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Doctor insights on: Natalizumab

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Tysabri (natalizumab)?

Tysabri (natalizumab)?

PML risk: Tysabri (natalizumab) is generally reserved for patients who have failed treatment with avonex, rebif, Betaseron (interferon beta 1b) and copaxone. It is usually easy to take, but there is a risk of activating a potentially lethal brain infection, progressive multifocal leukoencephalopathy (pml). If the test for prior infection with jc virus is negative, the risk of the infection may be very low. ...Read more

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Tysabri (natalizumab). Do you know about this pill?

Tysabri (natalizumab). Do you know about this pill?

MS: Tysabri (natalizumab) is not a pill. Gilenya is the sole oral agent on the market at this time. Tysabri (natalizumab) is infused through the vein once monthly. Although the most effective med on the market, there is risk of a deadly infection after use for greater than 2 years. Your neurologist can help decide whether this is the drug for you. ...Read more

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Which is better? Interferon or tysabri (natalizumab)?

Which is better? Interferon or tysabri (natalizumab)?

NO contest: Tysabri (natalizumab) is the second most potent MS drug on the market, but it has a risk, as can potentially cause Progressive Multi-focal Encephalopathy, and possibly melanoma. Interferons are drugs of the past, and being phased out over time, due to lack of efficacy, but they are quite safe in most patients. ...Read more

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What is the active ingredient of tysabri (natalizumab)?

I'm puzzled: The "active ingredient" in Tysabri is Tysabri. The generic name is natalizumab. This isn't Alka-Seltzer we're dealing with; it's a highly purified intravenous drug. Do I misunderstand your question? ...Read more

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What are the benefits of tysabri (natalizumab) v. Other MS drugs?

What are the benefits of tysabri (natalizumab) v. Other MS drugs?

Hard to answer: Tysabri (natalizumab) is a potentially effective treatment for MS but your question would be difficult to answer. Tysabri (natalizumab) is approved for the treatment of aggresive or refractory MS where other equally effective medications have not worked. This is because of a possibly fatal side effect called pml which may cause more damage than the disease. Use requires an experienced doctor and close monitoring. ...Read more

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Does anyone know where a tysabri (natalizumab) infusion center is?

Does anyone know where a tysabri (natalizumab) infusion center is?

MS: Typically, most medical schools use infusion centers on site. Many outpatient cancer centers can infuse tysabri (natalizumab) also. Many community hospitals can provide this service. ...Read more

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Does the benefit of tysabri (natalizumab) outweigh the risk of PML ?

Does the benefit of  tysabri (natalizumab) outweigh the risk of PML ?

Individualized: Tysabri/natalizumab is an immunosuppressant used in the treatment of relapsing forms of MS. PML (progressive multifocal leukoencephaolopathy),the result of JC virus infection, is a disastrous side effect.The decision to use this drug has to be very cautiously assessed by the MS patient & his doctor & administered through a restricted program. Risk/benefit analysis is complicated & challenging. ...Read more

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Has anyone ever taken tysabri (natalizumab) for multiple sclorosis with relief?

Has anyone ever taken tysabri (natalizumab) for multiple sclorosis with relief?

MS: Tysabri (natalizumab) is a well tolerated medicine, infused once monthly. It is clearly the most effective ms drug on the market but has a risk of a life threatening infection, pml. Does reduce relapses, disabiity, and MRI lesions, and seems to improve fatique and depression also. ...Read more

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Is "a sense of impending doom" a symptom that something could be wrong?  am taking bupropian and tysabri (natalizumab). Should I see a dr?

Is "a sense of impending doom" a symptom that something could be wrong?  am taking bupropian and tysabri (natalizumab). Should I see a dr?

See a doc: A sense of impending doom is one of the symptoms of a panic attack, though you do not mention other symptoms. First see your medcal doc and if all is well, see a psychiatrist. ...Read more

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Does tysabri / natalizumab increase the risk of shingles?

Does tysabri / natalizumab increase the risk of shingles?

Yes: If you have had chickenpox, then taking Natalizumab will increase your risk of developing shingles. Exactly how much your risk is increased is unknown but Natalizumab use has been associated with an increased risk of serious herpes virus infections (the virus that causes shingles is a herpes virus). ...Read more

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What expect when abruptly quitting natalizumab infusion? I'm being treated for ms

What expect when abruptly quitting natalizumab infusion? I'm being treated for ms

Risky idea: If you stop your infusions abruptly, and do not replace with a potent ms agent such as gilenya, you will be at very high risk for a relapse, and a substantial rebound of the disease, at about 3 months. If you do have a positive anti-jcv antibody test, you and your doctor might decide to stop tysabri (natalizumab) by 18-24 months, but you need to start a new medication. Discuss with your neurologist. ...Read more

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Dx w ms, yr ago. Tx: on 7 inf. Of tysabri (natalizumab). Feel cold coming on, hvn't been sick w cold/flu since. Worry abt getting sick w dx. Sugg meds, coping, etc-?

Dx w ms, yr ago. Tx: on 7 inf. Of tysabri (natalizumab). Feel cold coming on, hvn't been sick w cold/flu since. Worry abt getting sick w dx. Sugg meds, coping, etc-?

Advice: The Tysabri (natalizumab) will not make you infection necessarily worse, and you should be treated by your doctor in the standard approaches for colds or flus. Since viral infections might cause fever, worsening your symptoms, high temps should be controlled. Notify your neurologist, as a virus can promote a true relapse, also, and get meds, if your symptoms worsen longer than 24 hrs. ...Read more

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Is tysabri (natalizumab) a treatment for ms?

Yes: This is a monoclonal antibody, infused once monthly, and is the currently most potent medication on the market for MS. In several cases, a deadly infection called PML has occurred with pts taking this medication, but blood tests can predict risk, and if positive can prompt the discontinuation of Tysabri (natalizumab).. Drug can be used early or late, but is approved for first line. ...Read more

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Can I take vitamins while on tysabri (natalizumab)?

Can I take vitamins while on tysabri (natalizumab)?

MS: Yes, and many patients do take b and d supplements. Vitamin d-3 is used in many ms patients to further stabilize the immune process. There is evidence of relapse rate reduction and decreased MRI lesions occurs with appropriate vitamin d supplements. Discuss with your neurologist. ...Read more

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Can I take tamiflu if im on MS drug tysabri (natalizumab)?

Can I take tamiflu if im on MS drug tysabri (natalizumab)?

Yes, but see below: We have good evidence that flu vaccines with dead viruses are effective with tysabri (natalizumab).. Tamiflu is an antiviral med that may alleviate some of flu symptoms and shorten duration, and would be unlikely to cause problems with tysabri (natalizumab). Might be wiser, though, to get a flu shot, and avoid nasal vaccine, as it is a live attenuated virus and adds risk. ...Read more

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A can a person taking tysabri (natalizumab) have live vaccines?

A can a person taking tysabri (natalizumab) have live vaccines?

No.: Because of the effects of the drug on the immune system, live attenuated vaccines such as the shingles vaccine, the intranasal flu vaccine and MMR are not to be used. ...Read more

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Iis there anyone who has multiple sclerosis and taking tysabri (natalizumab)?

Iis there anyone who has multiple sclerosis and taking tysabri (natalizumab)?

Tysabri (natalizumab): I dont know the numbers but there are several patients who are taking injections of tysabri (natalizumab). ...Read more

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I was diagnosed with multiple sclerosis and dr wants me on tysabri;what is it?

I was diagnosed with multiple sclerosis and dr wants me on tysabri;what is it?

Tysabri (natalizumab): Tysabri is (natalizumab) injections.It is used to prevent episodes of symptons and slow the worsening of disability in people who have relapsing forms(course of disease where symptoms flare p from time to time)of multiple sclerosis. ...Read more

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I have multiple sclerosis, should I take tysabri (natalizumab)? For my medication

Maybe: Tysabri (natalizumab) is a highly effective, once-monthly IV therapy for relapsing forms of ms. It is generally used as a second or third line treatment due to the risk of a rare brain infection. However, depending on how your ms is acting, the risk may well be worth it in order to control your disease. This is a decision between you and your treating neurologist. Discuss concerns with him/her. ...Read more

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