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Doctor insights on: Multiple Myeloma Plasma Cells

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Is plasma cell myeloma hereditary?

Is plasma cell myeloma hereditary?

Majority Not: Majority of myeloma cases is not hereditary. A small but unknown fraction of cases are familial. The risk of developing myeloma is approximately 3.7-fold higher for persons with a first degree relative with myeloma. ...Read more

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Dr. Jeffrey Satinover
125 doctors shared insights

Kahler Disease (Definition)

I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more


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Plasma cell Myeloma Myelogram test shows- Plasma cell=24% No haemoparasites seen Leucopoisesis-More active with Plasmacytosis?

Plasma cell Myeloma
Myelogram test shows- Plasma cell=24%
No haemoparasites seen
Leucopoisesis-More active with Plasmacytosis?

Need more info: From what you stated, you have a serious disorder of the bone marrow and should consult a hematologist. The subject cannot be adequately addressed in this forum. ...Read more

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Are stem cell transplants for multiple myeloma effective?

Yes.: Autologous stem cells transplants (from yourself as donor when in near remission) result in improved progression free survival and probably overall survival. Allogeneic transplant (from someone else) is more complex, and many would consider it experimental. Although the procedure may cure the disease, there are significant complications and risks that may offset the benefits. ...Read more

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Can stem cell transplants cure multiple myeloma?

Can stem cell transplants cure multiple myeloma?

Remission: Multiple myeloma is treated classically with chemotherapy and autologous stem cell transplantation. Both modalities can put the disease on remission and prolong life substantially. I personally do not offer allogeneic stem cell transplant for multiple myeloma unless on clinical trial or under very stringent circumstances. Multiple myeloma remains an incurable but very treatable disease. ...Read more

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How bad is multiple myeloma with 40% abnormal plasma cells in bone marrow?

How bad is multiple myeloma with 40% abnormal plasma cells in bone marrow?

Depends: The number of plasma cells is not the only determinant of prognosis. Are there bone lesions on x-ray? Is kidney function normal? Has there been a response to therapy? Many patients with 40% plasma cells at diagnosis can do well for years. ...Read more

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Can 14 percent of plasma cells mean mgus?

Can 14 percent of plasma cells mean mgus?

Usually lower: In MGUS (monoclonal gam myopathy of unknown significance) the plasma cells usually comprise less than 10% of the marrow. In MGUS there are no lyric (destructive) lesions in the bones. A hematologist is the doctor to see, but even gopher may have difficulty distinguishing MGUS from smoldering myeloma. ...Read more

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How many plasma cells in the bone marrow need treatment fr smoldering myloma ?

How many plasma cells in the bone marrow need treatment fr smoldering myloma ?

Complex question: It's not just the number, but how they crowd out normal cells, and how much other problems they cause (elevated calcium, sludging, infiltration of bone, etc.) would probably need a special online consult to sort this out better. Without an actual examination, I cannot give specific medical advice on your particular health, ...Read more

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Can monoclonal IgM kappa light chain gammopathy turn into multiple myeloma?

It can: Yes, it can . It will depend on how much is the quantity of the monoclonal proteine, how many plasma cells on the bone marrow and ultimately whether one has end organ damages/ whether some other organs are affected significantly by the monoclonal protein. That is why some blood work, imaging study and bone marrow biopsy need to be done. ...Read more

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What types of treatment exist for multiple myeloma and other plasma cell cancer types?

"Many": Myeloma and other plasma cell dyscrasia treatments has evolved from standard cytotoxic approaches (eg mp, vad, hypercvad) to "novel" therapies. Immunomodulatory drugs (imids) - eg thalidomide, lenalolidomide, pomalidomide proteasome inhibitors - eg, bortezomib, carfilzomib, etc other: hsp90 inhibitors, hdaci, b-raf, etc. Over the last few years multiple new drugs have been approved for myeloma. ...Read more

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Stem cells for type1 daibetis?

Stem cells for type1 daibetis?

Stem Cells: Adult stem cells have helped Leukemia, lymphoma. We have been using limbal stem cell transplants in eye surgery for years with excellent results. See eyedoc2020@blogspot.com. Stem cell injections are now being used to treat painful joints (shoulders, hips, etc) Still there are few published studies proving its benefit in some of these conditions. No published study saying it cures Diabetes yet. ...Read more

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Life expectancy of myeloma patients after autologous stem cell transplant?

Life expectancy of myeloma patients after autologous stem cell transplant?

Myeloma : There are many things that go into predicting life expectancy of somebody with myeloma who has an autologous stem cell transplant. The rough estimate for somebody getting a transplant in first remission is about 6-7 years now. However, this is something your oncologist or transplant doctor can talk to you about with more specific information. ...Read more

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What differentiates embryonic stem cells from other stem cells?

What differentiates embryonic stem cells from other stem cells?

Origin: Embryonic stem cells are derived from fertilized eggs created to help couples who have difficulty conceiving. This is "murder" according to some religionists. Other stem cells come from other sources. However, since the striking success of embryonic stem cells in early studies on wet macular degeneration, even the conservative presidential candidate no longer seems opposed to their use. ...Read more

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Hypercellular Marrow,increased Trilineage Hematopoiesis,reactive lymphoplasmacytosis, Erythropoiesis normoblastic and decreased. Myeloblasts not increased Megakaryocytes increased, include young forms

Hypercellular Marrow,increased Trilineage Hematopoiesis,reactive lymphoplasmacytosis, Erythropoiesis normoblastic and decreased. Myeloblasts not increased Megakaryocytes increased, include young forms

Marrow confusion: Complex because the answer is dependent on the hematologists total examination and not just a marrow. There is a difference between dysmorphic cells and immature forms so no diagnosis can be made from your comments. Stick with the hematologist or concologist. ...Read more

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What lethal diseases are treated with bone marrow or stem cell transplants?

What lethal diseases are treated with bone marrow or stem cell transplants?

Many: The main lethal disease treated with stem cell transplants are hematologic malignancies such as leukemia, lymphoma and myeloma. Bone marrow failure (aplastic anemia) is also treated with stem cell transplants. Some life-threatening genetic disease can also be treated with a transplant. ...Read more

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What type of leukemia involves immature white blood cells: lymphocytic or myeloid?

What type of leukemia involves immature white blood cells: lymphocytic or myeloid?

Leukemias: Acute leukemias are those with large numbers of immature cells that grow quickly. They can be either myeloid or lymphoid in lineage. Chronic leukemias have more mature cells, a longer course, but can also be myeloid or lymphoid. A hematologist/oncologist is generally the treating physician, and a hematopathologist is the one who give the specific syping. ...Read more

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Immature white blood cells, leukemia, and gleevec, (imatinib) how are these related?

Immature white blood cells, leukemia, and gleevec, (imatinib) how are these related?

Gleevec (imatinib): Gleevec (imatinib) is indicated for a condition called chronic myelogeneous leukemia as well as given to patient with philadelphia positive acute lymphoblastic leukemia. Immature white blood cells which is called blast would be found in acute leukemia. It also can be found in chronic myelogenous leukemia. ...Read more

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Pls hematologist opinion blast cells less than 1 percent but 14 percent plasma cells in bone marrow aspiration means?

Pls hematologist opinion blast cells less than 1 percent but 14 percent plasma cells in bone marrow aspiration means?

Difficult to tell.: From my reading, a blast percentage of 6% is needed for a sure diagnosis of acute leukemia. Toxins, allergies, infections, diabetes, liver disease, inflammation, and anemias can all cause a leukeamoid reaction that causes plasmacytosis in the bone marrow usually lower than 20% but sometimes up to 50%. Immunohistological studies can give more information. Need more info like blood cell counts. ...Read more

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What is the prognosis (chance of recovery) for multiple myeloma and other plasma cell cancer types?

What is the prognosis (chance of recovery) for multiple myeloma and other plasma cell cancer types?

Better than before: Most patients can now achieve remission either with standard therapy or stem cell transplant. The remissions can be long lived although patients are not cured. Many live a decade or more with good quality of life and this time line continues to get longer with the new targeted therapies. The average life span used to be 2.5 years. ...Read more

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How are adult stem cells and embryonic stem cells different?

How are adult stem cells and embryonic stem cells different?

Stem Cells: Check out regenexx.Com for more info. Basically adult stem cells are usually from your own blood, fat or bone marrow. Embryonic stem cells are from fetal tissue and umbilical cord blood and tissue but are not your own unless you had this harvested when you were born. ...Read more

Dr. Liawaty Ho
753 doctors shared insights

Multiple Myeloma (Definition)

A cancer of the plasma cells, which are responsible for producing antibodies for your body. Symptoms include kidney insufficiency, anemia, bone ...Read more


Plasma (Definition)

It is the fluid portion of both the blood and lymph system in which the ...Read more