Doctor insights on:
What precautions should i take to decrease the episodes of crisis in sickle cell. I take folic acid & hydroxyurea as medication.
Hydration: Besides taking your medication, the most important thing you can do to reduce sickle crisis is to keep yourself well hydrated. You need to be exceeding 80 oz of water daily. Even the least little dehydration can lead to increased viscosity (thickness) of your blood, and this in turn can lead to increased sickling and a full-blown crisis. Avoid dehydrating things like sun, alcohol and caffeine. ...Read more
If a PLT is normal but starts to fall (even getting down to 8) & this is suspected to be a drug effect (Hydroxyurea) & the drug is ceased & the low PLT resolves itself within 7 days then would an undetected infection stop the PLT from normalising?
May i assume that: you're referring to your platelets and that they got down to 80,000? If not, you can ignore this response! Hydroxyuria can interfere with the production of platelets and discontinuing it may allow the platelet count to return to normal. An "undetected infection" shouldn't, by itself, prevent the platelets from normalizing, especially if they've already done so. Dr. Anne ...Read moreSee 1 more doctor answer
Risks vs. Benefits: Hydroxyurea is used to treat sickle cell anemia and some leukemias (blood cancers). As will most medications, there is no official time limit. A medicine that is helpful, is doing a good job, has no equal alternative, and thus is needed, can be used until it is no longer needed. The doctor can explain the risks of "not treating" and of drug side effects, versus the benefits of using hydroxyurea. ...Read moreSee 1 more doctor answer
Depends on situation: What is the reason Hydroxyurea is being given? One use of Hydroxyurea is to treat resistant chronic myelocytic leukemia (cml, a cancer of white blood cells). Cancers increase risk of blood clots (dvt), which can be treated w enoxaparin (clexane) in such a case, both would be given. If in hospital, meds like enoxaparin can be used to prevent dvt.Other scenarios exist in which both could be used. ...Read more
Mylocel allergy: Mylocel (Hydroxyurea) is a chemotherapy medication. An allergy occurs when your body’s immune system creates antibodies to a foreign substance causing a reaction that can be mild to severe. For potential adverse effects see: http://www.webmd.com/drugs/2/drug-20583/mylocel-oral/details ...Read more
Antimetabolite: Mylocel, or hydroxyurea, is a form of chemotherapy that works to lower blood counts particularly in patients with leukemia such as chronic myelogenous leukemia and myeloproliferative disorders including polycythemia rubra vera and essential thrombocytosis. Short term side effects may include nausea, hair loss, diarrhea, poor appetite, and nail thickening. Long term effects may include infertility. ...Read more
1 month old : Homozygous hemoglobin E disease (genetic; inherited from both parents) gives mild beta thalassemia & anemia & mildly enlarged spleen; probably doesn't need treatment. Hgb E beta thalassemia disease (E from 1 parent, beta thal from the other): severe incurable disease. Hydroxyurea safe in infants. My guess: start early as possible after 1 mo old. Do discuss this with your pediatric hematologist. ...Read more
"Hydroxyurea may affect fertility (ability to have children), whether a man or a woman."Please advice..
Chemotherapy: it is a chemotherapy drug (a mild one, that doesn't have severe side effects, once it has been checked, worries about it lowering blood counts too much are not much). It does lower sperm quality and that effect can last after it is stopped. http://www.ncbi.nlm.nih.gov/pubmed/17316339 ...Read more