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Doctor insights on: Methotrexate Still Sore And Stiff

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Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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Does methotrexate help with psoriatic psoriasis.stiffness in the joints,I am on 20mg weekly. Thanks?

Does methotrexate help with psoriatic psoriasis.stiffness in the joints,I am on 20mg weekly. Thanks?

It can: Typically, at any particular dose of methotrexate, it will take about 8 to 12 weeks to see what the level response will be with that dose. About 2/3rds of people will get a 20 to 50% decrease in joint pain/swelling within 3 months once the best/safest dose is determined. Sometimes even a better response! If you get < 20% improvement your MD may discuss options of a higher dose vs other meds. ...Read more

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I am on Methotrexate for Psoriasis.For the last 3 months I have stiffness in my joints on hands and knees.Could this be psoriatic Psoriasis.Thanks?

I am on Methotrexate for Psoriasis.For the last 3 months I have stiffness in my joints on hands and knees.Could this be psoriatic Psoriasis.Thanks?

Maybe: Approximately 20% of psoriasis patients get psoriatic arthritis (PSA). It depends on which joints are hurting and whether they are actually inflamed. There are other causes of joint pain unrelated to your psoriasis that need to be ruled out. A Rheumatologist can help you sort this out. ...Read more

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Leg muscles very sore since i started methotrexate 7.5 weekly is this a common side effect. 5mg of folate (folic acid) on days without mtx?

Leg muscles very sore since i started methotrexate 7.5 weekly is this a common side effect.  5mg of folate (folic acid) on days without mtx?

Methotrexate effects: Muscle soreness is not a common side effect, but can happen. You should get further laboratory work up to check your liver, kidney and muscle enzymes. Yes, folate (folic acid) supplementation is recommended while taking methotrexate. ...Read more

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Severe sore throat pain,sore tongue. Tiny red spots throughout the mouth. Mainly inside on cheeks. Dr said bad sinus?Could be the methotrexate I take?

Severe sore throat pain,sore tongue. Tiny red spots throughout the mouth. Mainly inside on cheeks. Dr said bad sinus?Could be the methotrexate I take?

Mucositis?: These don't sound like symptoms of sinusitis, and I think you are on the right track. This sounds like oral mucositis (medicalese for inflammation of mucous membranes), which is a well known side effect of many chemotherapeutic drugs, including methotrexate. http://www.ncbi.nlm.nih.gov/pubmed/23601229 ...Read more

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I take methotrexate and Orencia (abatacept) my RA. I have a cold (mucus, dry cough, sore throat). What over the counter meds can I take? Dayquil? Any others?.

I take methotrexate and Orencia (abatacept) my RA. I have a cold (mucus, dry cough, sore throat). What over the counter meds can I take? Dayquil? Any others?.

No contraindication: to the OTC cold medicines mentioned. Whether they work or not is another issue. I find that inhaling warm steam for a few minutes 2x daily for 3 days may help hasten recovery. ...Read more

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I fractured my fourth metatarsal over 7 months ago and to this day I still feel pain, soreness and stiffness everyday, is this normal?

I fractured my fourth metatarsal over 7 months ago and to this day I still feel pain, soreness and stiffness everyday, is this normal?

Foot pain: No it is abnormal;so go get a physical exam and possibly an Xray as well as appropriate therapy/advice based on findings ...Read more

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Bunionectomy with 2 surgical screws placed. I'm 5wk post op. Still very swollen/sore & stiffness in big toe joint area. Is this normal at this point?

Bunionectomy with 2 surgical screws placed. I'm 5wk post op. Still very swollen/sore & stiffness in big toe joint area. Is this normal at this point?

Healing: The healing process for most surgical wounds is 6-8 weeks. The inside part is usually around the same, but obviously variable. I would suggest calling your surgeon to find out for your case. May want to bring you in for a follow up exam as well. Time heals all wounds... Hope this helps! ...Read more

Dr. Robert Lowe
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Rheumatrex (Definition)

Rheumatrex ...Read more