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Doctor insights on: Methotrexate Or Dactinomycin Chemotherapy Medication

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Chemotherapy side effect question. Will I get nausea right away from dactinomycin?

Chemotherapy side effect question.  Will I get nausea right away from dactinomycin?

Dactinomycine&nausea: 75% of patients will experience nausea and vomiting, can be mild to moderate in severity.It may present within hours of administration , may be dose related and may be more intense two to four days after the end of five day course, usually require and respond to antiemetic therapy and may persist as long as a week after the therapy is stopped. ...Read more

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Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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I had a chemo regimen of etoposide, methotrexate, actinomycin D/cyclophosphamide, and Vincristine. 4 yrs later I suffer from constant body pain, why?

I had a chemo regimen of etoposide, methotrexate, actinomycin D/cyclophosphamide, and Vincristine. 4 yrs later I suffer from constant body pain, why?

No online answer: EMA/CO is most often used for aggressive gestational trophoblastic neoplasia (GTN), usually choriocarcinoma. Long term diffuse body pains are not an expected side effect. A Gyn-oncologist should confirm there is no recurrence and then an evaluation from a good physical medicine, rheumatology, or even pain management doc will hopefully find the cause and a way to make you feel better. ...Read more

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What are effective non-medication ways to ease body pain from vincristine chemotherapy treatments?

What are effective non-medication ways to ease body pain from vincristine chemotherapy treatments?

Join support group: You are undergoing the toughest part, and a cancer support group would ease your mind/spirit. Meditation, visualization exercises can also ease the pain, as having acupuncture done to relieve any nausea associated with treatment. Doing chair yoga to stretch your muscles may help. Also, if it's there's any stomatitis, sometimes Nystatin popsicles are helpful.Depends what type of pain you're having. ...Read more

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Does cancer weaken the immune system or does the medication for the cancer (chemotherapy) weaken the immune system?

Does cancer weaken the immune system or does the medication for the cancer (chemotherapy) weaken the immune system?

Cancer and immunity: Interesting question. Cancer usually either fools or overwhelms the immune system as the latter usually keeps cancer cells in check. Medications for cancer vary, some kill the good and the bad and wipe out the immune system with the cancer cells and the new biologics are targeted therapy that only kill cancer cells. Science is progressing, stay tuned.. ...Read more

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Why cant medication recognize the latent cell affected with HIV? + wont having chemotherapy + Medication of HIV kill the virus? There has to be a cure

Why cant medication recognize the latent cell affected with HIV? + wont having chemotherapy + Medication of HIV kill the virus? There has to be a cure

There is no cure: As of now, there is no cure for HIV, with one notable exception of a person receiving bone marrow transplant from a person genetically resistant to HIV. You may consult this site for info: https://www.cdc.gov/hiv/library/factsheets/index.html ...Read more

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Is there another medication to treat as besides methotrexate?

Is there another medication to treat as besides methotrexate?

Ankylosing spondylit: As treatment is to reduce inflammation , reduce and prevent complications. Rx consist of pt , breathing exercises, posture and meds .Of meds pain and nsaids are followed by dmrd which include sulfasalazine, steroids, mtx and Cyclosporine . Newer tnf blockers include embrel, humira, Remicade , tociizumab and Rituxan (rituximab) . Lung disease, heart (ai) , uveitis , joint replacements by specialists ...Read more

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Can i take cold medication if i'm taking methotrexate. ?

Can i take cold medication if i'm taking methotrexate.  ?

See below: As a good rule of thumb, if you have an infection, you would want to leave off your Methotrexate and Imuran (azathioprine) and when the infection resolves, you can resume them. ...Read more

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Expert opinions? What medications shows the greatest promise as a cancer chemotherapy agent?

Expert opinions? What medications shows the greatest promise as a cancer chemotherapy agent?

I wish I had: More than 400 characters but in my opinion, those new agents that target specific molecular processes in cancer cells that make them behave as cancer cells are the most exciting. They target cancer cells and spare (to a certain degree) normal cells so the side effects are less. They are not perfect and unfortunately they tend to be veeeery expensive, which is a big problem. ...Read more

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Is there an alternate medication for reducing blood platelets without using chemotherapy?

Is there an alternate medication for reducing blood platelets without using chemotherapy?

Not really: The treatment for essential thrombocytosis (too many platelets) can be Aspirin alone for patients with no symptoms. For patients with symptoms like blood clots, a low dose of oral chemotherapy is used. The drug is called hydroxyurea. It is very different from cancer chemotherapy and has very few side effects. Don't let the word chemotherapy scare you! it means "chemical treatment". Ie a drug. ...Read more

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I am about to move to Australia for at least a year and would like to take the max supply of my medications with me, symbicort, methotrexate, eczma creams?

I am about to move to Australia for at least a year and would like to take the max supply of my medications with me, symbicort, methotrexate, eczma creams?

So what's the ???: You have an interesting plan. Australia does have physicians and it's own system of laws concerning importation of pharmaceuticals. You need to address your questions to the medical department of your embassy to seek guidelines for what you can or cannot bring with you and find out how to access care while you live there. ...Read more

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Please describe the medication: methotrexate?

Please describe the medication: methotrexate?

Standard therapy: Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA and other rheumatologist diseases. ...Read more

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Which medication can reduce rheumatoid factor ? my RF is 201. methotrexate not working I take 15 mg weekly one year

RF Factor: RF is a blood test that can be used to evalauted for multiple conditions. In patients with rhumatological conditions there is no evidnece that a drop in the RF value is of any clinical significance while on therapy. The most important considerations for treating RA are the symptoms and any evidnece of joint destruciton on imagining. ...Read more

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I have stopped taking my Crohn's medication (methotrexate)i was suffering severe side effects. I'm still incredibly sick & wondering when it will stop?

I have stopped taking my Crohn's medication (methotrexate)i was suffering severe side effects. I'm still incredibly sick & wondering when it  will stop?

Could be Crohn's: Some of the most common side effects can be similar to symptoms of crohn's. These include mouth sores, fever, diarrhea, blood in your stools, body aches and abdominal pain. You may want to check with your doctor and make sure this is not a flare up of your disease. ...Read more

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When on methotrexate for ctd, how to know if mildly low white blood cell count is due to ctd or medication? I'm feeling great with no illnesses.

When on methotrexate for ctd, how to know if mildly low white blood cell count is due to ctd or medication? I'm feeling great with no illnesses.

Leukopenia: Unfortunately, there is no easy way to know whether your count is low due to your connective tissue disease or your medication other than doing a bone marrow biopsy. But this is extreme and unnecessary as long as your count isn't too bad and you're feeling well. ...Read more

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Are there any good chinese medications that could help with the side effects of chemotherapy?

Are there any good chinese medications that could help with the side effects of chemotherapy?

Ganoderma: There are many but my favorite is ganoderma (reishi). Over 600 studies at national library of medicine and many show that cancer patients taking this had fewer side effects of treatment, lived longer and had less recurrence of cancer following treatment. This would be my pick in large quantity. Check out www.Docshealthycoffee.Com for a unique delivery method for this wonderful herb. ...Read more

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If i've already taken my methotrexate for the week, is it ok to take a cold medication? If so, what is safe to use?

If i've already taken my methotrexate for the week, is it ok to take a cold medication? If so, what is safe to use?

Methotrexate: You may take cold medicine with methotrexate. One medicine not to use echinacea but most others are ok. ...Read more

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How does a cancer patient deal with the large fatigue issue at home following chemotherapy? Specifically, is there a medication for this side effect?

Fatigue is common: Many patients receiving chemotherapy feel tired. The causes can be due to low hemoglobin(Anemia), lack of sleep or depression. Your oncologist can determine the cause and treat it. In general we recommend increased daily activity/exercise such as walking daily . This will provide extra strength after some period of daily practice. ...Read more

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If i take primoultN to postpone my periods,want to know if it is safe while taking Rheumatoid medications Celebrex, (celecoxib)Prednison,sulfasalazi,methotrexate?

If i take primoultN  to postpone my periods,want to know if it is safe while taking Rheumatoid medications Celebrex, (celecoxib)Prednison,sulfasalazi,methotrexate?

Don't do ...: if not absolutely necessary. PrimoultN is a progestin. I could not find any worrisome interactions between this medication and the ones you list. However, both Celebrex (celecoxib) and prednisone (a cortisone drug) might unfavorably affect the blood clotting system; progestins like PrimoultN might promote this. With taking these 4 significant meds, I would avoid anything not absolutely necessary. Best wishes ...Read more

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Chemotherapy: If given weekly how long does it take for this medication to leave the body or does it stay for weeks?

Varies: The elimination time of cancer therapeutic agents varies according to the drug, the dose, the duration of administration and variations in patients metabolism. Some drugs have an extremely short 1/2 life (the time for blood levels to drop by 50%) and are almost completely gone in 24 hrs. Antibodies, in contrast, may linger for weeks. Some types of side effects appear long after the drug is gone. ...Read more

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Is there some cancer chemotherapy medication that does not cause hair loss?

Is there some cancer chemotherapy medication that does not cause hair loss?

Yes.: However, hair grows back and the most important thing is that you get what your oncologist believes is the best chemotherapy for you to fight your disease. ...Read more

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How often do I have to be monitored by any of these medications Prednisone, methotrexate, folic acid?

The timing depend: On how long you have been on methotrexate. The timing could be 2 to 12 weeks apart depend new start vs maintainence and whether if you had side effect in past. Should discuss this with your rheumatologist. ...Read more

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I have psoriatic arthritis and suffer chroinc fatigue. Can you suggest additional medication to ask my gp for in addition to methotrexate?

I have psoriatic arthritis and suffer chroinc fatigue. Can you suggest additional medication to ask my gp for in addition to methotrexate?

See details: If your disease is poorly controlled you need to be on a biologic agent in addition to the methotrexate. You need to be under the direct care of a rheumatologist even in the National Health System. Finally, stop smoking as this makes the psoriatic arthritis much worse. ...Read more

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Is the sancuso transdermal patch for chemotherapy induced nausea and vomiting really any better than pill medications or is it about equal in effect?

"non-inferior": Sancuso = granisetron in a transdermal patch. A study compared the granisetron patch with granisetron pills. Statistically speaking, there was "non-inferiority;" in other words, one was as effective as the other. The advantage is in the convenience of the patch compared with taking a pill several times a day. (study was by Boccia RV et al, published in Support Care Cancer. 2011;19(10):1609.) ...Read more

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I have rheumatoid arthritis and take methotrexate and humira (adalimumab) injections. I want to get look better by getting filler for my face. Please let me know which ones are not in conflict with my medications. Thanks?

I have rheumatoid arthritis and take methotrexate  and humira (adalimumab)  injections. I want to get look better by getting filler for my face. Please let me know which ones are not in conflict with my medications. Thanks?

Filler options: You need to avoid sculptra with RA as you may be at increased risk for nodule and granuloma formation. Ha fillers like juvederm or Restylane (dermal fillers) should be safe but last only a year or so. Fat transfer is a good long term option but has more down time. Consult with a local experienced facial plastic surgeon. ...Read more

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What do you think of the combination of celebrex (celecoxib) and sulfasalazine to treat RA beside taking other medications such as methotrexate and Enbrel ? Instead of Norco or motrin or tramadol

What do you think of the combination of celebrex (celecoxib) and sulfasalazine to treat RA beside taking other medications such as methotrexate and Enbrel ? Instead of Norco or motrin or tramadol

Depends on severity: It depends on the severity and activity of your RA. Enbrel and Methotrexate are great drugs if you have active. If it is not active Celebrex (celecoxib) and sulfasalazine are alternatives. We discourage people to use narcotic painkillers for non cancer pain for the long term since it is very addictive and people become tolerant for the doses and expect increasing doses ...Read more

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What are the names of chemotherapy's drugs in pill form?

Tthere are quite a f: Most chemo drugs are available injectable form only. The few that are in tablet form include capecitabine(Xeloda), Methotrexate and cyclophosphamide. The more modern, so called targeted drugs developed in the last 10-15 years are mostly made in tablet form. ...Read more

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How expensive are chemotherapy drugs?

Varies with each dru: Many of the older drugs, widely used even now, are not too expensive. This includes nearly all of Chemotherapy drugs. The more modern drugs called targeted agents are more expensive, typically costing 6K-10K USD per rmonth. The brand new drugs in the last 5 years have started costing 10K-12K USD/month, which has created a lot of unrest in the medical community as it is no longer affordbable. ...Read more

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Need to know about a drug called methotrexate?

Need to know about a drug called methotrexate?

Folic acid inhibitor: It inhibits Folic Acid and can help treat inflammatory disorders like rheumatoid arthritis, psoriasis, tumors, etc, it can help vasculitis also whether it is due to an inflammatory or infectious etiology. It needs to be carefully monitored, can cause liver disease so we recommend no alcohol, can cause low blood counts and mouth ulcers and hair loss so we supplement therapy with folic acid. ...Read more

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Is rituxan (rituximab) considered a chemotherapy drug?

Not really: Rituxan (rituximab) is used to treat certain cancers as well as other non-cancer conditions. In the oncology world, we don't think of it as "chemotherapy" because it is a monoclonal antibody that is selective. We use the term chemotherapy for drugs that non-specifically kill fast-growing cells. We call Rituxan (rituximab) a biologic therapy, not chemotherapy. Hope that helps! ...Read more

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Has Levaquin, or any fluoroquinolone med, ever been used as a chemotherapy drug?

Has Levaquin, or any fluoroquinolone med, ever been used as a chemotherapy drug?

Yes, you're correct!: Here's a link for you: http://www.collective-evolution.com/2014/10/15/fda-allows-chemo-drugs-prescribed-antibiotics/

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Are the drugs Methotrexate and Misoprostol used together for anything else other than abortions?

Maybe: Methotrexate is used in (many cancers) chemotherapy, rheumatoid arthritis, ectopic pregnancies, and molar pregnancies. Misoprostol is used in stomach ulcers (its FDA approved use), bleeding after a delivery of a baby,and bleeding after a miscarriage. We also sometimes use it in place of D&C to prevent an incomplete miscarriage or in term pregnancies to expel a retained placenta. ...Read more

Dr. Austina Cho
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Methotrexate Or Dactinomycin (Definition)

Chemotherapy drugs such as methotrexate and dactinomycin kill rapidly dividing cells. These drugs are given to kill any remaining cells ...Read more


Dr. Devon Webster
973 doctors shared insights

Chemotherapy (Definition)

The term chemotherapy typically is used to describe using chemicals to treat ...Read more