Doctor insights on:
Monoclonal Gammopathy Ig G Kappa
Free kappa light chain is high, FLC ratio is 2.205, no monoclonal gammopathy. IgA 389.43, lgM 125.95 and lgG 1771.02 H. Should we be worried? Thanks.
No: Abnormal FLC ratio is not diagnostic of any disease. More than 50% of the people with increased levels of gamma globulins have abnormal FLC ratio without a disorder of the plasma cells. ...Read more
A gammopathy is an abnormal gammaglobulin or gammaglobulin level. A monoclonal gammopathy is a single abnormal protein that can indicate a bone marrow cancer called multiple myeloma, or a lymphoma. Further evaluation is required to determine if a monoclonal gammopathy ...Read more
IgM is macroglobulin: Macroglobulinemia is the term for monoclonal igm. However what you described is confusing/erroneous term, igm kappa is not light chain gammopathy. Igm kappa, by definition is macroglobulin. ...Read more
I had a blood test done, what does it mean? Kappa monoclonal gammopathy. Is this rare? Does this mean cancer? Is this anything to worry about?
Not necessarily: You don't tell me why the test was done in the first place. Kappa chain is one of 2 light protein chains that are part molecule of an immunoglobulin. In your case, it is half of an igg. Even if you are asymptomatic, you may develop a problem over 20 years. If you have symptoms, you need further evaluation. If there is no specialist where you live, go to the university of washington in seattle. ...Read more
Is an IgM kappa monoclonal gammopathy mgus only specific for a possibility of developing waldenstrom's in future, or can it signify bladder cancer?
I am not aware: Of any association with bladder cancer.Get a more detailed answer ›
Mayo Clinic say: Plasma cells are a type of white blood cell. They are found in your bone marrow. Plasma cells produce some of the antibodies that help your body fight infection. Monoclonal gammopathy of undetermined significance occurs when plasma cells in your bone marrow produce an abnormal protein called monoclonal protein (m protein). ...Read more
MGUS: Is a common precancerous condition affecting people 50 years of age and older. It was first described by mayo clinic researchers in 1978 and is characterized by the presence of an abnormal protein in the blood called a (monoclonal) protein or m protein. Mgus has a small risk (1 percent each year) of progressing to a blood cancer called multiple myeloma or a related condition. ...Read more
It is a medical diso: A medical disorder where your body is making excess of proteins (Gamma Globulins). It can manifest in 2-3 different ways (MGUS or Multiple Myeloma). So you need your doctor to explain which of these conditions do you have and theen get further testing, monitoring and you may or may not need treatment depending on whether it is mGUS (early) or Myeloma (later developemnt...that is a type of Blood Cancer ...Read more
How reliable are blood tests that look for monoclonal gammopathy in elevated ImM levels? Are false negatives possible?
Blood & urine tests: Mgus is the presence of an abnormal protrein in the blood made by a type of white blood cell called a plasmacyte. In most cases, it is at a low level and is something that just has to be followed. However, it can be the precursor of the disease called multiple myeloma and as such a hematologist or medical oncologist will order tests to rule this out which may include blood, urine and simple x-rays. ...Read more
Not usually: The infection can cause a polyclonal rise. ...Read more
Nope: You don't treat an mgus, it is a condition that can ultimately lead to multiple myeloma (risk is about 1% per year) but as of itself does not need therapy (assuming it was correctly diagnosed). You need to have labs checked at least 1 or 2 times a year so you should follow up with your doc indefinitely. ...Read more
A monoclonal: Gammopathy is an elevation in a specific type of immune protein in the blood. The work-up includes tests of urine protein, bones and blood production. If no serious associated disease is found then the clinical finding is called mgus. The patient is followed over time to see if the gammopathy becomes "significant." some patients declare themselves later with multiple myemoma or lymphoma. ...Read more
What are possible causes of highly elevated ImM levels with low ImG levels with no monoclonal gammopathy present?
May not be a problem: This may depend on your genetic background and not be a medical problem. We would need an explanation of your problems, blurred vision, night sweats. Why are you on opiates ...Read more
I understand that monoclonal gammopathy can cause a high CRP. As a matter of interest, does it typically elevate the WBC as well?
Neither: Neither an elevated CRP nor elevated WBC are part of the pathology in uncomplicated monoclonal gammopathy. ...Read more
I understand that uncomplicated monoclonal gammopathy does not raise the WBC & CRP. But can MGUS lead to more serious conditions that do elevate both WBC & CRP? Would there be ANY other pathological data to look for if a worse condition comes about?
I just checked my health summary online and the doctor noted hyperglobulinemia and monoclonal gammopathies. I am also referred to a hematologist. What could be its meaning?
MGUS: Monoclonal gammopathy is the presence of a protein in your blood all produced from the daughter cells of one type of cell (plasma cells, which are one type of white blood cell.). This protein may be of no significance. Your hematogist can do additional testing to see if you are at risk of this becoming a more serious problem. ...Read more
What does elevated Igg-2364 and gamma globulin 2.2 mean with polyclonal gammopathy and Kappa and lambda typing increased?
Nothing serious: Polyclonal gammopathy does not have the seriousness of monoclonal gammpathy. Firstly your IgG and total globulin levels are only mildly elevated, so It may not mean any disease. One cause is chronic inflammation (infections) such as Chronic arthritis or chronic liver disease, conditions which can be checked out or ruled out easily if you ask your doctor and seek his/her advice about it. ...Read more
Plasma cell disorder: Monoclonal gammopathy refers to an abnormal production of proteins by cells in the immune system (plasma cells) that are growing out of control. It can be one of the signs of myeloma. A hematologist-oncologist can help. ...Read more
Immune cell problem: Igg-kappa is a type of antibody your body makes to help fight infections, etc. Normally one make lots of different types of igg-kappa. When it is monoclonal, one specific igg-kappa has become very predominant. This can happen in response to an infection, if the immune system is not regulated properly, or in certain malignancies like multiple myeloma. Talk with your doctor for more information. ...Read more
See details: A monoclonal spike is suggestive of a plasma cell disorder. It may be relatively benign (mgus) or much more serious (myeloma, Waldenstrom's) ...Read more
I had blood work done and results came back possible IgG kappa monoclonal band is observed. I am 22 years old. Is this possible?
Yes, but not:
Necessarily worrisome. A monoclonal response may be seen after an infection. See this site for more information. It would be prudent for you to follow your doctor's instructions for periodic follow-up testing.
http://www. Mayoclinic. Com/health/monoclonal-gammopathy/ds00870. ...Read more
See a specialist: You don't tell me how you were found to have that high level. If you have no symptoms to go with that finding and other laboratory blood tests are normal, you probably have what is called monoclonal gammopathy. If you have symptoms or tests are affected, there are several possible diagnosis. For proper evaluation, see an immunologist or hematologist. ...Read more
I am 22years old. I had blood work coming back saying possible IgG kappa monoclonal band is observed. What could this mean?
Needs more bloodwork:
Hi! This may be nothing- but still needs to be evaluated further with a serum protein electrophoresis and immunofixation to rule out a possible blood disorder.
Hope this helps- write back if you have any other questions.
Thanks. ...Read more
It can: Yes, it can. It will depend on how much is the quantity of the monoclonal proteine, how many plasma cells on the bone marrow and ultimately whether one has end organ damages/ whether some other organs are affected significantly by the monoclonal protein. That is why some blood work, imaging study and bone marrow biopsy need to be done. ...Read more
Multiple myeloma at age 22? Possibility of IgG kappa monoclonal band is observed in my blood work. I have the symptoms of mm. Is this possible at 22?
Kappa/lambda FLC ratio high (2.75) w/ normal K (10.21mg/dl) & low L (3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow
K/L ratio is not a useful test. About one third of patients without monoclonal immunoglboulin have an abnormal ratio, usually with kappa excess. If you must, the next step would be a bone marrow examination. You may consult this article that I wrote: https://www. Ncbi. Nlm. Nih. Gov/pubmed/27473738
At your age you are unlikely to have myeloma. ...Read more
Immunofixation, Serum FAH = Monoclonal IgG kappa immunoglobulin. Beta FAH = 10.5% Abnormal band, immunofixation to follow. I'm IgA deficient too.??
If I am understaning this right you have a monoclonal protien band?
The most important next steps here would be to identify the band (immunofixation) and then perfrom quantitvaive immunoglobulin levels. IF there is a monoclonal band, you may very well have reciprocal depriciation of alternative immunoglobulins and IgA deficiecny with an IgG monoclonal protein is possible. ...Read more
Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?
Clinical context: The use of light chains is limited in diseases other than monoclonal gammopathies, such as myeloma or amyloidosis. If this is the context that yours got checked the results do not suggest such a condition. With no gammopathy suggested by results the question regarding clonality has no grounds. As any other test, trending the results would help in integrating it in a meaningful clinical context. ...Read more
Excess of Plasma cel: Plasma cells in our bone marrow make antibodies. Sometimes they become overly active/reactive and produce abnormal proteins called paraproteins. Most such protein production is benign and not uncommon in older folks. Sometimes it is excessive (more than 1gram/day) then we get concerned about a condition called multiple myeloma (paraproteins over 3 grams). ...Read more
Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests. Having said that, your results are suggestive of chronic inflammation and may be liver disease. However, you should take it up with your doctor who knows more about your health. ...Read more
Benign overgrowth: Monoclonal gammopathy of uncertain significance, made of an immunoglobulin g with a kappa light chain. It means nothing. You have a slightly increased chance of getting plasma cell myeloma when you're old. There's nothing you can do about it, so simply resolve not to worry about it. ...Read more
Why do you ask?: If you've been found to have a paraprotein, the real question is, "Do we treat for plasma cell myeloma? " These paraproteins are very common, especially as folks get older; most never progress. The actual level of the paraprotein isn't the key. If this is grams per liter, a value below 10 is "low". If your labs are otherwise good and you feel well, I wouldn't give it another thought. Best wishes. ...Read more
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