Doctor insights on:
Methotrexate, Prednisone And Rheumatoid Arthritis
Many Options: Rheumatoid Arthritis is an autoimmune disease primarily affecting the joints. There is a very wide range of Disease Modifying antiRheumatic Drugs (DMARDs) available for treatment. There are older, less specific, but still effective DMARDs such as plaquenil, (hydroxychloroquine) sulfasalazine, leflunomide and methotrexate. NSAIDs and prednisone to treat flares. There are many newer biologic DMARDs like Anti-TNF agents. ...Read more
Arthritis is progressive degeneration of one or more joints. Symptoms may include joint pain, swelling, decreased motion, and stiffness. The two most common types of arthritis are osteoarthritis, which is associated first with articular cartilage breakdown with a component of inflammation, and rheumatoid arthritis, which is a systemic autoimmune disorder that affects joint linings first and secondarily ...Read more
My wife developed a dry cough. She has Rheumatoid Arthritis. She is on a biologic, methotrexate, and prednisone. What are possible causes for her coughing?
30yr old taking methotrexate,prednisone, and humira (adalimumab) for rheumatoid arthritis. AF on 4/14. Aweek later had spottin. BFN 4/23. Today Day11 of spotting
What would be the best treatment for my rheumatoid arthritis? I am presently taking prednisone, plaquenil, methotrexate shots, and actemra infusions. As has been the case in the past, I have built up a resistance to the actemra. In the past I have taken
Yes.: My colleagues believe it is the first choice (acr and eular), but while I use it as a second or third drug, the benefit/risk ratio is incredibly good. Methotrexate has little or no justification to be taken orally though. Unpredictable absorption, stomach concenbration build up, and going to the liver on first-pass! the liver sees 600x the ultimate concentration in the blood. ...Read more
My wife is on 10 pills of methotrexate a week all at once for Rheumatoid Arthritis. Is there an even higher doses for uncontrolled flare ups ?
Is plaquenil (hydroxychloroquine) with methotrexate without prednisone an effective treatment for moderate to severe rheumatoid arthritis ?
Yes: The combination is often a very effective treatment. ...Read more
Rheumatoid arthritis for 7 yrs. On methotrexate & prednisone. Tried so many drugs (orencia, enbrel, (etanercept) humira...). Feeling defeated. What else can I try?
Other choices: Some older drugs such as Plaquenil may help, especially with fatigue. There are also newer drugs that act via different mechanisms such as actemra (tocilizumab). I assume the diagnosis of RA is definite. If not, retest other possibilities. An exercise program may be very beneficial, especially if you start slowly and build up with hurting yourself. Don't give up hope. You can get better. ...Read moreSee 1 more doctor answer
I have Rheumatoid Arthritis and everynight around 930pm I have a fever that last about 1-2 hours. I take Methotrexate, Plaquenil, (hydroxychloroquine) Prednisone and Soma.
What is an analgesic drug other than nsaids ( because of interaction with methotrexate) for rheumatoid arthritis and stronger than paracetamol ?
Prednisone is a synthetic cortisone. The body makes cortisone, a natural hormone made in adrenal glands. The body converts it to Hydrocortisone to become active. 25 mg of cortisone has about same effect as 5 mgm prednisone. The average person would produce 3-6 mg of pred daily. So why use a substitute? The synthetic has more anti-inflammatory effect; but has less effect ...Read more
Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more
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