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Doctor insights on: Natalizumab

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Glatiramer acetate (copaxone) vs. Interferon?

Glatiramer acetate (copaxone) vs. Interferon?

See answer below: Both are used in rrms with similar efficacy levels. Copaxone (glatiramer) does not need blood monitoring and is administered as a subcutaneous sc injection daily. Side effects include injection site reactions. Interferons need lab work monitoring, can be a weekly injection into a muscle (avonex), every other day sc (betaseron) or three times a week sc (rebif). Most commo side effects include flu-like symptoms. ...Read more

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What expect when abruptly quitting natalizumab infusion? I'm being treated for ms

What expect when abruptly quitting natalizumab infusion? I'm being treated for ms

Risky idea: If you stop your infusions abruptly, and do not replace with a potent ms agent such as gilenya, you will be at very high risk for a relapse, and a substantial rebound of the disease, at about 3 months. If you do have a positive anti-jcv antibody test, you and your doctor might decide to stop tysabri (natalizumab) by 18-24 months, but you need to start a new medication. Discuss with your neurologist. ...Read more

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Which is better? Interferon or tysabri (natalizumab)?

Which is better? Interferon or tysabri (natalizumab)?

NO contest: Tysabri (natalizumab) is the second most potent MS drug on the market, but it has a risk, as can potentially cause Progressive Multi-focal Encephalopathy, and possibly melanoma. Interferons are drugs of the past, and being phased out over time, due to lack of efficacy, but they are quite safe in most patients. ...Read more

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Does tysabri / natalizumab increase the risk of shingles?

Does tysabri / natalizumab increase the risk of shingles?

Yes: If you have had chickenpox, then taking Natalizumab will increase your risk of developing shingles. Exactly how much your risk is increased is unknown but Natalizumab use has been associated with an increased risk of serious herpes virus infections (the virus that causes shingles is a herpes virus). ...Read more

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Is tysabri (natalizumab) a treatment for ms?

Is tysabri (natalizumab) a treatment for ms?

Yes: This is a monoclonal antibody, infused once monthly, and is the currently most potent medication on the market for MS. In several cases, a deadly infection called PML has occurred with pts taking this medication, but blood tests can predict risk, and if positive can prompt the discontinuation of Tysabri (natalizumab).. Drug can be used early or late, but is approved for first line. ...Read more

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What are the benefits of tysabri (natalizumab) v. Other MS drugs?

What are the benefits of tysabri (natalizumab) v. Other MS drugs?

Hard to answer: Tysabri (natalizumab) is a potentially effective treatment for MS but your question would be difficult to answer. Tysabri (natalizumab) is approved for the treatment of aggresive or refractory MS where other equally effective medications have not worked. This is because of a possibly fatal side effect called pml which may cause more damage than the disease. Use requires an experienced doctor and close monitoring. ...Read more

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Can switching from tysabri (natalizumab) to tecfidera wash out period?

Can switching from tysabri (natalizumab) to tecfidera wash out period?

Comments: Current opinion is best to have as brief a washout as possible, as relapse or rebound can readily occur by 3 months if another medication has not been started. You need to be aware, if you have positive anti-JCV antibody test, that Tecfidera can also cause PML infection, and a different med may be preferable. Discuss with MS specialist. ...Read more

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Iis there anyone who has multiple sclerosis and taking tysabri (natalizumab)?

Iis there anyone who has multiple sclerosis and taking tysabri (natalizumab)?

Tysabri (natalizumab): I dont know the numbers but there are several patients who are taking injections of tysabri (natalizumab). ...Read more

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I've read in healthtap about tecfidera, gilenya (fingolimod) and tisabry MS treatments. What's your opinion about interferon treatment (using rebif 44mg)?

Not first choice: Look, we are in a new age of treatment, and need to acknowledge that the older injectables were great to use, but the drugs you listed are far more effective, and avoid needles (except tysabri, (natalizumab) one infusion monthly) yet, risks are present with all three, and in comparison with rebif, absence of long-term safety data. If you are doing well, could stay on current med, but change if MRI is active. ...Read more

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Has anyone ever taken tysabri (natalizumab) for multiple sclorosis with relief?

Has anyone ever taken tysabri (natalizumab) for multiple sclorosis with relief?

MS: Tysabri (natalizumab) is a well tolerated medicine, infused once monthly. It is clearly the most effective ms drug on the market but has a risk of a life threatening infection, pml. Does reduce relapses, disabiity, and MRI lesions, and seems to improve fatique and depression also. ...Read more

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Cimzia (certolizumab pegol) 200 ? Uguale a humira?

Cimzia (certolizumab pegol) 200 ? Uguale a humira?

Similar medications: Cimzia (certolizumab pegol) and Humira both work by blocking tnf alpha. They are similar medications but not the same. They should not be used together. They both increase the risk of infection. They both increase the risk from tuberculosis. ...Read more

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Does anyone know where a tysabri (natalizumab) infusion center is?

Does anyone know where a tysabri (natalizumab) infusion center is?

MS: Typically, most medical schools use infusion centers on site. Many outpatient cancer centers can infuse tysabri (natalizumab) also. Many community hospitals can provide this service. ...Read more

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How close in relationship is tecfidera & copaxone (glatiramer)?

How close in relationship is tecfidera & copaxone (glatiramer)?

VERY DIFFERENT: Entirely different chemical classes, with distinct different mechanisms of action, and outcome data. Both seem safe, Copaxone (glatiramer) tho is injected daily, causes lipoatrophy, hypertension, and injection reactions. Tecfidera may be tough to tolerate due to flushing, nausea, diarrhea, stomach pain. Copaxone (glatiramer) relapse reduction is 29%, but tecfidera, drops 44-52%, oral twice daily, no needles. Talk to doc. ...Read more

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Are imuran (azathioprine) & betaferon effective treatments for ms?

Are imuran (azathioprine) & betaferon effective treatments for ms?

Yes they can be: The evidence is stronger for beta interferons (avonex, Rebif and betaseron) than it is for immuran. Interferons are fda approved and immuran is not (for ms) they all have a modest but definite effect in reducing the number of attacks in remitting relapsing forms the effect varies from patient to patient. ...Read more

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Would you recommend Gilenya (fingolimod) or Tecfidera as choice for new oral meds for MS?

Would you recommend Gilenya (fingolimod) or Tecfidera as choice for new oral meds for MS?

Reasonable, but...: It is a reasonable question; but, the answer is not that simple, maybe. I suggest you look at the National Multiple Sclerosis Society web site, where available meds are discussed. Both meds are outrageously expensive, even though the chemical in Tecfidera has been around for decades (arguably no justification for its cost). Tecfidera arguably has a better side-effect profile. Talk to your MD ...Read more

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What expect when abruptly quitting natalizumab infusion? I'm being treated for ms

Risky idea: If you stop your infusions abruptly, and do not replace with a potent ms agent such as gilenya, you will be at very high risk for a relapse, and a substantial rebound of the disease, at about 3 months. If you do have a positive anti-jcv antibody test, you and your doctor might decide to stop tysabri (natalizumab) by 18-24 months, but you need to start a new medication. Discuss with your neurologist. ...Read more

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A can a person taking tysabri (natalizumab) have live vaccines?

A can a person taking tysabri (natalizumab) have live vaccines?

No.: Because of the effects of the drug on the immune system, live attenuated vaccines such as the shingles vaccine, the intranasal flu vaccine and MMR are not to be used. ...Read more

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Does tysabri / natalizumab increase the risk of shingles?

Yes: If you have had chickenpox, then taking Natalizumab will increase your risk of developing shingles. Exactly how much your risk is increased is unknown but Natalizumab use has been associated with an increased risk of serious herpes virus infections (the virus that causes shingles is a herpes virus). ...Read more