Doctor insights on:
Mthfr Mutation Is It Irresponsible To Get Pregnant
Likely not much: The existing evidence does not support any strong connection between heterozygotes for either the c or a mutations of mthfr and poor pregnancy outcomes. Homozygotes may well be at greater risk. Depending on clinical history, different levels or surveillance and possible intervention can be considered. ...Read moreSee 2 more doctor answers
When your due date arrives, you will be more than ready to have your baby! Most women deliver the baby somewhere between 37 and 42 weeks. According to the American College of Obstetricians and Gynecologists, only 5% of babies arrive on the exact due date. Approximately 7% of babies are not delivered by 42 weeks, and when that happens, it is referred to ...Read more
I am pregnant and have a mthfr gene mutation and i recently read that folic acid is not good for me or the baby and I should take folate instead?
MTHFR: If you've been tested for mthfr mutations and do have one, then your body may not do well with Folic Acid at all. You would benefit more from methylfolate since it bypasses the metabolic step that your system has trouble with. You need a functional medicine or integrative medicine doc who really knows mutations in this enzyme ; can advise you plus collaborate with your ob-gyn doc too. ...Read moreSee 2 more doctor answers
I have mthfr c677t homozygous mutation, history of rectal cancer (dx@35y). Are these related? What is the serum folate (folic acid) level I should aim if want pregnant?
Not related: These are not related. Also recent data shows no clinical significance of having a mrhfr mutation. It is safe for pregnancy and there is no increase risk for miscarriage other than your normal risk factors. Do not need to follow folate (folic acid) or homocysteine levels. ...Read moreSee 2 more doctor answers
I am 5 weeks pregnant and am heterozygous for mthfr 677ct mutation. I had only stared prenatals (prena 1) two weeks before fertization. I am worried whether my baby will have neural tube defects!
Get more folate (folic acid): Ideally women should be utilizing folate (folic acid) for three months prior to pregnancy but in the real world that rarely happens. The chances of your baby having a problem are not high and there is not much impact you can have at this point. Due to your genetic mutation you should be using a higher dose folate (folic acid)/folinic on a regular basis. I would also use sublingual methyl B12 1 mg daily. ...Read moreSee 1 more doctor answer
Does heterozygous for MTHFR gene mutation affect pregnancy?, and what about taking synthetic folic acid supplement?
Controversial...: Some studies have shown an association between the MTHFR gene mutation and recurrent miscarriages but this is controversial. Aside from this possibility, it doesn't cause problems with pregnancy. If you have this mutation, its a good idea to take folic acid, vitamin B-12 and Vitamen B-6. Aspirin is also sometimes recommended for women for who have had recurrent miscarriages. Best wishes! ...Read more
Who can test me for vitamin levels and where can I get 5-mthf, also are there any doctors who specialize in mthfr mutation in san antonio texas?
How are mthfr mutations and chiari malformation related? Should i get tested if I have chiari? (and high B6 levels, for no good reason)
Forgive my frankness: One lab is promoting testing for mthfr mutations despite the fact that they merely identify folks who may be at slightly extra risk for this-and-that and who need to be extra-sure they get enough nutrients. A majority of people carry at least one 'mutant mghfr' and this is generating all kinds of scares. No relatioship to your chiari. ...Read more
How many micrograms of folic acid should I take with mthfr before I'm pregnant and after? Can you get too much folic acid?
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I have mthfr 2 mutations, i had 3 miscarriages one 2nd trimeste loss chances of this causing them?
MTHFR SNPs: Yes, methylation problems can definitely cause miscarriages and birth defects. Knowledge is powerful, though. Find a provider who understands how to evaluate and treat this. Have a look at www.mthfr.net there is a list of providers with extra training on MTHFR. ...Read moreSee 2 more doctor answers
Does FADH2 play the same role in MTHFR mutated forms as it does in the otherwise normal form, and could MTHFR mutation alone cause FADH2 depletion?
Homocysteine: The majority of population has at least a single MTHFR mutation and around 40% have a double mutation (either heterozygous (one of each) A1298C & C677T, homozygous (two) C677T or homozygous A1298C). The MTHFR enzyme metabolizes folic acid into 5-MTHF, needed to combine with homocysteine. What is often seen with MTHFR mutations are: elevated homocysteine levels and defective methylation. ...Read more
No: Look for another cause. 30% of white people have one dose and 5% have two. There are some correlations found by some groups but most people in the pathology community do not believe this is sufficient to explain clinical illness. I also see that you are on Methotrexate which can raise mcv, and an elevated B12 means nothing. ...Read moreSee 2 more doctor answers
Yes: The 1298 mutation is not as bad as the 677 mutation. You may have some decreased enzyme function, and would also benefit from methylfolate in small doses as needed. More information here: Http://drfairchild.blogspot.com/2013/10/mthfr.html ...Read more
Is a single mutation mthfr common in children with autism? If homocysteine levels are normal, should I be concerned?,
More research needed: The mutation mthfr has been implicated in a variety of psi strip illnesses from schizophrenia to down's syndrome. Homocysteine levels san be normal in autism. At this juncture no one has been able to find the cause of autism much more research is needed.Take mthfr with a grain of salt. There is absolutely no evidence that it can cause autism. ...Read moreSee 2 more doctor answers
I have 2 mutations mthfr clotting, 3 miscarriages one 2nd tri loss what order reasons can there be for losses I have one healthy live daughter ?
Many: Issues that could involve recurrent miscarriages can be uterine problems, blood clotting disorders (mthfr are a less likely cause), endocrine, and genetic causes. A large portion of causes are unexplained. I would recommend that you discuss this with a reproductive endocrinologist to discuss all options. ...Read more
At which temperature (bodily and external) the MTHFR enzyme, a result of heterozygous C677T mutation, becomes thermolabile, i.e.inactive? Thank you.
N/A: The mutation which causes dysfunction of the MTHFR enzyme is genetic - it doesn't happen because of a variation in body temperature. The rare disorder that this causes is characterized by a possibility of inappropriate clot formation, which can result in stroke or heart attack. However, a person proven to have this mutation may never actually experience such a thrombotic event. ...Read moreSee 2 more doctor answers
Does having the mthfr gene mutation put me at risk for life threatning illness more than the average person? Is there anything i can do 2 help
Depends: Depends on which mutation you have, and if you have one or two mutations. Having two copies of the 677 mutation is a bigger deal than having one copy of the 1298. The 677 and 1298 mutations are each treated differently. But yes, there is help for them. ...Read moreSee 2 more doctor answers
Does the MTHFR genetic mutation cause OCD? if you were treat the mutation, would the ocd improve? any articles or references about ocd and MTHFR?
In genetics, a mutation is a change in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal genetic element. Mutations result from unrepaired damage to dna or to RNA genomes (typically caused by radiation or chemical mutagens), from errors in the process of replication, or from the insertion or deletion of segments of dna ...Read more
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