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Doctor insights on: Monoclonal Paraproteinemia Symptoms

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What causes monoclonal paraproteinemia?

What causes monoclonal paraproteinemia?

Excess of Plasma cel: Plasma cells in our bone marrow make antibodies. Sometimes they become overly active/reactive and produce abnormal proteins called paraproteins. Most such protein production is benign and not uncommon in older folks. Sometimes it is excessive(more than 1gram/day) then we get concerned about a condition called multiple myeloma (paraproteins over 3 grams). ...Read more

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Is monoclonal paraproteinemia the same thing as myeloma?

Yes in most ways: Myeloma is one of the differential diagnosis, the other condition is called mgus ...Read more

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What is monoclonal gammopathy?

What is monoclonal gammopathy?

A tumor type: There are various grades of monoclonal gammopathy. The three types, in increasing order of malignancy are monoclonal gammapathy of undetermined significance (MGUS), smoldering myeloma and the last one, which is a cancer, multiple myeloma. ...Read more

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What is monoclonal gammopathy about?

MonoclonalGammopathy: Is paraproteinemia associated with multiple myeloma. The most important fact that it is not cancer. ...Read more

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What can cause monoclonal gammopathy?

What can cause monoclonal gammopathy?

Mayo Clinic say: Plasma cells are a type of white blood cell. They are found in your bone marrow. Plasma cells produce some antibodies that help your body fight infection. Monoclonal gammopathy of undetermined significance occurs when plasma cells in your bone marrow produce an abnormal protein called monoclonal protein (m protein). ...Read more

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What's monoclonal gammopathy of undetermined significance?

MGUS: Is a common precancerous condition affecting people 50 years of age and older. It was first described by mayo clinic researchers in 1978 and is characterized by the presence of an abnormal protein in the blood called a (monoclonal) protein or m protein. Mgus has a small risk (1 percent each year) of progressing to a blood cancer called multiple myeloma or a related condition. ...Read more

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Can I treat a possible monoclonal gammopathy of undetermined significance at home?

Nope: You don't treat a mgus, it is a condition that can ultimately lead to multiple myeloma (risk is about 1% per year) but as of itself does not need therapy (assuming it was correctly diagnosed). You need to have labs checked at least 1 or 2 times a year so you should follow up with your doc indefinitely. ...Read more

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What is the definition or description of: monoclonal gammopathy of undetermined significance?

What is the definition or description of: monoclonal gammopathy of undetermined significance?

A monoclonal: Gammopathy is an elevation in a specific type of immune protein in the blood. The work-up includes tests of urine protein, bones and blood production. If no serious associated disease is found then the clinical finding is called mgus. The patient is followed over time to see if the gammopathy becomes "significant." some patients declare themselves later with multiple myemoma or lymphoma. ...Read more

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What are possible causes of highly elevated ImM levels with low ImG levels with no monoclonal gammopathy present?

May not be a problem: This may depend on your genetic background and not be a medical problem. We would need an explanation of your problems, blurred vision, night sweats. Why are you on opiates ...Read more

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Is mononuclueosis associated at all with monoclonal gammopathy?

Is mononuclueosis associated at all with monoclonal gammopathy?

No: Ebv infection, the cause of mononucleosis is not usually related to monoclonal gammopathy. Ebv induced lymphoma may produce monoclonal gammopathy, but that would be an uncommon situation. ...Read more

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What is monoclonal gammopathy of undetermined significance (mgus)?

Blood & urine tests: Mgus is the presence of an abnormal protrein in the blood made by a type of white blood cell called a plasmacyte. In most cases, it is at a low level and is something that just has to be followed. However, it can be the precursor of the disease called multiple myeloma and as such a hematologist or medical oncologist will order tests to rule this out which may include blood, urine and simple x-rays. ...Read more

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IgA lambda monoclonal gammopathy meaning?

It is a medical diso: A medical disorder where your body is making excess of proteins(Gamma Globulins). It can manifest in 2-3 different ways(MGUS or Multiple Myeloma). So you need your doctor to explain which of these conditions do you have and theen get further testing, monitoring and you may or may not need treatment depending on whether it is mGUS(early) or Myeloma(later developemnt...that is a type of Blood Cancer ...Read more

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Can monoclonal gammopathy cause osteomyelitis?

Can monoclonal gammopathy cause osteomyelitis?

Not realy: It's estimated that between 10 and 25 percent of people with monoclonal gammopathy of undetermined significance develop a more serious condition, such as multiple myeloma or other cancers or blood disorders. Other complications include fractures and blood clots. ...Read more

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How reliable are blood tests that look for monoclonal gammopathy in elevated ImM levels? Are false negatives possible?

How reliable are blood tests that look for monoclonal gammopathy in elevated ImM levels? Are false negatives possible?

Very: The testing for gammoparhy at the present time is very sensitive. The means by how this gets measured and analyzed is so sensitive that I can t out all the different Antibody types. ...Read more

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Can you have a monoclonal gammopathy(and not mgus) while having a normal CBC w/differential?

Can you have a monoclonal gammopathy(and not mgus) while having a normal CBC w/differential?

Yes you can: CBC typically remains normal unless the bone marrow is heavily involved by multiple myeloma. Please check what the cause of your monoclonal gammopathy if it is not mgus? ...Read more

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Free kappa light chain is high, FLC ratio is 2.205, no monoclonal gammopathy. IgA 389.43, lgM 125.95 and lgG 1771.02 H. Should we be worried? Thanks.

No: Abnormal FLC ratio is not diagnostic of any disease. More than 50% of the people with increased levels of gamma globulins have abnormal FLC ratio without a disorder of the plasma cells. ...Read more

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Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

IgM is macroglobulin: Macroglobulinemia is the term for monoclonal igm. However, what you described is confusing/erroneous term, igm kappa is not light chain gammopathy. Igm kappa, by definition is macroglobulin. ...Read more

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I had a blood test done, what does it mean? Kappa monoclonal gammopathy. Is this rare? Does this mean cancer? Is this anything to worry about?

Not necessarily: You don't tell me why the test was done in the first place. Kappa chain is one of 2 light protein chains that are part molecule of an immunoglobulin. In your case, it is half of an igg. Even if you are asymptomatic, you may develop a problem over 20 years. If you have symptoms, you need further evaluation. If there is no specialist where you live, go to the university of washington in seattle. ...Read more

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I understand that monoclonal gammopathy can cause a high CRP. As a matter of interest, does it typically elevate the WBC as well?

Neither: Neither an elevated CRP nor elevated WBC are part of the pathology in uncomplicated monoclonal gammopathy. ...Read more

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I understand that uncomplicated monoclonal gammopathy does not raise the WBC & CRP. But can MGUS lead to more serious conditions that do elevate both WBC & CRP? Would there be ANY other pathological data to look for if a worse condition comes about?

I understand that uncomplicated monoclonal gammopathy does not raise the WBC & CRP. But can MGUS lead to more serious conditions that do elevate both WBC & CRP? Would there be ANY other pathological data to look for if a worse condition comes about?

See below: About 1-2% of the patients with MGUS develop multiple myeloma, a form of bone cancer, each year. It would be prudent to have yearly check ups. You may consult this site for info: http://www.mayoclinic.org/diseases-conditions/mgus/home/ovc-20199535 ...Read more

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Serum -tiny IgM kappa monoclonal protein b2 region, urine — tiny IgM k paraproteinemia in gamma region. Was a mistake made or is lab normal?

Serum -tiny IgM kappa monoclonal protein b2 region, urine — tiny IgM k paraproteinemia in gamma region. Was a mistake made or is lab normal?

Monoclonal: •multiple myeloma (g>a>m>e, d)
•primary macroglobulinemia (waldenstrøm’s, igm)
•monoclonal gammopathy of undetermined significance (mgus) (converts at 2% per year to myeloma)
•miscellaneous conditions
•(converts at 2% per year to myeloma)

These all have to be thought of by the hematologist. ...Read more

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My 81 yr old father is diagnosed with monoclon paraproteinemia, what does that mean and what are the causes?

My 81 yr old father is diagnosed with monoclon paraproteinemia, what does that mean and what are the causes?

MGUS: Monoclonal gammopathy of unknown significance (mgus) is a very insidious disease. I do not believe that it worsens his prognosis or lifespan significantly. ...Read more

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How are benign and malignant paraproteinemia different?

How are benign and malignant paraproteinemia different?

Different causes: Malignant paraproteinemia is a harmful presence of a single kind of antibody, made by a known malignancy such as lymphoma or myeloma. Benign paraproteinemia is a harmful presence of a single kind of antibody in someone who has no such malignancy. It is presumably due to a benign clonal expansion of one type of lymphocyte. ...Read more

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What is the difference in benign and malignant paraproteinemia?

What is the difference in benign and malignant paraproteinemia?

Abnormal Proteins/My: Paraproteins are abnormal proteins which are often produced by Cancer cells unless proven otherwise. So it requires detailed testing looking for cancerous cell called Plasma cells in the bone marrow. There is one variant which may behave beningnly and is called monoclonal gammopathy of undetermined significance(MGUS). But some patients with MGUS do develop multiple myeloma, causing paraprot ...Read more

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What causes paraproteinemia?

What causes paraproteinemia?

plasma cells: Paraproteins are abnormally produced immunoglobulins or immunoglobulin fractions made by overproductive and possibly malignant clones of plasma cells. This needs evaluation by a hematologist to determine if this is benign or malignant (cancer). ...Read more

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What are the consequences of paraproteinemia?

What are the consequences of paraproteinemia?

Varied: We have 3 entities which cause paraprotein production. The most benign is called MGUS which is often benign and the other two are Smoldering Myeloma and the most serious is called Multiple myeloma. You need to have your doctor explalin which of these conditions he/she thinks is causing this paraproteinemia. ...Read more

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Is there a cure medication to completely remove eradicate paraproteinemia from my blood stream it's at 1.5 level im told.or is it incurable?

Is there a cure medication to completely remove eradicate paraproteinemia from my blood stream it's at 1.5 level im told.or is it incurable?

Hematologist: You need to consult a hematologist/oncologist for treatment. There are effective treatments using chemotherapy and the using person's own stem cells to correct the defect. Consult this site for info.

http://www.mayoclinic.org/diseases-conditions/multiple-myeloma/basics/definition/con-20026607 ...Read more