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Doctor insights on: Mucinex Dm Benadryl

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Can I take Mucinex dm and Benadryl (diphenhydramine) together?

Can I take Mucinex dm and Benadryl (diphenhydramine) together?

Medician Question: This combination could make you very sleepy so be careful - in some cases there could be serious consequenses. See your doctor for more definitive treatment of your cough. ...Read more

Dr. John Chiu
1,049 Doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


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I took benadryl to help me sleep but im fighting a nasty cold can I take tissin dm?

I took benadryl to help me sleep but im fighting a nasty cold can I take tissin dm?

You can, but: If you are not allergic to the contents and have a cold, taking an OTC med with DM (dextromethorphan) may be taken and should help you sleep. I would not recommend taking the Benadryl and the OTC med with DM together. You can also check with your primary care MD. ...Read more

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How long after taking Benadryl (diphenhydramine) can I take Bromfed dm?

How long after taking Benadryl (diphenhydramine) can I take Bromfed dm?

Bromfed (brompheniramine) DM: The normal dosing of Bromfed (brompheniramine) dm is four hours, so I think it should be fine to take in four hours. ...Read more

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I gave my 2yr old bromfed dm 6hrs after giving her benadryl. Did I do something wrong? Will. She be ok?

I gave my 2yr old bromfed dm 6hrs after giving her benadryl. Did I do something wrong? Will. She be ok?

Define wrong?: Neither drug is recommended for kids under 6. They used to be given often but more than a decade ago we realized more kids ended up in ER's with an overdose than got any benefit from them. Their main "benefit" was it gave you something to do. But they thicken the kids secretions and make them harder to cough out. A little honey in lemon juice can actually help more. ...Read more

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If my 7 yr old is taking Bromfed Dm and got attacked by Mosquitos is it safe to use Benadryl (diphenhydramine) to help with itching while taking Bromfed Dm?

If my 7 yr old is taking Bromfed Dm and got attacked by Mosquitos is it safe to use Benadryl (diphenhydramine) to help with itching while taking Bromfed Dm?

Probably not: Probably not a good idea. Bromfed and Benadryl (diphenhydramine) both contain "antihistamine" medications which act via the same mechanism. This combination may cause excess sleepiness or lethargy. Bromfed should help with itching. ...Read more

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I'm 19 weeks pregnant and took robotussin dm about 4 hours ago. Can I take benadryl (diphenhydramine) to help me sleep so I can actually get some decent sleep?

I'm 19 weeks pregnant and took robotussin dm about 4 hours ago. Can I take benadryl (diphenhydramine) to help me sleep so I can actually get some decent sleep?

Which Robitussin DM (guaifenesin and dextromethorphan)?: There is one for night time, which contains antihistamine, doxylamine, so Benadryl (diphenhydramine) then would be an extra dose, you need to be careful. Or the other Robitussin max strength DM, which doesn't contain an antihistaminic, then it shouldn't be a problem with the antihistaminic, read the labels carefully, also read about warnings with pregnancy, good luck ...Read more

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I have been treating my 4 year old for a cold flu type virus she had ibuprofen at 9 pm and Benadryl (diphenhydramine) at 1030 mucin ex dm at 11 I thought I was giving T?

I have been treating my 4 year old for a cold flu type virus she had ibuprofen at 9 pm and Benadryl (diphenhydramine) at 1030 mucin ex dm at 11 I thought I was giving T?

Mgt: I would recommend using ibuprofen only for pain and a temperature of 101 or above. The benadryl (diphenhydramine) should be discontinued. A pediatric cough syrup can be used, but is not generally recommended. Using a nasal saline rinse can help to reduce post nasal drip and cough. ...Read more

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Is it ok to mix guafisen (mucinex) with diphenhydramine (benadryl)?

Is it ok to mix guafisen (mucinex) with diphenhydramine (benadryl)?

Yes.: The mix without interaction, but do not take more benedryl than indicated for your age, size, and weight. ...Read more

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I took mucinex dm two hours ago. Is it ok to take one 500 mg acetaminophen?

I took mucinex dm two hours ago. Is it ok to take one 500 mg acetaminophen?

Maybe...: If a person had no problems taking Mucinex DM in the past, and she had no problems taking acetaminophen (Tylenol) in the past, then she should be fine this time taking both medications (because the two medications have different ingredients) either together or apart... as along as she is not taking too much of either medicine than she should take in one day. ...Read more

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I took 100mg of Tramadol. If I was to take a Mucinex-DM tablet would there be any reaction or negative side effects?

I took 100mg of Tramadol. If I was to take a Mucinex-DM tablet would there be any reaction or negative side effects?

Several things: Could happen. Both medications can be sedating so combining the two may make you drowsy. Also both can enhance serotonin effects in the body like agitation, fever, tremors, palpitations, muscle spasms, and skin flushing. You may want to review this with your physician if it a combo you feel like you'll needs for several days or more. ...Read more

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Can you take 2 benadryls (diphenhydramine) and a Mucinex melt?

Can you take 2 benadryls (diphenhydramine) and a Mucinex melt?

Yes, if adult: Assuming the Benadryl (diphenhydramine) is 25mg per capsule, it is ok to take 2 with plain Mucinex for relief of cold symptoms with thick mucus drainage for adults. Realize that Benadryl (diphenhydramine) may cause sedation and should not be used if the individual will be driving or operating machinery. ...Read more

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Can I take cheratussin ac and mucinex dm 600 /30?

Can I take cheratussin ac and mucinex dm 600 /30?

Yes you can: But both are for cough, if no improvement, you better see a heathcare professional, good luck ...Read more

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Can I take mucinex-d and promethazine dm together?

Can I take mucinex-d and promethazine dm together?

Caution: You better try the plain mucinex though, as the 'D' part, pseudoephedrine may interact with promethazine. or don't take them at the same time

good that you asked, always exercise caution with multiple medications, ask you pharmacist / healthcare provider ...Read more

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Can I take mucinex DMV and 5 hours later take promethazine dm?

Can I take mucinex DMV and 5 hours later take promethazine dm?

No: Dextromethorphan has never been shown in studies to relieve any symptom of colds, flu, allergies, bronchitis or pneumonia, including cough, and can be dangerous in high doses.
If you have thick mucous, use PLAIN guafenesin (Mucinex). If you have nausea or a cough use PLAIN phenergan, or (for cough) phenergan + codeine or hydrocodone (but you will need an rx for phenergan + anything).
...Read more

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Can I take a benadryl (diphenhydramine) & Mucinex night together?

Can I take a benadryl (diphenhydramine) & Mucinex night together?

Yes: Benadryl (diphenhydramine) will help you sleep and help with excess mucus production. Mucinex (guaifenesin) is called an expectorant as it helps thin and loosen mucus to make your cough more effective at clearing the mucus from your lungs. There should be no problem taking these two medications together. ...Read more

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I was wondering if I can take coricidin hbp after taking mucinex dm? Thank u

I was wondering if I can take coricidin hbp after taking mucinex dm? Thank u

Perhaps: The coricidin HbP daytime is like mucinex dm, thus you are essentially doubling the dose which is likely ok for most people. The evening formula contains an antihistamine and I see with issue with the combination especially with nighttime formula ...Read more

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I just took a mucinex. Will I be okay if I take Benadryl (diphenhydramine) as well?

I just took a mucinex. Will I be okay if I take Benadryl (diphenhydramine) as well?

Not a good idea: You have to know Mucinex help thin the phlegm and Benadryl (diphenhydramine) has drying effect on mucous or phlegm, so you are defeating the purpose of taking musinex
if you need to take antihistamine with Mucinex for allergy, I will recommend takind over the counter Claritin which may not be as drying as benadryl, (diphenhydramine) and don't forget to drink lot of fluids. ...Read more

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Tonight I had 2 beers. It was two hours ago that I had my last one and I've also had two bottles of water. Can I safely take my mucinex DM?

Tonight I had 2 beers. It was two hours ago that I had my last one and I've also had two bottles of water. Can I safely take my mucinex DM?

Theoretically yes,: No interaction between beer and dextromethorphan, the cough sedating component of the Mucinex DM, but if two beers make you drowsy, and the dextromethorphan has this potential too, so it won't be advisable. Good that you asked, and good that you drank lot of plain water to flush your system, good luck ...Read more

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Adult dosing for Mucinex (guaifenesin) dm max?

Read below: For an adult taking Mucinex (guaifenesin) dm the max dose is 4 tablets in 24 hours. Ideally you take it 1-2 tablets every 12 hours. To maximize its effectiveness, you should drink plenty of water. If it is Mucinex (guaifenesin) dm maximum strength then max dose is 2 tabs/24 hours by taking 1 tab every 12 hours. ...Read more

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Can I take Mucinex (guaifenesin) dm if I am on nambutane?

Probably: Most over the counter mucolytic drugs have very few drug interacations; always best to ask the pharmacist but usually they don't interact with anti-inflammatory medications. ...Read more

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My husband took Mucinex (guaifenesin) DM at 4pm yesterday, 10pm last night, and 5:30 this morning. Is he going to be ok?

Mucinex (guaifenesin) time scale: Mucinex (guaifenesin) DM is an every 12 hour medication with a dosing of 1-2 tablets every 12 hours. If your husband took only one tablet each time reported he remains in the acceptable total amount for a 24 hour period. If he took 2 or more tablets each time he is outside the normal 24 hour dose. A one time misuse is unlikely to cause harm. Continued misuse could be harmful and certainly not advised. ...Read more

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I took 2 mucinex (guaifenesin) dm around 3 pm. I was going to bed and took another around 10:30pm and just took another around midnight. Should I be concerned?

I took 2 mucinex (guaifenesin) dm around 3 pm. I was going to bed and took another around 10:30pm and just took another around midnight. Should I be concerned?

Mgt: The dose at midnight should be delayed. If you experience dizziness or nausea please call your your PCP. Please follow the directions on the package. ...Read more

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Can I take both Virtussin AC and Mucinex DM?

Can I take both Virtussin AC and Mucinex DM?

Yes, but: Be careful when using Virtussin AC as it contains codeine, don't exceed the prescribed dose and don't take it with CNS suppressants or alcohol, best wishes ...Read more

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Hi docs, would Mucinex (guaifenesin) dm get you high?

Hi docs, would Mucinex (guaifenesin) dm get you high?

No: Dextromethorphan is in the Codeine family, but unlike Codeine or hydrocodone (Vicodin) it isn't an active opioid and therefore available OTC without prescription and unregulated by DEA as a controlled substance (unclassed). Cough medicine with Codeine would require a prescription because of abuse potential. ...Read more

Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


Mucinex (Definition)

Guaifenesin is a cough suppressant which is a kind of antihistamine type drug (common ...Read more