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Doctor insights on: Methacholine

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Dr. Michael Kleerekoper
53 doctors shared insights

Methacholine (Overview)

Methacholine is an asthma agent which is a kind of lung drug.


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Are people still doing the methacholine challenge, and are there risks to it?

Are people still doing the methacholine challenge, and are there risks to it?

Methacholine test: Mostly it is done where the diagnosis of asthma is doubtful. It should be done under the careful supervisision of a physician who has experience in the bronchial challenge tests. The test can be done in the hospital pulmonary lab or in the office setting with appropriate. Staff and safety equipment to treat asthma like symptoms. The test is still being done when indicated. ...Read more

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Dr. Michael Kleerekoper
53 doctors shared insights

Methacholine (Overview)

Methacholine is an asthma agent which is a kind of lung drug.


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How long does it take to get results of the methacholine challenge test?

How long does it take to get results of the methacholine challenge test?

Methacholine test: The test result is available as soon as the test is completed. It can take half to one hour. A physician has to interpret the test results. Some times the answer may not be clear cut. ...Read more

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How can I be less susceptible to the methacholine?

How can I be less susceptible to the methacholine?

Limited Options!: This drug, a muscarinic receptor agonist, non-selectively causes smooth muscle contraction in the airways and is used to diagnose "reactive" airway diseases. It also may slow the heart rate, lower the blood pressure and cause excess secretion of the salivary glands. There is genetic specificity for these "receptors, " so that you may be able to "blame your genes" for your susceptibility! avoid it! ...Read more

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Can a person fake a methacholine challenge?

It's hard: An experienced physician, pulmonologist, allergist, etc. Is able to tell when patients are not putting enough effort into a test. ...Read more

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How can i prepare to pass a methacholine challenge?

Methacholin: Challenge is used if the diagnosis of asthma is in question. There is nothing to do to prepare to pass the test.you need to follow your doctors instructions exactly and stop any medications as directed. This is a potentially dangerous test and should only be done in a pulmonary function lab or in a doctors office with those trained to treat acute bronchospasm. It is better in ruling out asthma. ...Read more

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What can cause false negative in a methacholine test?

Medications: A number of medications could cause false negative methacholine challenge test for asthma. A complete list of drugs need to be stopped prior to the test is too long too list here. Consult expert for details ...Read more

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How long will the methacholine challenge usually take?

How long will the methacholine challenge usually take?

Less than 1hr: Less than 1 hr. 30min is about average, depending on how efficient the staff performing the test is in setting up each step, etc. It also depends on whether you have a positive result early vs towards to the end of the test. ...Read more

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What causes false negative results in a methacholine test?

True or False Test?: A "false negative" test means the presence of a "confounding variable" that invalidates the test because it nullifies a test that would probably be positive if the variable were absent, like a brochodilator medicine (e.g.various inhalers and pills for asthma). So the test should be done in the absence of those medications, if possible-or-used as a validation as to the medication's effectiveness. ...Read more

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Is there a difference between histamine and methacholine?

Is there a difference between histamine and methacholine?

Yes different: Histamine a compound that is released by cells in response to injury and in allergic and inflammatory reactions, causing contraction of smooth muscle and dilation of capillaries. Methacholine is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system. both are use to test for airway reactivity in asthma. ...Read more

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How long until you get results of the methacholine challenge test?

Same day...: ... If your doctor is available when performing the test. They should be able to tell you immediately the results. ...Read more

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How long does it take to get results of the methacholine challenge test?

Methacholine test: The test result is available as soon as the test is completed. It can take half to one hour. A physician has to interpret the test results. Some times the answer may not be clear cut. ...Read more

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What factors could produce a negative methacholine challenge. Detail Please?

Maybe not asthma: A 19 yo with a negative methacholine challenge. A methacholine challenge test is ordered when a diagnosis of asthma is suspected but cannot be proven by history or in-office simple spirometry. A negative test usually means there is not a diagnosis of asthma. Please see your physician to determine exactly what is going on. ...Read more

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Are people still doing the methacholine challenge, and are there risks to it?

Methacholine test: Mostly it is done where the diagnosis of asthma is doubtful. It should be done under the careful supervisision of a physician who has experience in the bronchial challenge tests. The test can be done in the hospital pulmonary lab or in the office setting with appropriate. Staff and safety equipment to treat asthma like symptoms. The test is still being done when indicated. ...Read more

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What medication effects a methacholine challenge causing false negatives? In detail please?

What medication effects a methacholine challenge causing false negatives? In detail please?

There's a list of...: Things that may lead to a false negative: inhaled and oral bronchodilators, cromolyn, nedocromil, hydroxyzine, cetirizine, leukotriene modifiers, coffee, tea, cola drinks, and chocolate. Sometimes oral or inhaled corticosteroids are included in the list. Whether or not these things "cause" a negative depends on many factors. The list and more information is from the Cleveland Clinic website. ...Read more

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How does methacholine give you asthma symptom ?

Bronchospasm : Methacholine induces bronchospasm in susceptible patients. Once it is inhaled, you undergo pulmonary function testing looking for airway obstruction. Once present, it is them reversed with a bronchodilator inhaler. This fulfills the definition of asthma: reversible obstruction. Most patients will not experience any symptoms during this test, even if obstruction occurs. It is a very safe test. ...Read more

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What are the risks doing the methacholine challenge?

Asthma diagnosing: This test is indicated when the diagnosis of asthma is in question (eg, symptoms are atypical, baseline testing is normal). There are contraindications to test such as pregnancy, recent heart attack and severe asthma. Also there are medicines, such as bronchodilators and steroids that must be stopped before the test is done to make it valid. Risks include severe asthmatic attack or heart attack. ...Read more

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I just started using advair a week ago will this affect my methacholine test tomorrow?

48 hours prior: We usually recommend a medication like Advair to be discontinued 48 hours prior to testing ...Read more

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