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Doctor insights on: Mitochondrial Dna Analysis Is Best Suited For

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Had bloods for lyme, anca, anti DNA antibodies, anti mitochondrial all negative. If autoimmune started 7 years ago tho wouldn't blood repair to normal?

Had bloods for lyme, anca, anti DNA antibodies, anti mitochondrial all negative. If autoimmune started 7 years ago tho wouldn't blood repair to normal?

No: Autoantibodies rarely become negative if they were positive. It may rarely happen if the disease is in complete remission. However, that almost never happens. ...Read more

Dna (Definition)

Dna are the coding molecules found in all living things on earth which contain the instructions on how to build living things. Its is comprised the nucleotide molecules which are ...Read more


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Which type of doctor Dx's mitochondrial disease? Genetics? Neuro? Is there such thing as a mito specialist? Clinic best known for mito?

Which type of doctor Dx's mitochondrial disease? Genetics? Neuro? Is there such thing as a mito specialist? Clinic best known for mito?

Pediatric geneticist: Mitochondrial diseases produce particular syndromes that would be hereditary through the maternal line. The severity of the symptoms varies even within affected individuals in the same family. Closely looking at metabolic breakdwon products in urine and a muscle biopsy would diagnose nearly all of the cases. ...Read more

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Can you explain mitochondrial diseases in general?

Can you explain mitochondrial diseases in general?

Energy deficiency: Mitochondrial diseases result from dysfunctional mitochondria (powerhouses of cells). When they don’t function, the body has energy deficiency. Symptoms often come from organs that have high energy need such as brain (seizures, migraines), heart (weak heart muscle) liver, muscles, hormone system, etc. There is no cure yet for mitochondrial diseases but lot of active research to find a cure. ...Read more

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What are common complex III mitochondrial disorders?

What are common complex III mitochondrial disorders?

Most are rare: Mitochondrial complex iii deficiency means defect in the third "complex" (structural unit) of the mitochondrial respiratory chain (chain of protein units that produces energy for our cells). All forms of complex iii deficiencies are rare. United mitochondrial foundation has excellent information on various types of mitochondrial diseases, including complex iii: http://bit. Ly/1meless. ...Read more

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How does inheritance of a mitochondrial disease work?

How does inheritance of a mitochondrial disease work?

Maternal and Regular: A few mitochondrial diseases are passed from the mother to all of her children. This is because certain mitochondrial genes are inherited from the mitochondria in the egg's cytoplasm (outside the "nucleus" that contains the regular genes). Other mitochondrial diseases are inherited the regular way, from the genes in the egg "nucleus" and in the sperm, that code for new mitochondria in the embryo. ...Read more

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What are the major symptoms of mitochondrial disorder?

What are the major symptoms of mitochondrial disorder?

Chronic fatigue: Mitochondria are the "engines" of the cell. They develop the energy that enables each of your 70 to 100 trilion cells to function. The symptoms are many, depending on how many mitochondria in each cell are genetically affected. ...Read more

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Hi doctors, can you tell me what are mitochondrial disorders?

Hi doctors, can you tell me what are mitochondrial disorders?

Energy metabolism: Mitochondrial diseases result from dysfunctional mitochondria (powerhouses of cells). When they don’t function, the body has energy deficiency. Symptoms often come from organs that have high energy need such as brain (seizures, migraines), heart (weak heart muscle) liver, muscles, hormone system, etc. There is no cure yet for mitochondrial diseases but lot of active research to find a cure. ...Read more

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What is the definition or description of: Mitochondrial disorder?

What is the definition or description of: Mitochondrial disorder?

Energy production: Defect. Small organelles in the cells responsible for generation of energy required for metabolism may malfunction due to mutations in the genes. The most common manifestation involves abnormality in the function of the muscles, other systems may be affected depending on the type of mutation. ...Read more

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Please help! What is the mitochondrial disease known as m.N.G.I.E.?

Please help! What is the mitochondrial disease known as m.N.G.I.E.?

See this site: This should be helpful: http://ghr. Nlm. Nih. Gov/condition/mitochondrial-neurogastrointestinal-encephalopathy-disease. ...Read more

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How could mothers pass mitochondrial disorders onto their children without having it themselves?

How could mothers pass mitochondrial disorders onto their children without having it themselves?

Mutations: While the mitochondrial DNA is derived from the mother, it can mutate like other DNA and those mutations may cause problems to the new host. The mitochondria also derive much of their material from proteins encoded by the DNA of the main nucleus, derived from maternal and paternal input. So new mutations of the mitochondrial, or main DNA can all cause new onset disorders. ...Read more

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How do doctors diagnose mitochondrial disease?

How do doctors diagnose mitochondrial disease?

Big work up: All suspected patients get blood and urine tests. Then to see how widespread the disease is, ekg, echocardiogram, brain mri, audiology and eye exams are next. Patients with neurologic symptoms need spinal fluid tests, and people with developmental delays get neurogenetic testing and counseling. For more info and to find docs that take care of these diseases, see umdf. Org. Good luck. ...Read more

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Could tumors "trigger" a mitochondrial disease?

Could tumors "trigger" a mitochondrial disease?

Not very likely: Mitochondria are "power-houses"--they generate energy from inside all of your cells, except red blood cells. Thus, these are intracellular structures and diseases often result from mutation/genetic defect, drug, certain infections such as HIV/cytmegalovirus--as these go inside cells. Tumors result from mutation/defective DNAs, so possibly can cause mitochondrial disease, but low chance. ...Read more

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Can astigmatism be a symptom of mitochondrial disease?

Can astigmatism be a symptom of mitochondrial disease?

No: Astigmatism has to do with the shape of the eyeball which is heavily influenced by genetics. It is quite different from what happens inside the metabolism of functioning cells. The mitochondria are little work centers that process/make things in response to and in unison with the information provided by the cell nucleus. ...Read more

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Are mitochondrial diseases considered metabolic disorders?

Are mitochondrial diseases considered metabolic disorders?

No: No, mitochondrial diseases related to certain internal cellular issues and their discombobulation's. Metabolic diseases include for the most part diabetes, obesity, Dysmetabolic syndrome, which are a separate type of disease process than internal internal cellular constituents such as mitochondria ...Read more

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What are some mitochondrial disorder support groups in existence?

What are some mitochondrial disorder support groups in existence?

Look online: Since mitochondrial disorders are still considered rare disease entities, support groups at a local level would be very dificult to find. I suggest you go online to some of the big centers in the us who deal with the diagnosis and treatment of these disorders (ie. Children's hospital of philidelphia, cleveland clinic) and see if they have online support groups and parental geoups. ...Read more

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Hi doctors, can you tell me what is mitochondrial encephalopathy?

Hi doctors, can you tell me what is mitochondrial encephalopathy?

Mitochondria: Its a group of diseases that are due to defects in metabolism inside the mitochondria and the person was born with it. It tends to cause delay in milestones, seizures and often metabolic acidosis ...Read more

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What are some of the of non genetic or "acquired" mitochondrial disease?

What are some of the of non genetic or "acquired" mitochondrial disease?

Heavy metals: Lead and mercury toxicity, prolonged immobilization and lack of exercise, etc. - those are forms of secondary mitochondrial disease. ...Read more

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How is mitochondrial deficiency, gi, and hashimotos relate? Which appears first possibly creating or exacerbating the others?

How is mitochondrial deficiency, gi, and hashimotos relate? Which appears first possibly creating or exacerbating the others?

None are related!: All are not mitochondrial based diseases. Hashimoto's is common (5% of the population), and is the principle cause for hypothyroidism, which can exacerbate any problems! ...Read more

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Is mitochondrial vitamins good for fertility problems?

Is mitochondrial vitamins good for fertility problems?

There are none: There is no such thing as mitochondrial vitamins. Almost all vitamins are the same. Don't waste your money on this garbage. And don't get your medical information from friends, tv and the internet.
If you have fertility problems, talk w/your doctor instead. ...Read more

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Can you have a vaccine to prevent mitochondrial disease?

Can you have a vaccine to prevent mitochondrial disease?

No: There are no vaccines that actually prevent mitochondrial disease, but the vaccines can prevent infections that can trigger serious flareups of mitochondrial disease. ...Read more

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Please explain why haven't mitochondrial diseases phased themselves out?

New mutations: Just because it is labeled mitochondrial does not mean the information in these organelles is not subject to the same chance of new mutations as other dna bearing material. Many of the affected patients do not live long enough to pass the disorder to offspring as some might think. ...Read more

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What is mitochondrial disorder?

What is mitochondrial disorder?

Energy loss: Mitochondria are the "engines"of each cell throughout the body. Loss of energy changes normal functions and the symptoms are many. Mitochondria have their own genes and they are inherited from the mother alone. ...Read more

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What is (or are) a mitochondrial disease?

Definition of Mito.: Mitochondria are specific organelles within our cells. They are essentially the energy-producing factories of the cells; they produce (among other things) a molecule called ATP (adenosine triphosphate), which is the energy currency of the body. There are a few mitochondrial diseases; these diseases specifically affect this very important structure within our cells. ...Read more

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Which is the mitochondrial disease known as l.H.O.N.?

Which is the mitochondrial disease known as l.H.O.N.?

Lebers neuropathy: Lebers hereditary optic neuropathy

http://ghr. Nlm. Nih. Gov/condition/leber-hereditary-optic-neuropathy. ...Read more

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How long can people with mitochondrial myopathies live?

How long can people with mitochondrial myopathies live?

Highly variable: There is a wide range of mitochondrial myopathies, each with its own severity and expected lifespan. Some cause death in infancy, while others have no real impact on lifespan at all. A neurologist and/or geneticist can help you understand the specifics of your particular case. ...Read more

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Please help! What is the cause of mitochondrial disease?

Genetic change: Mitochondrial diseases can be caused by changes in mitochondrial dna (mtdna), inherited only from mother but most are caused by changes in genes inherited both from mother and father (nuclear genes). It can be inherited in other ways too. More info on the complex inheritance of mitochondrial diseases: http://www. Umdf. Org/site/c.8qkoj0mvf7lug/b.7940911/k.555f/inheritance__genetics. Htm. ...Read more

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Hi doctors, can you tell me what is mitochondrial encephalomyopathy?

Hi doctors, can you tell me what is mitochondrial encephalomyopathy?

Mitochondrial defect: Mitochondrial encephalomyopathy is a form of encephalomyopathy that is caused by dysfunctional mitochondrial. "encephalo-" refers to disease of brain. "myo" refers to muscle. "-pathy" means pathology/disease in general. Thus encephalomyopathies are diseases in which both brain and muscle are affected. ...Read more

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What are the minimum tests needed to diagnose mitochondrial disorder?

What are the minimum tests needed to diagnose mitochondrial disorder?

A good doctor: Mitochondria have their own dna, so mitochondrial gene mutations must be diagnosed at a lab such as dr. Boles at usc; but diagnosing mitochondrial dysfunction is a matter of appropriate interpretation of symptoms, as well as testing things such as vitamin B12 function (mma), mg (rbc), zn (rbc), and phase angle on body composition analysis. Find a doctor who knows mito disorders. ...Read more

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What is the mitochondrial disease known as l.h.o.n.? How is it treated?

What is the mitochondrial disease known as l.h.o.n.? How is it treated?

Hereditary blindness: LHON stands for Leber's hereditary optic neuropathy. It is inherited from mother to child. Usually a young man loses eyesight in the enter of one eye, and shortly after he loses eyesight in other eye. Women are less often affected. Gene mutations that are responsible for this disease is known. There are no curative treatments. If you carry this gene, you should avoid smoking, alcohol certain drugs. ...Read more

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How could a large deletion in the mitochondrial genome case a disease.?

How could a large deletion in the mitochondrial genome case a disease.?

It does cause diseas: Mitochondrial DNA Deletion syndrome are inherited and transmitted by maternal inheritance. There are three phenotypes and can cause Heart Block, hearing loss.endocrine disorders and others ...Read more

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What is the mitochondrial disease known as l.h.o.n.? How is it treated?

What is the mitochondrial disease known as l.h.o.n.? How is it treated?

Progressive vision: Loss occurs as a result of this condition which is the most common known mitochondrial disease. About 45 mutations have been linked to LHON. Although it is the most common, it is nevertheless rare and must be treated at a center with knowledge of and experience with mitochondrial disorders. ...Read more

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What is the mitochondrial disease known as m.n.g.i.e.? How is it treated?

What is the mitochondrial disease known as m.n.g.i.e.? How is it treated?

Mngie: MNGIE is a multi system autosomal recessive disorder characterized by gastrointestinal dysmotility and peripheral nervous system involvement death occurs before 35 years of life. Treatment options include allogeneic hematopoietic stem cell transplantation and carrier erythrocytes entrapped TP therapy. Hope this answers your question. Mitochondrial Neurogatrointestinal Encephalomyopathy ...Read more

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What testing should my child undergo for suspected mitochondrial disease?  

What testing should my child undergo for suspected mitochondrial disease?  

Consult a specialist: Mitochondrial diseases are quite complicated and best evaluated at a specialized research center or a university medical center. The united mitochondrial disease foundation website (www. Umdf. Org) lists several types of blood and urine tests, heart echo (ultrasound), brain mri, eye and audiology exams, heart ekg, spinal fluid tests, chromosome tests, muscle biopsy, etc... As possible test choices. ...Read more

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Is mitochondrial disease difficult to diagnose? How is a diagnosis reached?

Is mitochondrial disease difficult to diagnose? How is a diagnosis reached?

Often it is: Mitochondrial diseases can present from any organ system at any age. Diagnosis can be made by specific clinical criteria (symptoms, brain MRI imaging, muscle biopsy, elevated lactate in blood) or, by finding a genetic mutation either in mitochondrial dna or one of the hundreds of other genes that cause mitochondrial disease. Latter is a more accurate diagnosis. ...Read more

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What are symptoms of mitochondrial myopathy?

What are symptoms of mitochondrial myopathy?

Many symptoms: The mm are a group of disorders due to dysfunction of the mitochondria, which are the energy producing parts of the cell. Nerve and muscle cells need a great deal of energy and so are most affected. Symptoms depend on which enzymes / proteins are dysfunctional, but muscle, brain, heart and eye function can be affected. See: http://www. Ninds. Nih. Gov/disorders/mitochondrial_myopathy for more info. ...Read more

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What is mitochondrial myopathy? What causes it?

What is mitochondrial myopathy? What causes it?

Mitochondrial myo-: Pathies are a group of neuromuscular disorders inherited from one's mother. Find out the type & which organs it affects, then obtain information & support from mda. Org. Mitochondria are cellular power plants that convert fuel from food into energy molecules, particularly important in nerve & muscle cells. See more on genetics at mda. Org/disease/mitochondrial-myopathies/causes-inheritance ...Read more

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Is there a treatment for mitochondrial disorder?

Is there a treatment for mitochondrial disorder?

No cure yet: There is no curative treatment yet available for mitochondrial disorders. However, a lot of research is being done in this area. In the meantime, the treatment includes various supplements (vitamins and antioxidants) that may help some patients, maintaining healthy lifestyle, and avoiding triggers that may make disease worse such as certain medications that affect mitochondrial function. ...Read more

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What is mitochondrial myopathy? My sister has it.

What is mitochondrial myopathy? My sister has it.

Muscle biopsy proof: Myopathy associated with mitochondrial disease.
Maternal genetic transmission
Short stature, eye muscle paralysis, hearing loss & cardiac conduction defects. Overlap with other mitochondrial myopathies
She shold be under the care of neurologist & physiotherapist. ...Read more