Top
40
Doctor insights on: Monoclonal Paraproteinemia Treatment

Share
1

1
Is monoclonal paraproteinemia the same thing as myeloma?

Yes in most ways: Myeloma is one of the differential diagnosis, the other condition is called mgus ...Read more

2

2
What causes monoclonal paraproteinemia?

What causes monoclonal paraproteinemia?

Excess of Plasma cel: Plasma cells in our bone marrow make antibodies. Sometimes they become overly active/reactive and produce abnormal proteins called paraproteins. Most such protein production is benign and not uncommon in older folks. Sometimes it is excessive (more than 1gram/day) then we get concerned about a condition called multiple myeloma (paraproteins over 3 grams). ...Read more

3

3
What is monoclonal gammopathy?

What is monoclonal gammopathy?

A tumor type: There are various grades of monoclonal gammopathy. The three types, in increasing order of malignancy are monoclonal gammapathy of undetermined significance (MGUS), smoldering myeloma and the last one, which is a cancer, multiple myeloma. ...Read more

4

4
IgA lambda monoclonal gammopathy meaning?

It is a medical diso: A medical disorder where your body is making excess of proteins (Gamma Globulins). It can manifest in 2-3 different ways (MGUS or Multiple Myeloma). So you need your doctor to explain which of these conditions do you have and theen get further testing, monitoring and you may or may not need treatment depending on whether it is mGUS (early) or Myeloma (later developemnt...that is a type of Blood Cancer ...Read more

5

5
Can monoclonal gammopathy cause osteomyelitis?

Can monoclonal gammopathy cause osteomyelitis?

Not realy: It's estimated that between 10 and 25 percent of people with monoclonal gammopathy of undetermined significance develop a more serious condition, such as multiple myeloma or other cancers or blood disorders. Other complications include fractures and blood clots. ...Read more

6

6
How reliable are blood tests that look for monoclonal gammopathy in elevated ImM levels? Are false negatives possible?

How reliable are blood tests that look for monoclonal gammopathy in elevated ImM levels? Are false negatives possible?

Very: The testing for gammoparhy at at the present time is very sensitive. The means by how this gets measured and analyzed is so sensitive that I can t out all of the different Antibody types. ...Read more

7

7
What is monoclonal gammopathy about?

MonoclonalGammopathy: Is paraproteinemia associated with multiple myeloma. The most important fact that it is not cancer. ...Read more

8

8
Is mononuclueosis associated at all with monoclonal gammopathy?

Is mononuclueosis associated at all with monoclonal gammopathy?

No: Ebv infection, the cause of mononucleosis is not usually related to monoclonal gammopathy. Ebv induced lymphoma may produce monoclonal gammopathy, but that would be an uncommon situation. ...Read more

9

9
What is monoclonal gammopathy of undetermined significance (mgus)?

Blood & urine tests: Mgus is the presence of an abnormal protrein in the blood made by a type of white blood cell called a plasmacyte. In most cases, it is at a low level and is something that just has to be followed. However, it can be the precursor of the disease called multiple myeloma and as such a hematologist or medical oncologist will order tests to rule this out which may include blood, urine and simple x-rays. ...Read more

10

10
Can you have a monoclonal gammopathy (and not mgus) while having a normal CBC w/differential?

Can you have a monoclonal gammopathy (and not mgus) while having a normal CBC w/differential?

Yes you can: CBC typically remains normal unless the bone marrow is heavily involved by multiple myeloma. Please check what the cause of your monoclonal gammopathy if it is not mgus? ...Read more

11

11
Free kappa light chain is high, FLC ratio is 2.205, no monoclonal gammopathy. IgA 389.43, lgM 125.95 and lgG 1771.02 H. Should we be worried? Thanks.

No: Abnormal FLC ratio is not diagnostic of any disease. More than 50% of the people with increased levels of gamma globulins have abnormal FLC ratio without a disorder of the plasma cells. ...Read more

12

12
What can cause monoclonal gammopathy?

What can cause monoclonal gammopathy?

Mayo Clinic say: Plasma cells are a type of white blood cell. They are found in your bone marrow. Plasma cells produce some of the antibodies that help your body fight infection. Monoclonal gammopathy of undetermined significance occurs when plasma cells in your bone marrow produce an abnormal protein called monoclonal protein (m protein). ...Read more

13

13
What's monoclonal gammopathy of undetermined significance?

MGUS: Is a common precancerous condition affecting people 50 years of age and older. It was first described by mayo clinic researchers in 1978 and is characterized by the presence of an abnormal protein in the blood called a (monoclonal) protein or m protein. Mgus has a small risk (1 percent each year) of progressing to a blood cancer called multiple myeloma or a related condition. ...Read more

14

14
Can I treat a possible monoclonal gammopathy of undetermined significance at home?

Nope: You don't treat an mgus, it is a condition that can ultimately lead to multiple myeloma (risk is about 1% per year) but as of itself does not need therapy (assuming it was correctly diagnosed). You need to have labs checked at least 1 or 2 times a year so you should follow up with your doc indefinitely. ...Read more

15

15
What is the definition or description of: monoclonal gammopathy of undetermined significance?

What is the definition or description of: monoclonal gammopathy of undetermined significance?

A monoclonal: Gammopathy is an elevation in a specific type of immune protein in the blood. The work-up includes tests of urine protein, bones and blood production. If no serious associated disease is found then the clinical finding is called mgus. The patient is followed over time to see if the gammopathy becomes "significant." some patients declare themselves later with multiple myemoma or lymphoma. ...Read more

16

16
What are possible causes of highly elevated ImM levels with low ImG levels with no monoclonal gammopathy present?

May not be a problem: This may depend on your genetic background and not be a medical problem. We would need an explanation of your problems, blurred vision, night sweats. Why are you on opiates ...Read more

18

18
Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

IgM is macroglobulin: Macroglobulinemia is the term for monoclonal igm. However what you described is confusing/erroneous term, igm kappa is not light chain gammopathy. Igm kappa, by definition is macroglobulin. ...Read more

19

19
I had a blood test done, what does it mean? Kappa monoclonal gammopathy. Is this rare? Does this mean cancer? Is this anything to worry about?

Not necessarily: You don't tell me why the test was done in the first place. Kappa chain is one of 2 light protein chains that are part molecule of an immunoglobulin. In your case, it is half of an igg. Even if you are asymptomatic, you may develop a problem over 20 years. If you have symptoms, you need further evaluation. If there is no specialist where you live, go to the university of washington in seattle. ...Read more

20

20
I understand that monoclonal gammopathy can cause a high CRP. As a matter of interest, does it typically elevate the WBC as well?

Neither: Neither an elevated CRP nor elevated WBC are part of the pathology in uncomplicated monoclonal gammopathy. ...Read more

21

21
I understand that uncomplicated monoclonal gammopathy does not raise the WBC & CRP. But can MGUS lead to more serious conditions that do elevate both WBC & CRP? Would there be ANY other pathological data to look for if a worse condition comes about?

I understand that uncomplicated monoclonal gammopathy does not raise the WBC & CRP. But can MGUS lead to more serious conditions that do elevate both WBC & CRP? Would there be ANY other pathological data to look for if a worse condition comes about?

See below: About 1-2% of the patients with MGUS develop multiple myeloma, a form of bone cancer, each year. It would be prudent to have yearly check ups. You may consult this site for info: http://www. Mayoclinic. Org/diseases-conditions/mgus/home/ovc-20199535 ...Read more

23

23
Serum -tiny IgM kappa monoclonal protein b2 region, urine - tiny IgM k paraproteinemia in gamma region. Was a mistake made or is lab normal?

Serum -tiny IgM kappa monoclonal protein b2 region, urine - tiny IgM k paraproteinemia in gamma region. Was a mistake made or is lab normal?

Monoclonal: multiple myeloma (g>a>m>e, d)
•primary macroglobulinemia (waldenstrøm’s, igm)
•monoclonal gammopathy of undetermined significance (mgus) (converts at 2% per year to myeloma)
•miscellaneous conditions
• (converts at 2% per year to myeloma)

these all have to be thought of by the hematologist. ...Read more

24

24
My 81 yr old father is diagnosed with monoclon paraproteinemia, what does that mean and what are the causes?

My 81 yr old father is diagnosed with monoclon paraproteinemia, what does that mean and what are the causes?

MGUS: Monoclonal gammopathy of unknown significance (mgus) is a very insidious disease. I do not believe that it worsens his prognosis or lifespan significantly. ...Read more

25

25
Is there a cure medication to completely remove eradicate paraproteinemia from my blood stream its at 1.5 level im told. Or is it incurable?

Is there a cure medication to completely remove eradicate paraproteinemia from my blood stream its at 1.5 level im told. Or is it incurable?

Hematologist: You need to consult a hematologist/oncologist for treatment. There are effective treatments using chemotherapy and the using person's own stem cells to correct the defect. Consult this site for info.

http://www. Mayoclinic. Org/diseases-conditions/multiple-myeloma/basics/definition/con-20026607 ...Read more

26

26
What is monoclonal protein? How does this affect the body? What is IgG lamda and it's affects. What are the treatments.? What can this thing turn int?

What is monoclonal protein? How does this affect the body? What is IgG lamda and it's affects. What are the treatments.? What can this thing turn int?

Spike: You probably have either a monoclonal gammopathy of uncertain significance, which is a non-problem but has perhaps a 1% chance per year of turning into plasma cell ("multiple") myeloma, or myeloma itself. You need to get with your physician and find out which. Good luck. ...Read more

27

27
How are benign and malignant paraproteinemia different?

How are benign and malignant paraproteinemia different?

Different causes: Malignant paraproteinemia is a harmful presence of a single kind of antibody, made by a known malignancy such as lymphoma or myeloma. Benign paraproteinemia is a harmful presence of a single kind of antibody in someone who has no such malignancy. It is presumably due to a benign clonal expansion of one type of lymphocyte. ...Read more

28

28
What is the difference in benign and malignant paraproteinemia?

What is the difference in benign and malignant paraproteinemia?

Abnormal Proteins/My: Paraproteins are abnormal proteins which are often produced by Cancer cells unless proven otherwise. So it requires detailed testing looking for cancerous cell called Plasma cells in the bone marrow. There is one variant which may behave beningnly and is called monoclonal gammopathy of undetermined significance (MGUS). But some of the patients with MGUS do develop multiple myeloma, causing paraprot ...Read more

29

29
What causes paraproteinemia?

What causes paraproteinemia?

Plasma cells: Paraproteins are abnormally produced immunoglobulins or immunoglobulin fractions made by overproductive and possibly malignant clones of plasma cells. This needs evaluation by a hematologist to determine if this is benign or malignant (cancer). ...Read more

30

30
What are the consequences of paraproteinemia?

What are the consequences of paraproteinemia?

Varied: We have 3 entities which cause paraprotein production. The most benign is called MGUS which is often benign and the other two are Smoldering Myeloma and the most serious is called Multiple myeloma. You need to have your doctor explalin which of these conditions he/she thinks is causing this paraproteinemia. ...Read more

31

31
Best treatment for sea dickmess?

Best treatment for sea dickmess?

Antihistamines: For sea sickness:
dramamine (dimenhydrinate) is the most commonly used one. Other are Diphenhydramine (benadryl) and meclizine.

In order to prevent sea sickness you need to take them before you start feeling sick, preferably before you get on a boat. Meclizine has less of a drowsiness effect, the rest may make you drowsy. ...Read more

32

32
Treatment for multi objects vision?

Treatment for multi objects vision?

Polyopia: There are multiple causes for this and you need an eye exam to help reach a diagnosis. Sometimes neurology also has to be involved. Good luck. ...Read more

33

33
What is the best treatment for cold?

What is the best treatment for cold?

Boost immunity: 1. Throat coat liquorice tea: several times/day
2. Megafood Megaflora plus probiotics 4 caps 2 times/day for 1 week.
3. Sunshine for 30-45 minutes daily at noon or Vitamin D3 10, 000 IU/day (NOW brand is good)
4. Zinc supplement 50 mg/day (NOW brand is good) with food for 7-10 days
5. No milk products for 10-15 days ...Read more

34

34
What is the best treatment for shock?

What is the best treatment for shock?

Find the cause.: Shock is a general term that refers to a condition where the body is trying desperately to maintain stability of normal vital signs, but failing. There are several major types of shock, depending on the reason for the condition. Trauma, infection, spinal cord injury, and cardiac failure are some of the more typical reasons. The best treatment differs for each category. ...Read more

35

35
What are the treatment of cloudy sight?

What are the treatment of cloudy sight?

Depends: There are many causes for cloudy sight and the treatment depends upon what is the cause. Treatments include medication, surgery, eyeglasses, contact lenses and unfortunately, for a few conditions, no treatment. Your ophthalmologist can sort this out for you. V. ...Read more

36

36
What is the best treatment for bug bits?

What is the best treatment for bug bits?

Prevention: Prevention is key in avoiding bug bites. The treatment is usually based on the type of bug involved and most of the time is symptomatic, ie: itching, pain, etc.
Would not suggest any topical or local treatment since this is already an area of inflammation. ...Read more

37

37
Treatment for acidity in 15 months child?

Treatment for acidity in 15 months child?

Acid Reflux in Kids: I assume you mean diagnosed acid reflux disease? Read this==>http://www. Webmd. Com/heartburn-gerd/reflux-infants-children. This is unusual in children and can be caused by a variety of causes that are not in play in adults, so that the treatments may be different. In addition, there is some controversy about decreasing acid production for the long term. See your pediatrician. ...Read more

38

38
What is the treatment for purge overdose?

What is the treatment for purge overdose?

Pump the stomach: Patient is brought to treatment quickly after the overdose, the doctor may choose to “pump” the stomach, either by inducing vomiting with a medication or by giving the patient activated charcoal, which prevents the body from absorbing darvon. Activated charcoal is highly effective, reducing toxic absorption by up to 60%. Activated charcoal absorbs chemicals throughout the gastrointestinal tract. ...Read more

39

39
What is a treatment for trigenimal nerve?

What is a treatment for trigenimal nerve?

Med/ surg.: If you mean trigeminal neuralgia, the most effective medicine I've found is carbamazepine. There are invasive procedures that can help if medication fails to control the pain. ...Read more

40

40
Is there treatment for a rotator cup tear?

Is there treatment for a rotator cup tear?

Therapy vs repair: Not all rotator cuff tears are treated the same. Factors such as age of patient, age of the tear, size of tear, location of the tear, and most importantly the symptoms of the patient all help determine the best course of treatment. A trial of nonoperative management with therapy and perhaps an injection is the usual 1st line of treatment. Surgery may be indicated if nonoperative treatment fails. ...Read more