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Doctor insights on: Naloxone Challenge Test

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Can Narcan (naloxone) cause false negative on blood test?

Can Narcan (naloxone) cause false negative on blood test?

No: Narcan (naloxone) cannot produce a false negative drug screen. Narcan (naloxone) merely competitively inhibits opioids at the opioid receptor.

Dr. Colin Feeney
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Naloxone (Definition)

Naloxone is a drug that decreases narcotic effects which is a ...Read more


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How long does naloxone stay in your urine? For it not to show up in a drug test

How long does naloxone stay in your urine? For it not to show up in a drug test

Naloxone in urine: This will depend on the testing method used. I would ask the person ordering the test this question.

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If being tested SPECIFICALLY for naloxone, meaning only naloxone and nothing else, how long would it or its metabolites be detectable on a lab test?

Half life: Thank you for clarifying. To indirectly answer your question, half life of naloxone is about 1.6 hours. Metabolism is in the liver. 75% of all original product and metabolites will be cleared by 3days and over 90% in a week. The reported sensitivity of the serum test is to less than 1%, so extrapolating about 10 days would be required.

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Could drug screens at a pain management clinic test for naloxone?

Not usually: Naloxone is not screened for in most tests used for that purpose, although in larger amounts it may cross-react with the test for morphine/codeine. If confirmatory testing is done (gas chromatography/mass spectroscopy and others), Naloxone can be specifically identified, if one is looking for it. Did you od and get treated with naloxone? Your doctors need to know that immediately.

Dr. Alan Ali Dr. Ali
2 doctors agreed:
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Who should not take Narcan (naloxone)?

Dr. Alan Ali Dr. Ali
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Narcan (naloxone) contraindicat: Ones with hypersensitivity to Narcan (naloxone) or similar products.

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Is it possible to overdose on naloxone?

No: Naloxone is an opiate antagonist that does not lead to intoxication.

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How fast does Narcan (naloxone) typically work?

Really fast: If Narcan (naloxone) is given IV to overcome an opiate od, the effects are almost immediate. If it is given im the response is slower.

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Is there a maxiumum dosage for narcan (naloxone)?

Yes: The maximum dosage for any individual depends on many factors, however the manufacturer oftens states a maximum dosage for certain individuals. There is a maximum dosage for all medications.

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What happen if not enough Narcan (naloxone) is given?

What happen if not enough Narcan (naloxone) is given?

Reversal agents: Narcan (naloxone) is used as a reversal agent for opiates. If suboptimal doses are given, then the opiate side effect will not be blocked/reversed. Too much Narcan (naloxone) is also bad.

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How long does it take naloxone to get out of my system?

How long does it take naloxone to get out of my system?

Nifty Naloxone: Naloxone, or Narcan (naloxone) is intended to reverse narcotic overdose and is usually given in the vein, muscle or breathing tube (in emergencies). It has a very rapid onset of action but a short life in the body. It's half life is 64 minutes, which means in approximately 4 hours it is completely out of the body primarily through the kidneys. Diminished kidney function could prolong the drug effect.

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Naloxone, how long to get the drug out of my baby's system?

Not long: A few hours. Are you sure you are referring to the right drug?

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I need to know if there is a maxiumum dose for narcan (naloxone)?

Lexi Drugs answer: From one of the pharmacology books: "if no response is observed after 10 mg total, consider other causes of respiratory depression.".

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Can you be allergic to naloxone?

It is possible: It is possible to be allergic to any medication. A medication has other ingredients, such as stabilizers, preservatives, pH buffers, etc..., and a person may be allergic to one of the other ingredients. Also, a person can be ok with the drug, but react to a breakdown product of the drug, or react to a "bound" combination of the drug+substance (the substance may be from the person's own body).

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Can you take atropine with narcan (naloxone)?

Yes, but why?: Anesthesiologist use these combination occasionally, but under very controlled circumstances. These would be dangerous medications to mix by non anesthesiology trained people

Dr. Ionel Rad
90 Doctors shared insights

Narcan (Definition)

Narcan is a drug that decreases narcotic effects which is a ...Read more