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Doctor insights on: Methadone Benzodiazepines Interaction

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Dr. Ward Dean
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37 years in practice
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Benzodiazepines Level (Definition)

Testing blood levels of benzodiazepines is not a routine or common clinical test. It is done by simply taking a blood sample and testing it in the lab. It is most commonly done in research studies. An example of clinical use would be when there is a discrepancy between the prescribed dosage and ...Read more


Dr. David J. Rosenfeld
Board Certified, Pain Management
21 years in practice
22M people helped
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Dr. Ward Dean
Board Certified
37 years in practice
804K people helped
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Dr. Pamela Pappas
Board Certified, Psychiatry
36 years in practice
135M people helped
3

3
I take methadone and I am wanting to start a 3 day trial of plexus slim. Will this cause any drug interactions?

I take methadone and I am wanting to start a 3 day trial of plexus slim. Will this cause any drug interactions?

Plexus Slim: I agree with dr. Ibrahim. The main weight-loss ingredients in the supplement appear to be chlorogenic acid (like in green tea), garcinia cambogia, fiber, chromium, and components of hoodia. Other parts are sweeteners, flavorings, and antioxidants. This hasn't been tested in humans to see whether it interacts with medications (including methadone). It's ~$80/month after your 3 day "trial.". ...Read more

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Dr. Merrie Anne Hamburg Eylers
Board Certified, Anesthesiology
22 years in practice
60K people helped
4

4
Can they use Narcan to re-set methadone tolerance. I ake 35mg total a day and sick of it! constipaion and other drug interactions ?

Can they use Narcan to re-set methadone tolerance. I ake 35mg total a day and sick of it! constipaion and other drug interactions
?

Need evaluation: You should be seen by your pain dr. And discuss weaning yourself off this drug. Narcan is temporary and can cause symptoms of acute withdrawal. ...Read more

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Dr. Ward Dean
Board Certified
37 years in practice
804K people helped
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Dr. Mark Reynolds
Board Certified, Psychiatry
27 years in practice
2M people helped
5

5
What are the drug interactions between methadone and azithromycin ?

What are the drug interactions between methadone and azithromycin  ?

Arrthymia: There is a caution in combining the two medications due to the risk of qt prolongation resulting in an arrhythmia. ...Read more

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Dr. Donald Jacobson
Board Certified, Psychiatry
34 years in practice
17M people helped
6

6
What would be symptoms ofa bad reaction to methadone or interaction of it with cipro or cymbalta or sudafed?

What would be symptoms ofa bad reaction to methadone or interaction of it with cipro or cymbalta or sudafed?

Methadone interactio: Cipro and Methadone together cause problems with cardiac arrhythmias prolonging what's called the qt interval. If you're on this combination then monitoring with an ekg would be a good idea. Cipro can increase Cymbalta levels. If you are already having side effects from the cymbalta, these will increase. Cymbalta and Methadone together can very rarely cause serotonin syndrome. I would recommend the google that so you know what the symptoms are. There's not enough space here to allow me to write those all out. Best wishes. ...Read more

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Dr. Robert Grindstaff
Board Certified, Addiction Medicine
32 years in practice
2M people helped
7

7
What medications or drugs are not compatible with methadone?

There are hundreds: of drugs that have drug-drug interactions with methadone. Moderate difficulty mat occur with any other opioid and or any benzodiazepine like Xanax. ...Read more

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Dr. Paul Grin
Board Certified, Pain Management
30 years in practice
23M people helped
8

8
Husband takes at least 40mg methadone a day today he took about 25 .5 mg kolonopin as well. Is this dangerous?

Caution is advised: Methadone, a synthetic mu agonist opioid, has pharmacological activity similar to morphine. Klonopin is a member of the benzodiazepine family. No drug interaction, but caution is advised due to the additive effect. Combo may result in vasodilation, severe hypotension, CNS and respiratory depression. Keep the air way straight and open. Consult with your physician. ...Read more

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Dr. Lois Freisleben-Cook
Board Certified, Developmental and Behavioral Pediatrics
35 years in practice
3M people helped
9

9
Fiancé tried getting clean Now on methadone and sniffing his lorazapan to get high what can I do!? He sleeps so deeply ALOT. Should I be concerned?

Fiancé tried getting clean Now on methadone and sniffing his lorazapan to get high what can I do!? He sleeps so deeply ALOT. Should I be concerned?

YES: you should be concerned. What he is doing is dangerous. You are in no position to help him at this point. He is in no position to be anyone's fiancee. He needs intensive care for chemical dependency and cannot be expected to be ready for marriage for at least a year or two. Meanwhile, you can best help him by attending a support group for those affected by a loved one's addiction and counseling for yourself. ...Read more

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Dr. Philip Miller
Board Certified, Family Medicine
41 years in practice
13M people helped
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Dr. Stuart Wasser
611 doctors shared insights

Methadone (Definition)

Methadone is a synthetic opiate used for pain control and in the rehabilitation of opiate addicts. Methadone used in rehabilitation relieves craving, suppresses withdrawal symptoms, and blocks the euphoric effects associated with ...Read more


Benzodiazepine (Definition)

They are used for anxiety ...Read more


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