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Doctor insights on: Mixed Connective Tissue Disease

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Dr. Laura Herpel
77 doctors shared insights

Mixed Connective Tissue Disease (Overview)

This is an overlap syndrome with manifestations that can include those of rheumatoid arthritis systemic lupus, scleroderma, and polymyositis. Different patients will have different combination of these components, over the long term it appears that many can get scleroderma like findings. Two or more components can occur. It has a variety of specific laboratory studies especially the RNP blood test


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Is mixed connective tissue disease considered a separate disease entity?

Is mixed connective tissue disease considered a separate disease entity?

Yes: If diagnosed solely on basis of anti-rnp antibodies, no; but if diagnosed clinically on the basis of signs of multiple connective tissue diseases, but which do not allow a specific one to be diagnosed. ...Read more

Dr. Laura Herpel
77 doctors shared insights

Mixed Connective Tissue Disease (Overview)

This is an overlap syndrome with manifestations that can include those of rheumatoid arthritis systemic lupus, scleroderma, and polymyositis. Different patients will have different combination of these components, over the long term it appears that many can get scleroderma like findings. Two or more components can occur. It has a variety of specific laboratory studies especially the RNP blood test


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What are the major presenting symptoms of mixed connective tissue disease?

What are the major presenting symptoms of mixed connective tissue disease?

Joint, skin, interna: Mctd can have a variety of signs and sympotms whichcan change with times. By the name it is a mixture of a variety of connective tissue diseases: systemic lupus erythematosus, scleroderma, polymyositis and rheumatoid arthritis. Depending on which condition is prominent at the time. When you are evaluated your physician will look for causes of the symptoms from these categories. ...Read more

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Living with Coronary Artery Disease (Checklist)

Take meds as prescribed
Once
Exercise daily as recommended by your doctor or trainer
daily
Limit meat, dairy, and fats as much as possible
Once
Eat whole grains only - not white bread
Once
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What specialists can diagnose mixed connective tissue disease besides rheumatologists?

What specialists can diagnose mixed connective tissue disease besides rheumatologists?

Any physician: It depends on the expertise. As a rheumatologist we may not necessarily have a corner on the market, but depending on what signs and symptoms the patient has they may be diagnosed by other physicians. It is important to be clear what the true diagnosis is since mctd people can have skin, joint, muscle, lung, heart, kidney involvement to name some. It depends on the stage of the mctd. ...Read more

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What are the tests for mixed connective tissue disease?

What are the tests for mixed connective tissue disease?

Not my definition!: Mctd is a non-serious problem for most. The lab definition is usually an rnp antibody without a smith (sm) antibody. ...Read more

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Living with Addison's Disease (Checklist)

Wear a medic alert
Once
Take additional hydrocortisone/prednisone for fever or injury
Once
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Can a person have mixed connective tissue disease with a positive ANA and low positive rnp levels?

Can a person have mixed connective tissue disease with a positive ANA and low positive rnp levels?

Inprobable: Hight titers of anti rnp antibodies are the trade mark of mctd however it is possible to be in early phase of transformation from a lupus background were other anas are still dominant. The clinical picture would take precedent with overlapping signs such as raynaulds, myositis and other signs of scleroderma. None of these tests are diagnsotic in the absence of clinical illness. ...Read more

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Could undifferentiated connective tissue disease (poss sjogrens +\or lupus) cause increased feeling of being winded when it is humid outside?

Could undifferentiated connective tissue disease (poss sjogrens +\or lupus) cause increased feeling of being winded when it is humid outside?

Difficult question: And one that probably can not be answered on this sit specific to you. Some kinds of connective tissue diseases can cause constriction and make you feel short of breath, others not. It is vert variable. The ones you mentioned probably not ...Read more

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Does connective tissue disease mean you can't have a baby?

Does connective tissue disease mean you can't have a baby?

Can have babies: Connective tissue diseases range from mild to severe. Whether it is safe to have a baby or not depends on the degree of internal organ involvement that exists (if any) with that particular connective tissue disease. Many women have successful pregnancies. ...Read more

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What type of doctors treat connective tissue disease?

What type of doctors treat connective tissue disease?

Rheumatologists: Rheumatologists are specialists who treat autoimmune inflammatory diseases such as connnective tissue diseases. ...Read more

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Treating Pelvic Inflammatory Disease (Checklist)

Ask for STD testing
Once
Have your partner get STD testing
Once
Take all of your medication exactly as prescribed
Once
Use condoms when having intercourse to prevent STD transmission
Once
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I am being treated for undifferentiated connective tissue disease which can be debilitating during flares. Is it likely I will stay in this limbo diagnosis forever?

I am being treated for undifferentiated connective tissue disease which can be debilitating during flares. Is it likely I will stay in this limbo diagnosis forever?

Possible: As you probably now by now, this condition waxes and wanes with no rhyme or reason. Sometimes, however, patients enjoy long periods of remission which is quite possible to be the case here although no body can foretell. ...Read more

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What are the new methods for treating mixed connective tissue disease?

What are the new methods for treating mixed connective tissue disease?

Mixed CT Disease: The medications include nonsteroidal anti-inflammatory drugs (nsaids), cortisone drugs/steroids (such as prednisone), antimalarial drugs (hydroxychloroquine), and cytotoxic drugs (such as methotrexate, azathioprine, and cyclophosphamide). Organ damage, such as in the kidneys, can require additional treatments directed at high blood pressure, etc. ...Read more

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Managing Peripheral Vascular Disease (Checklist)

Try to continue walking
Once
Make sure risk factors are addressed (blood pressure, cholesterol)
Once
Inspect your feet daily -- call your MD with any wounds
Daily
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What is the treatment for mixed connective tissue disease?

What is the treatment for mixed connective tissue disease?

Little to more.: Mctd has its detractors believing it will eventually morph into another ctd. My treatment is based on treating what exists. Most pts do well on plaquenyl and an nsaid, if joint aching is a problem. ...Read more

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Are there genetic variations of marfans? I ask because i think my father may have had it and I have connective tissue disease.

Are there genetic variations of marfans? I ask because i think my father may have had it and I have connective tissue disease.

Marfan is collection: The marfan syndrome is actually a collection of more than 100 mutations of a specific gene on chromosome 15.About 15-30% are thought to represent a new mutation within the affected gene, all that are passed as an autosomal dominant disorder in successive generations.(50% risk of transmission with any conception).Variation among different forms are known, but blood lines show similarity of expression. ...Read more

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Living with Lyme Disease (Checklist)

Consult an infectious disease doctor.
once
Treat symptoms
once
See a specialist to treat the area where the symptoms are worst
once
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I'm 35 chest x-ray-showed mild thoracic degenerative disease. Have connective tissue disease. Could that be cause? How to prevent further damage?

I'm 35 chest x-ray-showed mild thoracic degenerative disease.  Have connective tissue disease. Could that be cause? How to prevent further damage?

Disks vs spine: If you have degerative disk disease, loosing weight, staying well hydrated, good posture, and maybe some otc joint supplement could help. Degeneration of the spine may be osteoporosis and needs evaluation but calcium and vitamin d can reduce that risk. ...Read more

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Is Mixed Connective Tissue Disease Hereditary?

Is Mixed Connective Tissue Disease Hereditary?

Partly: The exact cause of this disease is still unknown. We believe that there is a genetic or inherited predisposition and a second enviorental trigger for this disease. It is rate to see 2 family members with this disease. Basically this means it is not an inherited disease. The abity to get this disease may be inherited but not the disease itself. ...Read more

Tissue (Definition)

The body is composed of tissue that are classically described as beiing derived from three basic embyonic layers known as the endoderm, mesoderm and ectoderm that then differentiate into the structures that compose the body such as skin, soft tissues, bone, muscle, organs, etc. Stem cells are not differentiated and have the potential to ...Read more


Connective Tissue (Definition)

There are many types of connective tissue, but in general it is a mass of fibers and thick "goopy" fluids secreted by specialized cells. The body often uses connective tissue to help ...Read more