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Doctor insights on: Mthfr Deficiency Pregnancy

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Does mthfr heterozygous c677t mutation affect pregnancy?

Does mthfr heterozygous c677t mutation affect pregnancy?

Likely not much: The existing evidence does not support any strong connection between heterozygotes for either the c or a mutations of mthfr and poor pregnancy outcomes. Homozygotes may well be at greater risk. Depending on clinical history, different levels or surveillance and possible intervention can be considered. ...Read more

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Dr. Bernard Seif
4 doctors shared insights

Pregnancy (Definition)

When your due date arrives, you will be more than ready to have your baby! Most women deliver the baby somewhere between 37 and 42 weeks. According to the American College of Obstetricians and Gynecologists, only 5% of babies arrive on the exact due date. Approximately 7% of babies are not delivered by 42 weeks, and when that happens, it is referred to ...Read more


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Found out I have MTHFR homozygous 1298. Had one successful pregnancy before I ever knew, but worried about future pregnancies. Precautions to take?

Found out I have MTHFR homozygous 1298. Had one successful pregnancy before I ever knew, but worried about future pregnancies. Precautions to take?

Genetic questions: The best place to start when considering family planning in the context of a known mutation is to sit down with a genetics counselor. There are many facets to this conversation that should be discussed at one time for purposes of both safety and of reassurance. Please consider this first step. ...Read more

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Can you please define mthfr deficiency?

Can you please define mthfr deficiency?

Methylfolate: MTHFR is a gene that codes for an enzyme that makes methylfolate. Mutation can cause decreased enzymatic function resulting in less methylfolate being produced. Not everyone who has MTHFR needs to supplement methylfolate. Those who eat plenty of raw fruit and vegetables may get adequate methylfolate from their diet. ...Read more

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What to do if I have a successful pregnancy with mthfr?

MTHFR: Avoid unmethylated forms of vitamin B12 and folate (folic acid). Instead, use methylcobalamin and methylfolate (folic acid). Also, eat dark leafy greens, uncooked, twice a day. Work with a doctor who is well versed with MTHFR SNPs. You can check www.mthfr.net for a list of doctors trained in this. ...Read more

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What can I do to increase chance of a successful pregnancy with PAI and MTHFR ?

What can I do to increase chance of a successful pregnancy with PAI and MTHFR ?

Consult: I'm not familiar with the acronym PAI so you might want to rephrase your question describing that condition. I'm assuming it might have something to do with platelet problems. MTHFR used to indicate the need for Aspirin daily during conception and pregnancy. But that recommendation has been rescinded. Talk to a perinatologist for a definitive answer regarding PAI ...Read more

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3 miscarriages and a&c mthfr should I be on lovenox (enoxaparin) or heparin on next pregnancy ?

3 miscarriages and a&c mthfr should I be on lovenox (enoxaparin) or heparin on next pregnancy
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Discuss with doctor: Not sure what a&c means. Mthfr mutation is very weakly associated with miscarriage. If you are heterozygous then blood thinning medicines are not indicated. If you are homozygous then possibly. Ask about a fasting homocystine test. Your age of 41 is also a risk factor for miscarriage. ...Read more

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I have had thermal ablation and also have mthfr, is it possible for me to carry a pregnancy to term?

I have had thermal ablation and also have mthfr, is it possible for me  to carry a pregnancy to term?

Unsure: The mthfr should not really matter. Unless you homocysteine is elevated mthfr does not affect anything at all. It is very difficult to become pregnant after a thermal ablation and requires a fertility specialist to investigate and test the uterus to see if pregnancy is possible. ...Read more

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Positive mthfr heterozygous after multiple miscarriages, known pernicious anemia, what is the likelihood of having other b vitamin deficiencies?

Positive mthfr heterozygous after multiple miscarriages, known pernicious anemia, what is the likelihood of having other b vitamin deficiencies?

Not more likely but: Pernicious anemia is due to problems absorbing B12 but doesn't interfere with absorbing other vits.Mthfr mutations mean you have trouble converting Folic Acid to the active form, so take l-5-mthf.Genes don't affect absorption of other b vits but due to genetics some require higher amounts of b's than others-your other issues don't mean you're more likely to have this but it's safe to try b complex. ...Read more

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I have a mutation of the mthfr gene and have had a thermal ablation.I have had 4 pregnancies and lost them.Uterine lining is 3.74 can I carry a baby?

I have a mutation of the mthfr gene and have had a thermal ablation.I have had 4 pregnancies and lost them.Uterine lining is 3.74 can I carry a baby?

MTHFR Gene mutation: Here's some important information on the mthfr gene mutation... http://doccarnahan.blogspot.com/2013/10/whats-big-deal-about-methylation-update.html. ...Read more

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