Doctor insights on:
Multiple Myeloma Life Expectancy After Stem Cell Transplant
Myeloma: There are many things that go into predicting life expectancy of somebody with myeloma who has an autologous stem cell transplant. The rough estimate for somebody getting a transplant in first remission is about 6-7 years now. However, this is something your oncologist or transplant doctor can talk to you about with more specific information.
A stem cell transplant may be needed if you have a disease that damages the cells in the bone marrow or if your received high doses of chemotherapy or radiation. Depending on the type of transplant, your procedure may be called a bone marrow transplant, a cord blood transplant, or a peripheral blood stem cell transplant. All three use stem cells, which are immature cells that give rise to specific cell types. Stem cell transplants are similar to blood transfusions and generally ...Read more
Remission: Multiple myeloma is treated classically with chemotherapy and autologous stem cell transplantation. Both modalities can put the disease on remission and prolong life substantially. I personally do not offer allogeneic stem cell transplant for multiple myeloma unless on clinical trial or under very stringent circumstances. Multiple myeloma remains an incurable but very treatable disease.See 2 more doctor answers
Yes.: Autologous stem cells transplants (from yourself as donor when in near remission) result in improved progression free survival and probably overall survival. Allogeneic transplant (from someone else) is more complex, and many would consider it experimental. Although the procedure may cure the disease, there are significant complications and risks that may offset the benefits.
Yes: This is a very difficult question today because every situation with myeloma is different. We do not double transplant all myeloma patients like we have done in the past. It is sometimes reasonable if the first was previously successful and donor cells remain. We now have so many treatments for myeloma that sometimes we do an allogeneic transplant or treat with other drugs (velcade, carfilzomab.
Much better now: With all the new targeted drugs for myeloma and several to come, patients live many more years. Some have said this cancer is now more like a chronic disease - still dangerous and needing treatment but it is characterized by longer periods of remission after treatment. Therefore a 65 or 75 year old person may have a normal life span with this disease now.See 1 more doctor answer
Years: This really varies depending most importantly on the chromosome abnormalities. Patients with this diagnosis are living longer, whereas previously many died within 3 years, most are living much longer.
Depends on heart: The light chain deposition disease is unlikely to affect survival. In fact a review of myeloma and kidney failure published last year demonstrated no change in outcome in myeloma patients with or without kidney failure. The biggest predictor of outcome is response to chemotherapy. Velcade (bortezomib) (new chemo) has been a game changer. In addition, patients with cardiac involvement do very poorly.
I have multiple myeloma. How soon after the first transplant do you advocate doing the second transplant? What is the success rate for the tandem transplants?
It depends: I am not a "transplanter", but I would not word your question the way you have. Some mm patients benefit from a second (tandem) autologous sct. This is something that needs to be discussed with the transplant team and I don't think is amenable to a generic answer.See 1 more doctor answer
My father died about 5 years ago from multiple myeloma. I was the bone marrow donor for his transplant. I am an only child and am wondering about my risk factor for myeloma, especially since my marrow was considered a good match.
NCI Study...: An nci study is looking at characterizing families that may be at higher risk to identify causes: screening individuals and families at high risk for hematologic cancers nct00052234 http://clinicaltrials. Gov/ct2/show/nct00052234? Term=nct00052234&rank=1.See 1 more doctor answer
My friend HS phyllodes. Tumor ws removd. Tissue around negative. Sd breast b moved? She hd multiple myeloma & bone marow transplnt. In remission now. Tx
Depends: Phyllodes breast tumors are rare and most are benign. It depends on the final pathology findings. Benign tumors only need removal with clear margins. Cancerous phyllodes tumors may need mastectomy. See this site: http://m.Cancer.Org/healthy/findcancerearly/womenshealth/non-cancerousbreastconditions/non-cancerous-breast-conditions-phyllodes-tumors.
What is the prognosis (chance of recovery) for multiple myeloma and other plasma cell cancer types?
Better than before: Most patients can now achieve remission either with standard therapy or stem cell transplant. The remissions can be long lived although patients are not cured. Many live a decade or more with good quality of life and this time line continues to get longer with the new targeted therapies. The average life span used to be 2.5 years.See 1 more doctor answer
What types of questions should I ask my doctor regarding treatment for multiple myeloma or other plasma cell cancer?
1-2-3: Cancer 1-2-3: 1) diagnosis - myeloma vs.? 2a) stage - iss (not that relevant for individual) 2b) prognostic factors - eg cytogenetics, pcli (if avail), gep (new), bone disease, etc. 3) treatment -- goals (response or quality or....) and options. Some regiments are easy eg rd which is good for a low burden mm disease and working pt vs. More complicated "induction" regimen for high risk/burden.See 1 more doctor answer
"Many": Myeloma and other plasma cell dyscrasia treatments has evolved from standard cytotoxic approaches (eg mp, vad, hypercvad) to "novel" therapies. Immunomodulatory drugs (imids) - eg thalidomide, lenalolidomide, pomalidomide proteasome inhibitors - eg, bortezomib, carfilzomib, etc other: hsp90 inhibitors, hdaci, b-raf, etc. Over the last few years multiple new drugs have been approved for myeloma.See 1 more doctor answer
Does getting radiation, chemotherapy, and a stem cell transplant affect chances of having kids later in life?
Are there malignant cells in the semen of a man with multiple myeloma? If so can this be dangerous for a woman with a history of cervical dysplasia?
No: No, you can not tranfer cancer from person to person.
Why sickle cell anemeia / multiple myeloma cause diabetes insipidus? Is it because it may obstruct the blood flow to the kidneys and damage them?
Basically right: Even sickle cell trait ruins much of the concentrating ability of the kidneys by adulthood. Myeloma is more likely to damage and obstruct the tubules themselves. Both produce a kidney lesion that prevents the urine from becoming concentrated, rather than a pituitary diabetes insipidus.
Low red blood cells, very low anion gap, and high blood protein. Should I worry about multiple myeloma? Back/hip pain recent.
In medicine: a transfer from one body or body part to another of an organ (liver, heart, lung, kidney, pancreas bowel) or tissue (hand, face, hair). The immune system fights foreign invaders (like infections) so it will reject transplants from other people (allotransplants) because they look like infections. So transplants usually require drugs to ...Read more
I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more
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