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Doctor insights on: Methotrexate Still Sore And Stiff

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Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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Does methotrexate help with psoriatic psoriasis.stiffness in the joints,I am on 20mg weekly. Thanks?

Does methotrexate help with psoriatic psoriasis.stiffness in the joints,I am on 20mg weekly. Thanks?

It can: Typically, at any particular dose of methotrexate, it will take about 8 to 12 weeks to see what the level response will be with that dose. About 2/3rds of people will get a 20 to 50% decrease in joint pain/swelling within 3 months once the best/safest dose is determined. Sometimes even a better response! If you get < 20% improvement your MD may discuss options of a higher dose vs other meds. ...Read more

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I am on Methotrexate for Psoriasis.For the last 3 months I have stiffness in my joints on hands and knees.Could this be psoriatic Psoriasis.Thanks?

I am on Methotrexate for Psoriasis.For the last 3 months I have stiffness in my joints on hands and knees.Could this be psoriatic Psoriasis.Thanks?

Maybe: Approximately 20% of psoriasis patients get psoriatic arthritis (PSA). It depends on which joints are hurting and whether they are actually inflamed. There are other causes of joint pain unrelated to your psoriasis that need to be ruled out. A Rheumatologist can help you sort this out. ...Read more

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Leg muscles very sore since i started methotrexate 7.5 weekly is this a common side effect. 5mg of folate (folic acid) on days without mtx?

Leg muscles very sore since i started methotrexate 7.5 weekly is this a common side effect.  5mg of folate (folic acid) on days without mtx?

Methotrexate effects: Muscle soreness is not a common side effect, but can happen. You should get further laboratory work up to check your liver, kidney and muscle enzymes. Yes, folate (folic acid) supplementation is recommended while taking methotrexate. ...Read more

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Severe sore throat pain,sore tongue. Tiny red spots throughout the mouth. Mainly inside on cheeks. Dr said bad sinus?Could be the methotrexate I take?

Severe sore throat pain,sore tongue. Tiny red spots throughout the mouth. Mainly inside on cheeks. Dr said bad sinus?Could be the methotrexate I take?

Mucositis?: These don't sound like symptoms of sinusitis, and I think you are on the right track. This sounds like oral mucositis (medicalese for inflammation of mucous membranes), which is a well known side effect of many chemotherapeutic drugs, including methotrexate. http://www.ncbi.nlm.nih.gov/pubmed/23601229 ...Read more

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I fractured my fourth metatarsal over 7 months ago and to this day I still feel pain, soreness and stiffness everyday, is this normal?

I fractured my fourth metatarsal over 7 months ago and to this day I still feel pain, soreness and stiffness everyday, is this normal?

Foot pain: No it is abnormal;so go get a physical exam and possibly an Xray as well as appropriate therapy/advice based on findings ...Read more

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Bunionectomy with 2 surgical screws placed. I'm 5wk post op. Still very swollen/sore & stiffness in big toe joint area. Is this normal at this point?

Bunionectomy with 2 surgical screws placed. I'm 5wk post op. Still very swollen/sore & stiffness in big toe joint area. Is this normal at this point?

Healing: The healing process for most surgical wounds is 6-8 weeks. The inside part is usually around the same, but obviously variable. I would suggest calling your surgeon to find out for your case. May want to bring you in for a follow up exam as well. Time heals all wounds... Hope this helps! ...Read more

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I'm on methotrexate, can I still drink?

Absolutely NOT!: The combination of alcohol and Methotrexate has caused many people to have liver failure requiring a liver transplant to survive.Methotrexate can irritate the liver by itself but is quite safe at the low weekly doses used to treat many autoimmune conditions.Never drink any alcohol while on methotrexate.If you absolutely "must" drink alcohol, tell your doc so he/she can take you off methotrexate. ...Read more

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How can I stop neck soreness and stiffness?

How can I stop neck soreness and stiffness?

NSAIDs; massage: Anti-inflammatory medications-ibuprofen, Naproxen canhelp. Massage, accupuncture, cervical traction, moist heat can also be veryeffective. ...Read more

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Humira (adalimumab) every 2 weeks stopped working&got a bad psoriasis flare-up...Now on humira (adalimumab) weekly w/15mg methotrexate but still have bad psoriasis.U recommend?

Humira (adalimumab) every 2 weeks stopped working&got a bad psoriasis flare-up...Now on humira (adalimumab) weekly w/15mg methotrexate but still have bad psoriasis.U recommend?

Psoriasis: While Humira is an excellent therapy for severe psoriasis, there are times when it stops working. Another option for you may be stelara (ustekinumab) which is also an injectable treatment which works a little differently than does Humira and is extremely effective in many patients. ...Read more

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Is there any method or exercises that relieves back soreness, stiffness?

Is there any method or exercises that relieves back soreness, stiffness?

Stretching, yoga: There are many exercises to strengthen the core muscles but yoga (especially gentle stretching) yoga can be great to decrease back tightness. Regular massages, acupuncture, rolfing and feldenkrais are other methods to help with back pain. Try arnica instead of advil (ibuprofen) for pain relief since it does not have all the side effects. ...Read more

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I have stopped taking my Crohn's medication (methotrexate)i was suffering severe side effects. I'm still incredibly sick & wondering when it will stop?

I have stopped taking my Crohn's medication (methotrexate)i was suffering severe side effects. I'm still incredibly sick & wondering when it  will stop?

Could be Crohn's: Some of the most common side effects can be similar to symptoms of crohn's. These include mouth sores, fever, diarrhea, blood in your stools, body aches and abdominal pain. You may want to check with your doctor and make sure this is not a flare up of your disease. ...Read more

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What can I do for stiffness and soreness in me hands?

What can I do for stiffness and soreness in me hands?

Inflammation: If you are a healthy person and doing manual labor it is not unusual to have stiffness and soreness of the hands. If you have no stomach problems, bleeding tendency, or kidney or liver problems it is safe to take over the counter Motrin with food. Please take as recommended on the bottle or your physician. With rest and medication this should resolve in 1week. Otherwise see you primary doctor. ...Read more

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How can you stop neck soreness/stiffness & pain in shoulders?

How can you stop neck soreness/stiffness & pain in shoulders?

Depends: Depends on why this is occuring. Hate to keep punting on this, but at your young age, you need to find out what is causing this. A good place to always start is your pcp. Some things just cannot be answered safely without a look. ...Read more

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What can I do to reduce my muscle stiffness and also soreness?

What can I do to reduce my muscle stiffness and also soreness?

Rest, heat: Muscle "stiffness" after exercise is due to metabolite build up. This occurs when the work the muscle does exceeds the rate of oxygen supplied. It occurs during strength more than endurance training, that is when "bulking up". The real answer is to go more slowly in your training. But heat, massage and if very sore judicial use of an anti inflammatory such as advil or Aleve (naproxen) will help. ...Read more

Dr. Robert Lowe
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Rheumatrex (Definition)

Rheumatrex ...Read more