Doctor insights on:
Mthfr A1298c Gene Mutation
From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more
Does having the mthfr gene mutation put me at risk for life threatning illness more than the average person? Is there anything I can do 2 help
Depends: Depends on which mutation you have, and if you have one or two mutations. Having two copies of the 677 mutation is a bigger deal than having one copy of the 1298. The 677 and 1298 mutations are each treated differently. But yes, there is help for them.See 2 more doctor answers
My MTHFR gene mutation test says 'not detected' but the note below it says 'this assay detects the mutation C677T in MTHFR'. Does it mean I have it?
MTHFR mutations: MTHFR is the gene which produces methylenetetrahydrofolate reductase. Over 50 known mutations in this gene cause reduced function of the enzyme. The most common mutation causing homocystinuria is the C677T mutation, which among other problems increases the risk of stroke. I can't tell how many mutations your particular test could detect, but you do not have the C677T mutation.
Do all mthfr gene mutations benefit from folate over folic acid? Or certain stands? Is there different treatment for heterozygous v homozygous?
MTHFR: MTHFR has several forms. And treatments can vary. Look here for additional information. Http://mthfr. Net/mthfr-c677t-mutation-basic-protocol/2012/02/24/See 3 more doctor answers
Yes: The 1298 mutation is not as bad as the 677 mutation. You may have some decreased enzyme function, and would also benefit from methylfolate in small doses as needed. More information here: Http://drfairchild. Blogspot. Com/2013/10/mthfr. Html
Hi, I'm not really sure how this service works, but I'm going to send my question and see what happens. I have been having fertility treatment and was recently diagnosed with the homozygous C665T MTHFR gene mutation. There is a lot of conflicting inform
Sorry I: Cannot offer more help than this: The "story" is still "OUT" and this gene abnormality has now been blamed for just about EVERYTHING from early heart disease to frequent miscarriages! I would be VERY CAUTIOUS about accepting ANY ADVICE particularly the INTERNET about this "condition" If this is a MAJOR issue consult with a Board Certified GENETICIST! My Opinion only...hope it helps. Good Luck ZSee 2 more doctor answers
I am pregnant and have a mthfr gene mutation and I recently read that folic acid is not good for me or the baby and I should take folate instead?
MTHFR: If you've been tested for mthfr mutations and do have one, then your body may not do well with Folic Acid at all. You would benefit more from methylfolate since it bypasses the metabolic step that your system has trouble with. You need a functional medicine or integrative medicine doc who really knows mutations in this enzyme ; can advise you plus collaborate with your ob-gyn doc too.See 2 more doctor answers
I have a mutation of the mthfr gene and have had a thermal ablation. I have had 4 pregnancies and lost them. Uterine lining is 3.74 can I carry a baby?
MTHFR Gene mutation: Here's some important information on the mthfr gene mutation... http://doccarnahan. Blogspot. Com/2013/10/whats-big-deal-about-methylation-update. Html.See 2 more doctor answers
Does heterozygous for MTHFR gene mutation affect pregnancy?, and what about taking synthetic folic acid supplement?
Controversial...: Some studies have shown an association between the MTHFR gene mutation and recurrent miscarriages but this is controversial. Aside from this possibility, it doesn't cause problems with pregnancy. If you have this mutation, its a good idea to take folic acid, vitamin B-12 and Vitamen B-6. Aspirin is also sometimes recommended for women for who have had recurrent miscarriages. Best wishes!
Does the MTHFR genetic mutation cause OCD? If you were treat the mutation, would the ocd improve? Any articles or references about ocd and MTHFR?
OCD and other: Psychological issues have been found to be linked to the MTHFR mutation. the Spectracell lab in Texas has a test for this and some info on their website. The very best to you. Lots of room for hope.
What does the medical community make of the mthfr genetic mutation? I had a doctor tell me that they no longer look at it or feel it is a problem
MTHFR Gene mutation: If you'd like to do more reading on the health effects of mthfr gene mutation, here's a great article. .. http://doccarnahan. Blogspot. Com/2013/10/whats-big-deal-about-methylation-update. Html.See 1 more doctor answer
I am hetero for the mthfr genetic mutation c677t. Everything I've read says I should be gluten/folic acid/dairy free. Advice regarding this mutation?
I can't agree: ~1 person in 4 is like you. The pathology community is divided over MTHFR testing. I'm undecided. A majority of people who take the test will be told they have an 'abnormal' result and are therefore in need of special supplements which they may then be offered by the folks who have done the test. Talk with your own physician and if necessary an authentic genetic counsellor.See 1 more doctor answer
With bipolar ii, adhd, & c ptsd, what additional tests are beneficial? Ie: hormone, neurotransmitter, DNA mutation (mthfr, a1at. ..) methylation etc.
Yes: I would definitely check mthfr and comt. Both these are involved in methylation. One is involved in neurotransmitter synthesis, and the other in breakdown. Therefore polymorphisms can impact mood, etc, and if so, vitamins and supplements can help the methylation cycle. I check mthfr in most of my patients.See 4 more doctor answers
MTHFR mutation: The genetic finding can possibly increase clotting problems. The mthfr protein is responsible for metabolism of homocysteine. High homocysteine levels can aggravate vessel walls causing a higher risk of clotting. The high homocysteine levels can be treated with folate (folic acid) supplementation, which should decrease the risk.See 1 more doctor answer
If I am compound heterozygous for the mthfr gene, what kind of treatment will I receive when trying to conceive? I've had one stillborn son.
CONTROVERSY: Some rei drs recommend anticoagulation therapy anywhere from a baby Aspirin daily tpo Lovenox (enoxaparin) or Heparin injection until you deliver. Also, if you are mthfr deficient, taking l-methylfolate supplements (deplin) may be very helpful in decreasing depression and post-partum blues.See 2 more doctor answers
I have the MTHFR gene. Is it safe to take the Methyl CpG supplement? Which vitamins should I avoid? It has 2, 000mcg of folate, in the M.CpG Is it safe
Go ahead: This gene testing is being promoted by a lab to liability-wary physicians. The majority of folks tested are told they have an abnormal gene and that they should take these folks' supplements. Most of us pathologists think it's subscientific at best, though there's some interesting stuff. Health doesn't come out of a pill bottle and I hope you're eating sensibly and exercising. Best wishes.See 1 more doctor answer
Recessive defect: Canavan disease occurs when a baby inherits a mutated gene from both parents, that when normal codes for the production of an enzyme called aspartoacyclase. Having only one mutated gene allows production of the enzyme so carriers (the parents) have no problems.
No: Factor 7 mutation is very rare and causes increased risk of bleeding (not being able to clot). Factor 5 deficiency is the most common form of thrombophilia (increased risk of abnormal clotting).
Information's handy: There are plenty of evidence-based sites dealing with the BRCA genes and their mutations. Don't chase down a particular interview. The science is well-established. Be discerning and get with your physician if you feel you need to be tested.
In genetics, a mutation is a change in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal genetic element. Mutations result from unrepaired damage to dna or to RNA genomes (typically caused by radiation or chemical mutagens), from errors in the process of replication, or from the insertion or deletion of segments of dna ...Read more