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The question is not about me I understand that an acute transformation of overlap myeloproliferative/myelodyplastictiy disorder is the terminal phase of the disorder But what is a blastic transformation of the disorder? Is it the same thing as an ac?
Acute vs blastic?: In the chronic and dysplastic hematologic malignancies that you mention (CMML and MDS), the term "acute" transformation means an evolution to acute leukemia. This is defined as more than 20% "blast" cells microscopically. Therefore acute and blastic transformation are the same thing. ...Read moreSee 1 more doctor answer
Varaible: There are 3 main types- essential thrombocytosis (et), polycythemia vera (pv) and myelofibrosis (mf). In et, there is increased clotting and risk for strokes. In pv, there is generalized itchiness, ruddy face, and stroke risk. In mf, patients get low blood counts over time causing fatigue, large spleen, poor appetite, abdomen pain, transfusion need. ...Read more
See below: You may consult this site for info on this topic: http://www.umm.edu/health/medical/altmed/condition/myeloproliferative-disorders ...Read more
Is it unusual (even if possible) for overlap myeloproliferative-myelodysplastic disorder to lower an elderly person's oral temperature below 36C for about 50% of his temp readings over 2 weeks? The temperatures are highly likely to be accurate.
Can be normal : You don't need anything at all to see this is older folks. Trusting they are not hypothyroid, but if they are getting around okay, I would draw no conclusion. Different folks have different baselines and some older folks normally run a bit cooler ...Read moreSee 1 more doctor answer
Myeloid and: Lymphoid refer to blood and marrow elements. Mri cannot greatly help, but can show marrow signal abnormalities. A bone marrow follows evaluation of a smear to discern type and yes no to leukemia, imaging not in the line up unless symptom point to a bone, . ...Read moreSee 1 more doctor answer
Abnormal(high) blood: This disorder is suspected in individuals who have a very high WBC count(Like in CML) and also has a genetic abnormality(Philadelphia Chromosome present). Other patients have Myelofibrosis where there is a very big enlargement of the spleen. Occasionally it is just very platelet count(Essential Thrombocythemia(ET) ...Read more
What is the prognostic significance of a jak2 mutation in a person without the defining criteria for a myeloproliferative disorder ?
Need close follow-up: The specificity of the jak2 v617f pcr test for the diagnosis of myelpproliferative disorder is very high, near 100%. After excluding sample mix-up, any patient with a positive jak2 mutation should be carefully followed for the development of polycythemia vera, myelofibrosis, or essential throbocythemia. ...Read more
A friend of mine has a myeloproliferative blood disorder, which is the overproduction of blood cells. Could this be the start of leukemia?
Is it likely that the chronicity of overlap myeloproliferative-myelodysplastic disorder would by itself cause this rising CRP (30.5 mg/L 37.8; 54.3 ; 66.0; 110.0; 126.9; 148.5; 89.6; & 147.3)? It will be investigated bit I still desire an opinion now
Too many platelets: The myeloproliferative neoplasms (mpns) involve terminal myeloid cell expansion in the peripheral blood, resulting in various combinations of erythrocytosis (rbc's), leukocytosis (wbc's), thrombocytosis (platelets), bone marrow hypercellularity/fibrosis, and splenomegaly (enlarged spleen). Essential thrombocythemia is a diagnosis of exclusion, made when other forms of mpn are ruled out. ...Read more
Too many platelets: Myeloproliferative disorders are a set of marrow malignancies characterized by excessive production of certain types of blood cells. Essential thrombocytopenia is one of them, in which marrow makes too many platelets. There are well-tolerated oral agents which help. Other myelodysplastic syndromes are polycythemia vera and chronic myelogenous leukemia. ...Read more
Is overlap myelodysplasticity myeloproliferative disorder a name for one disorder with common features of two disorders or the one blood disorder ?
Spectrum of disease : Myelodyaplastic syndrome is a type of myeloproliferative disorder. So it's one disease but there is a spectrum. Myelodyaplasia means abnormal looking blood cells seen in your blood or in the bone marrow. This is usually due to an underlying bone marrow issue like infection or a possible bone marrow cancer and a bone marrow biopsy could be warranted at this point. Talk to your doctor . Take care. ...Read moreSee 1 more doctor answer
If a 91 year old has an acute transformation of his myeloproliferative disorder & is treated then would the treatment normally be given an in ICU?
Depends: Doctors usually recommend treatment based on the patients needs. ICU ensures close monitoring and fast response to any sign of major complication. For a 91 y/o it depends on his overall health status, prognosis and the extent of treatment elected by patient or his proxy. ...Read more
In general, if a 91 yr-old has acute transformation of a myeloproliferative disorder then is it worthwhile to treat the pt, if there is a treatment?
It depends: It depends on the Diagnosis of the new transformations(there are multiple ways transformation occurs...so tell us what is the new diagnosis and we can guide you further. ...Read more
Are there any treatments for acute transformation of overlap myelodysplascity/myeloproliferative disorder in an elderly patient If so, what are they?
Try hypomethylating: CMML is common form of overlap syndrome, can be treated with hypomethylating agent (VADAZA) as MDS. Efficay? If acute transformation to acute leukemia (AML), then should treat leukemia. If pt is older and not a candidate for intense induction, hypomethylating is also an option. For other acute transformation, treat them accordingly. Sometime, just supportive care or clinical trial consideration. ...Read more
Is there a medical definition of "immuncompromised"? Would someone with a neutrophil count of 14.1 x10^9 or myeloproliferative disorder qualify?
Yes: Immunocompromised means that you have an impaired immune system but the impairment may be different from one individual to another. People with myeloproliferative disorder can indeed be immune- compromised due to diminished and/or defective number of immune cells (mostly lymphocytes) produced . Low but not high neutrophils also increases the risk to get seriously ill from even minor infections. ...Read moreSee 1 more doctor answer
my mother had myeloproliferative disorder or syndrome & a dr. Tod me i will eventually turn into leukemia. It doesn't have to turn into l. Rt?
Correct: The myeloproliferative disorders are polycythemia vera, essential thrombocythemia, and myelofibrosis. Of these three, only myelofibrosis is known to progress to leukemia, and only rarely. Did you mis-hear and the diagnosis is actually myelodysplastic syndrome? Perhaps, since myelodysplastic syndrome can turn into leukemia. Perhaps double-check and ask which kind of mpd she has. ...Read more