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Doctor insights on: Methotrexate Amoxicillin Interaction

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I take 4 Methotrexate 2.5mg weekly for RA. My dentist prescribed today Amoxicillin 500mg, I read that there is serious interactions, is this true?

I take 4 Methotrexate 2.5mg weekly for RA. My dentist prescribed today Amoxicillin 500mg, I read that there is serious interactions, is this true?

Yes.: Talk to your doctor before using methotrexate together with amoxicillin. Medications like amoxicillin, especially when given at high dosages for infections, can sometimes increase the blood levels and effects of methotrexate. You may have increased side effects such as nausea, vomiting, mouth ulcers, and low blood cell counts. ...Read more

Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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A child is on methotrexate 12.5mg once weekly for JRA. She was prescribed amoxicillin for a sinus infection. Is it okay for her to be taking these together? I saw that there is a potential for interaction between the two.

A child is on methotrexate 12.5mg once weekly for JRA. She was prescribed amoxicillin for a sinus infection. Is it okay for her to be taking these together? I saw that there is a potential for interaction between the two.

Yes but not a major: Yes there is an interaction but not at the doses we use for arthritis. the amoxicillin can increase the level of methotrexate. This is a problem with the high anti-cancer doses we use to treat malignancy. But you may want to hold the methotrexate until the sinus infection clears. ...Read more

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Can you take amoxicillin with methotrexate?

Can you take amoxicillin with methotrexate?

Yes you can....: I have never encountered a problem using these two agents together, provided your renal and hepatic functions are within normal limits. ...Read more

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Child on methotrexate and has had 2 rounds of amoxicillin and omincef for a sinus infection the last month but it won't clear up any suggestions?

Child on methotrexate and has had 2 rounds of amoxicillin and omincef for a sinus infection the last month but it won't clear up any suggestions?

Call your doctor: Talk to your doctor. This may be a resistant or unusual type of infection. This may also be a part of your child's disease or an allergy rather than an infection. Sometimes your doctor may temporarily stop Methotrexate until infections are cured. The proper course depends on your child's underlying diagnosis, dose of methotrexate, and sinus symptoms. Sorry i couldn't be more specific. ...Read more

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Are cats claw, ecinecia, garlic, and goldenseal all okay to take with amoxicillin? Would this help or inhibit the drugs interaction? I have already been on the herbs for 5 days, and amoxicillin for 1, if it's a bad idea should I just stop taking them and

Are cats claw, ecinecia, garlic, and goldenseal all okay to take with amoxicillin? Would this help or inhibit the drugs interaction? I have already been on the herbs for 5 days, and amoxicillin for 1, if it's a bad idea should I just stop taking them and

Talk to your doctor: You should tell your doctor about all the medications/drugs/supplements you take. For now quit taking stuff that your doctor did not prescribe. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, low fat milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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Can methocarbamol have a drug interaction with methotrexate?

Can methocarbamol have a drug interaction with methotrexate?

Here's a link...: Consider checking this: http://www.drugs.com/drug_interactions.php

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What would be signs that amoxicillin was having an interaction with the effectiveness of Sprintec birth control?

What would be signs that amoxicillin was having an interaction with the effectiveness of Sprintec birth control?

Pregnancy: Although rare, antibiotics can interfere with birth control. You would not be aware of this until you miss a period. I recommend using a back up method of birth control, such as condoms, when on antibiotics. If your period does not come at the usual time, get tested. Good luck! ...Read more

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Can I drink zipsor and doxycycline hyclate together? Also get methotrexate injection once a week, is there any drug interactions?

Can I drink zipsor and doxycycline hyclate together? Also get methotrexate injection once a week, is there any drug interactions?

Doctor/Pharmacist: Have your doctor and pharmacist counsel you as the Zipsor and Doxycycline increase Methotrexate doses and possible toxicity/side effects. I would be extremely cautious with these interactions. ...Read more

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Wanting to take Pygeum (herb for enlarged prostate) but am on Augmentin (amoxicillin and clavulanate) for next few weeks. Any interaction I need to worry about?

Wanting to take Pygeum (herb for enlarged prostate) but am on Augmentin (amoxicillin and clavulanate) for next few weeks. Any interaction I need to worry about?

Enlarged prostate?: Pygeum has been reported to help benign prostatic hypertrophy (BPH) which would be very unusual at age 24-years. Hope UR consulting a urologist. There do not seem to to be any reports of interaction with Augmentin (amoxicillin and clavulanate) Wonder in fact if you have bacterial prostatitis which would be reason for antibiotics. Did U have urine or prostatic fluid culture? No more than 10% of prostatitis cases are bacterial! ...Read more

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What is the interaction between birth control pills, the morning after pill, and the antibiotic amoxicillin? What's the possibility of pregnancy?

What is the interaction between birth control pills, the morning after pill, and the antibiotic amoxicillin? What's the possibility of pregnancy?

No interaction.: If you are on birth control pills, took the morning after pill and are taking Amoxicillin for an unrelated reason, you are extremely unlikely to be pregnant. Check a home urine pregnancy test the after a missed period and if negative repeat in a week - that's the only way to be sure. Take Folic Acid 1 mg daily and best of luck! ...Read more

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Any interactions plaquenil methotrexate motrin800 Tylenol500 folic acid prilosec aspirin lopressor cartia imdur ambian singulair xyzal (levocetirizine) melatonin ?

Any interactions plaquenil methotrexate motrin800 Tylenol500 folic acid prilosec aspirin lopressor cartia imdur ambian singulair  xyzal (levocetirizine) melatonin ?

Too many: You are taking so many drugs that it is difficult to tell whether drug interaction may occur. Even if you run a profile in Epocrates , it is impossible to tell whether a combination with another drug may lead to interaction. Thus you will require close monitoring by your doctor and be on the lookout for any adverse effects. ...Read more

Amoxicillin (Definition)

Amoxicillin is in the penicillin class of antibiotics. All penicillins are distinguished by the presence of a beta-lactam ring, and are known to kill bacteria by inhibiting synthesis (production) ...Read more


Dr. Philip Miller
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Amoxil (Definition)

Amoxil is a third generation penicillin which is a kind of penincillin type drug (anti-bacterial ...Read more