Doctor insights on:
Metastic Colon Cancer
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
An average response to chemotherapy for Colon cancer lasts 9 to 12 months(range from 6 months to 2 years).
But it depends on how many tumors you have and their original size and the degree of tumor regression(shrinkage). Some tumors can regress nicely and may even go away, in which case you can gain some years of life and an occasional Cure is even possible. Ask your doctor to further address thi ...Read more
Depending how used: CEA first identified in 1965 by Phil Gold and Samuel O. Freedman in human colon cancer extracts. Thought to be valuable for dx colorectal Ca but the glycoprotein is also expressed in inflamed tissue so that smoking and enema can cause rise. Best used for monitoring so that if present in primary and rises it represents treatment failure and if diminishes during treatment it represents a response. ...Read moreSee 5 more doctor answers
Work w/ your Dr:
This is worth discussing w/ your Dr or getting a 2nd opinion. They spent years building a knowledge base and also have examined you! Some research finds it less beneficial alone than in combo: http://www.ncbi.nlm.nih.gov/pubmed/24560487
But talk about your case w/ your team. ...Read more
Uncertain: This sounds like an extraordinarily high value, and indicates either blockage if the bile flowing out of the liver, or failing liver function. It may or may not be due to the cancer, but is typically an ominous sign. Talk more about this with the treating physician. Hope this helps! ...Read moreSee 1 more doctor answer
So many variables: Too many variables to give you a pertinent answer. Consult your oncologist to help you with clinical decisions ...Read more
What kind of mets:
It depends on what kind of metastases we are talking about.
If the spread to the lymph nodes, surgery and chemotherapy, and possible radiation therapy could be very helpful.
If the spread to the liver the prognosis is less optimistic, unless the metastases are able to be resected.
Other metastases are less promising in spite of chemotherapy and radiation therapy.like bone and brain. ...Read more
Colon mets: Not having your chart and you in front of me makes it very hard to give you an accurate idea on prognosis. When chemo is started, that means your CA cells have gone beyond the boundaries which would have made txing it simple. The simpler the tx, the better the prgns. The harder the tx, the worse the prgns. On a positive note, f/u with your docs, stay faithful, and you might get a pleasant surprise ...Read more
I mean if chemotherapy does not work fir metastic colon cancer, can anything be done, any new drugs?
Yes: Depending on where mets are, direct therapy can be offered resecting lung lesions locally, using chemoembolization for lesions in liver and hyperthermic perfusion for peritoneal seeding. Immunotherapy for VEGF and epidermal growth factors can also be employed as well as new drugs in Phase II-III such as mAbs targeting post translational modification of MUC5ac and CEAcam 5,6`oncofetal proteins/ ...Read moreSee 1 more doctor answer
Dehydration Ca Colon: Hello Kanabar T, YES it can but only as part of the process of succumbing from it, since Stage 4 means it is spread throughout the body. This would be an excellent cause for a referral to Hospice. Thanks ...Read more
Some response: Meds like Xeloda have some tempoary benefit suppressing DNA function as an oral 5FU (fluorouracil). Long term responses are not seen requiring combination therapy to give an optimjum response. Eventually if cancer does show a good response, malignant stem cells will repopulate the site of the original metastasis. ...Read more
Modestly effective: Fluoropyrimidines (5-FU, Capecitabine and UFT) as a class have modest activity and one of these 3 needs to be combined with Oxaliplatin and or Irinotecan to achieve best results,as combination chemo is far superior in efficacy than any single chemo drug ...Read more
Yes: In colon cancer as with most malignancies as the lesion increases in size the greater the population of mutated cells with varying surface glycoproteins defining different sites of metastasis. With the metastasis alreadyu present each of these cells express a mutated form of mitochondrial DNA acting as immunogenic inhibitory molecules making treatment more difficult. ...Read more
Not often: Radiotherapy can be useful in certain select cases where the Cancer is localized to one or two spots only. This means 1 patient in 5 may be suitable candidate. But you need to seek consultation with a radiation oncologist before you can get a clear cut answer for your circumstances. ...Read moreSee 1 more doctor answer
Not always reliable: I assume that from ALP you meant Alkaline Phosphatase(a type of liver function test). But avoid using abbreviations. This test can sometimes be correct in showing tumor progression but we need more information than this test alone in order to assess tumor response. The additional tests that help are measuring the liver size, checking CEA level(Blood test) and for making final decision, CT scan. ...Read more