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Doctor insights on: Methadone Benzodiazepines Interaction

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Dr. Lawrence Kessler
111 doctors shared insights

Benzodiazepines Level (Definition)

Testing blood levels of benzodiazepines is not a routine or common clinical test. It is done by simply taking a blood sample and testing it in the lab. It is most commonly done in research studies. An example of clinical use would be when there is a discrepancy between the prescribed dosage and ...Read more


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Im taking liquid methadone and am ibterested in starting plexius slim. Will there be any interactions or withdrawls that i need to worry about?

Im taking liquid methadone and am ibterested in starting plexius slim. Will there be any interactions or withdrawls that i need to worry about?

As I review the: Plexus Slim label, I don't see anything that should be a problem: chromium, green coffee extract, garcinia cambogia, sweeteners. BUT, when you are taking something as strong as methadone, I think you should clear EVERYTHING -- all vitamins, supplements, OTCs, everything -- with your prescribing physician/program. Please check with him/her/them before proceeding. Good wishes:) ...Read more

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Im on 40mg of Paxil (paroxetine) and 135mg once daily dose of methadone. I know theres a interaction.but how risky is it? How bad is the interaction?

Im on 40mg of Paxil (paroxetine) and 135mg once daily dose of methadone. I know theres a interaction.but how risky is it? How bad is the interaction?

Rare: The interaction are minimal. The higher the dose of these meds the higher the risk. However, overall, you are fairly safe since we rarely see complications such as arrhythmias in real practice. ...Read more

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I take methadone and I am wanting to start a 3 day trial of plexus slim. Will this cause any drug interactions?

Plexus Slim: I agree with dr. Ibrahim. The main weight-loss ingredients in the supplement appear to be chlorogenic acid (like in green tea), garcinia cambogia, fiber, chromium, and components of hoodia. Other parts are sweeteners, flavorings, and antioxidants. This hasn't been tested in humans to see whether it interacts with medications (including methadone). It's ~$80/month after your 3 day "trial.". ...Read more

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What are the drug interactions between methadone and azithromycin ?

What are the drug interactions between methadone and azithromycin  ?

Arrthymia: There is a caution in combining the two medications due to the risk of qt prolongation resulting in an arrhythmia. ...Read more

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What would be symptoms ofa bad reaction to methadone or interaction of it with cipro (ciprofloxacin) or cymbalta or sudafed?

What would be symptoms ofa bad reaction to methadone or interaction of it with cipro (ciprofloxacin) or cymbalta or sudafed?

Methadone interactio: Cipro (ciprofloxacin) and Methadone together cause problems with cardiac arrhythmias prolonging what's called the qt interval. If you're on this combination then monitoring with an ekg would be a good idea. Cipro (ciprofloxacin) can increase Cymbalta levels. If you are already having side effects from the cymbalta, these will increase. Cymbalta and Methadone together can very rarely cause serotonin syndrome. I would recommend the google that so you know what the symptoms are. There's not enough space here to allow me to write those all out. Best wishes. ...Read more

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What to do if I am taking methadone I want to stop its been 2 years 105 ml a day .is ther anything I can take for withdrawal s?

TAPER THE METHADONE: If you stop cold turkey, you are going to feel like you have been hit by a truck for many weeks and even months. You will also very likely relapse to your drug of choice again after feeling that withdrawal day after day. The best way is to taper, ideally over at least a 90 day period. There are medications like clonidine that your doctor can prescribe, and you can treat the pain/diarrhea/nausea. ...Read more

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! hve been on 120 methadone maintenance for 16 yrs. I have weaned myself down to 50 n past 2 months . what dosage will be safe to just stop taking it?

Any dose: Withdrawal from methadone is safe for a reasonably healthy (and non pregnant) person from any dose. Having said that, you would be more comfortable continuing to taper slowly to about 5 or 10mg , then stopping. ...Read more

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How did i fail my drug test for methadone n benzos even when i haven't taken them?

How did i fail my drug test for methadone n benzos even when i haven't taken them?

Long half life: Certain benzo such as Klonopin (clonazepam) and valium have longer half life and stay in your body longer which is why they are detected a few days later, Methadone has the same property. ...Read more

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I am on methadone i can't sleep n I've gained , 50 lbs in two months n I have hives on ankles what is going on?

Go see your doctor: Methadone is used either to manage chronic pain or to treat heroin addiction. You didn't mention which but regardless, you need to see your prescribing doc. Methadone & other narcotics should be sedating rather than stimulating. Weight gain can be due to under active thyroid while insomnia can be due to over active thyroid. That's why you need to see your family doc who knows you to run right test. ...Read more

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How much methadone is too much for dosage?

Any dose that causes: The patient to nod off, act drunk, or stop breathing is too high. When i worked in a Methadone clinic in 1980 in chicago, the average dose was about 45 mg. With the increase in heroin potency, I am seeing patients who have been or are on 200-300 mg a day. ...Read more

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How can methadone work and what exactly is it ?

Long-acting opioid: Methadone is a long-acting opioid. Generally speaking, within any particular class of addictive drugs, the quicker the peak effect, and the shorter the duration of effect, the more addictive a drug will be. Because opioid-addiction can be tough to quit, Methadone - a long-acting opioid with a slow peak of action - can be used to replace the addictive opioid while one works on recovery. ...Read more

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Why is my methadone wearing off for me soo fast?

Chronic: If taking long time it creates own metabolism or some people are ultra rapid metabolized .Talk to your physician. ...Read more

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Why is my methadone wearing off for me soo fast?

Why is my methadone wearing off for me soo fast?

Several reasons: Tolerance, for one. You may need more or a different medicine. Ask you provider. Good luck! ...Read more

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Can you tell me the benefits of taking methadone?

Having worked in : Both Methadone maintenance clinics and having treated narcotics addicts with suboxone, i really see no benefit to methadone. Methadone is a narcotic just like a street drug. It is ultimately more expensive in many cases than suboxone treatment. It is by no means as convenient, and there is a tendency to continually escalate the dose. With suboxone dosage escalation rarely if ever occurs. Suboxone is much more well-tolerated and you don't have to deal with pick ups at a clinic where you are continually exposed to other narcotic addicts.If you were thinking about going on methadone, please consider the option of suboxone. ...Read more

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If i'm on methadone, should I feel stiff and achy?

Methadone: Depends. If you just started it, yes. Mostly i see it when people are trying to come off Methadone and they titrate off it too quickly. Dose of the drug has a lot to do with it. Higher dose the more likely it is to happen. ...Read more

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What causes methadone levels to rise in your system?

Variable half life: methadone has a variable half life from person to person and in and individual. A patient may ave different metabolic rates from time to time due to other medications or a nebulous metabolic change. This can make methadone dangerous as the level may increase with out increasing the dose and possibly be high enough to cause an overdose. ...Read more

Dr. Stuart Wasser
646 doctors shared insights

Methadone (Definition)

Methadone is a synthetic opiate used for pain control and in the rehabilitation of opiate addicts. Methadone used in rehabilitation relieves craving, suppresses withdrawal symptoms, and blocks the euphoric effects associated with ...Read more


Benzodiazepine (Definition)

They are used for anxiety ...Read more