Doctor insights on:
Msh2 Colon Cancer Punnett
Genetic mutations: HNPCC or hereditary nonpolyposis colorectal cancer is an autosomal dominant genetic condition that has a high risk of colon cancer The disease first described by Lynch and is associated with other cancers including endometrial ovary and stomach. The increased risk is due to inherited mutations that impair DNA mismatch repair. .Individuals with HNPCC have an 80% lifetime risk for colon ca. ...Read more
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
New3mm sessile/transverse;no path yet;1hyperplastic18yrs ago;biological mother-colorectal ca in50s;family w/lung&other CAs;I had breast ca;test4Lynch?
Genetic testing: Although there are some genetic diseases that increase the risk of both breast and colon cancer your history and family history do not seem to indicate that spectrum. A hyperplastic polyp is completely benign and does not even change the screening protocols for colon cancer screening. I would wait for the pathology to discuss the results and determine your best screening methods. ...Read more
Can be: The fastest-growers are the ones that follow genetic pathways associated with the lynch loci. They may not even be preceded by a polyp -- colonoscopy can be clean one year, and a year later, there's a cancer. That's actually quite fast as cancers go. Hope this helps. ...Read moreSee 1 more doctor answer
35yo. F. W/ hyporthyroidism. colonoscopy/endoscopy 11/20/14. Diminutive 3mm polyp of sigmoid colon. Random biopsies of ileum and colon done. Cancer?
Unfortunately: Metastatic disease (also known as stage 4) is usually not curable by todays treatments. Although use of chemotherapy may improve survival and may rarely put someone into a temporary remission the disease usually returns or more often does not go away and eventually progresses and the patient will eventually succumb to it. ...Read more
Some response: meds like Xeloda have some tempoary benefit suppressing DNA function as an oral 5FU (fluorouracil). Long term responses are not seen requiring combination therapy to give an optimjum response. Eventually if cancer does show a good response, malignant stem cells will repopulate the site of the original metastasis. ...Read more
Possibly: Removal of liver metastases can sometimes be helpful for patients with colon cancer. A remarkable amount of cancer can be removed usually after there has been some response to chemotherapy. If surgery is not recommended alternatives such as radioembolization, chemoembolization, radiosurgery, or rfa or cryoablation may be considered. Get with an experienced team to determine the best course! ...Read moreSee 5 more doctor answers
Screening tool: Msi test has a few uses in colorectal cancer screening and surveillance. While only 15 percent of colorectal cancers are msi positive, as many as 90 percent of patients with lynch syndrome (specific genetic etiology for colorectal cancer) have a positive msi test. The test may also be helpful in determining those patients with stage ii or iii cancer who may benefit from chemotherapy. ...Read moreSee 2 more doctor answers
For what reason colon part is usually prone to cancer in hnpcc (hereditary hereditary nonpolyposis colorectal cancer)?
Not directly usually: There is debate about how closely these 2 cancers are related. Both have hereditary natures and are more common generally in obese patients. Both often begin with more benign precursor lesions like dcis for breast cancer and benign polyps for colon cancer. Both are very common but there is little evidence that having either predisposes to having the other. ...Read moreSee 2 more doctor answers
No: Colon Cancer is induced for the most part in non hereditary disease by viral transfection. The most common organism is the polyoma virus. Ovarian cancer is not derived from this viral event. Colon cancer begins in the mucosa of the bowel where ovarian Ca is an epithelial disease similar to that of peritoneal carcinomatosis. The only relationship is when colon metastasizes to ovary. ...Read moreSee 2 more doctor answers
Colon surgery:tumor size=2cm.Pathologic staging(pt3, n1b, mx).2/17 lymph nodes show metastatic.Margins of resection free of carcinoma.Need chemotherapy?
Yes: Chemotherapy regimens based on the drug Fluorouracil (5-fu) have been part of the treatment for high-risk stage ii or stage iii colon cancer. Many clinical trials have shown that these regimens improve overall survival primarily by reducing the high risk of recurrence within the first two years after surgery. ...Read more
Depends on stage: Chemotherapy is never used for stage 1 cancers (early). It is sometimes used in stage 2 cancers (early but more advanced than stage 1). Chemotherapy is definitely beneficial in stage 3 cancers (locally advanced) and in stage 4 cancers (distant spread). ...Read moreSee 2 more doctor answers
Stage of cancer: This sounds very serious. Cancer is staged to help understand the treatments and expectations for success with treatment, part of the risk/benefit analysis. Stage 4 is cancer that has spread or progressed significantly outside the organ where it started. Stage 1, 2, 3 and 4 have diminishing expectations for treatment success. Take a friend with you to next appointment. You have choices. Be well. ...Read more
Lifestyle choices: Cigarette smoking, promiscuous unprotected sex, and low fiber diet or positve family history are simple answers for your listed afflictions, respectively. Screening tests for lung cancer (CT chest), and colon cancer (colonoscopy) are available. Check the American Cancer Society website to determine if you fit the appropriate category to have these exams. ...Read more
A minority is.: Pancreatic adenocarcinoma, arising from ducts/epithelial tissue, is mainly "sporadic", but can run in families. Pancreatic cancer has also been related to brca mutation, fammm syndrome, and some other inherited conditions. The familial pancreatic cancer registry is at johns hopkins. A minority of neuroendocrine tumors of the pancreas are associated with multiple endocrine neoplasia (men) syndromes. ...Read moreSee 1 more doctor answer
Can be: Most colon cancers relate more to lifestyle than inheritance but some patients do have an inherited predisposition, be it in the setting of multiple polyps (like fap or myh) or not (lynch syndrome). Families with this have early onset colon cancer and other cancers as well. Talk to your doc about this to see if you need to visit a specialist in inherited malignancies. Remember to live healthy. ...Read more
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