I have postural orthostatic tachycarda. Why low angioten?
All connected: I am not an expert on this and you don't mention your lab standards so it is hard to say, but they are all connected to each other to regulate the volume of fluid and salt held or released by your kidney and there for your blood pressure. Too little salt then too little volume of blood and BP drops when you stand. ...Read more
Patient female 44 years old with angiotensin converting enzyme results show 75 h 9-67 u/l. Autoimmune disease?
I have a positive ANA 1:640 homogenous nuclear staining. Does this mean scleroderma or lupus? I also have a very slightly elevated angiotensin conv en
Depends: No diagnosis can be firmly established with a single blood test even in your case. Bone pain is not the usual manifestation of an autoimmune disease. Why was the test ordered in the first place? If your doctor suspects the presence of an autoimmune disorder , more tests will be needed to pin down the diagnosis. ...Read more
Male 22 angiotensin II was 8ng/l and aldosterone 161 pmol/l i urinate a lot and have pots. Could this cause low blood volume?
Can't answer: Normal values vary from lab to lab. This question is complex and can't be answered in a vacuum. ...Read more