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Doctor insights on: Mlh1 And Msh2 Mutations Hnpcc

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If I have hnpcc, does this mean my children will as well?

If I have hnpcc, does this mean my children will as well?

50% chance: Hnpcc or lynch syndrome is passed on in an autosomal dominant fashion -- this means that your children have a 50% chance of inheriting the defective gene causing the syndrome. ...Read more

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Mutation (Definition)

In genetics, a mutation is a change in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal genetic element. Mutations result from unrepaired damage to dna or to RNA genomes (typically caused by radiation or chemical mutagens), from errors in the process of replication, or from the insertion or deletion of segments of dna ...Read more


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What is the genetic cause of hnpcc

What is the genetic cause of hnpcc

Gene mutation: Hereditary non-polyposis colon cancer or lynch syndrome is caused by a mutation in a "mismatch repair gene, " or a gene that codes for a protein which recognizes and repairs mistakes during dna replication. It is inherited in an autosomal dominant fashion (so having 1 mutated gene is enough to increase your lifetime cancer risk). ...Read more

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How much does the hnpcc genetic test cost these days?

How much does the hnpcc genetic test cost these days?

Depends: The cost of genetic testing is a moving target these days as the costs of sequencing has come down substantially. Several companies are offering panels of clinically relevant genes including genes that increase risk of colon cancer such as the hnpcc genes. An example of a company is ambry genetics. A genetic counselor can help you research different panels and costs. ...Read more

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Some of my Aunts had HNPCC 1 died colon cancer@ 34. I have no cancer yet and am 43 am I or my kids still @ higher risk of colon cancer?

Some of my Aunts had HNPCC 1 died colon cancer@ 34. I have no cancer yet and am 43 am I or my kids still @ higher risk of colon cancer?

Yes: With hereditary nonpolyposis colorectal cancer or Lynch syndrome there is an autosomal dominant genetic condition associated with a high risk of colon cancer as well as other cancers including endometrial cancer ovary, stomach, small intestine, This is due to inherited mutations that impair DNA mismatch repair. Absence of malignancy now can result in cancers appearing later. ...Read more

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I have an ileostomy and mucous fistula. I have hnpcc and want to know if my redundant bowel can be removed for my own comfort and preventative treatme?

I have an ileostomy and mucous fistula. I have hnpcc and want to know if my redundant bowel can be removed for my own comfort and preventative treatme?

Yes: The answer is essentially yes. It depends on how much colon is left and was your surgery done as emergency? Can it be studied with little inconvenience? But lesser the colon you have the better off you are. ...Read more

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Why is the colon prone to cancer in hnpcc (hereditary nonpolyposis colorectal cancer)?

Why is the colon prone to cancer in hnpcc (hereditary nonpolyposis colorectal cancer)?

Genetic mutations: HNPCC or hereditary nonpolyposis colorectal cancer is an autosomal dominant genetic condition that has a high risk of colon cancer The disease first described by Lynch and is associated with other cancers including endometrial ovary and stomach. The increased risk is due to inherited mutations that impair DNA mismatch repair. .Individuals with HNPCC have an 80% lifetime risk for colon ca. ...Read more

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What is hereditary non-polyposis colorectal cancer (hnpcc) vs familial adenomatous polyposis (fap)?

What is hereditary non-polyposis colorectal cancer (hnpcc) vs familial adenomatous polyposis (fap)?

Both inherited: In fap presents as colonic polyps ( gardners syn will have other tumors ) , autosomal recessive due to mutations in gate keeper, tumor suppres gene. On the contrary hnpcc or lynch syndrome. Is autosomal dominant, due to dna mismatch in repair, associated with other cancers of stomach, endomet. Ca, ovary, brain, skin etc. ...Read more

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For what reason colon part is usually prone to cancer in hnpcc (hereditary hereditary nonpolyposis colorectal cancer)?

For what reason colon part is usually prone to cancer in hnpcc (hereditary hereditary nonpolyposis colorectal cancer)?

Genetic disorder: Hnpcc also called lynch syndrome results from at least four type of genetic defects involving genes needed for repair of damaged dna. See this site for more info. http://ghr.nlm.nih.gov/condition/lynch-syndrome. ...Read more

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Who should undergo genetic counseling for hereditary non-polyposis colorectal cancer (hnpcc)?

Who should undergo genetic counseling for hereditary non-polyposis colorectal cancer (hnpcc)?

Family history: There are a number of different inherited defects that cause hnpcc. A person with strong family history of colon cancer, occurring at a young age should seek counseling. ...Read more