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Doctor insights on: Myeloma And Cbc

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I had blood work done and protein 9.1 and albumin 5.5 could it be multiple myeloma. Cbc all came back within normal range. Immunoglobulin was 460.?

I had blood work done and protein 9.1 and albumin 5.5 could it be multiple myeloma. Cbc all came back within normal range. Immunoglobulin was 460.?

Poly vs monoclonal: There are many causes of elevation of acute phase reactants and poly (many) clonal gammaglobulins (iga, igg, igm, etc). Polyclonal elevations are not the same as multiple myeloma (mm). Mm is cancer of plasma cells that produces a monoclonal (or sometimes oligoclonal or non-secretory) production of immunoglobulins. ...Read more

Dr. James Lin
126 Doctors shared insights

Kahler Disease (Definition)

I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more


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Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

False positive rate: There is 30% or so false positive rate of kappa/lambda ratio in people without MGUS, myeloma or other disorders.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex. ...Read more

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M57, cbc, serum albumin, serum protein all normal does this mean I am clear of multiple myeloma?

Not necessarily: There are more important tests to check, like quantitative immunoglobulins and m proteins in urine and blood, normal free light chain ratio, and. ...Read more

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CMP & CBC are normal except Globulin is 4.2 & Total Protein is 8.4? I am freaking out w/ Dr. Google. 33 years old.....myeloma?

Unlikely: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, it is unlikely that you have myeloma. There are other causes of elevated globulins. However it is not feasible to provide a meaningful opinion without physical examination and additional tests. Consult your doctor. ...Read more

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32 year old with lifelong HCV + a year of bone pain/discomfort (ribs, upper back, hips). Cbc normal, low ferritin/iron. Should I screen for myeloma?

32 year old with lifelong HCV + a year of bone pain/discomfort (ribs, upper back, hips). Cbc normal, low ferritin/iron. Should I screen for myeloma?

Not yet: You're young for myeloma and even in the unlikely event that you have it, there's little benefit to early diagnosis. Look for the cause of your iron loss instead -- a total-body lack of iron may make you feel ill long before it makes you anemic. Today, bone pain from vitamin d deficiency and/or diet-related osteomalacia is extremely common. Might this be the explanation? Stay proactive. ...Read more

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Would normal CBC, metabolic panel, ESR, CRP, PT, aPTT, d-dimer make multiple myeloma or waldenstrom macroglobulinemia unlikely? Given a presumptive diagnosis of von Willebrand at age 31 with no known family history. Concerned it may be acquired form.

Not right tests: If you wish to be tested for multiple myeloma or Waldenstrom, you should have serum protein electrophoresis and immunofixation electrophoresis and if needed similar studies on urine. It is not a do it yourself diagnosis and your doctor should order the tests, if warranted. ...Read more

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Is it possible to have mutiple mylenoma if CBC is ok and urine is ok. Ana positive 1:640 speckled pattrn?

Is it possible to have mutiple mylenoma if CBC is ok and urine is ok. Ana positive 1:640 speckled pattrn?

More information?: Multiple myeloma is a condition affecting the blone marrow. A blood count or urinalysis may be normal in this condition. A serum protein electropharesis (spep) is a common early test, but most patients with multiple myeloma have a bone marrow aspiration (biopsy) done. It's a complicated condition - but newer treatments hold great promise. Please talk to your doctor directly about your concerns. ...Read more

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All info about myeloma?

LLS etc websites: Www. Lls. Org, http://www.Cancer.Gov/cancertopics/types/myeloma, www. Themmrf. Org, http://www. Cancer. Org/cancer/multiplemyeloma/index, http://myelomasociety. Org/membership. Html, http://myeloma. Org. ...Read more

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How bad is pain in myeloma?

How bad is pain in myeloma?

Only if fracture +: Not everybody who has myeloma will have fracture when diagnosed. Yes, myeloma will involve the bone and there would be increased risk for fracture- however- just because one has myeloma-it does not mean that it is identical to pain unless you have fracture. And if you do-it depends on your tolerance to pain and how severe the fracture is. Pain is very subjective. Discuss with oncologist. ...Read more

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Wo is at risk for multipule myeloma?

Plasma cell & other: People who have diagnosis of plasma cell disorders- called mgus (monoclonal gammopathy of unknown significance) would be the one who is at risk for multiple myeloma. Other potential risk factors - include older age, male (hormone related?), black/african american, exposures to radiation, benzene, and other organic solvents, herbicides, and insecticides and other unknown risk factors. ...Read more

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Treatment for relapsed myeloma?

New agents: Pomalidomide and Kyprolis (carfilzomib) were recently approved for treatment of relapsed myeloma- should talk to a hematologist/oncologist for more details. ...Read more

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Is there a cure for multiple myeloma?

No: However, remission is possible in many cases and many patients can live fairly normal lives for quite some time with the many new advances in this disease. ...Read more

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Is multiple myeloma is still not curable?

Not curable: There are many treatments for multiple myeloma and the survival of patients with myeloma is much better than 10 years ago. But we still do not consider this a curable disease. ...Read more

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What is myeloma cancer & how is it treated?

What is myeloma cancer & how is it treated?

Myeloma: Myeloma is a cancer that starts in plasma cells in the bone marrow. The cause is unknown but its found more in the older patients. Blood tests usually detect it. Mild cases usually aren't treated but chemotherapy is often used. Radiation therapy is used to treat the bone pain that occurs. ...Read more

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How does multiple myeloma affect the kidney?

How does multiple myeloma affect the kidney?

Nephropathy: Myeloma produces proteins called light chains which can essentially "clog up" the kidney producing myeloma nephropathy. Myeloma also produces humoral substances which can damage the kidney. ...Read more

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Why not treat mgus before it becomes myeloma?

No affect: Only a small proportion of mgus progresses to myeloma. So we would be treating patients who do not treatment. Hope this helps. ...Read more

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How long do patients live with multiple myeloma?

How long do patients live with multiple myeloma?

Depends: Myeloma has a variable natural history. Many patients have had myeloma for years prior to diagnosis without realizing it, while others are diagnosed by screening for monoclonal protein in the blood.
Modern hematologists can use advanced treatments like velcade, revlimid, (lenalidomide) thalomid, and stem cell transplant, allowing myeloma patients to live longer than ever. More info: http://bit. Ly/lrzotm. ...Read more

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What is the treatment for young people with myeloma?

What is the treatment for young people with myeloma?

Myeloma treatment: Agressive therapy would be recommended in young people with myeloma. Treatment will include several cycles of combination of 3 different medication as induction then followed by stem cell collection for future autologous stem cell transplantation that can be done soon after completion of chemotherapy or later in the future as indicated- plus minus maintanance therapy. Discuss further with your md. ...Read more

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Can a person take hydroxycut if one has multiple myeloma?

No: I would not recommend hydroxycut under any circumstances. ...Read more

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Multi myeloma: what is the life expectancy/survival rate?

It is a Blood cancer: It is a form of blood cancer which begins in the bone marrow. Myeloma has good treatment options available, so most patients can live for 5 to 10 years, on an average. ...Read more

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What is the life expectancy of people with multiple myeloma?

Much better now: With all the new targeted drugs for myeloma and several to come, patients live many more years. Some have said this cancer is now more like a chronic disease - still dangerous and needing treatment but it is characterized by longer periods of remission after treatment. Therefore a 65 or 75 year old person may have a normal life span with this disease now. ...Read more

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What is the primary cause of multiple myeloma? Is it stress?

What is the primary cause of multiple myeloma? Is it stress?

Nobody knows: Bottom line is that nobody knows for sure. No serious studies have correlated multiple myeloma and stress, so this would be an unlikely cause. Genetic abnormalities ate involved in causing this disease but is hard to figure out what is exactly causing such genetic abnormalities. Best wishes, ariel. ...Read more

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What's the life expectancy of someone with multiple myeloma?

Years: This really varies depending most importantly on the chromosome abnormalities. Patients with this diagnosis are living longer, whereas previously many died within 3 years, most are living much longer. ...Read more

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Doctors, what are the symptoms of smoulding multiple myeloma?

Asymptomatic: Smoldering myeloma is a stage of Myeloma before patients become symptomatic. So it is discovered on routine checking of blood proteins or show up in a serum protein electrophoresis (SEP). Many of these patients develop symptoms within one or two years and the symptoms are bone/back pain or a broken bone due to myeloma. ...Read more

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How long are biphosphonates to be given for multiple myeloma?

Not clear: There is no correct answer for this. Many patients receiving bisphosphonates for active myeloma receive regular treatment for approximately 2 years. In some cases it may be given longer on a less frequent schedule. It may also be stopped or decreased in frequency if side effects develop. ...Read more

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Can you have a predisposition to multiple myeloma or lymphoma?

Yes - RR 2.0 to 4.0: Relative risk (rr) incr mgus 2.8, myeloma 2.9, lpl/wm 4.0, cll 2.0. From landgren et al.
http://www. Ncbi. Nlm. Nih. Gov/pubmed/19182202
the myeloma cytogenetics are reviewed in greenberg et al. May 2013 -- http://www. Ncbi. Nlm. Nih. Gov/pubmed/23647020. ...Read more

Complete Blood Count (Definition)

Share on twitter bookmark & share printer-friendly version a complete blood count (CBC) test measures the following: •the number of red blood cells (rbc count) •the number of white blood cells (wbc count) •the total amount of hemoglobin in the blood •the fraction of the blood composed of ...Read more


Cbc (Definition)

CBC stands for complete blood count. This is a lab test that counts the different formed elements- red and white ...Read more