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The question is not about me I understand that an acute transformation of overlap myeloproliferative/myelodyplastictiy disorder is the terminal phase of the disorder But what is a blastic transformation of the disorder? Is it the same thing as an ac?
Acute vs blastic?: In the chronic and dysplastic hematologic malignancies that you mention (CMML and MDS), the term "acute" transformation means an evolution to acute leukemia. This is defined as more than 20% "blast" cells microscopically. Therefore acute and blastic transformation are the same thing. ...Read moreSee 1 more doctor answer
Varaible: There are 3 main types- essential thrombocytosis (et), polycythemia vera (pv) and myelofibrosis (mf). In et, there is increased clotting and risk for strokes. In pv, there is generalized itchiness, ruddy face, and stroke risk. In mf, patients get low blood counts over time causing fatigue, large spleen, poor appetite, abdomen pain, transfusion need. ...Read more
Myeloid and: Lymphoid refer to blood and marrow elements. Mri cannot greatly help, but can show marrow signal abnormalities. A bone marrow follows evaluation of a smear to discern type and yes no to leukemia, imaging not in the line up unless symptom point to a bone, . ...Read moreSee 1 more doctor answer
Abnormal(high) blood: This disorder is suspected in individuals who have a very high WBC count(Like in CML) and also has a genetic abnormality(Philadelphia Chromosome present). Other patients have Myelofibrosis where there is a very big enlargement of the spleen. Occasionally it is just very platelet count(Essential Thrombocythemia(ET) ...Read more
What is the prognostic significance of a jak2 mutation in a person without the defining criteria for a myeloproliferative disorder ?
Need close follow-up: The specificity of the jak2 v617f pcr test for the diagnosis of myelpproliferative disorder is very high, near 100%. After excluding sample mix-up, any patient with a positive jak2 mutation should be carefully followed for the development of polycythemia vera, myelofibrosis, or essential throbocythemia. ...Read more
A friend of mine has a myeloproliferative blood disorder, which is the overproduction of blood cells. Could this be the start of leukemia?
Too many platelets: The myeloproliferative neoplasms (mpns) involve terminal myeloid cell expansion in the peripheral blood, resulting in various combinations of erythrocytosis (rbc's), leukocytosis (wbc's), thrombocytosis (platelets), bone marrow hypercellularity/fibrosis, and splenomegaly (enlarged spleen). Essential thrombocythemia is a diagnosis of exclusion, made when other forms of mpn are ruled out. ...Read more