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Doctor insights on: Metastatic Poorly Differentiated Adenocarcinoma Of Lung

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My husband is diagnosed with poorly differentiated adenocarcinoma of the right lung with alk & egfr mutations; stage 3b what is the prognosis and life?

My husband is diagnosed with poorly differentiated adenocarcinoma of the right lung with alk & egfr mutations; stage 3b what is the prognosis and life?

Fair: It is extremely unusual to have both mutations. They are mutually exclusive. Patients that do carry one of these mutations are eligible for various medications that target these mutations. Crizonitib for alk and tarceva (erlotinib) for egfr and new agent recently to the market. These new finding have improved the prognosis. Other factors do enter in. Age, ps, smoking history if any, wt. Loss, etc. ...Read more

Lung (Definition)

Deoxygenated blood enters the lungs from the right side of the heart and travels to the lungs. When you inspire, oxygen flows into the lungs, transverses the capilliares and attaches to hemoglobin down a gradient. At the same time, co2 diffuses into the capilaries and is expelled with exhalation. Oxygen rich blood then flows to the left side of the heart and into the ...Read more


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Hello can u tell me what I do histopathology report : section show poorly differentiated mucinous adenocarcinoma with ulceration of mucosal surface?

Cancer: It is a subtype of cancer that arises from cell of the glands that produces some mucin/mucous. Where is this located? Colon? You need to discuss further re- treatment plan with your oncology team. Treatment and everything will depend on what kind of cancer is this? The stage? The molecular pattern/biology of the cancer? Your overall condition? Etc. Good luck. ...Read more

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What can be done for poorly differentiated adenocarcinoma arising in the setting of intestinal metaplasia?

What can be done for poorly differentiated adenocarcinoma arising in the setting of intestinal metaplasia?

CUP?: Cancer 1-2-3 -- 1) diagnosis -- we know cancer , but what kind? May need additional information -- is this a colon polyp, now cancer or what? Pathologist can help and may need special testing. 7% of cancers have know known primary (cup or upc). 2) staging and prognostic factors. 3) treatment. Need all of the pieces of the puzzle before treating. ...Read more

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What's the option for a patient diagnosed with poorly differentiated adenocarcinomas with mixed inflammation?

Options for Cancer: Need more information, such as where is it located (adenocarcinomas can be in many different organs), is there lymph node involvement, etc Important to remember that there is alway more than one option or approach, including choosing not to treat. Talk it over thoroughly with your oncologist, ask lots of questions, have someone with you to take notes, get 2nd (and 3rd) opinions if necessary. GL ...Read more

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What has to be performed in order for the results to show a moderately differentiated adenocarcinoma?

Biopsy: but that result is a simple biopsy, making regular slides and regular coloring of it and looking under the microscope. Identical technology from the 19th century. ...Read more

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Is it possible for differentiated endometrioid adenocarcinoma to be cured?

Yes: endometrial cancer which begins in the endometrial mucosa, before invading myometrium or muscle of uterus is virtually 100% cureable. Even if D&C shows tumor cells spreading to blood stream this is not metastasis but cells pushed by curettage into the blood. Even early muscle invasion followed by hysterectomy with node diss. can be cured. ...Read more

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My husband was diagnosed with invasive moderately differentiated pulmonary adenocarcinoma. What is the course of treatment?

Your oncologist is t: Your oncologist should guide you in the decisions towards treatment. Cancer treatments are dictated by the stage of disease. So you need to know what stage of lung cancer he has. For early stages, surgery can be the best option but as it goes from stage 1 to 3, chemotherapy and radiotherapy are used in combination. For stage 4 it is mostly chemotherapy which is most useful. ...Read more

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64 YO female, biopse: ulcerated colonic mucosa with moderately differentiated adenocarcinoma ... what does it mean and is there a cure?

64 YO female, biopse: ulcerated colonic mucosa with moderately differentiated adenocarcinoma ... what does it mean and is there a cure?

Yes good out look: If localized has excellent prognosis , get it treated , follow your doctors advise , share your fears with your family and they will give you all the support you need and help you to pass this crisis. good Luck ...Read more

Differentiated (Definition)

The process by which cells become progressively more specialized; a normal process through which cells mature. This process of specialization for the cell comes at the expense of its breadth of potential. Stem cells can, for example, differentiate into secretory ...Read more


Dr. Riley Alexander
127 doctors shared insights

Adenocarcinoma (Definition)

Adenocarcinomas arise from glandular or secretory tissues. They are the common type of tumors (as opposed to sarcomas, from connective tissue) and include the common types colon, lung, ...Read more