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Several things.: In this sentence metastatic most likely means the disease has spread to other organs such as liver, lung, etc. And would be considered stage 4; alternatively it could mean spread to lymph nodes only and would represent stage 3 disease. Signet ring is a description of what the cell looks like. Adenocarcinoma is the type of tumor and can arise from the GI tract, prostate, lung, breast or stomach. ...Read moreSee 1 more doctor answer
Metastatic tumor: The treatment of metastatic adenocarcinoma depends on the nature of the primary, the site of metastasis and the degree of metastatic tumor. Pancreatic Ca with one lesion in the liver is unresectable and treated by chemo such as Gemzar (gemcitabine) Abraxane. Colon Ca with one lesion to liver is resected. When any met is unresectable chemo is always used alone or in combination with RT. ...Read more
Subtype of colon Ca: Mucin producing metastatic adenoca of the colon is derived from a primary adenoCa of colon producing large amounts of extracelluar mucin with greater than a 50% mucinous component.. The proximal colon and appendix represents 10-20% of these colorectal neoplasms . The rt. colon is the usual source for most of these lesions presenting with more advanced forms of disease than other colonic sites. ...Read more
My mum 67 was diagnosed with metastatic caecal adenocarcinoma, aggressive, stage 4. She started folfox. Can it be cured? Life expectancy?
Serious diagnosis: Stage 4 colon cancer has a very poor prognosis. No one can give you a life expectancy that is exact. It depends upon her response to the treatment. Some people respond very well. Of all people that have this diagnosis only about 8% of them are still alive at 5 years. But still she could be one of that 8%. I hope she responds well to the treatments. ...Read moreSee 1 more doctor answer
Regional spread: Many tumors, as they evolve, develop the potential to spread. The lesions develop matrix metalloproteinase which forms small e-cadherin from the cell cement and allows for spread. Regional nodes are a common site and for lesions on the arm and chest, spread is to the axilla. Lt. breast carcinomas as they grow and spread frequently are noted in the left axillary lymph nodes as metastatic adenoca ...Read more
My mother has been diagnosed with metastatic adenocarcinoma with mucinous features. Can you explain what this means?
Glandular activity: Primary tumors with mucinous features are those that are derived from organs producing mucin to allow the organ to function. The most common organ whose tumor,an adenocarcinoma, has mucinous features is that from colon. As such the metastatic tumors would have segmental areas within the spreading lesion that demonstrates the presence of fields of mucin on histologic exam. ...Read more
What do you suggest if my mother has been diagnosed with metastatic adenocarcinoma with mucinous features. what does this mean?
Many things: Adenocarcinoma means a cancer derived of epithelial cells of glandular origin (not from a gland necessarily). Metastatic means that it has spread. Mucinous features means that the pathologist saw areas of mucin outside the cells, the significance of this depends on how much and where. It being metastatic is probably the most important thing prognostically, but please discuss with oncologist. ...Read more
My mum 67 was diagnosed with metastatic caecal adenocarcinoma, aggressive stage 4 cancer.She's on folfox. Life expectancy??
Varies from months/y: The overall survival of stage 4 colon cancer varies from 1 to 3 years. Most patients have at least 2 years if their tumor responds to chemo. If you tumors regresses after chemo, it may even be surgically removable in which case long term survival(even a cure) can be possible. Ask more questions to your treating oncologist. ...Read more
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