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Doctor insights on: Myasthenia Gravis Panel

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Tested for acetylcholine receptor ab panel; both binding and blocking were 0, but modulating came back at 10. Does this mean I have myasthenia gravis?

Tested for acetylcholine receptor ab panel; both binding and blocking were 0, but modulating came back at 10. Does this mean I have myasthenia gravis?

AchRAntibodies: Binding antibodies are the most sensitive--they are positive in over 80% of ms patients. Blocking antibodies are positive in about half. Modulating antibodies alone don't support the diagnosis and have a lot oof false positives. In summary the achreceptor antibody panel does not suggest that ou have ms>. ...Read more

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Dr. Julian Bragg
366 doctors shared insights

Myasthenia Gravis (Definition)

A chronic autoimmune neuromuscular disease characterized by varying degrees of weakness of the skeletal (voluntary) ...Read more


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Can you tell me in myasthenia gravis why do you give an acetylcholine esterase inhibitor instead of a direct receptor agonist?

Can you tell me in myasthenia gravis why do you give an acetylcholine esterase inhibitor instead of a direct receptor agonist?

Because...: If you provide an agonist your muscles will contract continually. The acetylcholine esterase inhibitor prolongs the life of acetylcholine released naturally from your motor nerves so you only have muscle contraction when your brain orders it. ...Read more

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How safe is it to have a baby if I have myasthenia gravis? I know people do it, but what are the risks? Both to me and the baby? Will I have to go off my meds? Will i pass the disease on to my baby? I’d really like to have a baby, but i’m worried. My doc

How safe is it to have a baby if I have myasthenia gravis? I know people do it, but what are the risks? Both to me and the baby?  Will I have to go off my meds? Will i pass the disease on to my baby? I’d really like to have a baby, but i’m worried. My doc

The : The more common kind of myasthenia gravis is an acquired condition: your body is tricked into making antibodies that attack its own acetylcholine receptors on the surface of your muscles, reducing the ability of your nerves to activate them, and leading to weakness. There is another, much rarer type of myasthenia gravis that is not acquired, but genetic. Women with acquired myasthenia gravis won't pass the disease itself on to their children, but since the myasthnia antibodies made by mom can cross the placenta into the circulation of the fetus, the fetus can be affected temporarily (mom's antibodies can stay in the baby up to several weeks after birth). This condition is called neonatal myasthenia gravis. Newborns with neonatal myasthenia can have temporary weakness of limb muscles, breathing muscles, and feeding muscles. They can also have a condition called arthrogryposis, stiff joints with limited range of flexibility because they didn't move as much in the womb as they might have otherwise. This is why it is important to have acquired myasthenia gravis well-controlled throughout pregnancy. There are many different kinds of medications used to control myasthenia. Some of them, particularly the immunosuppressants (like methotrexate, azathioprine, mycophenolate mofetic) are known to cause harm to the baby if taken during pregancy, while breastfeeding, or even prior to conception. Other treatments such as steroids and ivig are less risky (but not zero risk). Women with myasthenia who are considering pregnancy should work very closely with a team including a neurologist experienced in the treatment of myasthenia gravis, an obstetrician and a neonatologist. This is the best way to reduce worry, and risk, as much as possible. For general information about myasthenia gravis, visit the myasthenia gravis foundation of america website at www.Myasthenia.Org. ...Read more

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Is myasthenia gravis disorder on agent orange list for benefits?

Contact the VA: This is a question for the va/dept of defense. Contact them to start the process. ...Read more

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My eyelid is red, painful, and slightly swollen. It looks like it's drooping. Is this myasthenia gravis or just inflammation of the eyelid?

My eyelid is red, painful, and slightly swollen. It looks like it's drooping. Is this myasthenia gravis or just inflammation of the eyelid?

It is a Sty: Most probably you have an acute hordeolum or sty which causes temporary drooping. Myasthenia gravis (mg) does not have red painful swollen eyelids. Mg may start with occasional drooping of eyelids or with speech problems. See an ophthalmologist for rx of your sty and possible blepharitis. ...Read more

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Does mestinon (pyridostigmine) effect diagnostic blood test results for myasthenia gravis?

NO, NOT AT ALL: Mestinon (pyridostigmine) enhances neuromuscular junctional efficiency by enhancing acetylcholine persistence, but is NOT an immune agent like a steroid. The standard testing for myasthenia gravis looks at antibody reactions, and would be positive or negative irregardless of use of Mestinon (pyridostigmine). ...Read more

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Tested for acetylcholine receptor ab panel; both binding and blocking were 0, but modulating came back at 10. Does this mean I have myasthenia gravis?

AchRAntibodies: Binding antibodies are the most sensitive--they are positive in over 80% of ms patients. Blocking antibodies are positive in about half. Modulating antibodies alone don't support the diagnosis and have a lot oof false positives. In summary the achreceptor antibody panel does not suggest that ou have ms>. ...Read more

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I live INACTIVE life due 2 having Myasthenia gravis & severe Osteo. SO, on days I do a LOT I'm worn. Normal? Or would it flare it I kept active or no?

See rheuma: I strongly recommend that you consult a rheumatologist to get your disease condition undercontrolled. I don't see why both conditions cannot be improved with today's medications. The less activities the more osteoporosis. Get the right help now. ...Read more

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Myasthenia Gravis, NOW severe osteoporosis &supposed to start Forteo shots daily! I'm scared as I DON'T want MG flare. Do u foresee any risks?

Myasthenia Gravis, NOW severe osteoporosis &supposed to start Forteo shots daily! I'm scared as I DON'T want MG flare. Do u foresee any risks?

No: Don't see any unusual risk from Forteo because of MG. It is important for you to get your osteoporosis treated since a major fracture will be devastating to someone who already has problem with muscle strength. ...Read more

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How common is Myasthenia Gravis?

Prevalence of MG?: It's estimated that MG is present in between 50-60K individuals in the U.S. It will increase as the age of the population increases. ...Read more

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Who is at risk myasthenia gravis?

Who is at risk myasthenia gravis?

Wide range of people: Myasthenia has been reported in people of all age groups, but it tends to be more common in people aged 50-70 or in women under 40. Conditions that increase your risk for developing myasthenia include: autoimmune disease (thyroid disease, lupus, rheumatoid, type i diabetes), thymoma, and exposure to certain medications (most famously an immunosuppressant and chelating agent called penicillamine). ...Read more

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What can I do if I have myasthenia gravis?

See specialist: Myasthenia gravis is a potentially life threatening but treatable condition.It has to be treated by a neurologist preferably one who whose sub specialty is neuromuscular disease. ...Read more

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What diseases are similar to myasthenia gravis?

Muscle weakness: Nerves and muscle disorders can give pictures similar to that of myasthenia gravis especially if the facial muscles and the muscles of the shoulder and pelvic girdle are involved. Please make sure that you have the proper diagnosis for myasthenia gravis. You will need blood tests for antibodies, and repetitive stimulation studies or even single fiber emg. You must be taken care of by a neurolog. ...Read more

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What are the main symptoms of myasthenia gravis?

What are the main symptoms of myasthenia gravis?

MG symptoms: Proximal muscle weakness with diurnal variation. Increased weakness of muscles brought by exercise. Periodic eye droop, low hoarse voice, shortness of breath. Not everybody will have all symptoms. ...Read more

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What foods do you recommend for myasthenia gravis?

No magic: Having myasthenia gravis is difficult enough without subscientific / non-evidence-based dietary recommendations. Eat sensibly -- enough protein, avoid very salty / greasy / sugary stuff. Almost all internet advice about particular foods to choose or avoid for particular illness is subscience at best, and primarily entertainment. ...Read more

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What are the typical symptoms of myasthenia gravis?

Muscle weakness: Weakness if the hallmark and this affects many muscles. See rheumatologist if you suspect you may have it. ...Read more

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Why aren’t my medications for myasthenia gravis working?

Why aren’t my medications for myasthenia gravis working?

Is it myasthenia?: While you may well have a particularly difficult-to-treat case, it is important to confirm that you do indeed have myasthenia. If you have a positive antibody test, the diagnosis more assured. If not, a more extensive workup might be indicated. The most sensitive electrodiagnostic test for myasthenia is a single-fiber emg, which can be performed by a neuromuscular specialist. ...Read more

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What is the definition or description of: Myasthenia gravis?

Neuromuscular dz: MG is an autoimmune disease of the neuromuscular junction, where there is inhibition of transmission of an impulse at the post-synaptic acetylcholine receptors. Patients present with involvement often of the ocular musculature (ptosis, double vision etc.) but can also have extremity weakness as well. EDx testing with repetitive stimulation and single fiber EMG can be helpful for diagnosis. ...Read more

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Which type of diseases could be mistaken for myasthenia gravis?

Rep stim studies: Many diseases that give few muscle weakness especially that of the muscles of the face, shoulder and pelvic girdle can give symptoms similar to myasthenia gravis. You need to have nerve conduction studies and repetitive stimulation studies to differentiate these diseases from one another. Please have yourself be evaluated by a neurologist or specialist in physical medicine and rehabilitation. ...Read more

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Need expert help here. What are some signs of myasthenia gravis?

Visual: Start out with double vision, droopy eyelids, and may just feel weak. A good evaluation from a neurologist is starting point if this is your concern. ...Read more

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What are the symptoms of myasthenia gravis? Could my symptoms fit?

See details: Myasthenia is an autoimmune disease characterized by varying degrees of skeletal muscle weakness. The weakness often increase with activity and improves with rest. Muscles of the extremities, respiration, eyes, voice and swallowing can be involved. If you think it fits you must see avneurologist. ...Read more

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Why is it difficult to exercise for someone having myasthenia gravis?

Why is it difficult to exercise for someone having myasthenia gravis?

Muscle fatigue: Mg is a disorder of neuromuscular transmission. As you continue to stimulate a nerve for muscular contraction, the degree of contraction gradually diminishes as the muscle fatigues. This is due to the breakdown in neuromuscular transmission. If the muscle(patient) rests, it(they) can return to exercise. Patients with mg usually tell you they are stronger in the am but fatigue as the day progresses. ...Read more

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Ach levels are normal but strabs positive. is it def myasthenia gravis or could it be something else?

Ach levels are normal but strabs positive. is it def myasthenia gravis or could it be something else?

MYASTHENIA GRAVIS: Myasthenia Gravis imay be difficult to confirm Make sure to have through discussion with your doctor/repeat exam and labs. Especially TFTS/VITAMIN LEVELS. Also Neuro & Rheum consults. EATON LAMBERT SYNDROME ALSO NEEDS TO BE EVALUATED.Also shift to a GLUTEN FREE DIET WHOLEAPPROACH.com. GUTBLISS.com. And high potency vitamins from REJUVENATION-SCIENCE.COM. UNIQUINOL/RIBOSE/CARNATINE. ...Read more