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Doctor insights on: Methotrexate Withdrawal

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Does anyone know the withdrawal effects of methotrexate?

Does anyone know the withdrawal effects of methotrexate?

No true withdrawal!: People are put on mtx for reasons. Many are rheumatic problems that cause pain with inflammation. Stopping the drug can allow inflammation to return causing pain and lethergy. ...Read more

Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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What are withdrawal symptoms of methotrexate? Dr.Stopping me after devolving chronic bronchitis and mild asthma.

No such thing: You do not get withdrawal symptoms from stopping methotrexate. The only issue is that the underlying disease it is treating can flare when it is stopped. It should be held when treating any infection. ...Read more

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Is it o.K. To tan while on methotrexate?

Is it o.K. To tan while on methotrexate?

No: While this is actually unlikely to cause problems, sunburn may be more likely while using methotrexate. Though it may depend on why and how you're using it. ...Read more

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Please describe the medication: methotrexate?

Standard therapy: Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA and other rheumatologist diseases. ...Read more

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Any methotrexate side effects?

Any methotrexate side effects?

Plenty : XX oral dos: Methotrexate is a surprisingly effective drug for many forms of arthritis and the consensus 1st choice for RA by the acr and eular (european). The oral dosage is more problematic because of variable absorption and first-pass effect through liver. It is completely absorbed with sucutaneous injection and doesn't bolus liver. Hair loss can be a problem. Everyone should take 2mg of folic acid. ...Read more

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Can methotrexate treat psoriasis?

Can methotrexate treat psoriasis?

Yes. Agree, but....: Methotrexate can be very effective. However, the first studies raising the specter of liver disease came from psoriasis patients on daily low dose oral mtx! . The first pass effect is dangerous for the liver. Mtx cannot be adjudicated aqs an oral drug. Absorption is variable (40-90%), causes GI upset, and hits the liver first. I only use subcutaneous mtx once weekly. This is the safest! ...Read more

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Is it harmful to take methotrexate?

Is it harmful to take methotrexate?

Yes, if no indicatio: It will be harmful if no indication to take. However, if there is a strong indication- it is something that is tolerable. Just like any other medication, there will be some possible adverse events- and this is something that you have to discuss with your doctor- to weigh the benefit and the risk and make a decision. ...Read more

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Is tanning ok while on methotrexate?

Is tanning ok while on methotrexate?

Yes, but: Tanning ages skin and causes cancer. But that having been said, Methotrexate does not make tanning more dangerous! ...Read more

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Is methotrexate safe to use with CKD?

Is methotrexate safe to use with CKD?

Avoid using Abbrevia: What is CKD? Is it chronic Kidney disease? If so, what is your kidney function in terms of your blood Creatinine levels? . What is the cause? Methotrexate is not safe to use for patients with kidney diseases.
Please clarify, so that we can guide you further. ...Read more

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I'm on methotrexate, can I still drink?

Absolutely NOT!: The combination of alcohol and Methotrexate has caused many people to have liver failure requiring a liver transplant to survive. Methotrexate can irritate the liver by itself but is quite safe at the low weekly doses used to treat many autoimmune conditions.Never drink any alcohol while on methotrexate. If you absolutely "must" drink alcohol, tell your doc so he/she can take you off methotrexate. ...Read more

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Should I take methotrexate if I have a cold?

See details: When in doubt it is always prudent to skip a week. This question is best directed to the doctor who is prescribing it. ...Read more

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How well does methotrexate work on psoriasis?

How well does methotrexate work on psoriasis?

Psoriasis: Methotrexate is a terrific therapy for severe psoriasis. It works well, is very inexpensive and is relatively safe when its effects are carefully monitored. ...Read more

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Need to know about a drug called methotrexate?

Need to know about a drug called methotrexate?

Folic acid inhibitor: It inhibits Folic Acid and can help treat inflammatory disorders like rheumatoid arthritis, psoriasis, tumors, etc, it can help vasculitis also whether it is due to an inflammatory or infectious etiology. It needs to be carefully monitored, can cause liver disease so we recommend no alcohol, can cause low blood counts and mouth ulcers and hair loss so we supplement therapy with folic acid. ...Read more

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Can methotrexate help herpes or cause a out break?

Outbreak...: Methotrexate is an immunosuppressive drug and is not an antiviral compound. Thus some patients can have flares of viruses like herpes or varicella (chickenpox and shingles) when they receive Methotrexate because their white blood cell numbers and/or activity are decreased. ...Read more

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What are some of the side effects of methotrexate?

Several.: Fatigue after taking your weekly dose. Gi quiziness. Hair loss. Potential liver issues, especially taken orally. Your white count can be lowered, as well as hemoglobin. Everyone on mtx should take folic acid. Monitoring for side effects (benefits too) should take place every three months or sooner. ...Read more

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How can we reduce the side effects of methotrexate?

How can we reduce the side effects of methotrexate?

See details: It really depends of the specific side effect. Dividing the dose or switching to the subcutaneous form can help with GI issues. Taking folic can reduce other risks. ...Read more

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How effective is methotrexate for treating leukemia?

How effective is methotrexate for treating leukemia?

Very: Many types of leukemia respond very rapidly to methotrexate. Everything is, of course, context-dependent and it matters whether we give in the blood or in the spine; the dose of methotrexate; the type of leukemia, and whether you mean "cure" or "treat." Best of luck to you and your loved ones. ...Read more

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What are the most common side effects of methotrexate?

Nausea, hair loss,: There are many described that can be lessened by also taken folic acid.
the things we look for are many including nausea - sometimes called ucks, hair loss, mouth sore, low blood counts, liver changes,

Rare one, include lung problems and a type of lymphoma. You need to discuss this with your physician and help monitor you and reduce these risks. ...Read more

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Can I have one drink a week on methotrexate injections?

No: Would not advise it Methotrexate and alcohol can accelerate liver damage that each can do alone. The combination is worse. ...Read more

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Can I take cold medication if I'm taking methotrexate.?

See below: As a good rule of thumb, if you have an infection, you would want to leave off your Methotrexate and Imuran (azathioprine) and when the infection resolves, you can resume them. ...Read more

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If one cuts down on methotrexate will it make them tired?

If one cuts down on methotrexate will it make them tired?

Yes but for what MTX: It's not clear why you're taking methotrexate. It is possible the methotrexate is controlling your underlying condition. If you slow down on it may not control as much and you maybe getting these symptoms you have ...Read more

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Is it safe to have a gin and tonic when taking methotrexate?

Maybe: Methrotrexate can be toxic to the liver. Excess alcohol is also toxic to the liver. In general alcohol use should be avoided when taking Methotrexate to avoid any possibility of liver damage. ...Read more

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Can methotrexate causes macrocytosis if so is this concerning?

Yes, and may be: Methotraxate blocks the metabolism of folic acid and folic acid is needed for normal red cell production. Macrocytosis is one of the side effects of methotraxate treatment. You doctor should be following you for any toxic effects from the treatment. ...Read more

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What is the standard dose of methotrexate for treating psoarisis?

15-25 mg weekly: There is no one standard dose. I have found that a range of 15-25 mg weekly works best for most of my psoriasis patients. ...Read more

Dr. Robert Lowe
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