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Doctor insights on: Mthfr Mutation Is It Irresponsible To Get Pregnant

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Does mthfr heterozygous c677t mutation affect pregnancy?

Does mthfr heterozygous c677t mutation affect pregnancy?

Likely not much: The existing evidence does not support any strong connection between heterozygotes for either the c or a mutations of mthfr and poor pregnancy outcomes. Homozygotes may well be at greater risk. Depending on clinical history, different levels or surveillance and possible intervention can be considered. ...Read more

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Dr. Dariush Saghafi
4 doctors shared insights

Pregnancy (Definition)

When your due date arrives, you will be more than ready to have your baby! Most women deliver the baby somewhere between 37 and 42 weeks. According to the American College of Obstetricians and Gynecologists, only 5% of babies arrive on the exact due date. Approximately 7% of babies are not delivered by 42 weeks, and when that happens, it is referred to ...Read more


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I am pregnant and have a mthfr gene mutation and i recently read that folic acid is not good for me or the baby and I should take folate instead?

I am pregnant and have a mthfr gene mutation and i recently read that folic acid is not good for me or the baby and I should take folate instead?

MTHFR: If you've been tested for mthfr mutations and do have one, then your body may not do well with Folic Acid at all. You would benefit more from methylfolate since it bypasses the metabolic step that your system has trouble with. You need a functional medicine or integrative medicine doc who really knows mutations in this enzyme ; can advise you plus collaborate with your ob-gyn doc too. ...Read more

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I have mthfr c677t homozygous mutation, history of rectal cancer (dx@35y). Are these related? What is the serum folate (folic acid) level I should aim if want pregnant?

Not related: These are not related. Also recent data shows no clinical significance of having a mrhfr mutation. It is safe for pregnancy and there is no increase risk for miscarriage other than your normal risk factors. Do not need to follow folate (folic acid) or homocysteine levels. ...Read more

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I am 5 weeks pregnant and am heterozygous for mthfr 677ct mutation. I had only stared prenatals (prena 1) two weeks before fertization. I am worried whether my baby will have neural tube defects!

Get more folate (folic acid): Ideally women should be utilizing folate (folic acid) for three months prior to pregnancy but in the real world that rarely happens. The chances of your baby having a problem are not high and there is not much impact you can have at this point. Due to your genetic mutation you should be using a higher dose folate (folic acid)/folinic on a regular basis. I would also use sublingual methyl B12 1 mg daily. ...Read more

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Does heterozygous for MTHFR gene mutation affect pregnancy?, and what about taking synthetic folic acid supplement?

Does heterozygous for MTHFR gene mutation affect pregnancy?, and what about taking synthetic folic acid supplement?

Controversial...: Some studies have shown an association between the MTHFR gene mutation and recurrent miscarriages but this is controversial. Aside from this possibility, it doesn't cause problems with pregnancy. If you have this mutation, its a good idea to take folic acid, vitamin B-12 and Vitamen B-6. Aspirin is also sometimes recommended for women for who have had recurrent miscarriages. Best wishes! ...Read more

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Who can test me for vitamin levels and where can I get 5-mthf, also are there any doctors who specialize in mthfr mutation in san antonio texas?

MTHFR Gene mutation: For more information on methy-folate supplementation and testing for mthfr gene mutations, read this... http://doccarnahan.blogspot.com/2013/10/whats-big-deal-about-methylation-update.html. ...Read more

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Could anybody get the mthfr-a1298c gene mutation?

Depends: The MTHFR 1298 mutation is not uncommon, but for any given individual to have the possibility of having it, one or both of their parents must have it. ...Read more

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How are mthfr mutations and chiari malformation related? Should i get tested if I have chiari? (and high B6 levels, for no good reason)

Forgive my frankness: One lab is promoting testing for mthfr mutations despite the fact that they merely identify folks who may be at slightly extra risk for this-and-that and who need to be extra-sure they get enough nutrients. A majority of people carry at least one 'mutant mghfr' and this is generating all kinds of scares. No relatioship to your chiari. ...Read more

Mutation (Definition)

In genetics, a mutation is a change in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal genetic element. Mutations result from unrepaired damage to dna or to RNA genomes (typically caused by radiation or chemical mutagens), from errors in the process of replication, or from the insertion or deletion of segments of dna ...Read more