Doctor insights on:
Metformin Cause Megaloblastic Anemia
It can: Megaloblastic anemia is caused by a deficiency in vitamin B12 or folic acid. Taking metformin can cause your body to "use up" vitamin b12, and become deficient in b12, which, in severe cases, could lead to megaloblastic anemia. This can usually be corrected with a vitamin B12 pill, unless there is also a problem with absorbing b12. ...Read more
It just does :):
your body needs Folic Acid to make red blood cells properly. If you do not have enough it compromises the process. The body will not be able to produce red blood cells as well (anemia) and they will be bigger than normal red blood cells (megaloblastic = big). Thankfully some Folic Acid replacement should fix the problem quite easily. ...Read more
We don't: Megaloblastic anemia caused by B12 deficiency is treated with b12. Folate (folic acid) deficiency also causes meg. Anemia. Some with B12 deficiency are also deficient in b12, but if one has low B12 ; isn't deficient in folate (folic acid) there's no need to supplement with it. But it won't hurt to take folate (folic acid);if you're among the 1/3 of people with problems converting Folic Acid to it's active form you should take l-5-mthf. ...Read more
Megaloblastic anemia: Megaloblastic anemia is macrocytic anemia (elevated mcv/large rbc) that results fron inhibition of dna synthesis in RBC production. This can be caused by deficiency in vit b12, folate (folic acid) or drug induced. If you are a strict vegan- you are at risk to have vit B12 deficiency-thus you should take vit B12 supplement. Check and discuss further in detail with your doctor. ...Read more
Pernicious = Vit B12: Megaloblastic anemia refers to any condition which causes large red blood cells (folate (folic acid) deficiency, vitamin B12 deficiency, etc.) pernicious anemia can be thought of as a *type* of megaloblastic anemia which is caused by vitamin B12 deficiency secondary to malabsorption. ...Read more
Big RBC: Pernicious anemia is deficiency of vitaminb12 due to autoimmune attack on cell of the stomach and antibody against intrinsic factor- presented with megaloblastic anemia. Pa is only one of the causes of megaloblastic anemia- however other causes that can cause def vitb12, or folate (folic acid) or other drug eg. Bactrim- that inhibits dna synthesis in RBC production also can cause megaloblastic anemia. ...Read more
Big red blood cell: Is a type of anemia presented with big size of red blood cells- that results from inhibition of dna synthesis during red blood cell production. This leads to continuing cell growth without division. It is most often due to hypovitaminosis, specifically a deficiency of vitamin B12 and/or folic acid, deficiency in micronutrient- as well as others including drugs/chemo etc. Work up needs to be done. ...Read more
Anemia: Megaloblastic anemia is anemia related most commonly to vitamin B12 and Folic Acid deficiency. These problems are easily treated with replacement of the deficient vitamin. There are other much rarer causes of megaloblastic anemia, and other illnesses that may look similar to megaloblastic anemia. ...Read more
Cause: Megaloblastic anemia is caused by vitamin B12 or Folic Acid deficiency, or rarely from other causes. In the blood, the red blood cells are large. In the bone marrow, there is delayed maturation of the red blood cell precursors that give a characteristic appearance when stained and looked at under the microscope. There is no "regular anemia". ...Read more
Call: Hi. Call a poison control center NOW! ...Read more
What you are.....: Describing is pagophagia, the consumption of ice in the setting of anemia, usually due to an fe deficiency state. The ice consumption is not causative, but rather emblematic. You should see your dr and be evaluated for fe deficiency. You may find that your dr checks your hematocrit and red cell indices, and if microcytic hypochromic anemia is detected, starts you on fe rx (cheaper than fe testing). ...Read more
Anemia and pain: Anemia can be caused by multiple underlying pathologies (ie. Iron deficiency, vit B12 deficiency, lead poisoning, chronic disease, blood cell dysfunction, sickle cell...). Some of these can lead to painful joints. If you have anemia the best thing to do is to find the source of it. You should also have your doctor perform a shoulder physical exam to rule-out internal pathologies. Hope that helps! ...Read more
Most likely no...: Although this is a complex issue where several factors contribute. Co2 generation is a function of aerobic metabolism and decarboxylation of tca cycle intermediates. Significant anemia reduces o2 delivery to tissues and increases reliance on anaerobic metabolism --> tissue acidosis. A metabolic acidosis leads to respiratory compensation (which lowers blood co2). Whole books written about this. ...Read more
Many: Iron only help if you are iron deficient, but anemia can be due to many reasons, you need to see your doctor for a full work up. Also note it takes more rhan a week to start improving if you just started iron., and your problem is iron def, also depends on if you are taking the right dose, normal absorbtion etc, also it is very important to find out why you are low in iron if that the real proble. ...Read more
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