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Doctor insights on: Monoclonal Band In Gamma

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"spep - all levels normal but at the bottom, test says 'faint band in gamma region suspicious for monoclonal immunoglobulin'. My pcp wasn't worried, didn't want to test further. Should i be concerned?

"spep - all levels normal but at the bottom, test says 'faint band in gamma region suspicious for monoclonal immunoglobulin'. My pcp wasn't worried, didn't want to test further. Should i be concerned?

At your age, no!: A monoclonal gammopathy is rare at your age. Number two, they takes decades usually to express themselves. Number three, not all become multiple myeloma, and number four, multiple myeloma is no quite treatable. I have many patients followed for years in late seventies, who still rquire no treatment. Simply repeat the test yearly. I would quantify the specific gammaglobulins as well, yearly. ...Read more

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Blood tests shows high gamma globulin & high igg. Ifx shows no monoclonal protein & free light chains are within normal range. What does this mean?

Blood tests shows high gamma globulin & high igg. Ifx shows no monoclonal protein & free light chains are within normal range. What does this mean?

It might be a benign: Many benign processed can cause hypergammaglobulinemia, which are benign elevations without a para -protein or m-spike on serum protein electrophoresis(spe)> it all depends on how high is the gammaglobulin level and making sure the liver functions are ok and there is no chronic inflammation(like rheumatoid arthritis, sarcoidosis etc) going on inside the body. ...Read more

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I've had an electrophoresis test done, serum & urine. Results show a spike in the beta and gamma regions. No monoclonal protein. What does this mean? I have proteinuria and fsgs stage 3. I am 50

I've had an electrophoresis test done, serum & urine. Results show a spike in the beta and gamma regions. No monoclonal protein. What does this mean? I have proteinuria and fsgs stage 3. I am 50

What is FSGS?: Please do not use abbreviations....They mean different things to different people. Ask your doctor to advise you about any relationship of your electrophoresis report to your underlying problem. I do not think this report is of any consequence or concern. ...Read more

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Serum -tiny IgM kappa monoclonal protein b2 region, urine - tiny IgM k paraproteinemia in gamma region. Was a mistake made or is lab normal?

Serum -tiny IgM kappa monoclonal protein b2 region, urine - tiny IgM k paraproteinemia in gamma region. Was a mistake made or is lab normal?

Monoclonal: multiple myeloma (g>a>m>e, d) •primary macroglobulinemia (waldenstrøm’s, igm) •monoclonal gammopathy of undetermined significance (mgus) (converts at 2% per year to myeloma) •miscellaneous conditions •(converts at 2% per year to myeloma) these all have to be thought of by the hematologist. ...Read more

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I have inconsistent tests that lean toward multiple myeloma or MGUS. First xray lytic lesion; globulin series serum & urine monoclonal positive to gamma; 24 hr electopherurine neg; beginning anemia; BUN off; other small abnormals. Bone survey neg.

I have inconsistent tests that lean toward multiple myeloma or MGUS. First xray lytic lesion; globulin series serum & urine monoclonal positive to gamma; 24 hr electopherurine neg; beginning anemia; BUN off; other small abnormals. Bone survey neg.

Need second opinion: The criteria for myeloma vs Mgus changed recently but both changes include exact percentages and size of lytic bone lesions. Your data as you summarized are not adequate and since mgus vs multiple myeloma are like dawn and day, you need to be seen and your precise numbers verified. That said, please see hemeonc in centers experienced in myeloma dx,management,and treatment. ...Read more

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Are IgG lambda monoclonal bands common?

IgG lambda rare: Only 20% of all human igg use lambda light chains. Monoclonal bands are not common in general and may be benign or a sign of myeloma. Most a kappa. ...Read more

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What will monoclonal bands in a lumbar puncture mean?

What will monoclonal bands in a lumbar puncture mean?

Monoclonal Bands: Oligoclonal bands are seen when a patient's blood or cerebrospinal fluid is analyzed. Each of the two to five oligoclonal bands represent proteins, although why exactly these bands are present, and which proteins these bands represent, has not yet been elucidated. Oligoclonal bands are present in 80-90% of patients and is an important indicator in the diagnosis of multiple sclerosis. ...Read more

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What is the significance of a "tiny" IgM kappa monoclonal protein migrating in beta 2 band?

What is the significance of a "tiny" IgM kappa monoclonal protein migrating in beta 2 band?

Monoclonal bands: A monclonal band suggests the abnormal production of antibody by a single expanded clone of a b-cell lymphocyte. Sometimes this is a malignancy issue (myeloma) some times it is not (mgus). In either case, this should be monitored by a hematology-oncology physician. ...Read more

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I had blood work done and results came back possible IgG kappa monoclonal band is observed. I am 22 years old. Is this possible?

I had blood work done and results came back possible IgG kappa monoclonal band is observed. I am 22 years old. Is this possible?

Yes, but not : Necessarily worrisome. A monoclonal response may be seen after an infection. See this site for more information. It would be prudent for you to follow your doctor's instructions for periodic follow-up testing. http://www.mayoclinic.com/health/monoclonal-gammopathy/ds00870. ...Read more

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I am 22years old. I had blood work coming back saying possible IgG kappa monoclonal band is observed. What could this mean?

Needs more bloodwork: Hi! this may be nothing- but still needs to be evaluated further with a serum protein electrophoresis and immunofixation to rule out a possible blood disorder. Hope this helps- write back if you have any other questions. Thanks. ...Read more