Doctor insights on:
Monoamine Oxidase Inhibitor
L-monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. The enzyme was originally discovered by mary bernheim in the liver and was named tyramine oxidase. They belong to the protein family ...Read more
See below: L-monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. The enzyme was originally discovered by mary bernheim in the liver and was named tyramine oxidase. They belong to the protein family of flavin-containing amine oxidoreductases.. ...Read more
Could monoamine oxidase increase be a solution for psychosis? If so how could I enhance it naturally?
Plz see psychiatrist: Combining this question together with your earlier one about dopamine, it sounds like you're interested in helping yourself (or someone you know) with psychosis -- but maybe trying to do this on your own? A psychiatrist is trained to help by assessing clinical situation, suggesting further diagnostic studies, & prescribing medications and/or other treatments -- as well as adjusting as needed. ...Read more
Is it right to say that there are currently three different effective drugs for depression: tricyclic, oxidace monoamine inhibitors, and prozac (fluoxetine)?
Antidepressants: There are multiple types of antidepressants. Tricyclics like imipramine, amitriptylene, desipramine; irreversible maoi's like nardil; mao-b inhibitors -- emsam; ssri's like prozac, celexa, ; lexapro; snri's like effexor, pristiq, (desvenlafaxine) and cymbalta; sari's -- tradozone; nassa -- remeron; ndri -- wellbutrin. So the list is longer than you might have thought, and some classes contain more than I named. ...Read more
What is the period of time between taking Rizatriptan and Sumatriptan and any MAOI inhibitors please?
Pharmacist: I am leery of taking any of those medications until you have been off MAO inhibitors for at least a week. The best authority to answer this question, however, is your pharmacist who has access to more information about these medications and interactions. ...Read more
Lamictal: May have a slight interaction with some MAOI requiring dose adjustment. Not the sort of potentially life threatening interaction one sees with combining MAOI's or MAOI's with adrenergic agents. ...Read more
How can I regenerate the monomines from the MAOI Nardil? It reached full tolerance and stopped working too early. I know people take it for years.
May not be able to: In my experience nardil was frequently more effective than other antidepressants and/or drugs for panic disorder--unfortunately it seemed to poop out in about 20% of patients--a few of these did report it worked for them after being off of it for a lengthy period of time. ...Read more
Antidepressants: Ssri such as prozac, Lexapro affects serotonin in brain, maoi such as Nardil block breakdown of amines, snri such as Effexor (venlafaxine) affects serotonin and norepinephrine, tca such as tofranil are tricyclic antidepressants and teca such as Remeron are tetracyclic antidepressants. ...Read more
No: Maoi = mono-amine oxidase inhibitor. This class of medication is intended to treat depression. Due to their many and severe interactions with other meds and food, they are rarely used any more. They are unrelated to thyroid hormone, either so-called "natural" armour, or synthetic levothyroxine. ...Read more
2 weeks: "Particular care must be exercised in switching patients from an MAOI to other antidepressant classes. For the patient who has completed an MAOI trial without therapeutic response, TCAs, SSRIs, bupropion, nefazodone, and other MAOIs should not be started until 10 to 14 days after the original MAOI has been discontinued. Although not currently designated an antidepressant, the serotonin agonist anxiolytic buspirone should also be included on this list. If possible, a similar waiting period should follow the discontinuation of a TCA or bupropion when an MAOI is to be administered. However, as noted above, MAOIs may be safely begun, with the appropriate precautions, even while a patient remains on some TCAs (Kahn et al. 1989)." ...Read more
If I overdosed on an MAOI 4 weeks ago, do I need to worry about any complications at this point? I have no symptoms. I didn't go to an ER or anything.
Most likely not: If you ran into any complications, you would have experienced them acutely. However, it is concerning that you did overdose. Please see your doctor if you are struggling. Your doctor can perform a comprehensive evaluation and make recommendations based on findings. Hope this is helpful. All the best. ...Read more
I have been taking maoi's fo. Most of my life and also use ritalin (methylphenidate) w/o problems. Do you think the concern over rise in BP is overrated?
No: There is no indication that you have bipolar and the treatment for it is now very advanced and helping patients greatly. ...Read more
MAOIs: In most cases maois are used when other antidepressants are ineffective. They are likely under utilized due to concerns over drug drug interactions and dietary restrictions leading most younger psychiatrists to lack expertise. One maoi, Emsam is available in a patch, which avoids oral absorption and can be a nice alternative for those that have undergone some forms of gastric bypass surgery. ...Read more
Diet: Go with diet first: increase fluids/fruits and veggies 4 to 5 servings/day. Activa yogurt with active probiotics 2-3 times daily can also help. If worsening, trial otc MiraLAX (polyethylene glycol) laxative powder: 1-2 capfuls in beverage daily until your stool is soft like pancake batter. ...Read more
Yes: Yes, there are potential dangers, namely deprenyl could cause marked elevations in the concentration of pea, which could cause a sudden spike in blood pressure, causing a potential stroke/cva. If you are already taking deprenyl, then I would be very careful about any supplements, and clear it with your neurologist before taking it to avoid negative drug interactions. ...Read more