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Doctor insights on: Myeloma Fibrosis

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Dr. William Singer
118 doctors shared insights

Kahler Disease (Definition)

I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more


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Test results came back and say Free Kappa Lt Chains, S 34.81 Free Lambda Lt Chains, s is 29.22Kappa,lambda ratio is 1.19. Is it myeloma What is test 4

Light chains: Light chains (kappa and lambda) are a part of the immunoglobulin molecues the body makes. A given plasma cell only makes one type of light chain, most commonly this is kappa. When immunoglobulin cells proliferate like a neoplasm, then one type will overwhelm the others. Your values are nearly even, and the ratio is not abnormal, so it is unlikely that you have myeloma or another Ig-producing lesion. ...Read more

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All info about myeloma?

LLS etc websites: www.lls.org, http://www.Cancer.Gov/cancertopics/types/myeloma, www.Themmrf.Org, http://www.Cancer.Org/cancer/multiplemyeloma/index, http://myelomasociety.Org/membership.Html, http://myeloma.Org.

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How bad is pain in myeloma?

How bad is pain in myeloma?

Only if fracture +: Not everybody who has myeloma will have fracture when diagnosed. Yes, myeloma will involve the bone and there would be increased risk for fracture- however- just because one has myeloma-it does not mean that it is identical to pain unless you have fracture. And if you do-it depends on your tolerance to pain and how severe the fracture is. Pain is very subjective. Discuss with oncologist. ...Read more

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Wo is at risk for multipule myeloma?

Plasma cell & other: People who have diagnosis of plasma cell disorders- called mgus ( monoclonal gammopathy of unknown significance) would be the one who is at risk for multiple myeloma. Other potential risk factors - include older age, male ( hormone related?), black/african american, exposures to radiation, benzene, and other organic solvents, herbicides, and insecticides and other unknown risk factors. ...Read more

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Treatment for relapsed myeloma?

New agents: Pomalidomide and Kyprolis (carfilzomib) were recently approved for treatment of relapsed myeloma- should talk to a hematologist/oncologist for more details. ...Read more

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Is there a cure for multiple myeloma?

No: However, remission is possible in many cases and many patients can live fairly normal lives for quite some time with the many new advances in this disease. ...Read more

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Can multiple myeloma affect the liver?

Can multiple myeloma   affect the liver?

Yes. Not common.: Yes. Multiple myeloma can effect any organ. However, liver involvement is not common. Myeloma generally involves the bones predominantly; however there are reports of nearly every organ being involved in including the brain. Liver involvement by any cancer can make some types of chemotherapy (that is processed by the liver) more difficult to give. ...Read more

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Is multiple myeloma is still not curable?

Not curable: There are many treatments for multiple myeloma and the survival of patients with myeloma is much better than 10 years ago. But we still do not consider this a curable disease. ...Read more

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