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Doctor insights on: Myeloma Kidney

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Dr. Lonnie Smith
124 doctors shared insights

Kahler Disease (Definition)

I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more


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How does multiple myeloma affect the kidney?

How does multiple myeloma affect the kidney?

Nephropathy: Myeloma produces proteins called light chains which can essentially "clog up" the kidney producing myeloma nephropathy. Myeloma also produces humoral substances which can damage the kidney. ...Read more

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My brother (51) is in the final stages of multiple myeloma and was told he will die of kidney failure. Blood tranfusions weekly. Timeline estimate?

My brother (51) is in the final stages of multiple myeloma and was told he will die of  kidney failure. Blood tranfusions weekly. Timeline estimate?

Get extra support: Agree with prior answer that difficult to say. If not already involved ask for a palliative medicine specialist to work with your hematology-oncology team. They might be able to provide additional prognostication opinions as they monitor his progress and also provide additional support for the time that he has. ...Read more

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Kidney biopsy shows the reason for kidney failure is multiple myeloma. No bone damage, hemo. More than 12. Will kimo therapy help to recover fully?

Seek opinion from a: This is unusual way to make a diagnosis of multiple myeloma(mm). Typically we need to do a bone marrow biopsy and look for cancer cells in the marrow. These cells produce abnormal proteins(m protein) which will show up either in the blood(commonly) or in the urine. We use a test called protein electrophoresis. If these tests have not been done, seek a second opinion. Chemo will help to control mm. ...Read more

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Could be myeloma in woman in early thirties? Only symptom is persistent low back pain.Had clear l spine xray/ clear CT scan for kidney stones. No uti.

Could be myeloma in woman in early thirties? Only symptom is persistent low back pain.Had clear l spine xray/ clear CT scan for kidney stones. No uti.

Diagnosis of myeloma: Your answer is longer than 400 characters. You can find the information you seek at this website: http://www.Cancer.Org/cancer/multiplemyeloma/detailedguide/multiple-myeloma-diagnosis good luck. ...Read more

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Would an l spine xray show or indicate myeloma in the back? What about a pelvic/abdominal CT to check for kidney stones?Low back pn/test reslts normal

Myeloma: Multiple myeloma can show several findings on a spinal x-ray including vertebral body collapse, and punched out bony lesions. You would be rather young for the condition. You need to consult with your doctor to determine if your symptoms warrant a search for kidney stones. ...Read more

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Why sickle cell anemeia / multiple myeloma cause diabetes insipidus ? Is it because it may obstruct the blood flow to the kidneys and damage them?

Why sickle cell anemeia / multiple myeloma cause diabetes insipidus ? Is it because it may obstruct the blood flow to the kidneys and damage them?

Basically right: Even sickle cell trait ruins much of the concentrating ability of the kidneys by adulthood. Myeloma is more likely to damage and obstruct the tubules themselves. Both produce a kidney lesion that prevents the urine from becoming concentrated, rather than a pituitary diabetes insipidus. ...Read more

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What tests diagnose myeloma?

Tests: You would need to have blood works, a skeletal bone survey/ or MRI of the spine as indicated , and definitely a bone marrow biopsy to diagnose a multiple myeloma. Please discuss further with your hematologist/oncologist. ...Read more

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Is there any chemical that cause myeloma?

Possibly: The United States government believes there is an association between agent orange that was used in vietnam and a variety of cancers including multiple myeloma. Although there is no conclusive proof of causation there are benefits for veterans exposed to agent orange who develop multiple myeloma. ...Read more

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What are the different stages is the myeloma?

ISS - Greipp et al.: International staging system -- the international staging system (iss) for myeloma was published by the intl myeloma working group in 2005: it is useful for comparing clinical trial , but has limited utility for each individual. Stage i: ?2-microglobulin (?2m) < 3.5 mg/l, Albumin >= 3.5 g/dl stage ii: ?2m < 3.5 & Albumin < 3.5 ; or ?2m 3.5- 5.5 irrespective of serum albumin stage iii: ?2m >= 5.5. ...Read more

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Does cytoxin cause myeloma?

Not really: Used to treat myeloma and very rarely (in high doses) associated with acute leukemia's. ...Read more

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What is the cause of IgE myeloma?

IgE myeloma rare: Ige myeloma is rare. Dr. Kyle recently reviewed IgD and ige myelomas -- http://www.Ncbi.Nlm.Nih.Gov/pubmed/24133829 the exact cause of myeloma is not well understood. ...Read more

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What are the causes of multiple myeloma?

No simple answer: Multiple myeloma has been associated with ionizing radiation (atomic bomb level), herbicides, petroleum products, analin hair dyes, autoimmune disease but there is no clear cut association. There are a few families which show an inheritance pattern along with other lymphomas. ...Read more

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Could multiple myeloma be treated and cured?

Yes: Multiple myeloma can certainly be treated. There a variety of new drugs available. We are likely curing some myeloma patients, but we don't necessarilyl know who these peopple are when we start treatment. Check out the #mmsm tweetchat including an upcoming topic of myeloma cure. ...Read more

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What is the objective of treating multiple myeloma?

Depends...: This answer depends. That might not be as satisfying but is true. For a 90yo pt it is palliative -- keeping crab symptoms away with minimal discomfort fro m tx. A new study from dr. Campagnaro in ecog will evaluate. For most, "control" as a chronic disease. For some cure. If young, we like to obtain a "deep" response w/ complete response (cr) & now looking at minimal residual disease (mrd) by flow. ...Read more

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What is the life expectancy for someone that has mutiple myeloma?

It depends: Survival in myeloma depends on a number of factors. First, is stage. Second is chromosomal abnormalities. Some have a good prognosis, others not so good. In general we think that myeloma is not usually curable with standard therapies, but survival is getting better with our newer agents, so that living 10 years is not unusual. Cure may be possible with allogeneic bone marrow transplant. ...Read more

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Treatment for relapsed myeloma?

New agents: Pomalidomide and Kyprolis (carfilzomib) were recently approved for treatment of relapsed myeloma- should talk to a hematologist/oncologist for more details. ...Read more

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Is there a cure for multiple myeloma?

Is there a cure for multiple myeloma?

No: However, remission is possible in many cases and many patients can live fairly normal lives for quite some time with the many new advances in this disease. ...Read more

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Kidney (Definition)

The kidneys are paired organs that lie on either side of the vertebral column. Part of their critical functions include the excretion of urine and removal of nitrogenous wastes products from the blood. They regulate acid-base, electrolyte, fluid balance and blood pressure. Through hormonal signals, the kidneys control the ...Read more