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Doctor insights on: Multiple Myeloma Stages And Prognosis Kidney Failure

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Dr. Lois Freisleben-Cook
124 doctors shared insights

Kahler Disease (Definition)

I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more


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My brother (51) is in the final stages of multiple myeloma and was told he will die of kidney failure. Blood tranfusions weekly. Timeline estimate?

My brother (51) is in the final stages of multiple myeloma and was told he will die of  kidney failure. Blood tranfusions weekly. Timeline estimate?

Get extra support: Agree with prior answer that difficult to say. If not already involved ask for a palliative medicine specialist to work with your hematology-oncology team. They might be able to provide additional prognostication opinions as they monitor his progress and also provide additional support for the time that he has. ...Read more

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Kidney biopsy shows the reason for kidney failure is multiple myeloma. No bone damage, hemo. More than 12. Will kimo therapy help to recover fully?

Seek opinion from a: This is unusual way to make a diagnosis of multiple myeloma(mm). Typically we need to do a bone marrow biopsy and look for cancer cells in the marrow. These cells produce abnormal proteins(m protein) which will show up either in the blood(commonly) or in the urine. We use a test called protein electrophoresis. If these tests have not been done, seek a second opinion. Chemo will help to control mm. ...Read more

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How does multiple myeloma affect the kidney?

How does multiple myeloma affect the kidney?

Nephropathy: Myeloma produces proteins called light chains which can essentially "clog up" the kidney producing myeloma nephropathy. Myeloma also produces humoral substances which can damage the kidney. ...Read more

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What is the current prognosis of african american women with multiple myeloma with renal failure?

What is the current prognosis of african american women with multiple myeloma with renal failure?

Depends: This can best be answered by your treating physician. It often depends on age, other medical disorders, previous treatments, response to velcade (bortezomib). Most patients will have improvement in renal failure if this is the first treatment they receive, and the treatment usually includes velcade (bortezomib). ...Read more

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What is the prognosis (chance of recovery) for multiple myeloma and other plasma cell cancer types?

What is the prognosis (chance of recovery) for multiple myeloma and other plasma cell cancer types?

Better than before: Most patients can now achieve remission either with standard therapy or stem cell transplant. The remissions can be long lived although patients are not cured. Many live a decade or more with good quality of life and this time line continues to get longer with the new targeted therapies. The average life span used to be 2.5 years. ...Read more

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What is the prognosis of multiple myeloma in terms of survival rates by stage?

See below: Treatment for multiple myeloma has improved markedly and drug treatment alone or drug treatment with auto or donor stem cell transplants can produce decades long remissions. See this site for more info. http://www.mayoclinic.org/diseases-conditions/multiple-myeloma/basics/definition/con-20026607 ...Read more

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Why sickle cell anemeia / multiple myeloma cause diabetes insipidus ? Is it because it may obstruct the blood flow to the kidneys and damage them?

Why sickle cell anemeia / multiple myeloma cause diabetes insipidus ? Is it because it may obstruct the blood flow to the kidneys and damage them?

Basically right: Even sickle cell trait ruins much of the concentrating ability of the kidneys by adulthood. Myeloma is more likely to damage and obstruct the tubules themselves. Both produce a kidney lesion that prevents the urine from becoming concentrated, rather than a pituitary diabetes insipidus. ...Read more

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I have Multiple Myeloma & I'm hypocellular I have been offered steroid injection for pain is it safe?

I have Multiple Myeloma & I'm hypocellular I have been offered steroid injection for pain is it safe?

Steroid is treatment: Steroids are part of the standard treatment of myeloma. Usually the steroid (typically dexamethasone) is administered with another agent. It is usually administered by mouth. It's not clear what your pain is or what kind of injection is proposed. ...Read more

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M54, if m protein is high, no mark on x ray, blood count normal. Does this means no multiple myeloma.

It depends on severa: Besides m protein level, a bone marrow eaxmination is required to determine the plasma cell number/count. If the bone marrow does not have more than 10% plasma cells, then it is not a myeloma, which usually has lots of plasma cells in the bone marrow. ...Read more

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I'm suffering from seizures after stopping thalidomide. I've used other to stop them but they won't go away. A Multiple Myeloma patient ?

I'm suffering from seizures after stopping thalidomide. I've used other to stop them but they won't go away. A Multiple Myeloma patient 
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? Relationship.: Thalidomide has neurological side effects but is not commonly thought to cause seizures. In fact, early studies suggested thalidomide might have anti-seizure activity. Myeloma does not commonly cause seizures either, although it might contribute to seizures if it causes electrolyte abnormalities or a skull tumor involves the surface of the brain. Work with your doc to evaluate and treat seizure ...Read more

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What is a young age for multiple myeloma? Under 50 years?

MM and age: Mm is a disease of older adults. The median age at diagnosis is 66 years; only 10% and 2% of patients are younger than 50 and 40 years, respectively. ...Read more

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What drugs are the standard of care in the us for multiple myeloma? What drugs are the standard of care in france, germany and canada? Why differe

Complex: Too complex to answer definitively in 400 characters. 1) country differences depends on different forms of "fda" & often cost/value calculations in other countries. 2) "standard" is really standards (plural) of care, which depends on untreated/relapsed, bmt candidate (possibly), & individual considerations (eg renal fn, oral vs. Iv, age, lifestyle, etc). This complexity reflects rapid change. ...Read more

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How long do patients live with multiple myeloma?

How long do patients live with multiple myeloma?

Depends: Myeloma has a variable natural history. Many patients have had myeloma for years prior to diagnosis without realizing it, while others are diagnosed by screening for monoclonal protein in the blood. Modern hematologists can use advanced treatments like velcade, revlimid, (lenalidomide) thalomid, and stem cell transplant, allowing myeloma patients to live longer than ever. More info: http://bit.Ly/lrzotm. ...Read more

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What do you suggest if my dad was just diagnosed with multiple myeloma?

What do you suggest if my dad was just diagnosed with multiple myeloma?

Treatment helps: The majority of people with myeloma have a significant benefit from treatment. He should see an oncologist, of course. Learn more about it here: http://www.cancer.gov/cancertopics/pdq/treatment/myeloma/Patient ...Read more

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Lenalidomide is one of the earliest drug to cure multiple myeloma, is this true?

Not true: lenalidomide is one of agents /treatments we use to treat multiple myeloma. combining with other agents, it has demonstrated response and survival, however, unfortunately we still are unable to cure mutliple myeloma at this time. pomalidomide is newer line of lenalidomide. ...Read more

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Y total portin 8.2 normal to 8.3 albumin 3.8 and normal to 4.8 mean globulin is high could it be to multiple myeloma?

Not necessarily: In most cases of elevated globulin, no multiple myeloma is present. Globulin elevation is often non-specific and can be present in cases of inflammation such as colds, infections, etc. To rule in multiple myeloma, there must be certain globulin fractions present. Electrophoresis of the blood and/or urine will be able to determine that. ...Read more

Kidney (Definition)

The kidneys are paired organs that lie on either side of the vertebral column. Part of their critical functions include the excretion of urine and removal of nitrogenous wastes products from the blood. They regulate acid-base, electrolyte, fluid balance and blood pressure. Through hormonal signals, the kidneys control the ...Read more


Dr. Tarek Naguib
594 doctors shared insights

Kidney Failure (Definition)

A condition in which your kidneys suddenly stop working normally. Since your kidneys remove waste products and help balance water and salt and other minerals (electrolytes) in your blood, when your kidneys stop working, waste products, fluids, and electrolytes build up in your body. This can cause problems ...Read more