Doctor insights on:
Multiple Myeloma Life Expectancy After Stem Cell Transplant
Myeloma: There are many things that go into predicting life expectancy of somebody with myeloma who has an autologous stem cell transplant. The rough estimate for somebody getting a transplant in first remission is about 6-7 years now. However, this is something your oncologist or transplant doctor can talk to you about with more specific information. ...Read more
A stem cell transplant may be needed if you have a disease that damages the cells in the bone marrow or if your received high doses of chemotherapy or radiation. Depending on the type of transplant, your procedure may be called a bone marrow transplant, a cord blood transplant, or a peripheral blood stem cell transplant. All three use stem cells, which are immature cells that give rise to specific cell types. Stem cell transplants are similar to blood transfusions and generally ...Read more
Remission: Multiple myeloma is treated classically with chemotherapy and autologous stem cell transplantation. Both modalities can put the disease on remission and prolong life substantially. I personally do not offer allogeneic stem cell transplant for multiple myeloma unless on clinical trial or under very stringent circumstances. Multiple myeloma remains an incurable but very treatable disease. ...Read more
Yes.: Autologous stem cells transplants (from yourself as donor when in near remission) result in improved progression free survival and probably overall survival. Allogeneic transplant (from someone else) is more complex, and many would consider it experimental. Although the procedure may cure the disease, there are significant complications and risks that may offset the benefits. ...Read more
Yes: This is a very difficult question today because every situation with myeloma is different. We do not double transplant all myeloma patients like we have done in the past. It is sometimes reasonable if the first was previously successful and donor cells remain. We now have so many treatments for myeloma that sometimes we do an allogeneic transplant or treat with other drugs (velcade, carfilzomab. ...Read more
How do I get the statistics for high risk myeloma stem cell transplant results. Autologous transplant.
Try this link: Http://www. Uptodate. Com/contents/autologous-hematopoietic-cell-transplantation-in-multiple-myeloma.Get a more detailed answer ›
Much better now: With all the new targeted drugs for myeloma and several to come, patients live many more years. Some have said this cancer is now more like a chronic disease - still dangerous and needing treatment but it is characterized by longer periods of remission after treatment. Therefore a 65 or 75 year old person may have a normal life span with this disease now. ...Read more
Years: This really varies depending most importantly on the chromosome abnormalities. Patients with this diagnosis are living longer, whereas previously many died within 3 years, most are living much longer. ...Read more
Depends on heart: The light chain deposition disease is unlikely to affect survival. In fact a review of myeloma and kidney failure published last year demonstrated no change in outcome in myeloma patients with or without kidney failure. The biggest predictor of outcome is response to chemotherapy. Velcade (bortezomib) (new chemo) has been a game changer. In addition, patients with cardiac involvement do very poorly. ...Read more
My father died about 5 years ago from multiple myeloma. I was the bone marrow donor for his transplant. I am an only child and am wondering about my risk factor for myeloma, especially since my marrow was considered a good match.
An nci study is looking at characterizing families that may be at higher risk to identify causes:
screening individuals and families at high risk for hematologic cancers
http://clinicaltrials. Gov/ct2/show/nct00052234? Term=nct00052234&rank=1. ...Read more
My friend HS phyllodes. Tumor ws removd. Tissue around negative. Sd breast b moved? She hd multiple myeloma & bone marow transplnt. In remission now. Tx
Depends: Phyllodes breast tumors are rare and most are benign. It depends on the final pathology findings. Benign tumors only need removal with clear margins. Cancerous phyllodes tumors may need mastectomy. See this site: http://m.Cancer.Org/healthy/findcancerearly/womenshealth/non-cancerousbreastconditions/non-cancerous-breast-conditions-phyllodes-tumors. ...Read more
What is the prognosis (chance of recovery) for multiple myeloma and other plasma cell cancer types?
Better than before: Most patients can now achieve remission either with standard therapy or stem cell transplant. The remissions can be long lived although patients are not cured. Many live a decade or more with good quality of life and this time line continues to get longer with the new targeted therapies. The average life span used to be 2.5 years. ...Read more
Depends: The number of plasma cells is not the only determinant of prognosis. Are there bone lesions on x-ray? Is kidney function normal? Has there been a response to therapy? Many patients with 40% plasma cells at diagnosis can do well for years. ...Read more
What types of questions should I ask my doctor regarding treatment for multiple myeloma or other plasma cell cancer?
1) diagnosis - myeloma vs.?
2a) stage - iss (not that relevant for individual)
2b) prognostic factors - eg cytogenetics, pcli (if avail), gep (new), bone disease, etc.
3) treatment -- goals (response or quality or....) and options. Some regiments are easy eg rd which is good for a low burden mm disease and working pt vs. More complicated "induction" regimen for high risk/burden. ...Read more
Myeloma and other plasma cell dyscrasia treatments has evolved from standard cytotoxic approaches (eg mp, vad, hypercvad) to "novel" therapies.
Immunomodulatory drugs (imids) - eg thalidomide, lenalolidomide, pomalidomide
proteasome inhibitors - eg, bortezomib, carfilzomib, etc
other: hsp90 inhibitors, hdaci, b-raf, etc.
Over the last few years multiple new drugs have been approved for myeloma. ...Read more
Does getting radiation, chemotherapy, and a stem cell transplant affect chances of having kids later in life?
Are there malignant cells in the semen of a man with multiple myeloma? If so can this be dangerous for a woman with a history of cervical dysplasia?
Why sickle cell anemeia / multiple myeloma cause diabetes insipidus? Is it because it may obstruct the blood flow to the kidneys and damage them?
Basically right: Even sickle cell trait ruins much of the concentrating ability of the kidneys by adulthood. Myeloma is more likely to damage and obstruct the tubules themselves. Both produce a kidney lesion that prevents the urine from becoming concentrated, rather than a pituitary diabetes insipidus. ...Read more
Low red blood cells, very low anion gap, and high blood protein. Should I worry about multiple myeloma? Back/hip pain recent.
Anything Is possible: There are numerous possible causes. Have your doctor order a serum protein electrophoresis blood test. If there is no monoclonal spike then myeloma is ruled out. ...Read more
My husband had a stem cell transplant in sept. He is having difficulty urinating. Mri was normal. Could this be life threatening or more likely something simple?
Probably something: That is treatable and not life threatening. ...Read more
Refractory ALL in adolescent male 21 years management other than Allogeneic Stem Cell Transplant?
Complex question: Only experts in the field, hematologists/oncologists would answer this question after careful review of the case and different options available, I know it might be frustrating at times, but complex condition as ALL need to be managed in specialized hospitals/institutions, it's your right as a patient to have second and even third opinion, but in the end you have to trust the treating team, good luck ...Read more
It does no: Only kidney transplant can help to replace a non functional kidney...No stem cells available yet! ...Read more
See below: To this date I am not aware that stem cell transplant helps kidney disease. You need a organ transplant to replace kidney function when the native kidneys have lost all function. There is research ongoing for adding some biological function with kidney cells in artificial kidneys. ...Read more
Select patients: Allogeneic (donor) stem cell transplants can be conducted using less intensive (non-ablative) regimens with excellent results for patients with CLL. It is not the first line of therapy, since patients can have remissions of several years with simpler therapies. Fatal complications still may occur in 25% of patients, but unlike other treatments, the remainder have a good chance of being cured. ...Read more
I have stem cell transplant like 80 days ago now im notice that I have infection in my gum what should I do?
Realistic chance of survival for 5 year old with stage 4 neuroblastoma? Currently on 3rd of 6 rounds of chemo, will have stem cell transplant.
Around 30%: Neuroblastoma is mainly a childhood disease usually diagnosed at around 1 year, up to about 5 years. It is derived from the primitive cells of the adrenal gland and while appearing in retroperitoneum can be found in chest and head and neck, spreading to lungs and bone. The approach here is chemo, more becoming available followed by stem cell treatment. Today survival is around 30% for stage 4 ...Read more
I was told at age ten that the chemo, stem cell transplant would damage my reprodctive parts, my cycle is irregular should I discuss birthcontrol?
When Stem Cell Transplant Therapy will be used to cure or Improve MS patients? Why every cure took so long to use for patients? Please find the cure.
Be careful: This is being promoted to desperate people. It is very expensive and if it has any benefit, it's not obvious. The theoretical considerations these folks have offered don't square that well with what I know about the disease. More generally, progress in therapy would proceed faster if the public accepted more risks in trials of new treatments -- but that's for the lawyers and ethicists. ...Read more
After relapsing with nhl (diffuse large b-cell) is it better to do auto stem cell transplant or the collection only and then rituxan (rituximab) maintenance?
In medicine: a transfer from one body or body part to another of an organ (liver, heart, lung, kidney, pancreas bowel) or tissue (hand, face, hair). The immune system fights foreign invaders (like infections) so it will reject transplants from other people (allotransplants) because they look like infections. So transplants usually require drugs to ...Read more
I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more