Doctor insights on:
Myeloma And Cbc
I had blood work done and protein 9.1 and albumin 5.5 could it be multiple myeloma. Cbc all came back within normal range. Immunoglobulin was 460.?
Poly vs monoclonal: There are many causes of elevation of acute phase reactants and poly (many) clonal gammaglobulins (iga, igg, igm, etc). Polyclonal elevations are not the same as multiple myeloma (mm). Mm is cancer of plasma cells that produces a monoclonal (or sometimes oligoclonal or non-secretory) production of immunoglobulins. ...Read more
I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more
Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.
False positive rate:
There is 30% or so false positive rate of kappa/lambda ratio in people without MGUS, myeloma or other disorders.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex. ...Read more
CMP & CBC are normal except Globulin is 4.2 & Total Protein is 8.4? I am freaking out w/ Dr. Google. 33 years old.....myeloma?
Unlikely: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, it is unlikely that you have myeloma. There are other causes of elevated globulins. However it is not feasible to provide a meaningful opinion without physical examination and additional tests. Consult your doctor. ...Read more
32 year old with lifelong HCV + a year of bone pain/discomfort (ribs, upper back, hips). Cbc normal, low ferritin/iron. Should I screen for myeloma?
Not yet: You're young for myeloma and even in the unlikely event that you have it, there's little benefit to early diagnosis. Look for the cause of your iron loss instead -- a total-body lack of iron may make you feel ill long before it makes you anemic. Today, bone pain from vitamin d deficiency and/or diet-related osteomalacia is extremely common. Might this be the explanation? Stay proactive. ...Read more
Would normal CBC, metabolic panel, ESR, CRP, PT, aPTT, d-dimer make multiple myeloma or waldenstrom macroglobulinemia unlikely? Given a presumptive diagnosis of von Willebrand at age 31 with no known family history. Concerned it may be acquired form.
Not right tests: If you wish to be tested for multiple myeloma or Waldenstrom, you should have serum protein electrophoresis and immunofixation electrophoresis and if needed similar studies on urine. It is not a do it yourself diagnosis and your doctor should order the tests, if warranted. ...Read more
Is it possible to have mutiple mylenoma if CBC is ok and urine is ok. Ana positive 1:640 speckled pattrn?
More information?: Multiple myeloma is a condition affecting the blone marrow. A blood count or urinalysis may be normal in this condition. A serum protein electropharesis (spep) is a common early test, but most patients with multiple myeloma have a bone marrow aspiration (biopsy) done. It's a complicated condition - but newer treatments hold great promise. Please talk to your doctor directly about your concerns. ...Read more
Only if fracture +: Not everybody who has myeloma will have fracture when diagnosed. Yes, myeloma will involve the bone and there would be increased risk for fracture- however- just because one has myeloma-it does not mean that it is identical to pain unless you have fracture. And if you do-it depends on your tolerance to pain and how severe the fracture is. Pain is very subjective. Discuss with oncologist. ...Read more
Plasma cell & other: People who have diagnosis of plasma cell disorders- called mgus (monoclonal gammopathy of unknown significance) would be the one who is at risk for multiple myeloma. Other potential risk factors - include older age, male (hormone related?), black/african american, exposures to radiation, benzene, and other organic solvents, herbicides, and insecticides and other unknown risk factors. ...Read more
Myeloma: Myeloma is a cancer that starts in plasma cells in the bone marrow. The cause is unknown but its found more in the older patients. Blood tests usually detect it. Mild cases usually aren't treated but chemotherapy is often used. Radiation therapy is used to treat the bone pain that occurs. ...Read more
Nephropathy: Myeloma produces proteins called light chains which can essentially "clog up" the kidney producing myeloma nephropathy. Myeloma also produces humoral substances which can damage the kidney. ...Read more
Myeloma has a variable natural history. Many patients have had myeloma for years prior to diagnosis without realizing it, while others are diagnosed by screening for monoclonal protein in the blood.
Modern hematologists can use advanced treatments like velcade, revlimid, (lenalidomide) thalomid, and stem cell transplant, allowing myeloma patients to live longer than ever. More info: http://bit. Ly/lrzotm. ...Read more
Myeloma treatment: Agressive therapy would be recommended in young people with myeloma. Treatment will include several cycles of combination of 3 different medication as induction then followed by stem cell collection for future autologous stem cell transplantation that can be done soon after completion of chemotherapy or later in the future as indicated- plus minus maintanance therapy. Discuss further with your md. ...Read more
No: I would not recommend hydroxycut under any circumstances. ...Read more
Much better now: With all the new targeted drugs for myeloma and several to come, patients live many more years. Some have said this cancer is now more like a chronic disease - still dangerous and needing treatment but it is characterized by longer periods of remission after treatment. Therefore a 65 or 75 year old person may have a normal life span with this disease now. ...Read more
Nobody knows: Bottom line is that nobody knows for sure. No serious studies have correlated multiple myeloma and stress, so this would be an unlikely cause. Genetic abnormalities ate involved in causing this disease but is hard to figure out what is exactly causing such genetic abnormalities. Best wishes, ariel. ...Read more
Years: This really varies depending most importantly on the chromosome abnormalities. Patients with this diagnosis are living longer, whereas previously many died within 3 years, most are living much longer. ...Read more
Asymptomatic: Smoldering myeloma is a stage of Myeloma before patients become symptomatic. So it is discovered on routine checking of blood proteins or show up in a serum protein electrophoresis (SEP). Many of these patients develop symptoms within one or two years and the symptoms are bone/back pain or a broken bone due to myeloma. ...Read more
Not clear: There is no correct answer for this. Many patients receiving bisphosphonates for active myeloma receive regular treatment for approximately 2 years. In some cases it may be given longer on a less frequent schedule. It may also be stopped or decreased in frequency if side effects develop. ...Read more
Yes - RR 2.0 to 4.0:
Relative risk (rr) incr mgus 2.8, myeloma 2.9, lpl/wm 4.0, cll 2.0. From landgren et al.
http://www. Ncbi. Nlm. Nih. Gov/pubmed/19182202
the myeloma cytogenetics are reviewed in greenberg et al. May 2013 -- http://www. Ncbi. Nlm. Nih. Gov/pubmed/23647020. ...Read more
Share on twitter bookmark & share printer-friendly version a complete blood count (CBC) test measures the following: •the number of red blood cells (rbc count) •the number of white blood cells (wbc count) •the total amount of hemoglobin in the blood •the fraction of the blood composed of ...Read more