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Doctor insights on: Methotrexate Memory Loss

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Does methotrexate. Cause memory loss or is it RA itself? If so how to prevent and strengthen my memory?

Does methotrexate. Cause memory loss or is it RA itself?  If so how to prevent and strengthen my memory?

Methotrexate: Methotrexate affects cells in the hippocampus, part of the brain with an important role in memory. Studies are looking at how other drugs, such as prozac, (fluoxetine) can protect the hippocampus from Methotrexate damage. In addition, symptoms of RA (pain, fatigue) can interfere with concentration and information processing. To be at your best, try to follow a healthy diet, exercise, and get enough sleep. ...Read more

Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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How to stop hair loss when am on methotrexate for my Ra?

How to stop hair loss when am on methotrexate for my Ra?

Some thoughts: I have seen hundreds of people on Methotrexate for their rheumatoid arthritis and then I agree that hair loss is a bothersome side effect. Nonetheless, at the doses used treat RA I never saw aperson go bald. You're going to have hair loss and there's no good therapy to prevent that. However, some women do notice benefit with using OTC rogaine (minoxidil) in concert with partial hairpieces on social engageme ...Read more

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On methotrexate 25mg/weekly for psoriasis/psoriatic arthritis from your experience & opinion will I experience hair loss?

On methotrexate 25mg/weekly for psoriasis/psoriatic arthritis from your experience & opinion will I experience hair loss?

Possibly: Some hair loss is common in patients taking methotrexate. Some experience hair loss at low doses and others on high doses like yourself have no such problem. One can try leucovorin if hair loss is a problem as this can reduce the problem is one is occurring. ...Read more

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Can methotrexate make you sick?

Can methotrexate make you sick?

Methotrexate: The side effects of Methotrexate include liver dysfunction, increased risk of infection, blood count abnormalities, fatigue on the day of treatment and gastrointestinal distress. ...Read more

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My friend is pergenant, can use methotrexate?

My friend is pergenant, can use methotrexate?

No: Methotrexate can cause serious birth defects. If she is pregnant and is taking methotrexate, she needs to notify her prescribing physician and her OB and stop the medication. ...Read more

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What dosage for methotrexate tablets are safe?

Up to 25 mg weekly: Standard Methotrexate doses for RA and rheumatologic diseases are up to 25 mg weekly. With any dose of methotrexate, routine lab studies are necessary to screen for side effects. ...Read more

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How much time will I have to be on methotrexate?

Not enough info: Why are you taking it? What is it intended to treat? Provide specifics if you want an answer. ...Read more

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Can you tell me about having the methotrexate shot?

See details: It is given as a subcutaneous injection, similar to an insulin shot. The discomfort is very minimal. If you have any other questions, list them. ...Read more

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While taking methotrexate is there any foods I should avoid, for example grapefruit?

Also, milk rich food: If you take oral Methotrexate (tablets) along with milk or milk-rich foods, it may decrease absorption. This is not toxic but may result in getting a lower dose than you need to keep your disease under control. This can be avoided by taking injections under the skin of Methotrexate which are not painful and you can guarantee 100% absorption. As you probably know, always avoid any alcohol. ...Read more

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Can methotrexate treat psoriasis?

Can methotrexate treat psoriasis?

Yes. Agree, but....: Methotrexate can be very effective. However, the first studies raising the specter of liver disease came from psoriasis patients on daily low dose oral mtx!. The first pass effect is dangerous for the liver. Mtx cannot be adjudicated aqs an oral drug. Absorption is variable (40-90%), causes GI upset, and hits the liver first. I only use subcutaneous mtx once weekly. This is the safest! ...Read more

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Is methotrexate safe to use with CKD?

Avoid using Abbrevia: What is CKD? Is it chronic Kidney disease? If so, what is your kidney function in terms of your blood Creatinine levels?. What is the cause? Methotrexate is not safe to use for patients with kidney diseases.
Please clarify, so that we can guide you further. ...Read more

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I'm on methotrexate, can I still drink?

Absolutely NOT!: The combination of alcohol and Methotrexate has caused many people to have liver failure requiring a liver transplant to survive. Methotrexate can irritate the liver by itself but is quite safe at the low weekly doses used to treat many autoimmune conditions. Never drink any alcohol while on methotrexate. If you absolutely "must" drink alcohol, tell your doc so he/she can take you off methotrexate. ...Read more

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How well does methotrexate work on psoriasis?

How well does methotrexate work on psoriasis?

Psoriasis : Methotrexate is a terrific therapy for severe psoriasis. It works well, is very inexpensive and is relatively safe when its effects are carefully monitored. ...Read more

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Need to know about a drug called methotrexate?

Need to know about a drug called methotrexate?

Folic acid inhibitor: It inhibits Folic Acid and can help treat inflammatory disorders like rheumatoid arthritis, psoriasis, tumors, etc, it can help vasculitis also whether it is due to an inflammatory or infectious etiology. It needs to be carefully monitored, can cause liver disease so we recommend no alcohol, can cause low blood counts and mouth ulcers and hair loss so we supplement therapy with folic acid. ...Read more

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What are some side effects of methotrexate?

Several.: Fatigue after taking your weekly dose. Gi quiziness. Hair loss. Potential liver issues, especially taken orally. Your white count can be lowered, as well as hemoglobin. Everyone on mtx should take folic acid. Monitoring for side effects (benefits too) should take place every three months or sooner. ...Read more

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Doctors, what are your experiences with methotrexate / how does it feel like?

Doctors, what are your experiences with methotrexate / how does it feel like?

Very good drug.: Mtx tabs are 2.5mg. Taken orally, they are in the gut @600x that will be in the blood strea. Absorption is variable-40-90%. Then to the liver which sees 400x that which will be diluted out. None of these are significant issues when given by a weekly subcutaneous injection. Mtx is a valuable drug for inflammatory arthritis, psoriasis, and many autoimmune diseases. I only gibe it subcu! ...Read more

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What are the top 3 things that I should be careful of/expect while taking a methotrexate for Crohn's disease?

Many side effects: Probably the three most common side effects include skin- rash hair loss or sores in the mouth, abnormal liver enzymes and possible effects on the blood, lowering blood and platelets counts. ...Read more

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Child on 25mg methotrexate her ALT levels went from 29 to 45 in 3 months. 45 is slightly high is this concerning?

Child on 25mg methotrexate her ALT levels went from 29 to 45 in 3 months. 45 is slightly high is this concerning?

No: Mild elevations should be monitored but do not demand that the dose be lowered. If it continues to rise then dosage adjustments will be necessary. ...Read more

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Do I take methotrexate for arthritis?

Do I take methotrexate for arthritis?

For inflammatory art: Methyltrexate is not use for degenerative arthritis but inflammatory arthritises like rheumatoid arthritis. ...Read more

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Can nsaids be taken with methotrexate?

Yes: NSIDs can be taken with Methotrexate. With or without Methotrexate, NSAIDs have many possible side effects and need to be used carefully. Gastrointestinal issues such as ulcers/gastritis can occur. Studies continue to show NSAIDs are associated with increased risks of cardiovascular side effects such as heart attacks and strokes. Routine labs are needed to watch for other side effects of both meds ...Read more

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What are methotrexate and fluconazole?

What are methotrexate and fluconazole?

Meds: Methotrexate is a medicine that treats several kinds of cancer, including cancer of the blood, bone, lung, breast, head, or neck. Also, treats rheumatoid arthritis and psoriasis (a skin disease).

Fluconazole prevents and treats certain fungus infections. Belongs to a class of drugs called antifungals. ...Read more

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Can you take methotrexate for arthritis?

Can you take methotrexate for arthritis?

See below: Methotrexate is often prescribed for rheumatoid arthritis and some other inflammatory arthritides. It is not used for osteoarthritis. ...Read more

Dr. Bennett Machanic
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Memory Loss (Definition)

There can be short term memory loss such as "where did I put my keys?" or long term memory loss such as "where did I live as a child?" There also can be catastrophic memory loss such ...Read more


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