Doctor insights on:
Multiple Hereditary Osteochondromatosis
Yes/No: In a sense all cancer is "genetic" involving changes to the DNA or epi-genetic - changes to DNA modifiers such as methylation. A related question is is multiple myeloma inherited. The answer is sometimes. The risk is about double with a family history. Here is one clinical trial studying this: https://clinicaltrials.gov/ct2/show/NCT00582621 ...Read moreSee 2 more doctor answers
In part: Hereditary risk is one factor, but the interplay between genetic background and environment is likely in this disease. Identical twins studies show about a 30% risk for MS if one twin has the disease (certainly not 100%). Population studies show certain ancestry may increase or decrease risk (e.g. Northern european ancestry high, whereas asian, african, aboriginal very low). ...Read moreSee 2 more doctor answers
Yes and no: Parathyroid disorder can occur in anyone but it could also be hereditary (that is if a family member has hyperparathyrodiism, you are at higher risk of developing the disease). There is also a condition called men (multiple endocrine neoplasm) that can increase your risk of parathyroid disease if someone in your family has it. ...Read moreSee 2 more doctor answers
Yes: No single gene for MS has been found or likely to be found. Multiple genes have been identified which in different population studies worldwide seem to increase risk or protect against ms. The vast majority of these genes relate to immune system function. Genetic background, combined with environmental trigger likely trigger this disorder. ...Read moreSee 2 more doctor answers
3 major types: (nf 1 consists of two or more neurofibromas on or under the skin, or one plexiform neurofibroma, café au lait spots (pigmented, light brown macules, freckles of armpit and groin, lisch nodules (hamartomas of iris), optic nerve gliomas and skeletal deformities. Nf2 centrla nf with bilateral acoustic neuromas(balance, hearing, ringing ears) .Nf3 schwannomas develop cranial, spinal and peripheral nerves. ...Read moreSee 1 more doctor answer
Yes: Genetic diseases by definition are carried in the dna of the patient. This can be evident early, like total albinism, or not be evident until very late in life like huntington disease. They may be inherited from their parents or emerge as a new mutation. New mutations, if not lethal, can be passed to future generations. ...Read more
Can be: Many tumors can and do have a genetic inheritance pattern associated with them. However, many people develop tumors spontaneously without any family history and without any known risk factors. If you have something specific that you would like to discuss please feel free to write to me at: www.healthtap.com/drsaghafi And use Key Code: PDXFNR IF PROMPTED. ...Read more
Several.: The types of colorectal cancers you refer to include hnpcc (hereditary nonpolyposis colorectal cancer) and fap (familial adenomatous polyposis). However, each of these can also arise form a new mutation with no family history. Garden variety colorectal cancer also has some heritability, though far less than those noted above. ...Read moreSee 1 more doctor answer
Not similar diseases: Als is very different, and is a disease of "mis-folded proteins" like alzheimers and parkinson's, and all of these affect older people. Ms is an autoimmune disease afflicting younger patients who have hereditary susceptibilities and environmental exposures. Ms can be successfully treated and controlled, but ALS does not respond well to current therapies. ...Read more
Not Mendelian: Not hereditary in the mendelian sense. Some families have higher incidence of aneurysms. Cofactors such as hypertension, diet and smoking habits may play a role in this. Connective tissue disorders are hereditary and some of these are associated with aneurysms but this is an indirect effect. I do not routinely screen family members but a negative mra can be reassuring. ...Read moreSee 2 more doctor answers
Many types: Metabolic syndrome is insidious. Many features of disease are initially asymptomatic. High blood pressure in early stages is not perceived. Cholesterol issues are asymptomatic unless present for some time. Women may have symptoms of irregular menses, or increased facial hair, but may think this not too abnormal. If you have increasing weight, most on the gut, get checked out by your pcp. ...Read more
BRCA 1 and 2: The breast-ovarian cancer (brca 1 and 2) genes are the only ones so far proven to cause susceptibility to ovarian cancer (as high as 50% lifetime risk for ovarian, 85% for breast cancer if you have a mutation. Other ovarian cancer susceptibility genes may be identified by ongoing research. ...Read moreSee 1 more doctor answer
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