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Doctor insights on: Multiple Myeloma Plasma Cells

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Dr. Daniel Saurborn
113 doctors shared insights

Kahler Disease (Definition)

Kahler disease is also known as Multiple myeloma. I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more


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What is the definition or description of: multiple myeloma?

What is the definition or description of: multiple myeloma?

Plasma cell cancer: Multiple myeloma is a cancer of plasma cells (pcs). Pcs are the specialized b lymphocytes that produce antibodies. When there is a cancer or one (mono-) clone (= monoclonal, m) pc population they can product m-proteins. Symptoms include crab - hypercalcemia, renal (kidney) insufficiency, anemia, bone disease; also infection and pain. More: http://www.Cancer.Net/cancer-types/multiple-myeloma. ...Read more

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How will my doctor know if I have multiple myeloma? 

Labs, xrays: There are a series of blood and urine tests that will give the doctor a good idea if you have the disease. These are usually followed by x-rays looking for tell-tale signs of myeloma and a bone marrow test which would identify the cancer cells themselves. ...Read more

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What is the prognosis (chance of recovery) for multiple myeloma and other plasma cell cancer types?

What is the prognosis (chance of recovery) for multiple myeloma and other plasma cell cancer types?

Better than before: Most patients can now achieve remission either with standard therapy or stem cell transplant. The remissions can be long lived although patients are not cured. Many live a decade or more with good quality of life and this time line continues to get longer with the new targeted therapies. The average life span used to be 2.5 years. ...Read more

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What types of treatment exist for multiple myeloma and other plasma cell cancer types?

"Many": Myeloma and other plasma cell dyscrasia treatments has evolved from standard cytotoxic approaches (eg mp, vad, hypercvad) to "novel" therapies. Immunomodulatory drugs (imids) - eg thalidomide, lenalolidomide, pomalidomide proteasome inhibitors - eg, bortezomib, carfilzomib, etc other: hsp90 inhibitors, hdaci, b-raf, etc. Over the last few years multiple new drugs have been approved for myeloma. ...Read more

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What types of questions should I ask my doctor regarding treatment for multiple myeloma or other plasma cell cancer?

What types of questions should I ask my doctor regarding treatment for multiple myeloma or other plasma cell cancer?

1-2-3: Cancer 1-2-3: 1) diagnosis - myeloma vs. ? 2a) stage - iss (not that relevant for individual) 2b) prognostic factors - eg cytogenetics, pcli (if avail), gep (new), bone disease, etc. 3) treatment -- goals (response or quality or....) and options. Some regiments are easy eg rd which is good for a low burden mm disease and working pt vs. More complicated "induction" regimen for high risk/burden. ...Read more

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How bad is multiple myeloma with 40% abnormal plasma cells in bone marrow?

How bad is multiple myeloma with 40% abnormal plasma cells in bone marrow?

Depends: The number of plasma cells is not the only determinant of prognosis. Are there bone lesions on x-ray? Is kidney function normal? Has there been a response to therapy? Many patients with 40% plasma cells at diagnosis can do well for years. ...Read more

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Can stem cell transplants cure multiple myeloma?

Can stem cell transplants cure multiple myeloma?

Remission: Multiple myeloma is treated classically with chemotherapy and autologous stem cell transplantation. Both modalities can put the disease on remission and prolong life substantially. I personally do not offer allogeneic stem cell transplant for multiple myeloma unless on clinical trial or under very stringent circumstances. Multiple myeloma remains an incurable but very treatable disease. ...Read more

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Are stem cell transplants for multiple myeloma effective?

Yes.: Autologous stem cells transplants (from yourself as donor when in near remission) result in improved progression free survival and probably overall survival. Allogeneic transplant (from someone else) is more complex, and many would consider it experimental. Although the procedure may cure the disease, there are significant complications and risks that may offset the benefits. ...Read more

Dr. Liawaty Ho
734 doctors shared insights

Multiple Myeloma (Definition)

Multiple myeloma is a cancer of plasma cells (pcs). Pcs are the specialized b lymphocytes that produce antibodies. When there is a cancer or one (mono-) clone (= monoclonal, m) PC population they can product m-proteins. Symptoms include crab - hypercalcemia, renal (kidney) insufficiency, anemia, bone disease; also infection ...Read more


Plasma (Definition)

It is the fluid portion of both the blood and lymph system in which the ...Read more