Doctor insights on:
Methotrexate, Prednisone And Rheumatoid Arthritis
Many Options: Rheumatoid Arthritis is an autoimmune disease primarily affecting the joints. There is a very wide range of Disease Modifying antiRheumatic Drugs (DMARDs) available for treatment. There are older, less specific, but still effective DMARDs such as plaquenil, sulfasalazine, leflunomide and methotrexate. NSAIDs and prednisone to treat flares. There are many newer biologic DMARDs like Anti-TNF agents. ...Read more
Prednisone is a synthetic cortisone. The body makes cortisone, a natural hormone made in adrenal glands. The body converts it to Hydrocortisone to become active. 25 mg of cortisone has about same effect as 5 mgm prednisone. The average person would produce 3-6 mg of pred daily. So why use a substitute? The synthetic has more anti-inflammatory effect; but has less effect ...Read more
My wife developed a dry cough. She has Rheumatoid Arthritis. She is on a biologic, methotrexate, and prednisone. What are possible causes for her coughing?
30yr old taking methotrexate,prednisone, and humira for rheumatoid arthritis. AF on 4/14. Aweek later had spottin. BFN 4/23. Today Day11 of spotting
Is plaquenil with methotrexate without prednisone an effective treatment for moderate to severe rheumatoid arthritis ?
Yes: The combination is often a very effective treatment. ...Read more
Rheumatoid arthritis for 7 yrs. On methotrexate & prednisone. Tried so many drugs (orencia, enbrel, humira...). Feeling defeated. What else can I try?
Other choices: Some older drugs such as Plaquenil may help, especially with fatigue. There are also newer drugs that act via different mechanisms such as actemra. I assume the diagnosis of RA is definite. If not, retest other possibilities. An exercise program may be very beneficial, especially if you start slowly and build up with hurting yourself. Don't give up hope. You can get better. ...Read moreSee 1 more doctor answer
What would be the best treatment for my rheumatoid arthritis? I am presently taking prednisone, plaquenil, methotrexate shots, and actemra infusions. As has been the case in the past, I have built up a resistance to the actemra. In the past I have taken
I have Rheumatoid Arthritis and everynight around 930pm I have a fever that last about 1-2 hours. I take Methotrexate, Plaquenil, Prednisone and Soma.
My wife is on 10 pills of methotrexate a week all at once for Rheumatoid Arthritis. Is there an even higher doses for uncontrolled flare ups ?
Yes.: My colleagues believe it is the first choice (acr and eular), but while I use it as a second or third drug, the benefit/risk ratio is incredibly good. Methotrexate has little or no justification to be taken orally though. Unpredictable absorption, stomach concenbration build up, and going to the liver on first-pass! the liver sees 600x the ultimate concentration in the blood. ...Read more
Any explanation to why I am not feeling relief on 20mg daily prednisone for rheumatoid arthritis or lupus symptoms/pain?
Couple: Of possibilities. If this is your regular pain involving multiple joints and not controlled by the dose that usually controls your flares you might need a higher dose of Prednisone along with a different agent- Plaquenil/ Methotrexate for example. If this time the pain is different or involving only a joint or other organs it may be due to a different condition and you will need to see your doc. ...Read more
Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more
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