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Doctor insights on: Methacholine Medication

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What medication effects a methacholine challenge causing false negatives? In detail please?

What medication effects a methacholine challenge causing false negatives? In detail please?

There's a list of...: Things that may lead to a false negative: inhaled and oral bronchodilators, cromolyn, nedocromil, hydroxyzine, cetirizine, leukotriene modifiers, coffee, tea, cola drinks, and chocolate. Sometimes oral or inhaled corticosteroids are included in the list. Whether or not these things "cause" a negative depends on many factors. The list and more information is from the Cleveland Clinic website. ...Read more

Dr. Suzanne Galli
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Provocholine (Definition)

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Will benadryl (diphenhydramine) have an effect on a methacholine challenge since its a anticholinergic drug?

Will benadryl (diphenhydramine) have an effect on a methacholine challenge since its a anticholinergic drug?

Possibly: To get the best indication of bronchial hyper reactivity, you should not take any antihistamines for 3 to 7 days before the challenge. Unless, of course, the point is to see if Benadryl (diphenhydramine) will diminish the reactivity. That's why you need to discuss such questions with the physician who ordered the test. ...Read more

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How can I be less susceptible to the methacholine?

How can I be less susceptible to the methacholine?

Limited Options!: This drug, a muscarinic receptor agonist, non-selectively causes smooth muscle contraction in the airways and is used to diagnose "reactive" airway diseases. It also may slow the heart rate, lower the blood pressure and cause excess secretion of the salivary glands. There is genetic specificity for these "receptors, " so that you may be able to "blame your genes" for your susceptibility! Avoid it! ...Read more

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Can a person fake a methacholine challenge?

Can a person fake a methacholine challenge?

It's hard: An experienced physician, pulmonologist, allergist, etc. Is able to tell when patients are not putting enough effort into a test. ...Read more

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How can I prepare to pass a methacholine challenge?

Methacholin: Challenge is used if the diagnosis of asthma is in question. There is nothing to do to prepare to pass the test. You need to follow your doctors instructions exactly and stop any medications as directed. This is a potentially dangerous test and should only be done in a pulmonary function lab or in a doctors office with those trained to treat acute bronchospasm. It is better in ruling out asthma. ...Read more

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What can cause false negative in a methacholine test?

Medications: A number of medications could cause false negative methacholine challenge test for asthma. A complete list of drugs need to be stopped prior to the test is too long too list here. Consult expert for details ...Read more

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How long will the methacholine challenge usually take?

How long will the methacholine challenge usually take?

Less than 1hr: Less than 1 hr. 30min is about average, depending on how efficient the staff performing the test is in setting up each step, etc. It also depends on whether you have a positive result early vs towards to the end of the test. ...Read more

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What causes false negative results in a methacholine test?

True or False Test?: A "false negative" test means the presence of a "confounding variable" that invalidates the test because it nullifies a test that would probably be positive if the variable were absent, like a brochodilator medicine (e.g.various inhalers and pills for asthma). So the test should be done in the absence of those medications, if possible-or-used as a validation as to the medication's effectiveness. ...Read more

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Is there a difference between histamine and methacholine?

Is there a difference between histamine and methacholine?

Yes different: Histamine a compound that is released by cells in response to injury and in allergic and inflammatory reactions, causing contraction of smooth muscle and dilation of capillaries. Methacholine is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system. Both are use to test for airway reactivity in asthma. ...Read more

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How long until you get results of the methacholine challenge test?

Same day...: ... If your doctor is available when performing the test. They should be able to tell you immediately the results. ...Read more

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How long does it take to get results of the methacholine challenge test?

Methacholine test: The test result is available as soon as the test is completed. It can take half to one hour. A physician has to interpret the test results.
Some times the answer may not be clear cut. ...Read more

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What factors could produce a negative methacholine challenge. Detail Please?

Maybe not asthma: A 19 yo with a negative methacholine challenge. A methacholine challenge test is ordered when a diagnosis of asthma is suspected but cannot be proven by history or in-office simple spirometry. A negative test usually means there is not a diagnosis of asthma. Please see your physician to determine exactly what is going on. ...Read more

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Are people still doing the methacholine challenge, and are there risks to it?

Are people still doing the methacholine challenge, and are there risks to it?

Methacholine test: Mostly it is done where the diagnosis of asthma is doubtful. It should be done under the careful supervisision of a physician who has experience in the bronchial challenge tests. The test can be done in the hospital pulmonary lab or in the office setting with appropriate. Staff and safety equipment to treat asthma like symptoms. The test is still being done when indicated. ...Read more

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What are the risks doing the methacholine challenge?

Asthma diagnosing: This test is indicated when the diagnosis of asthma is in question (eg, symptoms are atypical, baseline testing is normal). There are contraindications to test such as pregnancy, recent heart attack and severe asthma. Also there are medicines, such as bronchodilators and steroids that must be stopped before the test is done to make it valid. Risks include severe asthmatic attack or heart attack. ...Read more

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How does methacholine give you asthma symptom?

Bronchospasm: Methacholine induces bronchospasm in susceptible patients. Once it is inhaled, you undergo pulmonary function testing looking for airway obstruction. Once present, it is them reversed with a bronchodilator inhaler. This fulfills the definition of asthma: reversible obstruction. Most patients will not experience any symptoms during this test, even if obstruction occurs. It is a very safe test. ...Read more

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I just started using advair a week ago will this affect my methacholine test tomorrow?

48 hours prior: We usually recommend a medication like Advair to be discontinued 48 hours prior to testing ...Read more

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I just started using advair a week ago will this affect my methacholine test tomorrow? Will this make false negatives?

Potentially: For a methacholine test to yield accurate results you should not take any medications that would mask the response. The most common reason for canceling this test is ablack of adequate patient preparation. Recommended periods for withholding medications are based on their duration of action. Call your testing center and address your concerns before going in. You may need to reschedule. ...Read more

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I've been taking advair 500/50 diskus for about a week and a half now and I have a methacholine test tomorrow will the produce a false negative result?

Yes: You will need to stop it for at least 2 weeks to get an accurate result unless the test is being done for research purpose trying to find out how much the airway reactivity has changed from taking the drug. Else you may end up with a false-negative result for asthma. ...Read more

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How affective is the methacholine test for asthma?

How affective is the methacholine test for asthma?

See below: It is difficult to calculate the exact sensitivity of a methacholine challenge for the diagnosis of asthma, as a gold standard for diagnosing asthma does not exist. The sensitivity is felt to approach 100 percent, or if there is asthma, it will almost always be detected. There may be false positives, though, when the test is positive but you don't really have asthma. ...Read more

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Will Spiriva affect a methacholine test?

The New Spiriva Test: Spiriva inhibits wheezing while the test is used to provoke it so, yes, the test will be affected. At that point maybe call it a "Spiriva Test" in that, if it resists the effects of the methacholine, then it would probably work for you! But, of course, that's not how the test is done. They'd want you off that med for a day or two before doing the test-and any other respiratory meds you take, if possible ...Read more

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Will Budesonide effect a methacholine challenge?

Medications: Yes it can by reducing inflammation and treating your asthma, bronchial responsiveness may be effected.
Please consult with your PFT lab technician regarding which medications will need to be stopped prior to testing. ...Read more

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Will singulair (montelukast) significantly effect a methacholine test?

Will singulair (montelukast) significantly effect a methacholine test?

R/O RAD/ASTHMA: UNLIKELY BUT STOP TO GET BASELINE. RAD and underlying allergies which frequently coexist. You need a through exam blood work /CXR/ PFTS WITH DLCO. Depending on the results treatment will be indicated. You also need a personal peak flow meter to keep track of peak flow and treat accordingly if numbers are low with albuterol. If you are using it a lot you may need a long acting inhaler like advair. ...Read more

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Will 10mg Singulair (montelukast) cause a negative in methacholine test?

Please elaborate: Why did your Dr recommend a Methacholine challenge test when you already have a diagnosis of Asthma? ...Read more

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Will Budesonide flex-haler cause negative results in a methacholine test?

Budesonide+methachol: Hello Kevin823
Budesonide is a steroid alone inhaler and does not appear on the list of drugs to be avoided before a methacholine challenge test. The drugs to avoid are the beta-2 stimulants, like albuterol, salmeterol, formoterol, theophylline. thanks ...Read more

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Will singulair (montelukast) significantly effect a methacholine challenge test?

Will singulair (montelukast) significantly effect a methacholine challenge test?

Yes it will: Before doing Methacholine Chalenge test you are adviced to stop taking long acting Bronchodilaters, Allergy Meds Steroids and Singular as it may affect the test
Singular needs to be stopped at least 24 hour before your test
It can significantly affect the test ...Read more

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Would taking allegra (fexofenadine) before a methacholine challenge effect the results?

Would taking allegra (fexofenadine) before a methacholine challenge effect the results?

It can: You should obviously avoid asthma inhalers. The longer the work, the longer you should stop them for (eg advair for 24hrs). Antihistamines may not have as big an impact on the test as inhalers, but they should also be avoided for 24-48hrs. ...Read more

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Why do doctors tell you not smoke or to use caffeine before a methacholine challenge test?

Why do doctors tell you not smoke or to use caffeine before a methacholine challenge test?

For unaltered result: Since both caffeine (which can relax the bronchial muscle tone) and smoking - (which can irritate bronchial muscle tone making it more sensitive) - can affect the test - these factors and others are to be avoided ahead of a methacholine test which is trying to guage the patient's baseline bronchial reactivity (often to investigate the presence of asthma). ...Read more

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Why do doctors tell you not smoke or to use caffine before the methacholine challenge test?

Why do doctors tell you not smoke or to use caffine before the methacholine challenge test?

For unaltered result: Since both caffeine (which can relax the bronchial muscle tone) and smoking - (which can irritate bronchial muscle tone making it more sensitive) - can affect the test - these factors and others are to be avoided ahead of a methacholine test which is trying to guage the patient's baseline bronchial reactivity (often to investigate the presence of asthma). ...Read more

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I had the methacholine challenge test and it triggered bronchospasm on the lowest dose. What does this mean? Should I be on bronchodialators? I'm 27.

I had the methacholine challenge test and it triggered bronchospasm on the lowest dose. What does this mean? Should I be on bronchodialators? I'm 27.

Probably: It means you may have reactive airways disease. There are many inhaled drugs that can treat this, and published guidelines. Talk with your doctor about any further testing and follow his/her advice. ...Read more

Dr. Stephen Scholand
53 Doctors shared insights

Methacholine (Definition)

Methacholine is an asthma agent which is a ...Read more