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Doctor insights on: Multiple System Atrophy Cerebellar

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Can multiple system atrophy cause abnormal emg?

Can multiple system atrophy cause abnormal emg?

Yes: Any thing that effects a particular nerve and the muscles it innervates could lead to abnormal EMG ...Read more

Atrophy (Definition)

Atrophy usually refers to the skin-as you get older or if you have had alot of sun in the past-the dermis (that is the layer below the top layer which is called the epidermis) gets thinner and the skin looks more wrinked. Muscles and fat can also get thinner -this is another form of atrophy. Even the top layer gets thinner ...Read more


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How are cerebellar degeneration, cerebellar ataxia and paraneoplastic cerebellar related?

How are cerebellar degeneration, cerebellar ataxia and paraneoplastic cerebellar related?

Ataxia: Cerebellar degneration means that the part of the brain that controlls coordination and balance is losing cells and likely getting smaller. Ataxia is the clumsiness, imbalance, slurred speech and/or abnormal eye movements that can accompany cerebellar degeneration. A paraneoplastic cerebellar syndrome is when the body's immune response to cancer somewhere else damages the cerebellum "by mistake". ...Read more

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Which system does multiple sclerosis attack?

Which system does multiple sclerosis attack?

MS: Initially brain and / or spinal cord. But many other systems are attached to nervous system such as; muscle causing weakness and stiffness urinary bladder causing dysfunction behavior causing mood disturbance peripheral nerves causing numbness eyes causing blindness, pain and loss of color vision balance and falls. ...Read more

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Can multiple system atrophy affect the heart muscle?

Can multiple system atrophy affect the heart muscle?

Unfortunately yes: As MSA progresses, every muscle in the body eventually gets affected by the degeneration of the autonomic nerves & other derangements which cannot be compensated for anymore by the "voluntary" nervous system. I have a patient who is likely going through his last stages & it is a relentless disease process for which he now refuses any & all interventions to help him with breathing or swallowing. ...Read more

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Does spinal cerebellar ataxia effect the heart musscle?

Does spinal cerebellar ataxia effect the heart musscle?

Yes: Friedrich's ataxia, a form described in the 1860's, does cause a hypertrophic cardiomyopathy, classically. Some of the other forms may or may not involve the heart. ...Read more

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MRI brain results Impression- there is cerebral atrophy with subcortical WMC, consistent wit microangiopathic disease, demyelination, or giliosis?

MRI brain results  Impression- there is cerebral atrophy with subcortical WMC, consistent wit microangiopathic disease, demyelination, or giliosis?

Covering the bases: That signal that is seen in patients who age is seen very frequently. Most of the time it is what has become known as microangiopathic disease or small vessel disease. Demyelination and gliosis come with a more notable history. Gliosis or scarring and demyelination also produces symptoms that MRI is useful for. Depends on why you had the MRI in the first place. The first entity more common than 2 ...Read more

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What's olivopontine cerebellar atrophy?

What's olivopontine cerebellar atrophy?

Degenerative disease: A large group of sporadic and inherited disorders with symptom onset in the 5th decade of life. Main manifestations include ataxia, first in the legs then arms, hands and facial muscles.Characterized by extensive degeneration of the cerebellum, pontine nuclei and medullary olivary nuclei, opca's have been described with many other clinical findings. Treatment is symtom specific and variable. ...Read more

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What's mechanism of action of isoniazid in cerebellar ataxia in multiple sclerosis?

What's mechanism of action of isoniazid in cerebellar ataxia in multiple sclerosis?

Tough to treat: Cerebellar ataxia is a tough problem too control, but Isoniazid is not going to help. In fact, the only drug that has ever seemed useful symptomatically was buspar, and it helped only a small percentage. Better, if you have ms is to immediately treat all relapses, and use a potent disease modifying agent, such as tysabri, (natalizumab) gilenya, or tecfidera, as there is a chance that some problems may reverse. ...Read more

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What are the last stages of motor neurons disease, bulbar palsy?

What are the last stages of motor neurons disease,  bulbar palsy?

Impaired cranial nn: Cranial nerves 9 - 12. Are usually affected in bulbar palsy (a lower motor neuron disease, as compared to pseudobulbar palsy, which i just discussed). Again, there are multiple causes, different ones though. Common symptoms can afftect speech (dysarthria), swallowing (dysphagia), choke on liquids, voice problem (dysphonia). Aspiration of food or fluids can lead to pneumonia and death. ...Read more

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Optic neuritis (nmo) or multiple sclerosis (ms)? What are the different victims?

Optic neuritis (nmo) or multiple sclerosis (ms)? What are the different victims?

Say what???: This question is confusing! optic neuritis (abbreviated on) is one of many symptoms of ms and results from inflammation in one or both optic nerves. It is one of the most common symptoms of ms and typically causes eye pain and decreased vision in one eye. It does not typically cause complete blindness. Multiple sclerosis (ms) is an autoimmune disorder of the center nervous system. See below. ...Read more

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S+s of end stage primary brain cancer, (aa iii) r medial temporal lobe, diffuse numerous cells. Growing!/brainstem and posterior temp./basal ganglia?

S+s of end stage primary brain cancer, (aa iii) r medial temporal lobe, diffuse numerous cells. Growing!/brainstem and posterior temp./basal ganglia?

Ask for more info: Signs and symptoms can vary greatly with any 'end-stage' cancer. Things like if it has spread to other organs, impacting functional status and alertness (sleeping more, in bed most of the time), causing pain/seizures, and so on. His doctors can maybe determine what is most likely. If not involved already ask for hospice or palliative care help as they could also help answer what the s/s might be. ...Read more

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What are ataxia, cerebellar or spinocerebellar degeneration?

Progressive disorder: Genetic and familial conditions can lead to a progressive degeneration of the cerebellum and brainstem structures. There are many different types. Multiple sclerosis can also cause progressive balance problems that can mimic degenerative disease. Tumors can also mimic degenerative disease. A quality MRI and good neurological evaluation is necessary. ...Read more

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Ventricular system and extra ventricular CSF spaces show mild prominence, suggestive of mild cerebral atrophy. Patient can't walk. Age 26 years male.?

Ventricular system and extra ventricular CSF spaces show mild prominence, suggestive of mild cerebral atrophy.
Patient can't walk. Age 26 years male.?

See another cause: Men in their twenties may have mild cerebral atrophy from alcohol abuse, schizophrenia, birth injury, some other cause, or an overread by a radiologist. None of these will stop him from walking. Look for another explanation. ...Read more

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What are the differences between striatonigral degeneration & multiple system atrophy?

What are the differences between striatonigral degeneration & multiple system atrophy?

MSA and SND: are rare Parkinson's plus degenerative conditions. The tend not to respond to medications for Parkinson's disease. The differences are subtle but many. I suggest you google "Parkinson's plus" for a good explanation. It would take more than the 400 character limit to scratch the surface. ...Read more

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Dad, 66, is affected with "chronic ischemic changes in periventri white matter" and "disprop prominence of ventri system c/p to cortical sulci" cure?

Dad, 66, is affected with "chronic ischemic changes in periventri white matter" and "disprop prominence of ventri system c/p to cortical sulci" cure?

Chronic ischemia: What you are seeing on the mr are common aging changes seen on mr. As for a "cure" being available, not at the moment and likely years before any solution. ...Read more

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Which peripheral nerves are affected with guillain barre syndrome ?

Which peripheral nerves are affected with guillain barre syndrome ?

Affected nerves are:: Any peripheral sensory-motor branch of nerves that affect the anterior musculature of the leg and foot. Becuase gb causes upper motor nerve disruption of muscular function, the most affected nerves are those in the lower leg and foot that are part of the "swing" phase of gait, namely the extensor muscle of the foot and anterior tibialis muscle. The nerve roots affected are l3-l4-l5-s1. ...Read more

Cerebellum (Definition)

An area in the back of the brain that helps coordinate movement, speech, and eye movements. It has connections to the frontal lobes also and may play a role in helping you ...Read more