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Doctor insights on: Methotrexate Or Dactinomycin Chemotherapy After Suction Curettage

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For a liver met, is systemic chemo like irinotecan best or chemo embolization ?

For a liver met, is systemic chemo like irinotecan best or chemo embolization ?

It depends: Chemotherapy is the proven best treatment for most such cases . If there is only 1-2 mets, such tumors can be removed and may be curable with combined use chemotherapy and surgery. Chemo-embolization is not a standard treatment, although it has been used effectively by some oncologists. Ask your oncologist the pros and cons of your multiple choices or you should seek a second opinion to explore ...Read more

Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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Ciii ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin. In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?

Ciii  ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin.  In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?

Many options: Choosing chemo depends on many factors, so only your doctor can decide what might work for you. Drugs you haven't mentioned include altretamine, capecitabine, cytoxan, (cyclophosphamide) vinorelbine, ifosfamide, etoposide, and irinotecan. There are also several hormonal agents. And a clinical trial might be an option. Check out www.Cancer.Gov for more info. And good luck. ...Read more

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Is taking herceptin (trastuzumab) better during or after chemotherapy?

Is taking herceptin (trastuzumab) better during or after chemotherapy?

Depends on the chemo: Herceptin should not be given in combination with adraimycin. It would increase the risk of heart toxicity. We do commonly give Herceptin in combination with other drugs like Carboplatin and taxotere, or paclitaxol in an adjuvant setting. Herceptin alone is done to complete 1 year of treatment. In the setting of advanced disease we give it in combination with drugs like Xeloda and navelbine (vinorelbine). ...Read more

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Age 79, male, colon cancer Pt3n1b, surgery finished. Chemotherapy or radiotherapy recommended ? or both?

Age 79, male, colon cancer Pt3n1b, surgery finished. Chemotherapy or radiotherapy recommended ? or both?

More info: The molecular and some of the subtle microscopic features must also be considered. Then the odds with and without different modalities can be reviewed. It will be your choice. ...Read more

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Stage iii-b crc removed surgically 2 weeks ago, 3 days ago surgery was performed to remove post op adhesion blocking the small intestines, suggested chemo is capeox. When should treatment begin?

Adjuvant chemo: Adjuvant chemo for stage iii colorectal cancer would be combination of 5fu/oxaliplatin or capecitabine/oxaliplatin. Chemo can be started as soon as you are recovering well from your surgery. It can be started 4-6 weeks from surgery-providing that all surgical site is healed. Good luck. It is not a common thing to have a colon cancer at age of 30- thus a genetic counselling/testing is recommended. ...Read more

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Relief from mouth sore following doxil (liposomal doxorubicin) chemo ?

Relief from mouth sore following doxil (liposomal doxorubicin) chemo ?

MAGIC MOUTHWASH: Mouth sores can be a sign that your white blood cells have dropped. Get labs drawn. For relief of symptoms while discomfort resolves several combinations exist. My favorite: nystatin/maalox/carafate - very soothing. Other include: benadryl/nystatin/maalox - can burn and viscous lidocaine/nystatin/maalox - will numb your entire mouth/tounge. ...Read more

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Cea analysis was increased to 1500 before treatment of secondary bone cancer but after radiation therapy and 3 chemotherapy sessions dropped to 1000?

Cea analysis was increased to 1500 before treatment of secondary bone cancer but after radiation therapy and 3 chemotherapy sessions dropped  to 1000?

CEA: The declining of the cancer marker here tells you that you respond quite well to the radiation and chemotherapy that you received. Btw, what is the primary cancer? ...Read more

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Cytoxan (cyclophosphamide) related t1 g3 bladder cancer. Not candidate for cystectomy, or chemo due to previous chemo, any studies that radx is worthwhile alone.

See below: Please clarify a few things for me - you said t1, high grade disease? Chemo is not needed. The standard of care is still intravesical immunotherapy with bcg. Intravesical Mitomycin c, bcg with interferon, or gemcitabine are also used. Cystectomy for t1 disease is typically reserved for bcg-refractory cases. Most radiation data is from europe and involves >t2 tumors. ...Read more

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Why is treatment with monoclonal antibodies better than using chemo or radiotherapy?

Why is treatment with monoclonal antibodies better than using chemo or radiotherapy?

Not always: Monoclonal antibodies are just one class of drugs used to fight certain cancers. Often, they have to be used with chemotherapy to get the best results (examples: Rituxan with chemotherapy in some lymphomas or Avastin (bevacizumab) with chemotherapy in colon cancer). Sometimes monoclonal antibodies can be used by themselves also. They aren't necessarily better than chemotherapy, just different. ...Read more

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Can alopecia areata be treated in pregnancy with kenalog (triamcinolone) injections or should expectant mothers wait until after delivery?

Can alopecia areata be treated in pregnancy with kenalog (triamcinolone) injections or should expectant mothers wait until after delivery?

I would not advise: Kenalog (triamcinolone) is a Category C agent. Animal studies show adverse fetal harm but no controlled human studies have been done. The OB will be the one to make that call. ...Read more

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Why is adriamycin (doxorubicin) chemotherapy pushed manually rather than administered through an iv? Are premeds given with a/c chemo? If so what are they?

Why is adriamycin (doxorubicin) chemotherapy pushed manually rather than administered through an iv? Are premeds given with a/c chemo? If so what are they?

It is IV: ...Just given as an IV push instead of an IV drip to reduce, amongst other things, the risk of leakage to surrounding tissues leading to a chemical burn. The choice depends on the particular institution and the chemo protocol. As to premeds, most people use zofran (ondansetron) or one of its cousins plus steroids. Many use emend as well right from the start. If this is about you, best wishes. ...Read more

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Suffering with mouth cancer under stage 4b. Doctors suggest chemotherapy after which decision can b taken regarding surgery.

Suffering with mouth cancer under stage 4b. Doctors suggest chemotherapy after which decision can b taken regarding surgery.

Best doctors!: I'm sorry to hear about your cancer. Even if you had the best doctors answering questions on this website, they would need to see you personally along with all your test results in order to try to advise you. If i were in your position, i would seek the best head and neck surgeon and oncologist, either in or out of your country for consultation.Perhaps get a few opinions. Then follow their advice. ...Read more

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After doxorubicin and ifosfamide chemotherapy how long until hair grows back?

Begins about 1 month: Hair growth should begin in about 1-2 months after completing chemotherapy. Hair grows relatively slowly, so return of long hair would be many months away. ...Read more

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I've had a small squamous cell carcinoma of the eye removed (<5mm). Treatment with mitomycin during removal only. Any suggested follow up procedures?

I've had a small squamous cell carcinoma of the eye removed (<5mm). Treatment with mitomycin during removal only. Any suggested follow up procedures?

Follow up needed!: The nice thing here is that you can be followed up clinically and observed. Follow your surgeon's directions. Should likely be seen every 4-6 months for a 2 years or so. If no recurrence, then at least annually! ...Read more

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Q. About paloma-2 trial, exclusion "prior neo adjuvant treatment with letrozole or anastrozole with dfi d 12-months from completion of treatment." still on arimidex since 2009, am i excluded?

Q. About paloma-2 trial, exclusion "prior  neo adjuvant treatment with letrozole or anastrozole with dfi d 12-months from completion of treatment." still on arimidex since 2009, am i excluded?

Maybe not!: This trial is for patients with metastatic breast cancer, and you cannot have received any treatment for your metastatic disease. This has to be the first treatment. So if you've been taking Arimidex (which is anastrozole) to treat metastatic breast cancer, you are excluded. But if you developed metastatic disease while taking Arimidex for your initial breast cancer, you're not excluded! ...Read more

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After taxol (paclitaxel) reaction for 3b squamous nsclc, husband is on weekly treatment, 2 wks abraxane, then 1 w/ abraxane/carboplatin. Is it normal & effective?

After taxol (paclitaxel) reaction for 3b squamous nsclc, husband is on weekly treatment, 2 wks abraxane, then 1 w/ abraxane/carboplatin.  Is it normal & effective?

Yes its a good alter: If your husband has allergy to Taxol, (paclitaxel) then using Abraxane as an alternative is a good decision. This treatment works well in about half (50%) of the patients, not in the others. You will know within 6 to 8 weeks of chemotherapy treatments. ...Read more

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Husband is being put on carboplatin/arbraxane for 3b squamous nsclc, after taxol (paclitaxel) reaction. Concurrent radation therapy. Is this an effective plan?

Yes it is!: This is the current recommended chemotherapy(along with concurrent radiotherapy) treatment plan. Hopefully it should work well. But it will take 6-8 weeks to see the full benefit. ...Read more

Dr. Adam Lewis
3 doctors shared insights

Methotrexate Or Dactinomycin (Definition)

Chemotherapy drugs such as methotrexate and dactinomycin kill rapidly dividing cells. These drugs are given to kill any remaining cells ...Read more


Curettage (Definition)

The removal of tissue or growths from the interior of a body cavity, such as the uterus, by ...Read more