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Doctor insights on: Molecular Biology Lab Manual

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With bipolar ii, adhd, & c ptsd, what additional tests are beneficial? Ie: hormone, neurotransmitter , DNA mutation (mthfr, a1at ...) methylation etc.

Yes: I would definitely check mthfr and comt. Both these are involved in methylation. One is involved in neurotransmitter synthesis, and the other in breakdown. Therefore polymorphisms can impact mood, etc, and if so, vitamins and supplements can help the methylation cycle. I check mthfr in most of my patients. ...Read more

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Dr. Eric Weisman
4 doctors shared insights

Laboratory (Definition)

Is facility that provides controlled conditions in which scientific research, experiments & measurements are performed. An example is medical (clinical) lab where tests are done on clinical specimens in order to get info. About the health of a patient in terms ...Read more


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Marrow aspirate flow cytometry. Whats importance of the dominant markers in lymphocyte vs. blast gates? Eg. Lymph CD2~5~7~38 Blast 22~34~45~117~hladr

Marrow aspirate flow cytometry. Whats importance of the dominant markers in lymphocyte vs. blast gates? Eg. Lymph CD2~5~7~38 Blast 22~34~45~117~hladr

Exactly400Characters: I'm not here to answer.This is beyond my expertise. But I would like to remind you,& others,that we are restricted to 400 characters(not words,but individual letters,etc).I would suspect that a question like this would require some more information before someone would want to commit to an answer and,anyways,the person who ordered and/or did the aspirate should be consulted for definitive answers. ...Read more

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TSH with human anti-mouse antigen lab test correlation and purpose ?

TSH  with human anti-mouse antigen lab test correlation and purpose ?

Unclear questions: Mouse antibodies are used in many immunoassays, including test for TSH. Could you please restate your questions as it is not clear in its present form. You may visit this site for information on TSH. http://www.nlm.nih.gov/medlineplus/ency/article/003684.htm ...Read more

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Is afirma thyroid fna analysis-molecular marker test by veracyte any good for diagnosing papillary thyroid cancer? Http://carolinaendocrine.Com

Pathologist: Already answered(and saw some other answers) to this post earlier today; there is no better way to diagnose this than with a tissue biopsy and an experienced pathologist. ...Read more

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Is there a reliable molecular test for assessing remission status of Mantle Cell Lymphoma?

Is there a reliable molecular test for assessing remission status of Mantle Cell Lymphoma?

Mantle Cell Lymphoma: ...is a type of non Hodgkin's lymphoma characterized by the genetic rearrangement of two chromosomes. This causes an abnormal fusion of two genes: Immunoglobulin (IgH) and Cyclin D1. Molecular studies that can detect this abnormality includes either FISH or RT-PCR. Flow cytometry is also good at identifying abnormal cells based on cell surface antigen expression. ...Read more

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Do different labs give different lab result #s? How accurate is quest diagnostic lab?

Do different labs give different lab result #s? How accurate is quest diagnostic lab?

Slight differences: When labs use different methods for testing, the results are slightly different. Each lab provides its normal ranges and that should be used as a guide. Quest is accredited by the american college of pathologists and that requires maintaining good testing practices. ...Read more

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Had triage sob, hepatic panel, complete blood count, hepatic profile, basic metabolic profile, liver 1, lipid profile, hemo a1c, serum-serum all done?

Had triage sob, hepatic panel, complete blood count, hepatic profile, basic metabolic profile, liver 1, lipid profile, hemo a1c, serum-serum all done?

Maybe: It seems as though you've had quite a few tests ordered. Whether or not you're done will likely depend on the reason why they were ordered along with the test results that you'll discuss with your doctor. Good luck. ...Read more

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Fatigue studies (CFS?): Merit of mitochondrial tests e.g. ATP-ATP, ANT/AAC, Mg-ATP, mito. O2 util., Zn/Cu-SOD, Mn-SOD, GSHPx? Any viable treatments?

Fatigue studies (CFS?): Merit of mitochondrial tests e.g. ATP-ATP, ANT/AAC, Mg-ATP, mito. O2 util., Zn/Cu-SOD, Mn-SOD, GSHPx? Any viable treatments?

No proven Rx: CFS remains a puzzling problem and there is no specific test to pinpoint the cause. I have a feeling that your tests were ordered by someone not in traditional medicine . There are many ways people with CFS may obtain relief but supplements (if that doctor wants to sell you some ) are not likely to offer proven benefits. . ...Read more

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What are some good concrete metrics in defining remission for waldenstrom's macroglobulinemia - in terms of bone marrow analysis and IgM level?

What are some good concrete metrics in defining remission for waldenstrom's macroglobulinemia - in terms of bone marrow analysis and IgM level?

50%, 90%, 100%: Con?rmation of response in wm has been adopted from response criteria for multiple myeloma. See http://www.Iwmf.Com/docs/ghobrial_clincial_trials.Pdf especially see tables xi, xii. The treatment of wm is aimed at control of symptomatic disease. Risk/benefits of various therapies are highly individualized based on patient and disease characteristics. ...Read more

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What do these labs mean? CBC/Diff f WBC 11.2 4.4-11.0 K/mm3 CBC/Diff-f-RBC 4.19 4.5-5.5 CBC/Diff-f-Hct 43.1 35.9-44.6 Comprehensive Metabolic Panel-Creatinine 1.05 0.57-1.00 mg/dL

What do these labs mean? 
CBC/Diff f WBC	11.2	4.4-11.0 K/mm3
CBC/Diff-f-RBC	4.19	4.5-5.5
CBC/Diff-f-Hct	43.1	35.9-44.6
Comprehensive Metabolic Panel-Creatinine	1.05	0.57-1.00 mg/dL

Ask Provider: Labs indicate slightly elevated White Blood Count, slightly low Red Blood Count, Normal Hematocrit and slight elevated Creatinine. Your provider needs to interpret those in connection with the physical exam and any symptoms or issues you may be having but alone they are not alarming values. ...Read more

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Spec.chemistry TEST NAME PSA SCREEN 0.18 then space is blank=1= FREE T4 1.18. TSH 1.863 COMM. =1=the PSA assay is a direct chemiluminometric immunoasy?

Spec.chemistry TEST NAME PSA SCREEN 0.18 then space is blank=1= FREE T4 1.18. TSH 1.863 COMM. =1=the PSA assay is a direct chemiluminometric immunoasy?

See below: All laboratory tests need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the results you provided are all normal. ...Read more

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Can biology research or chemistry research help cure cancer?

Can biology research or chemistry research help cure cancer?

My goodness: I need more than 400 characters to answer that question! the answer is yes, cell and molecular biology research has led to better understanding of cancer and significant improvements in therapy. The limitation i see to this is the tremendous cost of the new medicines derived from said research. Prevention and early detection are still very important and will be even more as the population ages. ...Read more

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How leukemia works at the molecular level?

How leukemia works at the molecular level?

In 400 characters?: There are many types of leukemia. So are very well defined at the molecular level. For example chronic myeloid leukemia and acute promyelocytic leukemia. If you can repost a more focused question I am sure you will get helpful feedback. ...Read more

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LDH Isoenzymes lab test results: LDH total- 153. LD1- 32, LD2-30, LD3, 20, LD4- 8, LD5- 10. Are these results normal? Is the LD1&LD2 ratio abnormal?

LDH Isoenzymes lab test results: 
LDH total- 153. LD1- 32, LD2-30, LD3, 20, LD4- 8, LD5- 10. Are these results normal? Is the LD1&LD2 ratio abnormal?

Historic test: Matthew, the LDH isoenzyme test is ancient history, almost never ordered nowadays. And your LDH is normal. The old 1-2 ratio is an antique screen for a heart attack, and it's neither sensitive nor specific. I know you're obsessing over the idea that you have lymphoma, and a few websites suggest this as a screening test -- but it's not. Focus on building a life for yourself. ...Read more

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Sev. Dev. Delay -array comparative genetic hybridization (acgh) results indicate no abnormalities- would full genetic sequencing be advised (knome)?

Sev. Dev. Delay -array comparative genetic hybridization (acgh) results indicate no abnormalities- would full genetic sequencing be advised (knome)?

Not necessarily: Newer genetic tests provide incite into a variety of issues like autism & other developmental variations.Yet causation remains elusive in many cases.Sadly, an injury to the developing brain centers from an unrecognized event in an otherwise normal pregnancy is a likely cause for many.This occurs in at least half of cerebral palsy cases & dev.Delay could be produced in others, yet hard to prove. ...Read more

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Is there a new tx for aca stage 4 nsclc with mets to brain and pelvis depending on tissue sampling match for kras mutation: chem & radia t, stopped.

Is there a new tx  for aca stage 4 nsclc with mets to brain and pelvis depending on tissue sampling match for kras mutation: chem & radia t, stopped.

No: Treatment of stage 4 nsclc is chemotherapy/ radiation therapy. Surgery is no an option unless it is for symptom control (bleeding). Immunotherapy, radiofrequency ablation, cryoablation, and other therapies are being tested and utilized, but if the primary therapies are no longer in use, then supportive care should be considered. ...Read more

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