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Doctor insights on: Methotrexate Amoxicillin Interaction

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I take 4 Methotrexate 2.5mg weekly for RA. My dentist prescribed today Amoxicillin 500mg, I read that there is serious interactions, is this true?

I take 4 Methotrexate 2.5mg weekly for RA. My dentist prescribed today Amoxicillin 500mg, I read that there is serious interactions, is this true?

Yes.: Talk to your doctor before using methotrexate together with amoxicillin. Medications like amoxicillin, especially when given at high dosages for infections, can sometimes increase the blood levels and effects of methotrexate. You may have increased side effects such as nausea, vomiting, mouth ulcers, and low blood cell counts. ...Read more

Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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A child is on methotrexate 12.5mg once weekly for JRA. She was prescribed amoxicillin for a sinus infection. Is it okay for her to be taking these together? I saw that there is a potential for interaction between the two.

A child is on methotrexate 12.5mg once weekly for JRA. She was prescribed amoxicillin for a sinus infection. Is it okay for her to be taking these together? I saw that there is a potential for interaction between the two.

Yes but not a major: Yes there is an interaction but not at the doses we use for arthritis. the amoxicillin can increase the level of methotrexate. This is a problem with the high anti-cancer doses we use to treat malignancy. But you may want to hold the methotrexate until the sinus infection clears. ...Read more

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Can you take amoxicillin with methotrexate?

Can you take amoxicillin with methotrexate?

Yes you can....: I have never encountered a problem using these two agents together, provided your renal and hepatic functions are within normal limits. ...Read more

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Child on methotrexate and has had 2 rounds of amoxicillin and omincef for a sinus infection the last month but it won't clear up any suggestions?

Child on methotrexate and has had 2 rounds of amoxicillin and omincef for a sinus infection the last month but it won't clear up any suggestions?

Call your doctor: Talk to your doctor. This may be a resistant or unusual type of infection. This may also be a part of your child's disease or an allergy rather than an infection. Sometimes your doctor may temporarily stop Methotrexate until infections are cured. The proper course depends on your child's underlying diagnosis, dose of methotrexate, and sinus symptoms. Sorry i couldn't be more specific. ...Read more

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Are cats claw, ecinecia, garlic, and goldenseal all okay to take with amoxicillin? Would this help or inhibit the drugs interaction? I have already been on the herbs for 5 days, and amoxicillin for 1, if it's a bad idea should I just stop taking them and

Are cats claw, ecinecia, garlic, and goldenseal all okay to take with amoxicillin? Would this help or inhibit the drugs interaction? I have already been on the herbs for 5 days, and amoxicillin for 1, if it's a bad idea should I just stop taking them and

Talk to your doctor: You should tell your doctor about all the medications/drugs/supplements you take. For now quit taking stuff that your doctor did not prescribe. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, low fat milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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Can methocarbamol have a drug interaction with methotrexate?

Can methocarbamol have a drug interaction with methotrexate?

Here's a link...: Consider checking this: http://www.drugs.com/drug_interactions.php

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What would be signs that amoxicillin was having an interaction with the effectiveness of Sprintec birth control?

What would be signs that amoxicillin was having an interaction with the effectiveness of Sprintec birth control?

Pregnancy: Although rare, antibiotics can interfere with birth control. You would not be aware of this until you miss a period. I recommend using a back up method of birth control, such as condoms, when on antibiotics. If your period does not come at the usual time, get tested. Good luck! ...Read more

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Amoxicillin (Definition)

Amoxicillin is in the penicillin class of antibiotics. All penicillins are distinguished by the presence of a beta-lactam ring, and are known to kill bacteria by inhibiting synthesis (production) ...Read more


Dr. Philip Miller
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Amoxil (Definition)

Amoxil is a third generation penicillin which is a kind of penincillin type drug (anti-bacterial ...Read more