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Monoclonal Gammopathy Of Undetermined Significance In Children
MGUS: Is a common precancerous condition affecting people 50 years of age and older. It was first described by mayo clinic researchers in 1978 and is characterized by the presence of an abnormal protein in the blood called a (monoclonal) protein or m protein.Mgus has a small risk (1 percent each year) of progressing to a blood cancer called multiple myeloma or a related condition. ...Read more
A gammopathy is an abnormal gammaglobulin or gammaglobulin level. A monoclonal gammopathy is a single abnormal protein that can indicate a bone marrow cancer called multiple myeloma, or a lymphoma. Further evaluation is required to determine if a monoclonal gammopathy ...Read more
Nope: You don't treat an mgus, it is a condition that can ultimately lead to multiple myeloma (risk is about 1% per year) but as of itself does not need therapy (assuming it was correctly diagnosed). You need to have labs checked at least 1 or 2 times a year so you should follow up with your doc indefinitely. ...Read more
A monoclonal: Gammopathy is an elevation in a specific type of immune protein in the blood. The work-up includes tests of urine protein, bones and blood production. If no serious associated disease is found then the clinical finding is called mgus. The patient is followed over time to see if the gammopathy becomes "significant." some patients declare themselves later with multiple myemoma or lymphoma. ...Read moreSee 1 more doctor answer
Blood & urine tests: Mgus is the presence of an abnormal protrein in the blood made by a type of white blood cell called a plasmacyte. In most cases, it is at a low level and is something that just has to be followed. However, it can be the precursor of the disease called multiple myeloma and as such a hematologist or medical oncologist will order tests to rule this out which may include blood, urine and simple x-rays. ...Read moreSee 1 more doctor answer
Mayo Clinic say: Plasma cells are a type of white blood cell. They are found in your bone marrow. Plasma cells produce some of the antibodies that help your body fight infection. Monoclonal gammopathy of undetermined significance occurs when plasma cells in your bone marrow produce an abnormal protein called monoclonal protein (m protein). ...Read more
What are possible causes of highly elevated ImM levels with low ImG levels with no monoclonal gammopathy present?
It is a medical diso: A medical disorder where your body is making excess of proteins(Gamma Globulins). It can manifest in 2-3 different ways(MGUS or Multiple Myeloma). So you need your doctor to explain which of these conditions do you have and theen get further testing, monitoring and you may or may not need treatment depending on whether it is mGUS(early) or Myeloma(later developemnt...that is a type of Blood Cancer ...Read more
Not usually : The infection can cause a polyclonal rise. ...Read more
How reliable are blood tests that look for monoclonal gammopathy in elevated ImM levels ? Are false negatives possible?
Are any of (1) overlap myeloproliferative/myelodysplastictiy disorder (2) monoclonal B cell lymphocytosis or(3) monoclonal gammopathy ever familial?
Familial blood dx:
Yes. there can be a familial component. Monoclonal gammopathies in some cases may be increased in blood relatives
Familial monoclonal gammopathy of undetermined significance and multiple myeloma: epidemiology, risk factors, and biological characteristics.
Greenberg AJ1, Rajkumar SV, Vachon CM. Blood. 2012 Jun 7;119(23):5359-66.
f/u/ w/ doc ...Read more
Free kappa light chain is high, FLC ratio is 2.205, no monoclonal gammopathy. IgA 389.43, lgM 125.95 and lgG 1771.02 H. Should we be worried? Thanks.
No: Abnormal FLC ratio is not diagnostic of any disease. More than 50% of the people with increased levels of gamma globulins have abnormal FLC ratio without a disorder of the plasma cells. ...Read more
I had a blood test done, what does it mean? Kappa monoclonal gammopathy. Is this rare? Does this mean cancer? Is this anything to worry about?
Not necessarily: You don't tell me why the test was done in the first place. Kappa chain is one of 2 light protein chains that are part molecule of an immunoglobulin. In your case, it is half of an igg. Even if you are asymptomatic, you may develop a problem over 20 years. If you have symptoms, you need further evaluation. If there is no specialist where you live, go to the university of washington in seattle. ...Read moreSee 1 more doctor answer
I understand that monoclonal gammopathy can cause a high CRP. As a matter of interest, does it typically elevate the WBC as well?
I understand that uncomplicated monoclonal gammopathy does not raise the WBC & CRP. But can MGUS lead to more serious conditions that do elevate both WBC & CRP? Would there be ANY other pathological data to look for if a worse condition comes about?
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