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Doctor insights on: Moderate To Poorly Differentiated Adenocarcinoma

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What's the option for a patient diagnosed with poorly differentiated adenocarcinomas with mixed inflammation?

What's the option for a patient diagnosed with poorly differentiated adenocarcinomas with mixed inflammation?

Options for Cancer: Need more information, such as where is it located (adenocarcinomas can be in many organs), is there lymph node involvement, etc Important to remember that there is alway more than one option or approach, including choosing not to treat. Talk it over thoroughly with your oncologist, ask lots of questions, have someone with you to take notes, get 2nd (and 3rd) opinions if necessary. GL ...Read more

Differentiated (Definition)

The process by which cells become progressively more specialized; a normal process through which cells mature. This process of specialization for the cell comes at the expense of its breadth of potential. Stem cells can, for example, differentiate into secretory ...Read more


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What can be done for poorly differentiated adenocarcinoma arising in the setting of intestinal metaplasia?

CUP?: Cancer 1-2-3 -- 1) diagnosis -- we know cancer, but what kind? May need additional information -- is this a colon polyp, now cancer or what? Pathologist can help and may need special testing. 7% of cancers have know known primary (cup or upc). 2) staging and prognostic factors. 3) treatment. Need all the pieces of the puzzle before treating. ...Read more

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Hello can u tell me what I do histopathology report : section show poorly differentiated mucinous adenocarcinoma with ulceration of mucosal surface?

Cancer: It is a subtype of cancer that arises from cell of the glands that produces some mucin/mucous.
Where is this located? Colon?
You need to discuss further re- treatment plan with your oncology team. Treatment and everything will depend on what kind of cancer is this? The stage? The molecular pattern/biology of the cancer? Your overall condition? Etc. Good luck. ...Read more

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My husband is diagnosed with poorly differentiated adenocarcinoma of the right lung with alk & egfr mutations; stage 3b what is the prognosis and life?

My husband is diagnosed with poorly differentiated adenocarcinoma of the right lung with alk & egfr mutations; stage 3b what is the prognosis and life?

Fair: It is extremely unusual to have both mutations. They are mutually exclusive. Patients that do carry one of these mutations are eligible for various medications that target these mutations.
Crizonitib for alk and tarceva (erlotinib) for egfr and new agent recently to the market. These new finding have improved the prognosis. Other factors do enter in. Age, ps, smoking history if any, wt. Loss, etc. ...Read more

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What is adenocarcinoma, moderately differentiated mean?

It is cancer: Adenocarcinoma is a cancer that originates from glandular epithelial cells. This is usually classified as poorly, moderately or well differentiated based on the resemblance of these cells to normal epithelium with the well-differentiated cells being most similar in appearance to the normal cells. The poorer the differentiation, the more aggressive and poorer prognosis. ...Read more

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What has to be performed in order for the results to show a moderately differentiated adenocarcinoma?

Biopsy: But that result is a simple biopsy, making regular slides and regular coloring of it and looking under the microscope. Identical technology from the 19th century. ...Read more

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What is differentiated adenocarcinoma endometrium?

Cancer of the uterus: This is a medical expression used when doctors report a diagnosis of Cancer of the Uterus lining(endometrium).
Your gynecologist can explain further, so call him/her up ASAP and ask how to get this disease treated soon. ...Read more

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Is it possible for differentiated endometrioid adenocarcinoma to be cured?

Yes: Endometrial cancer which begins in the endometrial mucosa, before invading myometrium or muscle of uterus is virtually 100% cureable. Even if D&C shows tumor cells spreading to blood stream this is not metastasis but cells pushed by curettage into the blood. Even early muscle invasion followed by hysterectomy with node diss. Can be cured. ...Read more

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The biopsy results says invasive moderately differentiated adenocarcinoma. Please what does this means and what is the medical cure for this?

What organ?: The report you described means cancer. The treatment depends on the stage of the tumor and organ affected. It is not an issue for self treatment, please see your doctor. ...Read more

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My husband was diagnosed with invasive moderately differentiated pulmonary adenocarcinoma. What is the course of treatment?

Your oncologist is t: Your oncologist should guide you in the decisions towards treatment. Cancer treatments are dictated by the stage of disease. So you need to know what stage of lung cancer he has. For early stages, surgery can be the best option but as it goes from stage 1 to 3, chemotherapy and radiotherapy are used in combination. For stage 4 it is mostly chemotherapy which is most useful. ...Read more

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64 YO female, biopse: ulcerated colonic mucosa with moderately differentiated adenocarcinoma ... what does it mean and is there a cure?

64 YO female, biopse: ulcerated colonic mucosa with moderately differentiated adenocarcinoma ... what does it mean and is there a cure?

Yes good out look: If localized has excellent prognosis, get it treated, follow your doctors advise, share your fears with your family and they will give you all the support you need and help you to pass this crisis. Good Luck ...Read more

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My fil,68 yrs, biopsy report stating "well differentiated papillary adenocarcinoma" @ rectosigmoid junction. Dr suggests surgery -R we doing right?

My fil,68 yrs, biopsy report stating "well differentiated papillary adenocarcinoma" @ rectosigmoid junction.  Dr suggests surgery -R we doing right?

Sounds right: With the limited information you have provided, it appears he has cancer of that portion of his colon. Surgery is usually the definitive treatment for such. Good luck. ...Read more

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Any hope for 87 yr old w/ moderately differentiated adenocarcinoma infiltrating lamina propria & muscularis mucosa w/ assoc. Ulceration & necrosis?

Yes: Yes. Which part — colon or rectum? Has it been removed or is this known by ultrasound? Need more info but don't just give up. ...Read more

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30 year old female, stage iii-b well differentiated adenocarcinoma in sigmoid colon 4 lymph nodes affected was surgically removed. What's better xelox or folfox for chemo? And why?

30 year old female, stage iii-b well differentiated adenocarcinoma in sigmoid colon 4 lymph nodes affected was surgically removed. What's better xelox or folfox for chemo? And why?

Trust oncologist: 30 yr old stage iii b needs all that is needed to prevent recurrence, both drugs have oxaplatin , folfox has 5 fu & Folic Acid, xelox has Capecitabine, all comparative studies showed almost equal results, please rely on and trust your oncologist advise, as therapies are changing so fast for good, will encourage if you want to take a second opinion good luck ...Read more

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Biopsy: "sigmoid colon, well differentiated adenocarcinoma, grade i" does this indicate that the tumor won't probably metastasize? Triphasic CT shows a lesion in the liver (1cm) as well.

Biopsy: "sigmoid colon, well differentiated adenocarcinoma, grade i" does this indicate that the tumor won't probably metastasize? Triphasic CT shows a lesion in the liver (1cm) as well.

Grade 1 is a good: Sign, but nothing is guaranteed. Need to further understand the liver lesion as well.

Work with the medical team to put together the best treatment plan for the individual patient situation. ...Read more

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Will a moderate stroke from 1.5 years ago still show on an MRI? And do "old" damage and newer old damage look alike, or can they be differentiated?

Will a moderate stroke from 1.5 years ago still show on an MRI? And do "old" damage and newer old damage look alike, or can they be differentiated?

Stroke and MRI: New strokes look different on an MRI (depending on the type and stage / swelling / bleeding) The best way to distinguish the difference is to compare to a previous study. Clinical assessment may not always inform you what has transpired as many strokes are clinically silent. ...Read more

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What is poorly differentiated squamous cell cancer?

What is poorly differentiated squamous cell cancer?

Very malignnt.: This is a kind of squamous cancer that is poorly organized, or has no resemblance to what squamous lining should look like. It follows that this is a very serious cancer that must be treated very aggressively for any chance of a favorable outcome. ...Read more

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What is the average life span after diagnosis of metastatic ovarian cancer that is poorly differentiated?

What is the average life span after diagnosis of metastatic ovarian cancer that is poorly differentiated?

Varies: Nobody can really give you a specific time period. We usually look at 5 year survival rates. If you know the stage of cancer, you can easily find the corresponding 5-year survival rate on the internet. This tells you what percentage of patients with that stage of cancer will live beyond 5 years. Hope this helps. ...Read more

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My mom, 81, was diagnosed with stage 3 poorly differentiated squamous cells. Now is told she instead has stage 2 Lymphoma. Which one is accurate?

My mom, 81, was diagnosed with stage 3 poorly differentiated squamous cells. Now is told she instead has stage 2 Lymphoma. Which one is accurate?

Lymphoma: Stage II ymphoma same side of diaphragm or in a nearby organ IIE.
Stage III is in nodes on both sides of the diaphragm or into an area or organ next to the lymph nodes is noted with an E,IIIE, or into the spleen IIIS or both III SE. Stage IV is in an organ not right next to a lymph node and bulky disease has an X qualifier. Good luck to your Mom and God bless. ...Read more

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Is poorly differentiated squamous cell carcinoma something that can be cured?

Is poorly differentiated squamous cell carcinoma something that can be cured?

Yes: Squamous cell Ca is a malignancy of tissues arising cutaneously (skin) and abutting internal structures such as bronchus and vagina/ cervix. High grade malignancies arising from such structures such as Ca of skin, bronchogenic Ca and cervix cancer can be cured iif not in metastatic phase, by wide resection, followed by RT — chemo when needed ...Read more

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What is meant by "poorly differentiated" squamous cell carcinoma? Does that mean that it is at the initial stage?

What is meant by "poorly differentiated" squamous cell carcinoma? Does that mean that it is at the initial stage?

Pathologists use: Descriptive terms, now being replaced by molecular markers... Poorly differentiated signified more deranged cellular findings, and conveyed an indication of a higher malignant potential... Not verified, but worse than well-differentiated or moderately differentiated. ...Read more

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67 female, post RT 2 years, pap smear +ve for poorly differentiated cervix carcinoma (Recurrence) while MRI shows no such evidence. What can v do next?

67 female, post RT 2 years, pap smear +ve for poorly differentiated cervix carcinoma (Recurrence) while MRI shows no such evidence. What can v do next?

Your Gynecologist ha: Your gynecologist has the answer for you. Did you ask her what the pap smeatr means and what you should do next?
A pelvic exam can look at the cervix and be able to tell if there is any growth present or not. That is much better way to find the answer than MRI or any other X-rays. If a PAP testi s abnormal the gynecologist would do a pelvic exam and biopsy of any abnomrmal looking area. & get an ...Read more

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My uncle (65 yrs) has focus of poorly differentiated squamous cell carcinoma at the base of the tongue. What does this mean?

My uncle (65 yrs) has focus of poorly differentiated squamous cell carcinoma at the base of the tongue. What does this mean?

Cancer: I'm sorry to hear about your uncle. Squamous cell carcinoma is a type of cancer that affects the head and neck. Risk factors for this cancer at the tongue base (the very back of your tongue) are tobacco, alcohol, and a virus called HPV. He should be seen by a head and neck surgeon to get further workup. The treatment depends on several factors such as the stage. ...Read more

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What do you suggest if my uncle of age 65 yrs has focus of poorly differentiated squamous cell carcinoma at the base of the tongue he?

What do you suggest if my uncle of age 65 yrs has focus of poorly differentiated squamous cell carcinoma at the base of the tongue he?

Resection: Most squamous Ca's of the tongue are on the lateral anterior 2/3 of tongue. If in the posterior tongue, the approach is by transhyoid pharyngotomy followed by RT and chemo if tumor large. This is especially true if bilateral cervical nodal disease is present. ...Read more

Dr. Riley Alexander
129 doctors shared insights

Adenocarcinoma (Definition)

Adenocarcinomas arise from glandular or secretory tissues. They are the common type of tumors (as opposed to sarcomas, from connective tissue) and include the common types colon, lung, ...Read more