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Doctor insights on: Methotrexate, Prednisone And Rheumatoid Arthritis

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What do doctors prescribe for rheumatoid arthritis?

What do doctors prescribe for rheumatoid arthritis?

Many Options: Rheumatoid Arthritis is an autoimmune disease primarily affecting the joints. There is a very wide range of Disease Modifying antiRheumatic Drugs (DMARDs) available for treatment. There are older, less specific, but still effective DMARDs such as plaquenil, (hydroxychloroquine) sulfasalazine, leflunomide and methotrexate. NSAIDs and prednisone to treat flares. There are many newer biologic DMARDs like Anti-TNF agents. ...Read more

Dr. Thomas Namey
2,350 doctors shared insights

Arthritis (Definition)

Arthritis is progressive degeneration of one or more joints. Symptoms may include joint pain, swelling, decreased motion, and stiffness. The two most common types of arthritis are osteoarthritis, which is associated first with articular cartilage breakdown with a component of inflammation, and rheumatoid arthritis, which is a systemic autoimmune disorder that affects joint linings first and secondarily ...Read more


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My wife developed a dry cough. She has Rheumatoid Arthritis. She is on a biologic, methotrexate, and prednisone. What are possible causes for her coughing?

My wife developed a dry cough. She has Rheumatoid Arthritis. She is on a biologic, methotrexate,  and prednisone. What are possible causes for her coughing?

Dry cough: She is at higher risk of infection of course. Has she travelled? Fever? Could be viral, bacterial or less likely fungal. Sorry I cannot give a more detailed answer without more information! ...Read more

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Methotrexate for rheumatoid arthritis dose it work and anyone had side effects?

Methotrexate for rheumatoid arthritis dose it work and anyone had side effects?

Yes.: My colleagues believe it is the first choice (acr and eular), but while I use it as a second or third drug, the benefit/risk ratio is incredibly good. Methotrexate has little or no justification to be taken orally though. Unpredictable absorption, stomach concenbration build up, and going to the liver on first-pass! the liver sees 600x the ultimate concentration in the blood. ...Read more

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Rheumatoid arthritis for 7 yrs. On methotrexate & prednisone. Tried so many drugs (orencia, enbrel, (etanercept) humira...). Feeling defeated. What else can I try?

Other choices: Some older drugs such as Plaquenil may help, especially with fatigue. There are also newer drugs that act via different mechanisms such as actemra (tocilizumab). I assume the diagnosis of RA is definite. If not, retest other possibilities. An exercise program may be very beneficial, especially if you start slowly and build up with hurting yourself. Don't give up hope. You can get better. ...Read more

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I have Rheumatoid Arthritis and everynight around 930pm I have a fever that last about 1-2 hours. I take Methotrexate, Plaquenil, (hydroxychloroquine) Prednisone and Soma.

I have Rheumatoid Arthritis and everynight around 930pm I have a fever that last about 1-2 hours. I take Methotrexate, Plaquenil, (hydroxychloroquine) Prednisone and Soma.

Nightly fever: Medications like benadryl (diphenhydramine) can raise your temperature through anticholinergic activity. With all those immunosuppressive agents on board I'd run this by your doctor. You may need to get some cultures drawn. ...Read more

Dr. Thomas Namey
2,503 doctors shared insights

Prednisone (Definition)

Prednisone is a synthetic cortisone. The body makes cortisone, a natural hormone made in adrenal glands. The body converts it to Hydrocortisone to become active. 25 mg of cortisone has about same effect as 5 mgm prednisone. The average person would produce 3-6 mg of pred daily. So why use a substitute? The synthetic has more anti-inflammatory effect; but has less effect ...Read more


Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more