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Doctor insights on: Mysoline

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Dr. Linda Callaghan
13 doctors shared insights

Mysoline (Overview)

Mysoline is a seizure agent which is a kind of brain and nerve drug.


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Mysoline (primidone) -- how long does it take to work?

Mysoline (primidone) -- how long does it take to work?

15 minutes plus: Mysoline (primidone) is only available for oral use. Therefore, it will take at least 15 minutes before a useful blood level can be reached. It can take much longer depending on factors such as person's age, general health, weight, fever, type of condition treated, etc. ...Read more

Dr. Linda Callaghan
13 doctors shared insights

Mysoline (Overview)

Mysoline is a seizure agent which is a kind of brain and nerve drug.


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I recently changed anti seizure meds to mysoline (primidone) (250mg 2xday) and occasionally take klonopin 2 mg prn. Any known interactions btw the 2?

I recently changed anti seizure meds to mysoline (primidone) (250mg 2xday) and occasionally take klonopin 2 mg prn. Any known interactions btw the 2?

Mysoline (primidone): They are potent CNS depressant. Tiredness, sleepiness, drowsiness, k poor concentration, slow reaction time, lethargy are expected symptoms when used in combination. ...Read more

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Mysoline (primidone) -- how long does it take to work?

15 minutes plus: Mysoline (primidone) is only available for oral use. Therefore, it will take at least 15 minutes before a useful blood level can be reached. It can take much longer depending on factors such as person's age, general health, weight, fever, type of condition treated, etc. ...Read more

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Please tell me about mysoline (primidone) tabs? Is it for seizures?

Please tell me about mysoline (primidone) tabs?  Is it for seizures?

Yes: Mysoline, generically known as primidone, is an anti-convulsive drug. It is also useful for treating certain types of tremor. This is an "old" drug, but still useful in the right situations. ...Read more

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I recently changed anti seizure meds to mysoline (primidone) (250mg 2xday) and occasionally take klonopin 2 mg prn. Any known interactions btw the 2?

Mysoline (primidone): They are potent CNS depressant. Tiredness, sleepiness, drowsiness, k poor concentration, slow reaction time, lethargy are expected symptoms when used in combination. ...Read more

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I wanna check if it is ok to take one Ritalin and full pill of mysoline and full pill Paxil (paroxetine)? Because my doctor said it is but I feel weird

I wanna check if it is ok to take one Ritalin and full pill of mysoline and full pill Paxil (paroxetine)?  Because my doctor said it is but I feel weird

Different time: Please do not take them together. Take them at different time of the day Also please talk to your doctor, if possible to stop mysoline and just take Ritalin and Paxil (paroxetine) ...Read more

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Can primidone 100mg/day cause cognitive deficits?

Can primidone 100mg/day cause cognitive deficits?

Maybe: Primidone does have sedative properties which can cause cognitive deficits but not permanently. However, I cannot speak for the original condition the drug has been prescribed which may cause cognitive deficits. ...Read more

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Why would someone need a primidone blood measurement?

Why would someone need a primidone blood measurement?

To prevent toxicity: Primidone has a complex metabolism and active metabolites. It is affected by failure of other organ systems so levels must be monitored. ...Read more

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Can I take primidone while breastfeeding?

Can I take primidone while breastfeeding?

Yes: Caution should be taken if breastfeeding while on this med. Both primadone and a metabolite Phenobarbital will pass to baby and can produce sedation in the neonatal period. Relative transfer <9% of mothers dose, with serum levels from trace to <1/2 therapuetic for both. Harriet lane c2-caution, hale L3 moderately safe. See medications and mothers milk 14ed. Hale, 2010. ...Read more

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Taking primidone and alkaline phosphatase is going up. Do I care?

Alk Phos: While Primidone may be the culprit, bone or liver disease must be ruled out. I would recommend a fractionated alk phos (shows which isoenzyme is elevated) and then proceed accordingly -- you may benefit from a right upper quadrant ultrasound (if liver isoenzyme is elevated) or a bone scan (if bone isoenzyme is elevated). ...Read more

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My hands jerk n I don't know if it's from my medication? Please help, I take primidone 250mg n it's not working.

Get diagnosed: Your jerks might represent myoclonus, and unlikely that Primidone is culprit, as it usually suppresses tremors, and focal seizures. But in some cases, older anti-epileptic drugs, especially those metabolized to barbiturates, could worsen myoclonus. Get this phenomenon diagnosed, and revise therapy as needed. Get referred to a neurologist. ...Read more

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I've heard seroquel (quetiapine) makes you shake, is this true? Cause every day I shake n I have r to take primidone.

I've heard seroquel (quetiapine) makes you shake, is this true? Cause every day I shake n I have r to take primidone.

See both abilify (aripiprazole) ;: Seroquel (quetiapine) listed under medications. Both of these meds can be very effective but have potential for different types of movements: shaking, akathisia, tremor ; tardive dyskinesia. Don't know why you are taking these medications since you re only listed conditions are "anxiety" ; "anxiety disorder". It is always important to know why a particular medication is being ordered ; possible side effects,. ...Read more

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Primidone what is the dosage for essential tremor?

Primidone what is the dosage for essential tremor?

Essential Tremor: Primidone (mysoline) is a structural analogue of phenobarbital. The drug reduces tremor amplitude by 60% to 70%. Although Primidone therapy reduces hand tremor, tremors of the head, voice, and other areas improve less. The starting dose of Primidone should be low (12.5-25 mg), taken at bedtime, and gradually increased until tremor reduction is achieved. The maximum dosage is 750 mg/day divide tid. ...Read more

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Taking primidone for tremors. Supposed to increase from 25mg to 50 mg tomorrow. It makes me dizzy will this go away or should I ask for new meds?

Slow titration: Primidone may be side effect prone, but with continuation of medication, these side effects can subside. Continuing on the same dose for a longer period prior to titrating upwards may be one strategy to lessen side effects and improve tolerability. ...Read more

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Pat. With essential tremor not response to propranolol and primidone. What is next management?

Many: Propranolol can be incr to as much as 320 mg a day if hr and BP permit. Primidone can be increased to as much as 750 mg/day, limited initially by n, v, and ataxia (incoordination). Other drugs are: gabapentin, alprazolam, topiramate and finally, deep brain stimulation. Tremor that does not cause impairment or embarrassment does not require treatment. ...Read more

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Medicine prescribed for benign essential tremor (sounds like myciline) 50 mg bid?

Mysoline (primidone): Primidone is old medicine which break to phenobarbitol, it helps essential tremors, usually taken starting 50 mg. ...Read more

Dr. Bernard Seif
14 doctors shared insights

Primidone (Definition)

Primidone is a seizure agent which is a kind of ...Read more


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