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Doctor insights on: Mole Etiologies

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Biopsy shows spitz nevus cells under another type of benign mole. Melenoma can't be ruled out yet. Can melanoma grow under a benign mole?

Biopsy shows spitz nevus cells under another type of benign mole. Melenoma can't be ruled out yet. Can melanoma grow under a benign mole?

Yes: In fact, this is fairly common. No one knows where spitz nevus leaves off and a melanoma capable of metastasizing begins. This is one of the hardest calls in pathology, and some say it's impossible. The burning question will be whether to do additional surgery. ...Read more

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Dr. Coyle Connolly
1,110 doctors shared insights

Moles (Definition)

A mole (also called a nevus) is a localized overgrowth of pigment-producing cells (melanocytes) in the skin. Most moles are benign. However, these cells can become cancerous. This is known as melanoma, ...Read more


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What causes (normal) moles to be raised vs. flat moles?

What causes (normal) moles to be raised vs. flat moles?

Moles: Some have thicker base and are raised. Depends on the genes turned on in the mole. Show to your Dr. ...Read more

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Mole grew back 6 weeks after shave. Report compound melanocytic nevus architectural disorder moderate cytologic atypia. What's this mean, melanoma ?

Mole grew back 6 weeks after shave. Report compound melanocytic nevus architectural disorder moderate cytologic atypia. What's this mean, melanoma ?

Seek 2nd opinion: Recurrence of a mole makes it likely that it is a melanoma. You should get further surgery done by a melanoma expert(surgical Oncologist). It always useful to seek 2 or 3 opinions and go with the aggregate of the recommendation, provided to you. ...Read more

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Could liver nodules be a recurrence of past malignant melanoma?

Could liver nodules be a recurrence of past malignant melanoma?

Possible: Nodules in the liver can be caused by many different things. A patient with a history of melanoma and the development of new liver lesions would warrant further investigation. ...Read more

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Can a irregular shaped mole be benign?

Can a irregular shaped mole be benign?

Yes: If the mole has not change in size, shape, color, has not developed a nodule or started bleeding, it is likely to be benign. Unrelated to your question - If you do not wish to be pregnant, use contraception all the time, every time. You may consider implanted contraceptive, or IUD. Practice safe sex. Get HPV vaccine. ...Read more

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Can a birthmark mole become malignant?

Can a birthmark mole become malignant?

Maliganat % of mole: There are a small % of birthmarks that have the potential of becoming cancerous. Best to see a doctor in person for examination. ...Read more

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Recent abnormal mammo, amorphous microcalcs, 6 mnth FU. Benign conditions that cause areola shape change + edges to be less defined, like color bleed?

Recent abnormal mammo, amorphous microcalcs, 6 mnth FU. Benign conditions that cause areola shape change + edges to be less defined, like color bleed?

Tough question: Most important thing is to make sure you get proper follow up regarding those mirocalcifications. I think at some point you may end up having a stereotactic biopsy so that a pathologist can look at what's causing those microcalcs. Concerning areola shape/color fading, I would guess that wight gain, hormonal changes and pregnancy would be the things that could cause the diameter to increase. ...Read more

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Pigmented lesion ..Back...Biopsy sheets dermoepidermal junction nests pigmented bland looking round cells &nuclei.......Whats diagnosis plz?

Pigmented lesion ..Back...Biopsy sheets dermoepidermal junction  nests pigmented bland looking round cells &nuclei.......Whats diagnosis plz?

Sounds benign: This description sounds like a benign mole or what a pathologist would call a junctional nevus. There should be a final diagnosis on the report in addition to the description. Doesn't sound worrisome or atypical to me. ...Read more

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New raised mole on skin: could it be melanoma?

New raised mole on skin: could it be melanoma?

Could be: It could be, particularly if it is asymmetrical in its color distribution, has irregular border, has color variation, and a diameter larger than a pencil eraser. Get it checked out if it concerns you; a good dermatologist can suggest if this really needs to be biopsied or removed. ...Read more

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Pigmented lesion . In face..Recent increase size..Irregular border....Biopsy reveals malignant cells infiltration ...Whats diagnosis plz?

Pigmented lesion . In face..Recent increase size..Irregular border....Biopsy reveals malignant cells infiltration  ...Whats diagnosis plz?

Can be melanoma.: This sounds like melanoma. You're lucky to have found this out on biopsy, as removal of this can be 100% curative. It's really smart to talk this over with your doctor, as well as the treatment options so you know what you're dealing with. ...Read more

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Could a flat mole (single freckle/beauty mark) become cancerous like regular past the surface moles do?

Could a flat mole (single freckle/beauty mark) become cancerous like regular past the surface moles do?

Yes: The presence of a flat mole, one that is irregular in shape and has variegated colors withi grey and dark brown areas represent the superficial moles that undergo malignant transformation leading to a nodular growth. The superficial melanomas less than 1mm thick are for the most part in-situ but as thickness (Breslow) develops , not so much as depth of penetration (Clark),it is now invasive. ...Read more

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Pathology moderate atypical dysplastic nevus, recommend further excision. Is this cancer/melanoma?

Pathology moderate atypical dysplastic nevus, recommend further excision. Is this cancer/melanoma?

Not yet: It may develop into a malignancy but is not yet. The borders may be incompletely excused, or te pathologist may feel that a wide enough clear margin has not been achieved. ...Read more

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Can seborehhic keratosis lesions be two different colors?

Can seborehhic keratosis lesions be two different colors?

Sure: They usually start as small, rough bumps, then slowly thicken and get a warty surface. Most are tan or brown and can be multiple shades. They have a waxy, "pasted on" appearance...they look like a dab of warm, brown candle wax on the skin. There are some skin lesions, especially smooth moles, with various pigments which should be checked, especially if very dark/black suggesting melanoma. ...Read more

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Can a scratched malignant melanoma/amelanotic nodular melanoma heal to look like normal skin?

Can a scratched malignant melanoma/amelanotic nodular melanoma heal to look like normal skin?

They grow deep.: It's doubtful that a melanoma with the top scratched off in any way would appear like normal skin, as they tend to grow deep and not superficially. But if there's really any concern about melanoma, see a Dermatologist right away. ...Read more

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What constitutes stage 4 melanoma on a superficial mole that has gone malignant?

Metastasis: Stage IV (4) melanoma is the highest stage that a melanoma can reach. It is diagnosed by finding distant spread or metastasis to other parts of the body. Stage is different from clark's levels and breslow levels, although these can impact lower stages. (ajcc cancer staging manual, 7th ed., 2010). ...Read more

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Are skin biopsies performed on conditions other than suspicious moles?

Skin biopsy: Skin biopsies are performed to determine the histopathology of the skin condition. This tells the type of rash a person has. Also there are many other types of growths besides moles such as precancerous actinic keratosis, and other skin cancers. Skin biopsies are essential for accurate diagnosis. ...Read more

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What causes dysplastic nevi syndrome?

It is a familial: condition, but a lot is still not understood about transfer in families. Patients with this syndrome are at higher risk for abnormal moles and melanoma. So regular checks with dermatology is imperative ...Read more

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What causes a nevus to appear?

Melanocyctes: The cells are already there and grow large enough to become visible. ...Read more

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With "recurrent Nevus phenomenon" could a previously benign mole now appear dysplastic if pathologist not aware of previous biopsy or laser ablation?

With "recurrent Nevus phenomenon" could a previously benign mole now appear dysplastic if pathologist not aware of previous biopsy or laser ablation?

Yes. Hx is important: When a benign nevus grows back after biopsy, and is re-biopsied or excised, it may now show features that closely mimic a dysplastic nevus or even melanoma under the microscope. This melanoma-like pattern is called "recurrent nevus phenomenon." A pathologist might accidentally misdiagnose a benign, recurrent nevus as a DN or melanoma, if they don't know (or suspect) it was previously treated. ...Read more

Dr. Coyle Connolly
479 doctors shared insights

Nevi (Definition)

Nevi ...Read more