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Doctor insights on: Monoclonal Paraproteinemia Symptoms

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What causes monoclonal paraproteinemia?

What causes monoclonal paraproteinemia?

Excess of Plasma cel: Plasma cells in our bone marrow make antibodies. Sometimes they become overly active/reactive and produce abnormal proteins called paraproteins. Most such protein production is benign and not uncommon in older folks. Sometimes it is excessive (more than 1gram/day) then we get concerned about a condition called multiple myeloma (paraproteins over 3 grams).

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Is monoclonal paraproteinemia the same thing as myeloma?

Yes in most ways: Myeloma is one of the differential diagnosis, the other condition is called mgus

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What is monoclonal gammopathy?

What is monoclonal gammopathy?

A tumor type: There are various grades of monoclonal gammopathy. The three types, in increasing order of malignancy are monoclonal gammapathy of undetermined significance (MGUS), smoldering myeloma and the last one, which is a cancer, multiple myeloma.

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What is monoclonal gammopathy about?

MonoclonalGammopathy: Is paraproteinemia associated with multiple myeloma. The most important fact that it is not cancer.

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What can cause monoclonal gammopathy?

What can cause monoclonal gammopathy?

Mayo Clinic say: Plasma cells are a type of white blood cell. They are found in your bone marrow. Plasma cells produce some of the antibodies that help your body fight infection. Monoclonal gammopathy of undetermined significance occurs when plasma cells in your bone marrow produce an abnormal protein called monoclonal protein (m protein).

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What's monoclonal gammopathy of undetermined significance?

MGUS: Is a common precancerous condition affecting people 50 years of age and older. It was first described by mayo clinic researchers in 1978 and is characterized by the presence of an abnormal protein in the blood called a (monoclonal) protein or m protein. Mgus has a small risk (1 percent each year) of progressing to a blood cancer called multiple myeloma or a related condition.

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Can I treat a possible monoclonal gammopathy of undetermined significance at home?

Nope: You don't treat an mgus, it is a condition that can ultimately lead to multiple myeloma (risk is about 1% per year) but as of itself does not need therapy (assuming it was correctly diagnosed). You need to have labs checked at least 1 or 2 times a year so you should follow up with your doc indefinitely.

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What is the definition or description of: monoclonal gammopathy of undetermined significance?

What is the definition or description of: monoclonal gammopathy of undetermined significance?

A monoclonal: Gammopathy is an elevation in a specific type of immune protein in the blood. The work-up includes tests of urine protein, bones and blood production. If no serious associated disease is found then the clinical finding is called mgus. The patient is followed over time to see if the gammopathy becomes "significant." some patients declare themselves later with multiple myemoma or lymphoma.

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What are possible causes of highly elevated ImM levels with low ImG levels with no monoclonal gammopathy present?

May not be a problem: This may depend on your genetic background and not be a medical problem. We would need an explanation of your problems, blurred vision, night sweats. Why are you on opiates

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Is mononuclueosis associated at all with monoclonal gammopathy?

Is mononuclueosis associated at all with monoclonal gammopathy?

No: Ebv infection, the cause of mononucleosis is not usually related to monoclonal gammopathy. Ebv induced lymphoma may produce monoclonal gammopathy, but that would be an uncommon situation.

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What is monoclonal gammopathy of undetermined significance (mgus)?

Blood & urine tests: Mgus is the presence of an abnormal protrein in the blood made by a type of white blood cell called a plasmacyte. In most cases, it is at a low level and is something that just has to be followed. However, it can be the precursor of the disease called multiple myeloma and as such a hematologist or medical oncologist will order tests to rule this out which may include blood, urine and simple x-rays.

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IgA lambda monoclonal gammopathy meaning?

It is a medical diso: A medical disorder where your body is making excess of proteins (Gamma Globulins). It can manifest in 2-3 different ways (MGUS or Multiple Myeloma). So you need your doctor to explain which of these conditions do you have and theen get further testing, monitoring and you may or may not need treatment depending on whether it is mGUS (early) or Myeloma (later developemnt...that is a type of Blood Cancer

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Can monoclonal gammopathy cause osteomyelitis?

Can monoclonal gammopathy cause osteomyelitis?

Not realy: It's estimated that between 10 and 25 percent of people with monoclonal gammopathy of undetermined significance develop a more serious condition, such as multiple myeloma or other cancers or blood disorders. Other complications include fractures and blood clots.

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How reliable are blood tests that look for monoclonal gammopathy in elevated ImM levels? Are false negatives possible?

How reliable are blood tests that look for monoclonal gammopathy in elevated ImM levels? Are false negatives possible?

Very: The testing for gammoparhy at at the present time is very sensitive. The means by how this gets measured and analyzed is so sensitive that I can t out all of the different Antibody types.

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Can you have a monoclonal gammopathy (and not mgus) while having a normal CBC w/differential?

Can you have a monoclonal gammopathy (and not mgus) while having a normal CBC w/differential?

Yes you can: CBC typically remains normal unless the bone marrow is heavily involved by multiple myeloma. Please check what the cause of your monoclonal gammopathy if it is not mgus?

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Free kappa light chain is high, FLC ratio is 2.205, no monoclonal gammopathy. IgA 389.43, lgM 125.95 and lgG 1771.02 H. Should we be worried? Thanks.

No: Abnormal FLC ratio is not diagnostic of any disease. More than 50% of the people with increased levels of gamma globulins have abnormal FLC ratio without a disorder of the plasma cells.

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Is mononucleosis associated with monoclonal gammopathy?

Not usually: The infection can cause a polyclonal rise.

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Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

IgM is macroglobulin: Macroglobulinemia is the term for monoclonal igm. However what you described is confusing/erroneous term, igm kappa is not light chain gammopathy. Igm kappa, by definition is macroglobulin.

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I had a blood test done, what does it mean? Kappa monoclonal gammopathy. Is this rare? Does this mean cancer? Is this anything to worry about?

Not necessarily: You don't tell me why the test was done in the first place. Kappa chain is one of 2 light protein chains that are part molecule of an immunoglobulin. In your case, it is half of an igg. Even if you are asymptomatic, you may develop a problem over 20 years. If you have symptoms, you need further evaluation. If there is no specialist where you live, go to the university of washington in seattle.

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