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Doctor insights on: Myloproliferative Disorder

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What problems can I expect with myloproliferative disorder?

What problems can I expect with myloproliferative  disorder?

Depends on type: There are 4 types and each have different problems. There can be clotting problem, bleeding problems, infections, leukemia. But again it depends on which type. ...Read more

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What causes myloproliferative disorder?

In most csses: There is no identifiable cause. It is acquired not genetic (inherited). ...Read more

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The question is not about me I understand that an acute transformation of overlap myeloproliferative/myelodyplastictiy disorder is the terminal phase of the disorder But what is a blastic transformation of the disorder? Is it the same thing as an ac?

Acute vs blastic?: In the chronic and dysplastic hematologic malignancies that you mention (CMML and MDS), the term "acute" transformation means an evolution to acute leukemia. This is defined as more than 20% "blast" cells microscopically. Therefore acute and blastic transformation are the same thing. ...Read more

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What are the real symptoms of myeloproliferative disorders?

What are the real symptoms of myeloproliferative disorders?

Varaible: There are 3 main types- essential thrombocytosis (et), polycythemia vera (pv) and myelofibrosis (mf). In et, there is increased clotting and risk for strokes. In pv, there is generalized itchiness, ruddy face, and stroke risk. In mf, patients get low blood counts over time causing fatigue, large spleen, poor appetite, abdomen pain, transfusion need. ...Read more

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How do you know who is most likely to get myeloproliferative disorders?

Not able to know: We do not know who is most likely to develop a myeloproliferative disorder. It is, however, a disease that increases in incidence with age. ...Read more

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Can myeloproliferative disorder be diagnosed by an mri?

Can myeloproliferative disorder be diagnosed by an mri?

Myeloid and: Lymphoid refer to blood and marrow elements. Mri cannot greatly help, but can show marrow signal abnormalities. A bone marrow follows evaluation of a smear to discern type and yes no to leukemia, imaging not in the line up unless symptom point to a bone, . ...Read more

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What blood tests would indicate a Myeloproliferative disorder?

What blood tests would indicate a Myeloproliferative disorder?

Abnormal(high) blood: This disorder is suspected in individuals who have a very high WBC count(Like in CML) and also has a genetic abnormality(Philadelphia Chromosome present). Other patients have Myelofibrosis where there is a very big enlargement of the spleen. Occasionally it is just very platelet count(Essential Thrombocythemia(ET) ...Read more

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What is the prognostic significance of a jak2 mutation in a person without the defining criteria for a myeloproliferative disorder ?

What is the prognostic significance of a jak2 mutation in a person without the defining criteria for a myeloproliferative disorder ?

Need close follow-up: The specificity of the jak2 v617f pcr test for the diagnosis of myelpproliferative disorder is very high, near 100%. After excluding sample mix-up, any patient with a positive jak2 mutation should be carefully followed for the development of polycythemia vera, myelofibrosis, or essential throbocythemia. ...Read more

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Is overlap myelodysplasticity myeloproliferative disorder a name for one disorder with common features of two disorders or the one blood disorder ?

Is overlap myelodysplasticity myeloproliferative disorder a name for one disorder with common features of two disorders or the one blood disorder ?

Spectrum of disease : Myelodyaplastic syndrome is a type of myeloproliferative disorder. So it's one disease but there is a spectrum. Myelodyaplasia means abnormal looking blood cells seen in your blood or in the bone marrow. This is usually due to an underlying bone marrow issue like infection or a possible bone marrow cancer and a bone marrow biopsy could be warranted at this point. Talk to your doctor . Take care. ...Read more

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