Doctor insights on:
Multiple Hereditary Osteochondromatosis
What to do if I have osteochondromatosis and live in a first floor flat, need to move as the I can't manage the stairs?
Ask your orthopedic: Your orthopedic doctor can advice you best. ...Read more
My 14yr old daughter has osteochondromatosis, active in sports, hard time stretching legs, lumps side of knees, do u suggest therapy?
No good way so far: This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In some cases, an affected person inherits the mutation from one affected parent. Other cases result from new mutations in the gene and occur in people with no history of the disorder in their family. So it very hard to control. ...Read more
In part: Hereditary risk is one factor, but the interplay between genetic background and environment is likely in this disease. Identical twins studies show about a 30% risk for MS if one twin has the disease (certainly not 100%). Population studies show certain ancestry may increase or decrease risk (e.g. Northern european ancestry high, whereas asian, african, aboriginal very low). ...Read moreSee 2 more doctor answers
Not primary cause: Ms is clearly influenced by genetics, as we are aware of risk profiles increasing genetic susceptibility and some genetic protective profiles; but, without a number of environmental influences, will not occur. So, like folks who get flu frequently, this is a vulnerability, but not a hereditary illness. ...Read more
Yes: No single gene for MS has been found or likely to be found. Multiple genes have been identified which in different population studies worldwide seem to increase risk or protect against ms. The vast majority of these genes relate to immune system function. Genetic background, combined with environmental trigger likely trigger this disorder. ...Read moreSee 2 more doctor answers
My 10 yr old son has multiple hereditary osteochondroma (30 or more) from his father. Father had the disease as well as chondrosarcoma/should i worry?
Be Careful: A person with hme has an increased risk of developing a rare form of bone cancer called chondrosarcoma as an adult. Problems may be had in later life and these could include weak bones and nerve damage. The reported rate of transformation ranges from as low as 0.57% to as high as 8.3% of people with hme. ...Read more
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