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Doctor insights on: Monoclonal Band In Gamma

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What is the significance of a "tiny" IgM kappa monoclonal protein migrating in beta 2 band?

What is the significance of a "tiny" IgM kappa monoclonal protein migrating in beta 2 band?

Monoclonal bands: A monclonal band suggests the abnormal production of antibody by a single expanded clone of a b-cell lymphocyte. Sometimes this is a malignancy issue (myeloma) some times it is not (mgus). In either case, this should be monitored by a hematology-oncology physician. ...Read more

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Serum immunofixation says IgM kappa in beta2, but urine immunofixation says small discrete band noted in gamma region, no m protein. Is this mgus?

Serum immunofixation says IgM kappa in beta2, but urine immunofixation says small discrete band noted in gamma region, no m protein. Is this mgus?

MGUS: Sounds like monoclonal gammopathy of undetermined significance (mgus). Cannot say much more without knowing other clinical features -- eg lymphadenopathy, cbc, "crab" symptoms (hypercalcemia, renal insufficiency, anemia, bone disease). ...Read more

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Can monoclonal IgM kappa light chain gammopathy turn into multiple myeloma?

Can monoclonal IgM kappa light chain gammopathy turn into multiple myeloma?

It can: Yes, it can . It will depend on how much is the quantity of the monoclonal proteine, how many plasma cells on the bone marrow and ultimately whether one has end organ damages/ whether some other organs are affected significantly by the monoclonal protein. That is why some blood work, imaging study and bone marrow biopsy need to be done. ...Read more

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Can a monclonal IgM kappa light chain gammopathy turn into macrogobulinemia-waldenstrom?

Can a monclonal IgM kappa light chain gammopathy turn into macrogobulinemia-waldenstrom?

Yes it is possible: It would be one of differntial diagnosis. You need a bone marrow biopsy basically to check if this is caused by plasma cells or lymphplasmacytic cells etc. ...Read more

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Immunifixation identifies m spike as IGg Kappa polyclonal gamma globulin to consist mainly of IGg Kappa n Lamda with fair amounts of Iga means what?

Immunifixation identifies m spike as IGg Kappa polyclonal gamma globulin to consist mainly of IGg Kappa n Lamda with fair amounts of Iga means what?

?? Chronic Infection: M spike of polyclonal IgG (kappa & lambda) globulin mostly suggest chronic infectious or inflammatory process & rarely hematologic malignancies. You need a complete work up for ch. liver disease, hepatitis B/C, ch.bacterial, viral & fungal infection, HIV, autoimmune diseases & if negative then evaluate for hematological disorder. CHECK FOR Ch. INFECTION & HEPATITIS. Update me with your result. ...Read more

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Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

IgM is macroglobulin: Macroglobulinemia is the term for monoclonal igm. However what you described is confusing/erroneous term, igm kappa is not light chain gammopathy. Igm kappa, by definition is macroglobulin. ...Read more

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Is a tiny IgM kappa monoclonal protein migrating in beta2 region considered specific for waldenström's macroglobulinemia irrespective of size?

No. MGUS: Mgus = monoclonal gammopathy of unknown significance. Igm is associated more with waldenstrom's macroglobulinemia (vs igg, iga, igd, ige with multiple myeloma). More info on background is here: http://bloodjournal.Hematologylibrary.Org/content/109/12/5096.Full" rel="nofollow" ta. ...Read more

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Parents -nh-lymphoma and multiple myeloma. My blood work - "igg lambda monoclonol protein migrating in gamma region. Thoughts?

It may or may not be: A hematologist should be able to help you, because there are many benign cases with abnormalities like yours. We see these type of consultations quite frequently and there is a pretty standard evaluation routine. ...Read more

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Serum -tiny IgM kappa monoclonal protein b2 region, urine - tiny IgM k paraproteinemia in gamma region. Was a mistake made or is lab normal?

Serum -tiny IgM kappa monoclonal protein b2 region, urine - tiny IgM k paraproteinemia in gamma region. Was a mistake made or is lab normal?

Monoclonal: multiple myeloma (g>a>m>e, d) •primary macroglobulinemia (waldenstrøm’s, igm) •monoclonal gammopathy of undetermined significance (mgus) (converts at 2% per year to myeloma) •miscellaneous conditions •(converts at 2% per year to myeloma) these all have to be thought of by the hematologist. ...Read more

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What does faint ill-defined band of igg, type kappa and igm, type lambda detected in blood mean?

What does faint ill-defined band of igg, type kappa and igm, type lambda detected in blood mean?

Myeloma: This test is a specific lab evaluation looking to determine if one has multiple myeloma or a variant of this disease. The results would best be answered by the doctor who ordered the test since they know your medical history and whatever prompted them to look for this disorder. ...Read more

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High KAPPA/LAMBDA LIGHT CHAIN/slightly high ratio.No Monoclonal protein immunofixation or serum electrophoresis. Is this a type of cancer?Normal WBC

High KAPPA/LAMBDA LIGHT CHAIN/slightly high ratio.No Monoclonal protein immunofixation or serum electrophoresis. Is this a type of cancer?Normal WBC

I bet it's nothing: Without free light chains or a monoclonal protein in blood or urine, the ratio's meaningless. And like most lab tests, the reference range is set so that a few percent of healthies fall outside on either end. ...Read more

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Ideop Neurop, IPE=Monoclonal IGGlambada present. No free lambda light chains seen. Mprotein seen below threshold IPE. SI all in ranges Igg 1.4. mean?

Ideop Neurop, IPE=Monoclonal IGGlambada present. No free lambda light chains seen.  Mprotein seen below threshold IPE. SI all in ranges Igg 1.4. mean?

Neuropathy in MGUS: Periphral neuropathy is common in gammopathies. If just sensory (numbness/tingling) we follow it or treat symptoms. If there is motor involvement (muscle weakness) it may need treatment. Risk of converson to a bone marrow disease is about 1% per year. You need to be followed by a neurologist/rheumatologist (if interested in neuropathies). MGUS means monoclonal gammopathy of unknown signifcance. ...Read more

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Are IgG lambda monoclonal bands common?

IgG lambda rare: Only 20% of all human igg use lambda light chains. Monoclonal bands are not common in general and may be benign or a sign of myeloma. Most a kappa. ...Read more

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What does elevated Igg-2364 and gamma globulin 2.2 mean with polyclonal gammopathy and Kappa and lambda typing increased?

Nothing serious: Polyclonal gammopathy does not have the seriousness of monoclonal gammpathy. Firstly your IgG and total globulin levels are only mildly elevated, so It may not mean any disease. One cause is chronic inflammation(infections) such as Chronic arthritis or chronic liver disease, conditions which can be checked out or ruled out easily if you ask your doctor and seek his/her advice about it. ...Read more

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Immunofixation, Serum FAH = Monoclonal IgG kappa immunoglobulin. Beta FAH = 10.5% Abnormal band, immunofixation to follow. I'm IgA deficient too. ??

Possibly: If I am understaning this right you have a monoclonal protien band? The most important next steps here would be to identify the band (immunofixation) and then perfrom quantitvaive immunoglobulin levels. IF there is a monoclonal band, you may very well have reciprocal depriciation of alternative immunoglobulins and IgA deficiecny with an IgG monoclonal protein is possible. ...Read more

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What does monoclonal spike known as IGg kappa mean in an immunofixation report?

What does monoclonal spike known as IGg kappa mean in an immunofixation report?

See details: A monoclonal spike is suggestive of a plasma cell disorder. It may be relatively benign (mgus) or much more serious (myeloma, Waldenstrom's) ...Read more

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Lumbar puncture results: Multiple IgG oligoclonal bands detected in CSF and serum, most bands unique to CSF. IgG value 9.43, range 6 - 15 Is this MS?

Lumbar puncture results:
Multiple IgG oligoclonal bands detected in CSF and serum, most bands unique to CSF.
IgG value 9.43, range 6 - 15 
Is this MS?

Consistent: But diagnosis of MS should be based on history, physical exam, results of MRI films, and spinal fluid is useful in ambiguous cases. However, elevation of oligoclonal bands can be seen in several disorders and NOT definitive on its own. Have your doctor now put the whole picture in place. Most likely MS, but other possibilities exist. ...Read more