Doctor insights on:
My Dad Just Died Of Acute Leukemia He Was In His Late 70s Is Leukemia Hereditary
Leukemia is a malignant hematologic neoplasm that originates in the bone marrow and represents a clonal proliferation of hematopoietic elements belonging to any of the myeloid, lymphoid, erythroid, and megakaryocytic lineages. Of note, other hematologic neoplasms like lymphoma or myeloma may demonstrate a leukemic phase without actually originating in the bone marrow ...Read more
My uncle and cousin (uncles daughter)both had acute leukemia at 65 and 50 years old. I didn't think leukemia was hereditary?
It is not: But I have certainly seen clustering of blood cancers in some families. ...Read more
Great uncle had acute leukemia and now his daughter has it at 50 years old. Is this likely hereditary or can it be spontaneous?
Probably not : Did your great uncle had leukemia at an advanced age? Is it cll? Cll is a very common type of leukemia in old people, and no hereditary trend. On the other hand his daughter at 50 probably developed aml. If my guesses are correct, i don't see any hint of heredity. However, if the great uncle had aml, or all, and if other members of the family had cancer (breast, brain, colon etc.) then it could be. ...Read more
What happens if polycythemia vera is diagnosed late, does that increase the chances of getting acute leukemia?
Probably no: Untreated PCV typically causes problems with thrombotic events (venous blood clots, strokes, heart attacks) long before it transitions to AML, Radioactive phosphorus and some chemotherapy are thought to increase this risk of transition to AML. Therefore, being diagnosed late my make it less likely that PCV will transition to AML. ...Read more
I'm just wondering, if you are diagnosed with a form of chronic leukemia can it change to an acute leukemia?
Yes, sometimes: There are two separate types of chronic leukemia;these go by the names CML and cll. They follow a separate course and can have a long course of disease. CML often ends up as acute leukemia(called blastic change which is a type of acute leukemia bearing poor survival once this transformation has taken place. Fortunately the risk of this happening is much reduced with the modern treatments for cml. ...Read more
Common symptoms: Symptoms at presentation of an acute leukemia are typically related to infiltration of the bone marrow with cancerous cells. This can cause bone pain. Additionally, the marrow is where the blood cells are made. So anemia - fatigue, paleness; low platelets - easy bruising, bleeding, petechiael rash; and abnormal white cells - fever, infection; are all common symptoms. ...Read moreSee 1 more doctor answer