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Doctor insights on: Methadone Xanax Interaction

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Dr. Alan Ali
952 Doctors shared insights

Alprazolam (Definition)

Alprazolam is a short acting benzodiazepine, it does not last long in the system. So when used regularly with multiple doses to treat anxiety, it is associated with inter-dose withdrawal, tolerance and a resulting increase level of baseline anxiety. So in anxiety clinics, we use it only in cases of " flight, dentist or other infrequent anxieties, ...Read more


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What are the side effects of methadone and Xanax (alprazolam) when they are taken together?

What are the side effects of methadone and Xanax (alprazolam) when they are taken together?

Sedation, and others: Sedation, confusion, lethargy, tiredness, yawning. Increased risk of dependence and addiction. If addicted to either, stopping use is difficult. Withdrawal symptoms can be very uncomfortable. Nausea, vomiting, chills, cramping and aching pain, restlessness, insomnia, agitation, hallucinations and seizures. Very dangerous combination. ...Read more

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Wascourt mandated to stop taking xanax/methadone, I completed the program and have since become a supervisor and father. Ineed to get backonthese, how?

Wow- Addiction is: Even listed as one of your conditions. It would be unethical for a physician to instruct an addict how to rekindle his addiction. In a situation in which you were court mandated - you are putting a lot at risk (being a parent, being a supervisor, your recovery, your health, your sanity). ...Read more

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I take low dose methadone, 7.5mg pm and 2.5mg am for RLS. I have. 25mg Xanax (alprazolam) for occasional anxiety. Is it ok to take these together at these doses?

I take low dose methadone, 7.5mg pm and 2.5mg am for RLS. I have. 25mg Xanax (alprazolam) for occasional anxiety. Is it ok to take these together at these doses?

Yes but......: Methadone for RLS? RLS is typically treated with Iron (if you have RLS form low iron -called Ekbom Syndrome this usually works great. If you have RLS and your iron is normal the treatment is usually Dopamine agonists. Are you sure you are treating RLS and not neuropathy or some other condition? ...Read more

Dr. Paul Grin Dr. Grin
2 doctors agreed:
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Prescribed 2mg Xanax (alprazolam) 4x a day taken it only for 7 day cuz my opiate dependence methadone place turned down for the Xanax (alprazolam) what is Xanax (alprazolam) detection time?

Dr. Paul Grin Dr. Grin
2 doctors agreed:

Long half-life: The elimination half-life of xanax (alprazolam) is about 11.2-26.9 hours. It takes almost 6 elimination half-life's for a drug to be cleared from the human body. Well... It could take a maximum of 161.4 hours or 6.7 days (6 x 26.9 hours) for xanax (alprazolam) to be completely eliminated. Rec. See your prescribing physician to express your concerns. ...Read more

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Hi there dr. Danny I am 24 and on methadone maintenance my current dose is 70mg I was wondering if I could take. 25 mg of Xanax at least 12 hours later 2 sleep is it safe? Not every day jus when I'm not able to sleep I haven't taken a Xanax in years

Good question.: But directed to the wrong people. Your question should be directed to your MM prescriber, who can evaluate the risks of adding alprazolam, with respect to respiratory depression and addiction; and he should be on top of which medicines you are taking in addition to methodone. ...Read more

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Hello dr. Andrew I have a quick question I am 24 and on methadone maintenance my dose is 70mg for 2 months when I work all day I feel as if I sweat out a lot of my methadone and was wondering if when I'm ready to go to sleep can I take. 25 mg of Xanax? It

Hello dr. Andrew I have a quick question I am 24 and on methadone maintenance my dose is 70mg for 2 months when I work all day I feel as if I sweat out a lot of my methadone and was wondering if when I'm ready to go to sleep can I take. 25 mg of Xanax? It

Methadone, Xanax (alprazolam): I understand your need to have good sleep.
Your Health is Precious!
Using Xanax (alprazolam) with Methadone may increase dizziness, drowsiness, and difficulty concentrating. You may also experience some impairment in thinking and judgment.
Be the Captain of your pain, not victim.
Feel good about your achievements.

See Psychiatrist for Diagnosis, Therapy to cope with pain, anxiety and depression; Relaxation ...Read more

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I take methadose (liquid methadone) and klonopin. But I get no relief from panikc attacks. I have used Xanax (alprazolam) with my dose and have never died?

Risk of accidental: Overdose. Call your treating physician and ask for guidance. Get into therapy to learn relaxation techniques. An antidepressant anxiolytic would be safer. Think airway first. Without it all else fails. ...Read more

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I'm taking methadone and Xanax (alprazolam) to get off tabs and have epilepsy and had a seizure this morning, is that because I didn't take xanax (alprazolam)?

I'm taking methadone and Xanax (alprazolam) to get off tabs and have epilepsy and had a seizure this morning, is that because I didn't take xanax (alprazolam)?

Maybe: First of all Methadone and Xanax (alprazolam) is not a great combination. People rarely accidentally overdose on either Methadone or xanax (alprazolam). However the combo is much more dangerous. The seizure could just be a seizure or it could be due to rapid Xanax (alprazolam) wean. ...Read more

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I am 30 years old and I have had 2 back surgeries by the time I was 18 I had been seeing a doctor in town for 7 years and he up and left he treated me with methadone 40 mg a day and xanax 1 mg 3 times a day for my static nerve damage my low back pain and

I am 30 years old and I have had 2 back surgeries by the time I was 18 I had been seeing a doctor in town for 7 years and he up and left he treated me with methadone 40 mg a day and xanax 1 mg 3 times a day for my static nerve damage my low back pain and

What is the question: We don't know what your question is.Methadone and Xanax is not a treatment most doctors prescribe these days for low back pain due to any cause. You need to see a pain management specialist and may need to be weaned of Methadone and Xanax both highly habit forming drugs. And you will need the appropriate treatment including physical Therapy and other modalities as indicated ...Read more

Dr. Alan Ali Dr. Ali
1 doctor agreed:
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Xanax (alprazolam) and xl-3 drug interactions okay?

Dr. Alan Ali Dr. Ali
1 doctor agreed:

Xanax (alprazolam): Xl-3 cold & cough medicine added to Xanax (alprazolam) can cause more sedation. Please consult your doctor first. ...Read more

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Can mdma have negative interaction with xanax (alprazolam)?

Mind Altering: Mind altering substances, when used together, lead to increased negative health consequences, overdose, and addiction. The serotonin swings can be more severe when you are already using a mind altering substance when you add mdma. This may not be the smartest choice you have ever made if you have already done this. If you are going to use mdma do not use the xanax (alprazolam). ...Read more

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There any interaction between Xanax (alprazolam) and trazadon?

Xanax (alprazolam) and trazodon: There is an interaction. Xanax (alprazolam) and trazodone both increase sedation and drowsiness. This two medication often prescribed for depression and anxiety. Talk to your prescribing physician for more information. ...Read more

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Is there an interaction between Xanax (alprazolam) and caffeine?

Caffeine/Xanax: Caffeine is Central nervous stimulant, Xanax (alprazolam) is sedative, hence possible interaction is reversal of effect of one another. ...Read more

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Are there any harmful interactions between B12 and xanax (alprazolam)?

Are there any harmful interactions between B12 and xanax (alprazolam)?

No interactions: No, there are no harmful interactions between vitamin B12 and xanax (alprazolam). Hoping you're eating a healthy diet overall. It's not common that someone as young as you (at 23) needs B12 supplementation. ...Read more

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Is there interaction between Xanax (alprazolam) and macropen. Taking xanax (alprazolam) 3 times a day 0.25 mg, now affraid it can do me harm?

No bad reports: It should be safe, but ALWAYS discuss this sort of thing w/ the Dr prescribing! Always! Also consider CBT therapy to learn how to manage so much anxiety w/ less drugs. 3X/day says you can probably do better w/ learning. I hope you feel better soon - try not to worry but do take the opportunity to talk about your anxiety in non-drug ways. ...Read more

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I'm taking liquid methadone and am ibterested in starting plexius slim. Will there be any interactions or withdrawls that I need to worry about?

I'm taking liquid methadone and am ibterested in starting plexius slim. Will there be any interactions or withdrawls that I need to worry about?

As I review the: Plexus Slim label, I don't see anything that should be a problem: chromium, green coffee extract, garcinia cambogia, sweeteners. BUT, when you are taking something as strong as methadone, I think you should clear EVERYTHING -- all vitamins, supplements, OTCs, everything -- with your prescribing physician/program. Please check with him/her/them before proceeding. Good wishes:) ...Read more

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I'm on 40mg of Paxil (paroxetine) and 135mg once daily dose of methadone. I know there's a interaction. But how risky is it? How bad is the interaction?

I'm on 40mg of Paxil (paroxetine) and 135mg once daily dose of methadone. I know there's a interaction. But how risky is it? How bad is the interaction?

Rare: The interaction are minimal. The higher the dose of these meds the higher the risk. However, overall, you are fairly safe since we rarely see complications such as arrhythmias in real practice. ...Read more

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Which is safer to take daily bus par or Xanax (alprazolam)? I realize Xanax (alprazolam) can be habit forming and want to know safety on side effects and interaction type stuff

Is Xanax (alprazolam) safer?: Xanax (alprazolam), a short acting benzo, is prescribed to treat anxiety symptoms, as is Buspar (buspirone), (buspirone) which effects serotonin receptors. At 1st glance, a doc might be quick to point out that there is risk of dependence on Xanax, among other risks, while Buspar (buspirone) has fewer dangerous side effects. Still, the best way to find out about *your* risk/benefit SE profile is to discuss your case w ur MD. :) ...Read more

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I'm on 60mg methadone daily dose and I took a 50 mg tapentadol IR pill because of a big pain I was feeling today. Are there any interactions between th?

Yes: Unless you are following your doctors prescriptions you could have a fatal result mixing methadone with other meds especially Tapentadol another narcotic.
Both cause sedation and respiratory depression.
Please go to ER if need help or call 911. ...Read more

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Is there an interaction between tenormin and Xanax (alprazolam)?

Tenormin and Xanax (alprazolam): I understand your concern.
Tenormin is a medication for treatment of High Blood Pressure
Anxiety can increase blood pressure.
Xanax (alprazolam) is a medication for treatment of Anxiety.
Tenormin and Xanax (alprazolam) taken together may also have increased side effects, including
Dizziness, Lightheadedness
Tiredness
Fainting
Please see your family physician and a psychiatrist for monitoring of medication and Therapy. ...Read more

Dr. Alan Ali Dr. Ali
1 doctor agreed:
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Are there drug interactions between lortadine and xanax (alprazolam)?

Dr. Alan Ali Dr. Ali
1 doctor agreed:

Loratidine: Zertec normally has no side-effects, & is well tolerated if taken as prescribed. Mixing it with xanax (alprazolam) should be safe. ...Read more

Dr. Stuart Wasser
651 Doctors shared insights

Methadone (Definition)

Methadone is a synthetic opiate used for pain control and in the rehabilitation of opiate addicts. Methadone used in rehabilitation relieves craving, suppresses withdrawal symptoms, and blocks the euphoric effects associated with ...Read more


Xanax (Definition)

Alprazolam is a short-acting benzodiazepine which is a kind of sleep-inducing drug ...Read more