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Doctor insights on: Methotrexate Or Dactinomycin Chemotherapy After Suction Curettage

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For a liver met, is systemic chemo like irinotecan best or chemo embolization ?

For a liver met, is systemic chemo like irinotecan best or chemo embolization ?

It depends: Chemotherapy is the proven best treatment for most such cases . If there is only 1-2 mets, such tumors can be removed and may be curable with combined use chemotherapy and surgery. Chemo-embolization is not a standard treatment, although it has been used effectively by some oncologists. Ask your oncologist the pros and cons of your multiple choices or you should seek a second opinion to explore ...Read more

Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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Ciii ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin. In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?

Ciii  ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin.  In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?

Many options: Choosing chemo depends on many factors, so only your doctor can decide what might work for you. Drugs you haven't mentioned include altretamine, capecitabine, cytoxan, (cyclophosphamide) vinorelbine, ifosfamide, etoposide, and irinotecan. There are also several hormonal agents. And a clinical trial might be an option. Check out www.Cancer.Gov for more info. And good luck. ...Read more

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Is taking herceptin (trastuzumab) better during or after chemotherapy?

Is taking herceptin (trastuzumab) better during or after chemotherapy?

Depends on the chemo: Herceptin should not be given in combination with adraimycin. It would increase the risk of heart toxicity. We do commonly give Herceptin in combination with other drugs like Carboplatin and taxotere, or paclitaxol in an adjuvant setting. Herceptin alone is done to complete 1 year of treatment. In the setting of advanced disease we give it in combination with drugs like Xeloda and navelbine (vinorelbine). ...Read more

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Age 79, male, colon cancer Pt3n1b, surgery finished. Chemotherapy or radiotherapy recommended ? or both?

Age 79, male, colon cancer Pt3n1b, surgery finished. Chemotherapy or radiotherapy recommended ? or both?

More info: The molecular and some of the subtle microscopic features must also be considered. Then the odds with and without different modalities can be reviewed. It will be your choice. ...Read more

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Stage iii-b crc removed surgically 2 weeks ago, 3 days ago surgery was performed to remove post op adhesion blocking the small intestines, suggested chemo is capeox. When should treatment begin?

Adjuvant chemo: Adjuvant chemo for stage iii colorectal cancer would be combination of 5fu/oxaliplatin or capecitabine/oxaliplatin. Chemo can be started as soon as you are recovering well from your surgery. It can be started 4-6 weeks from surgery-providing that all surgical site is healed. Good luck. It is not a common thing to have a colon cancer at age of 30- thus a genetic counselling/testing is recommended. ...Read more

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Relief from mouth sore following doxil (liposomal doxorubicin) chemo ?

Relief from mouth sore following doxil (liposomal doxorubicin) chemo ?

MAGIC MOUTHWASH: Mouth sores can be a sign that your white blood cells have dropped. Get labs drawn. For relief of symptoms while discomfort resolves several combinations exist. My favorite: nystatin/maalox/carafate - very soothing. Other include: benadryl/nystatin/maalox - can burn and viscous lidocaine/nystatin/maalox - will numb your entire mouth/tounge. ...Read more

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Cea analysis was increased to 1500 before treatment of secondary bone cancer but after radiation therapy and 3 chemotherapy sessions dropped to 1000?

Cea analysis was increased to 1500 before treatment of secondary bone cancer but after radiation therapy and 3 chemotherapy sessions dropped  to 1000?

CEA: The declining of the cancer marker here tells you that you respond quite well to the radiation and chemotherapy that you received. Btw, what is the primary cancer? ...Read more

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Cytoxan (cyclophosphamide) related t1 g3 bladder cancer. Not candidate for cystectomy, or chemo due to previous chemo, any studies that radx is worthwhile alone.

See below: Please clarify a few things for me - you said t1, high grade disease? Chemo is not needed. The standard of care is still intravesical immunotherapy with bcg. Intravesical Mitomycin c, bcg with interferon, or gemcitabine are also used. Cystectomy for t1 disease is typically reserved for bcg-refractory cases. Most radiation data is from europe and involves >t2 tumors. ...Read more

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Why is treatment with monoclonal antibodies better than using chemo or radiotherapy?

Why is treatment with monoclonal antibodies better than using chemo or radiotherapy?

Not always: Monoclonal antibodies are just one class of drugs used to fight certain cancers. Often, they have to be used with chemotherapy to get the best results (examples: Rituxan with chemotherapy in some lymphomas or Avastin (bevacizumab) with chemotherapy in colon cancer). Sometimes monoclonal antibodies can be used by themselves also. They aren't necessarily better than chemotherapy, just different. ...Read more

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Can alopecia areata be treated in pregnancy with kenalog (triamcinolone) injections or should expectant mothers wait until after delivery?

Can alopecia areata be treated in pregnancy with kenalog (triamcinolone) injections or should expectant mothers wait until after delivery?

I would not advise: Kenalog (triamcinolone) is a Category C agent. Animal studies show adverse fetal harm but no controlled human studies have been done. The OB will be the one to make that call. ...Read more

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Why is adriamycin (doxorubicin) chemotherapy pushed manually rather than administered through an iv? Are premeds given with a/c chemo? If so what are they?

Why is adriamycin (doxorubicin) chemotherapy pushed manually rather than administered through an iv? Are premeds given with a/c chemo? If so what are they?

It is IV: ...Just given as an IV push instead of an IV drip to reduce, amongst other things, the risk of leakage to surrounding tissues leading to a chemical burn. The choice depends on the particular institution and the chemo protocol. As to premeds, most people use zofran (ondansetron) or one of its cousins plus steroids. Many use emend as well right from the start. If this is about you, best wishes. ...Read more

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Suffering with mouth cancer under stage 4b. Doctors suggest chemotherapy after which decision can b taken regarding surgery.

Suffering with mouth cancer under stage 4b. Doctors suggest chemotherapy after which decision can b taken regarding surgery.

Best doctors!: I'm sorry to hear about your cancer. Even if you had the best doctors answering questions on this website, they would need to see you personally along with all your test results in order to try to advise you. If i were in your position, i would seek the best head and neck surgeon and oncologist, either in or out of your country for consultation.Perhaps get a few opinions. Then follow their advice. ...Read more

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After doxorubicin and ifosfamide chemotherapy how long until hair grows back?

Begins about 1 month: Hair growth should begin in about 1-2 months after completing chemotherapy. Hair grows relatively slowly, so return of long hair would be many months away. ...Read more

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I've had a small squamous cell carcinoma of the eye removed (<5mm). Treatment with mitomycin during removal only. Any suggested follow up procedures?

I've had a small squamous cell carcinoma of the eye removed (<5mm). Treatment with mitomycin during removal only. Any suggested follow up procedures?

Follow up needed!: The nice thing here is that you can be followed up clinically and observed. Follow your surgeon's directions. Should likely be seen every 4-6 months for a 2 years or so. If no recurrence, then at least annually! ...Read more

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Q. About paloma-2 trial, exclusion "prior neo adjuvant treatment with letrozole or anastrozole with dfi d 12-months from completion of treatment." still on arimidex since 2009, am i excluded?

Q. About paloma-2 trial, exclusion "prior  neo adjuvant treatment with letrozole or anastrozole with dfi d 12-months from completion of treatment." still on arimidex since 2009, am i excluded?

Maybe not!: This trial is for patients with metastatic breast cancer, and you cannot have received any treatment for your metastatic disease. This has to be the first treatment. So if you've been taking Arimidex (which is anastrozole) to treat metastatic breast cancer, you are excluded. But if you developed metastatic disease while taking Arimidex for your initial breast cancer, you're not excluded! ...Read more

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After taxol (paclitaxel) reaction for 3b squamous nsclc, husband is on weekly treatment, 2 wks abraxane, then 1 w/ abraxane/carboplatin. Is it normal & effective?

After taxol (paclitaxel) reaction for 3b squamous nsclc, husband is on weekly treatment, 2 wks abraxane, then 1 w/ abraxane/carboplatin.  Is it normal & effective?

Yes its a good alter: If your husband has allergy to Taxol, (paclitaxel) then using Abraxane as an alternative is a good decision. This treatment works well in about half (50%) of the patients, not in the others. You will know within 6 to 8 weeks of chemotherapy treatments. ...Read more

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Husband is being put on carboplatin/arbraxane for 3b squamous nsclc, after taxol (paclitaxel) reaction. Concurrent radation therapy. Is this an effective plan?

Yes it is!: This is the current recommended chemotherapy(along with concurrent radiotherapy) treatment plan. Hopefully it should work well. But it will take 6-8 weeks to see the full benefit. ...Read more

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Chemotherapy side effect question. Will I get nausea right away from dactinomycin?

Chemotherapy side effect question.  Will I get nausea right away from dactinomycin?

Dactinomycine&nausea: 75% of patients will experience nausea and vomiting, can be mild to moderate in severity.It may present within hours of administration , may be dose related and may be more intense two to four days after the end of five day course, usually require and respond to antiemetic therapy and may persist as long as a week after the therapy is stopped. ...Read more

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I had a chemo regimen of etoposide, methotrexate, actinomycin D/cyclophosphamide, and Vincristine. 4 yrs later I suffer from constant body pain, why?

I had a chemo regimen of etoposide, methotrexate, actinomycin D/cyclophosphamide, and Vincristine. 4 yrs later I suffer from constant body pain, why?

No online answer: EMA/CO is most often used for aggressive gestational trophoblastic neoplasia (GTN), usually choriocarcinoma. Long term diffuse body pains are not an expected side effect. A Gyn-oncologist should confirm there is no recurrence and then an evaluation from a good physical medicine, rheumatology, or even pain management doc will hopefully find the cause and a way to make you feel better. ...Read more

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How do you cope taste changes from chemotherapy?

How do you cope taste changes from chemotherapy?

Taste and chemo: Make sure you use your nausea medicine on a regular basis. Sweet potatoes and black berry wine also help with nausea which can affect taste. Otherwise you really need to try foods you did not like before, mild foods, and think of the food you are eating as medicine and not optional. Hang in there...It will get better! ...Read more

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How long do chemotherapy sessions usually go for?

How long do chemotherapy sessions usually go for?

Depends on the type: Chemotherapy is a general term for a form of treatment. There are various drugs used and every one is given in a certain way and schedule, so it all depends on the drugs being used and the cancer being treated. ...Read more

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If your child does not want to receive chemotherapy?

If your child does not want to receive chemotherapy?

Chemotherapy : Chemotherapy is a life saver for many cancer conditions, like leukemia, lymphoma, etc. Not giving chemotherspy can cause severe side effects, including death. Talking to the child rationally usually helps to convince him/ her about the necessity of chemotherapy. Parent acceptance of the need for chemotherapy might convince the child. ...Read more

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How much time did your chemotherapy regimen last for?

How much time did your chemotherapy regimen last for?

?: Don't understand your question. Different regimens have different durations and take a different time to administer. Maybe you can be more specific. ...Read more

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Can I drive myself to and from a chemotherapy appointment?

No.: In general, no. Many times the medicines that are given to prevent allergic reactions like Benadryl (diphenhydramine) can make you drowsy and people may feel ill following chemotherapy if the anti-nausea medicines wear off. Obviously, there is no problem driving in, it is the drive home that is bad. ...Read more

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Please describe the most common way to get chemotherapy done?

Please describe the most common way to get chemotherapy done?

Go see an Oncologist: Chemotherapy is commonly given as IV infusion but there are increasing numbe rof new medicines which come in the form of pills or capsules which can be taken by mouth. ...Read more

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What information do I have to bring along to do the chemotherapy?

What need to ask: You need to know all treatment options available for you- chemo ; surgery; radiation etc. Specifically about chemo- you need to know the name of chemo that you will get, the frequency/schedule, the risk/possible side effects and how to anticipate the problems. The benefits of chemo. Things that you should do and should not do while on chemo-and when the WBC is low. Neutropenic precaution etc. ...Read more

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What type of cells tend to be damaged the most during chemotherapy?

Cancer cells: Chemotherapy is designed to kill cancer cells, which is does quite well. There is some effect on normal cells(blood cells) yet it is much less than to cancer cells and it is temporary effect on blood cells which recover in 3-4 weeks time.. They are back to normal. ...Read more

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Can you let me know how many times can a person go thru chemotherapy?

Can you let me know how many times can a person go thru chemotherapy?

Variable: There r many different types of chemotherapy. Some can only be given a certain number of times before your body can't handle anymore, often limited by liver or bone marrow or kidney toxicity. Some can be given indefinitely at lowered doses as a maintenance regimen. It really depends on weighing patient health against specific disease and drug. ...Read more

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What is the best way to start exercising while undergoing chemotherapy?

Slow: Diet and exercise appear to have benefit in various cancers. Most data is in breast cancer. However, while on chemo, start slowly. I would suggest walking as tolerated. Focus on getting through chemo, then consider a personal trainer or post-cancer group to help you gradually acclimate to exercise and work on diet. ...Read more

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Why do chemotherapy regimens consist of multiple drugs instead of just one?

Sometimes not: Your oncologist will search out the most likely single or combination program, that you can tolerate to kill the cancer with out killing you... To put it bluntly. This takes a great deal of experience and trials with close follow up of your response to manage. ...Read more

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How can I explain to someone close what chemotherapy is and its real effect?

Very different: Chemotherapy varies for the type of treatment. It can go from very little to very disturbing. It can cause one to lose their hair. Can cause mouth ulcers, generalized weakness , nausea , vomiting and long term chemo can cause one to develop a neuropathy. Discuss each kind with your doctor to know what one is getting into. ...Read more

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Why has my personality changed since i started chemotherapy. Is this normal?

Why has my personality changed since i started chemotherapy. Is this normal?

Many possibilities: There are many things that can cause these changes...Here are a few. 1. Stress of having cancer at 35. 2. The stages of cancer include anger, denial and these things can change your personality. 3. Chemotherapy at 35 can affect the ovaries and reduce estrogen levels that can cause these changes. 4. Worrying about family and future. Solution: talk it out, find a support group, 1 day at a time. ...Read more

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What happens if you do not respond to chemotherapy? What are the other options?

What happens if you do not respond to chemotherapy? What are the other options?

Depends: The answer depends on the type of cancer you have. Cancer cells are different in each body location. There are different chemo medications as well. If you do not respond, then another chemotherapy agent might be an option. Surgery and/or radiation may be indicated as well. Speak with your oncologist about options. Don't be afraid to get a 2nd opinion by another oncologist. ...Read more

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Can chemotherapy make you get a headache?

Can chemotherapy make you get a headache?

Zofran (ondansetron)?: The more common issue is that the antinausea medicine causes the headache--especially zofran, (ondansetron) kytril, aloxi. So check your meds and ask your nurse or doctor. ...Read more

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Dr. Creighton Wright
3 doctors shared insights

Methotrexate Or Dactinomycin (Definition)

Chemotherapy drugs such as methotrexate and dactinomycin kill rapidly dividing cells. These drugs are given to kill any remaining cells ...Read more


Curettage (Definition)

The removal of tissue or growths from the interior of a body cavity, such as the uterus, by ...Read more