Doctor insights on:
Multiple: Many drugs have the side effect of increasing blood pressure, which can be accomplished by retaining salt and excess fluid (eg, fludrocortisone and other gluocorticoid and adrenocorticoid hormones), or by stimulating the autonomic nervous system (increasing heart rate and vasoconstriction). it is rarely indicated to increase blood pressure, usually we seek the benefits of a lower blood pressure. ...Read more
How can a drug like midodrine that constricts SOME vessels and not all of them, can cause higher pressure on ALL vessels walls??
Potentially: This stuff is used to raise blood pressure, especially in folks with orthostatic hypotension (BP drops when they stand up) the normal dose is 10 mg 3 times a day.....So I would be afraid of trying 40 mg at once. Most folks start slowly, and do not even take 10mg at a time...Some suggest starting with 2.5 mg....So I say no to 40mg! ...Read more
About half: Half life of midodrine is 3-4 hours so about half would be left although there are lots of variables that could affect the true levels. ...Read more
Midodrine: People react differently to the same dose of drugs, you should discuss with the dr. Who knows you. ...Read more
Potentially: This stuff is used to raise blood pressure, especially in folks with orthostatic hypotension (BP drops when they stand up) overdosing can cause severe elevation of BP and severe drop in heart rate. Those things can cause significant difficulties. It can also cause erythema multiforme, which can also be deadly. So if you have a stroke, or heart block, or deadly skin reaction...That sound awful. ...Read more
It depends: Midodrine is a medication which helps to raise blood pressure in patients who have a drop in their blood pressure as the cause of syncope. It will not treat all types of syncope and has it's own side effects. A specialist who knows your condition can determine whether midodrine is right for your condition. ...Read more
Midodrine overdose: An overdose occurs when an excessive / dangerous dose of a drug is used. "Symptoms of a midodrine overdose may include increased blood pressure (flushing, headache, pounding heartbeat, blurred vision), goosebumps, difficulty urination, a feeling of being cold, and loss of consciousness." REF: http://www. Rxlist. Com/proamatine-drug/patient-images-side-effects. Htm#overdose ...Read more
Sometimes my sitting hr is 50-56 any move makes it back up 65-75. I have dysautonomia. Can I take midodrine 2.5mg or hr too slow?
A slow heart rate by itself is not necessarily an issue. What is more important is the cause of the slow heart - which your pcp can evaluate. Mitodrine can treat dysautonomia in those patients who develop lightheadedness standing up. It will not affect the heart rate.
Good luck. ...Read more
Unlikely but possibl: When pts have the indication, midodrine can raise BP by increase vessel tone. At night while lying down BP goes up due to increase return. Midodrine can further increase the BP if given too close to bed and in susceptible pts, can cause a spike in BP and cause a stroke. ...Read more
Midodrine: Midodrine is a vasoconstrictor typically used for patients with difficult neurally-mediated syncope or significant orthostasis. As such, it can drive the BP up higher. In someone with a volatile bp, such a drug could precipitate a very high BP that could increase ones risk for stroje. ...Read more
OK: There are no listed drug interactions - there is no contraindication. ...Read more
Yes: There is no significant drug interactions between these two medications. ...Read more
Call Poison Control:
If overdose is suspected, you should call your local poison control center or emergency room immediately. Us residents can call the us national poison hotline at 1-800-222-1222. Symptoms of overdose may include "goose bumps, " difficulty urinating, feeling cold.
Recommended general treatment, based on the pharmacology of the drug, making them vomit and giving an alpha-sympatholytic med. ...Read more
Side effects: All drugs have a potential for idiosyncratic potential adverse reactions. If I were you, I'd stop the midodrine. Try simple remedies like liberalizing your salt and water intake (eat daily potato chips and salted nuts and drink plenty of water with them). Good luck! ...Read more
Midodrine use: Midodrine (m) is used to treat low blood pressure. It works by stimulating nerve endings in blood vessels, causing the blood vessels to tighten. As a result, blood pressure is increased. It would be unusual to have both m and Cozaar (losartan) (c) used together, as c treats hypertension. Ask the physician (p) who treating the patient what the p is thinking if both m and c are being used together. ...Read more