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Doctor insights on: Myasthenia Gravis Panel

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Tested for acetylcholine receptor ab panel; both binding and blocking were 0, but modulating came back at 10. Does this mean I have myasthenia gravis?

Tested for acetylcholine receptor ab panel; both binding and blocking were 0, but modulating came back at 10. Does this mean I have myasthenia gravis?

AchRAntibodies: Binding antibodies are the most sensitive--they are positive in over 80% of ms patients. Blocking antibodies are positive in about half. Modulating antibodies alone don't support the diagnosis and have a lot oof false positives. In summary the achreceptor antibody panel does not suggest that ou have ms>. ...Read more

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Dr. Julian Bragg
358 doctors shared insights

Myasthenia Gravis (Definition)

Myasthenia gravis is an autoimmune condition in which the body produces a protein that blocks information transmission along nerves. This leads to symptoms such as droopy ...Read more


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Can you tell me in myasthenia gravis why do you give an acetylcholine esterase inhibitor instead of a direct receptor agonist?

Can you tell me in myasthenia gravis why do you give an acetylcholine esterase inhibitor instead of a direct receptor agonist?

Because...: If you provide an agonist your muscles will contract continually. The acetylcholine esterase inhibitor prolongs the life of acetylcholine released naturally from your motor nerves so you only have muscle contraction when your brain orders it. ...Read more

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How safe is it to have a baby if I have myasthenia gravis? I know people do it, but what are the risks? Both to me and the baby? Will I have to go off my meds? Will i pass the disease on to my baby? I’d really like to have a baby, but i’m worried. My doc

How safe is it to have a baby if I have myasthenia gravis? I know people do it, but what are the risks? Both to me and the baby?  Will I have to go off my meds? Will i pass the disease on to my baby? I’d really like to have a baby, but i’m worried. My doc

The : The more common kind of myasthenia gravis is an acquired condition: your body is tricked into making antibodies that attack its own acetylcholine receptors on the surface of your muscles, reducing the ability of your nerves to activate them, and leading to weakness. There is another, much rarer type of myasthenia gravis that is not acquired, but genetic. Women with acquired myasthenia gravis won't pass the disease itself on to their children, but since the myasthnia antibodies made by mom can cross the placenta into the circulation of the fetus, the fetus can be affected temporarily (mom's antibodies can stay in the baby up to several weeks after birth). This condition is called neonatal myasthenia gravis. Newborns with neonatal myasthenia can have temporary weakness of limb muscles, breathing muscles, and feeding muscles. They can also have a condition called arthrogryposis, stiff joints with limited range of flexibility because they didn't move as much in the womb as they might have otherwise. This is why it is important to have acquired myasthenia gravis well-controlled throughout pregnancy. There are many different kinds of medications used to control myasthenia. Some of them, particularly the immunosuppressants (like methotrexate, azathioprine, mycophenolate mofetic) are known to cause harm to the baby if taken during pregancy, while breastfeeding, or even prior to conception. Other treatments such as steroids and ivig are less risky (but not zero risk). Women with myasthenia who are considering pregnancy should work very closely with a team including a neurologist experienced in the treatment of myasthenia gravis, an obstetrician and a neonatologist. This is the best way to reduce worry, and risk, as much as possible. For general information about myasthenia gravis, visit the myasthenia gravis foundation of america website at www.Myasthenia.Org. ...Read more

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Is myasthenia gravis disorder on agent orange list for benefits?

Contact the VA: This is a question for the va/dept of defense. Contact them to start the process. ...Read more

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My eyelid is red, painful, and slightly swollen. It looks like it's drooping. Is this myasthenia gravis or just inflammation of the eyelid?

My eyelid is red, painful, and slightly swollen. It looks like it's drooping. Is this myasthenia gravis or just inflammation of the eyelid?

It is a Sty: Most probably you have an acute hordeolum or sty which causes temporary drooping. Myasthenia gravis (mg) does not have red painful swollen eyelids. Mg may start with occasional drooping of eyelids or with speech problems. See an ophthalmologist for rx of your sty and possible blepharitis. ...Read more

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Does mestinon (pyridostigmine) effect diagnostic blood test results for myasthenia gravis?

NO, NOT AT ALL: Mestinon (pyridostigmine) enhances neuromuscular junctional efficiency by enhancing acetylcholine persistence, but is NOT an immune agent like a steroid. The standard testing for myasthenia gravis looks at antibody reactions, and would be positive or negative irregardless of use of Mestinon (pyridostigmine). ...Read more

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Tested for acetylcholine receptor ab panel; both binding and blocking were 0, but modulating came back at 10. Does this mean I have myasthenia gravis?

AchRAntibodies: Binding antibodies are the most sensitive--they are positive in over 80% of ms patients. Blocking antibodies are positive in about half. Modulating antibodies alone don't support the diagnosis and have a lot oof false positives. In summary the achreceptor antibody panel does not suggest that ou have ms>. ...Read more

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I live INACTIVE life due 2 having Myasthenia gravis & severe Osteo. SO, on days I do a LOT I'm worn. Normal? Or would it flare it I kept active or no?

See rheuma: I strongly recommend that you consult a rheumatologist to get your disease condition undercontrolled. I don't see why both conditions cannot be improved with today's medications. The less activities the more osteoporosis. Get the right help now. ...Read more