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Doctor insights on: Methacholine Side Effects

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Provocholine (Definition)

Provocholine is an asthma agent which is a ...Read more


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What medication effects a methacholine challenge causing false negatives? In detail please?

What medication effects a methacholine challenge causing false negatives? In detail please?

There's a list of...: Things that may lead to a false negative: inhaled and oral bronchodilators, cromolyn, nedocromil, hydroxyzine, cetirizine, leukotriene modifiers, coffee, tea, cola drinks, and chocolate. Sometimes oral or inhaled corticosteroids are included in the list. Whether or not these things "cause" a negative depends on many factors. The list and more information is from the Cleveland Clinic website. ...Read more

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How can I be less susceptible to the methacholine?

How can I be less susceptible to the methacholine?

Limited Options!: This drug, a muscarinic receptor agonist, non-selectively causes smooth muscle contraction in the airways and is used to diagnose "reactive" airway diseases. It also may slow the heart rate, lower the blood pressure and cause excess secretion of the salivary glands. There is genetic specificity for these "receptors, " so that you may be able to "blame your genes" for your susceptibility! avoid it! ...Read more

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Can a person fake a methacholine challenge?

It's hard: An experienced physician, pulmonologist, allergist, etc. Is able to tell when patients are not putting enough effort into a test. ...Read more

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How can i prepare to pass a methacholine challenge?

Methacholin: Challenge is used if the diagnosis of asthma is in question. There is nothing to do to prepare to pass the test.you need to follow your doctors instructions exactly and stop any medications as directed. This is a potentially dangerous test and should only be done in a pulmonary function lab or in a doctors office with those trained to treat acute bronchospasm. It is better in ruling out asthma. ...Read more

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What can cause false negative in a methacholine test?

Medications: A number of medications could cause false negative methacholine challenge test for asthma. A complete list of drugs need to be stopped prior to the test is too long too list here. Consult expert for details ...Read more

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How long will the methacholine challenge usually take?

How long will the methacholine challenge usually take?

Less than 1hr: Less than 1 hr. 30min is about average, depending on how efficient the staff performing the test is in setting up each step, etc. It also depends on whether you have a positive result early vs towards to the end of the test. ...Read more

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What causes false negative results in a methacholine test?

True or False Test?: A "false negative" test means the presence of a "confounding variable" that invalidates the test because it nullifies a test that would probably be positive if the variable were absent, like a brochodilator medicine (e.g.various inhalers and pills for asthma). So the test should be done in the absence of those medications, if possible-or-used as a validation as to the medication's effectiveness. ...Read more

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Is there a difference between histamine and methacholine?

Is there a difference between histamine and methacholine?

Yes different: Histamine a compound that is released by cells in response to injury and in allergic and inflammatory reactions, causing contraction of smooth muscle and dilation of capillaries. Methacholine is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system. both are use to test for airway reactivity in asthma. ...Read more

Dr. Mark Ingerman
47 doctors shared insights

Methacholine (Definition)

Methacholine is an asthma agent which is a ...Read more